UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	C32D5.12	C32D5.12	0	chrII 6,357,672	contains similarity to Pfam domains PF07993 (Male sterility protein) , PF01370 (NAD dependent epimerase/dehydratase family) , PF01073 (3-beta hydroxysteroid dehydrogenase/isomerase family) contains similarity to Interpro domains IPR002225 (3-beta hydroxysteroid dehydrogenase/isomerase), IPR001509 (NAD-dependent epimerase/dehydratase), IPR016040 (NAD(P)-binding), IPR013120 (Male sterility, NAD-binding)
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	F47C12.1	F47C12.1	n/a	chrIV 4,001,937	contains similarity to Pfam domains PF00008 (EGF-like domain) (4), PF00754 (F5/8 type C domain) , PF07645 (Calcium binding EGF domain) (2), PF07699 (GCC2 and GCC3) (3), PF00431 (CUB domain) , PF07974 (EGF-like domain) , PF02494 (HYR domain) (2), PF00084 (Sushi domain (SCR repeat)) (6)contains similarity to Interpro domains IPR001438 (EGF-like, type 2), IPR000742 (EGF-like, type 3), IPR003410 (Hyalin), IPR000436 (Sushi/SCR/CCP), IPR006209 (EGF-like), IPR000152 (Aspartic acid and asparagine hydroxylation site), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR008979 (Galactose-binding like), IPR000859 (CUB), IPR011641 (GCC2 and GCC3), IPR001881 (EGF-like calcium-binding), IPR016060 (Complement control module), IPR009030 (Growth factor, receptor), IPR013032 (EGF-like region, conserved site), IPR000421 (Coagulation factor 5/8 type, C-terminal), IPR013111 (EGF, extracellular), IPR013091 (EGF calcium-binding)
4	W04E12.7	W04E12.7	n/a	chrV 19,731,742	contains similarity to Pfam domain PF06162 Caenorhabditis elegans protein of unknown function (DUF976) contains similarity to Interpro domains IPR010381 (Protein of unknown function DUF976, Caenorhabditis species), IPR016125 (Peptidase C15, pyroglutamyl peptidase I-like)
5	F30A10.2	F30A10.2	n/a	chrI 9,479,884	contains similarity to Staphylococcus aureus ATP-depentend DNA helicase.; TR:Q8NVT1
6	T19D7.3	T19D7.3	n/a	chrX 657,345	contains similarity to Pfam domains PF02822 (Antistasin family) (3), PF00093 (von Willebrand factor type C domain) (4)contains similarity to Interpro domains IPR011061 (Proteinase inhibitor I14/I15, hirudin/antistatin), IPR008037 (Proteinase inhibitor I19, pacifastin), IPR006552 (VWC out), IPR004094 (Proteinase inhibitor I15, antistasin), IPR001007 (von Willebrand factor, type C)
7	C17F4.2	C17F4.2	n/a	chrII 3,249,035
8	nhr-130	T01G6.8	n/a	chrV 482,090	C. elegans NHR-130 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
9	R09D1.12	R09D1.12	n/a	chrII 9,451,202	contains similarity to Pfam domains PF07714 (Protein tyrosine kinase) , PF00069 (Protein kinase domain) contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR008266 (Tyrosine protein kinase, active site)
10	dos-2	K10G6.2	n/a	chrII 3,977,041	C. elegans DOS-2 protein ;
11	C06A6.5	C06A6.5	n/a	chrIV 7,833,492	contains similarity to Pfam domain PF00085 Thioredoxin contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR013766 (Thioredoxin domain), IPR006662 (Thioredoxin-related)
12	T13H5.3	T13H5.3	n/a	chrII 8,522,122	contains similarity to Pfam domain PF00704 Glycosyl hydrolases family 18 contains similarity to Interpro domains IPR011583 (Chitinase II), IPR017853 (Glycoside hydrolase, catalytic core), IPR001223 (Glycoside hydrolase, family 18, catalytic domain), IPR013781 (Glycoside hydrolase, subgroup, catalytic core), IPR001579 (Glycoside hydrolase, chitinase active site), IPR001002 (Chitin-binding, type 1)
13	H23N18.5	H23N18.5	n/a	chrV 4,912,068	contains similarity to Interpro domains IPR016090 (Phospholipase A2), IPR013090 (Phospholipase A2, active site)
14	col-131	C39E9.3	n/a	chrIV 13,066,496	C. elegans COL-131 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR008161 (Collagen helix repeat), IPR008160 (Collagen triple helix repeat)
15	C34C12.6	C34C12.6	n/a	chrIII 3,483,701	contains similarity to Pfam domains PF01105 (emp24/gp25L/p24 family/GOLD) , PF00650 (CRAL/TRIO domain) contains similarity to Interpro domains IPR001251 (Cellular retinaldehyde-binding/triple function, C-terminal), IPR009038 (GOLD), IPR011074 (Phosphatidylinositol transfer protein-like, N-terminal), IPR000348 (emp24/gp25L/p24)
16	gna-1	B0024.12	n/a	chrV 10,319,821	gna-1 encodes one of two C. elegans glucosamine 6-phosphate N-acetyltransferases (GNAs); by homology, GNA-1 is predicted to be required for the formation of UDP-N-acetylglucosamine, a substrate in chitin synthesis, Golgi and cytoplasmic glycosylation, and GPI anchoring; gna-1, like chs-2, is expressed pharyngeally rather than in germline, and (unlike its paralog gna-2) does not have an osmotically-sensitive embryonic lethal RNAi phenotype; as loss of gna-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GNA-1 in C. elegans development and/or behavior is not yet known.
17	W08G11.1	W08G11.1	n/a	chrV 16,348,431	contains similarity to Pfam domains PF00788 (Ras association (RalGDS/AF-6) domain) , PF02204 (Vacuolar sorting protein 9 (VPS9) domain) contains similarity to Interpro domains IPR013995 (Vacuolar sorting protein 9, subgroup), IPR003123 (Vacuolar sorting protein 9), IPR000159 (Ras-association)
18	C38C6.3	C38C6.3	n/a	chrII 14,633,822	contains similarity to Schizosaccharomyces pombe Hypothetical transmembrane protein.; TR:O74525
19	C44C1.2	C44C1.2	n/a	chrX 959,222	contains similarity to Interpro domains IPR011583 (Chitinase II), IPR017853 (Glycoside hydrolase, catalytic core), IPR013781 (Glycoside hydrolase, subgroup, catalytic core)
20	F53H4.5	F53H4.5	n/a	chrX 15,883,542	contains similarity to Pfam domain PF01342 SAND domain contains similarity to Interpro domains IPR010919 (SAND-like), IPR000770 (SAND)
21	dao-3	K07E3.3	n/a	chrX 8,085,329	dao-3 encodes a protein containing tetrahydrofolate dehydrogenase/cyclohydrolase catalytic and NAD(P)-binding domains; by similarity to mammalian enzymes, DAO-3 is predicted to function in one-carbon unit metabolism and thus, in amino acid and nucleotide biosynthesis; dao-3 expression appears to be regulated by daf-2-mediated insulin signaling: microarray experiments suggest that it is upregulated in daf-2 mutant adults, while differential display and Northern analyses suggest that it is down-regulated; a dao-3 promoter gfp fusion is expressed in larvae in the hypodermis and in the nervous system, including tail neurons and phasmids.
22	T14D7.2	T14D7.2	n/a	chrII 8,850,480	T14D7.2 encodes an acyltransferase; large-scale RNAi experiments indicate that T14D7.2 activity is required for egg laying, coordination locomotion, and normal vulval morphology.
23	K09B3.1	K09B3.1	n/a	chrIV 3,795,512	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
24	F18C5.5	F18C5.5	n/a	chrII 6,566,049	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR002373 (cAMP/cGMP-dependent protein kinase)
25	ZC250.3	ZC250.3	n/a	chrV 5,796,478	contains similarity to Pfam domain PF04142 Nucleotide-sugar transporter contains similarity to Interpro domains IPR004689 (UDP-galactose transporter), IPR007271 (Nucleotide-sugar transporter)
26	H03G16.5	H03G16.5	n/a	chrX 15,056,081	contains similarity to Saccharomyces cerevisiae Myo1 is a type II myosin, is localized to the actomyosin ring and is important for cytokinesis.; SGD:YHR023W
27	ptr-6	C54A12.1	n/a	chrII 5,244,628	ptr-6 encodes an ortholog of Drosophila and human PTCHD3, which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; PTR-6 is weakly required for normal molting from L4 to adult stages; however, PTR-6 in conjunction with PTR-1 and PTR-10 is strongly required for both molting and viability, with triple ptr-1/-6/-10 RNAi animals showing pronounced molting defects and lethality; PTR-6 is also required for normal growth to full size and locomotion.
28	C24B5.4	C24B5.4	n/a	chrV 9,196,537	contains similarity to Pfam domain PF08925 Domain of Unknown Function (DUF1907) contains similarity to Interpro domain IPR015021 (Region of unknown function DUF1907)
29	F40F9.5	F40F9.5	n/a	chrV 9,721,836	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
30	ugt-32	F47C10.6	n/a	chrV 3,842,918	C. elegans UGT-32 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
31	lips-9	F58G1.5	n/a	chrII 12,934,548	C. elegans LIPS-9 protein; contains similarity to Pfam domain PF01674 Lipase (class 2) contains similarity to Interpro domain IPR002918 (Lipase, class 2)
32	Y38H6C.16	Y38H6C.16	n/a	chrV 20,532,568	contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domain IPR004151 (C. elegans Sre G protein-coupled chemoreceptor)
33	C02F4.4	C02F4.4	n/a	chrIV 10,514,479	contains similarity to Listeria monocytogenes Hypothetical protein lmo1466.; TR:Q8Y746
34	aps-2	F02E8.3	n/a	chrX 4,458,734	aps-2 encodes an adaptin: specifically, it encodes an ortholog of the sigma2 subunit of adaptor protein complex 2 (AP2), which mediates endocytosis from the plasma membrane; APS-2 is required for embryonic and larval development and for normal body morphogenesis, but is not required for endocytosis of yolk protein in developing oocytes; APS-2 is expressed in nearly all cells during embryogenesis, but during larval and adult stages, expression is confined to neurons and some hypodermal cells, including vulval hypodermal cells during the fourth larval stage.
35	C07E3.10	C07E3.10	n/a	chrII 10,346,620	contains similarity to Saccharomyces cerevisiae Ring finger protein involved in the DNA damage response with possible recombination role; genetically identified by synthetic lethality with SGS1 (DNA helicase) and TOP3 (DNA topoisomerase); sporulation role; interacts with Slx8p and Lin1p; SGD:YDL013W
36	ugt-7	C13D9.9	n/a	chrV 4,998,788	C. elegans UGT-7 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
37	R03E9.2	R03E9.2	n/a	chrX 6,731,598	contains similarity to Interpro domain IPR001220 (Legume lectin, beta domain)
38	C14F11.6	C14F11.6	n/a	chrX 6,238,566	contains similarity to Pfam domain PF00908 dTDP-4-dehydrorhamnose 3,5-epimerase contains similarity to Interpro domains IPR000888 (dTDP-4-dehydrorhamnose 3,5-epimerase related), IPR011051 (Cupin, RmlC-type), IPR014710 (RmlC-like jelly roll fold)
39	T19B10.3	T19B10.3	n/a	chrV 11,224,368	The T19B10.3 gene encodes an ortholog of the human gene GALACTOSIDASE, BETA 1 (GLB1), which when mutated leads to gangliosidosis type I (OMIM:230500).
40	atf-2	K08F8.2	n/a	chrII 8,752,891	C. elegans ATF-2 protein; contains similarity to Pfam domains PF07716 (Basic region leucine zipper) (2), PF00170 (bZIP transcription factor) contains similarity to Interpro domains IPR011700 (Basic leucine zipper), IPR004827 (Basic-leucine zipper (bZIP) transcription factor), IPR011616 (bZIP transcription factor, bZIP-1)
41	sel-7	K04G11.2	n/a	chrX 14,336,558	sel-7 encodes a novel protein with two predicted PEST sequences that is conserved in the related nematode C. briggsae and several parasitic nematodes, but has no known homologs in other organisms; sel-7 was identified in screens for suppressors of dominant lin-12 mutations that result in vulvaless and egg-laying defective animals; although loss of SEL-7 function via mutation or RNAi results in no obvious defects in a wild-type background, genetic studies suggests that SEL-7 acts downstream of LIN-12/Notch to positively regulate LIN-12 signaling, perhaps by regulating the activity or formation of the LAG-1, LIN-12(intra), SEL-8 nuclear complex; in vitro, SEL-7 self-associates and also interacts with TIR-1 (F13B10.1B), a protein that contains sterile alpha and Toll interleukin receptor motifs, and MDT-29 (K08E3.8), a glutamine-rich protein similar to mediator complex subunits, however the functional significance of these interactions is not yet known; a SEL-7::GFP translational fusion reveals expression in the nuclei of several cell types, including vulval precursor cells and those of the developing gonad.
42	C31E10.6	C31E10.6	n/a	chrX 13,997,720	contains similarity to Saccharomyces cerevisiae Mlp proteins restrict telomere length by influencing the Rif1-Tel1 pathway of telomerase regulation; also involved in the translocation of macromolecules between the nucleoplasm and the NPC; SGD:YKR095W
43	pqn-55	R09E10.7	n/a	chrIV 10,289,947	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
44	plx-2	K04B12.1	n/a	chrII 14,421,292	C. elegans PLX-2 protein; contains similarity to Pfam domains PF01833 (IPT/TIG domain) (3), PF01437 (Plexin repeat) (3), PF08337 (Plexin cytoplasmic region) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR002165 (Plexin), IPR008936 (Rho GTPase activation protein), IPR002909 (Cell surface receptor IPT/TIG), IPR001627 (Semaphorin/CD100 antigen), IPR003659 (Plexin/semaphorin/integrin), IPR016201 (Plexin-like fold), IPR013548 (Plexin cytoplasmic region), IPR015943 (WD40/YVTN repeat-like)
45	hnd-1	C44C10.8	n/a	chrX 11,685,111	hnd-1 encodes a Hand bHLH transcription factor required for normal viability, gonadogenesis, and posterior body morphology; HND-1 is required for the formation of both somatic gonadal precursors and primordial germ cells, but not for later gonadogenesis; HND-1 is expressed embryogenesis in embryonic mesodermal precursor cells generating (mostly) body wall muscle, in somatic gonad precursor cells, and in some unidentified head cells; the primary defect in hnd-1 mutants may be, nonautonomously, in mesodermal precursor cells; somatic gonad precursor cells are normally generated in hnd-1 mutants, but not maintained.
46	T21B4.3	T21B4.3	n/a	chrII 12,495,897	contains similarity to Pfam domain PF01681 C6 domain contains similarity to Interpro domain IPR002601 (Protein of unknown function C6)
47	T19B10.5	T19B10.5	n/a	chrV 11,235,863	T19B10.5 encodes a protein with partial similarity to human PERIAXIN (PRX; OMIM:605725), which when mutated leads to Dejerine-Sottas neuropathy.
48	M153.1	M153.1	n/a	chrX 12,147,684	contains similarity to Pfam domains PF03807 (NADP oxidoreductase coenzyme F420-dependent) , PF01210 (NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus) contains similarity to Interpro domains IPR004455 (NADP oxidoreductase, coenzyme F420-dependent), IPR000304 (Delta 1-pyrroline-5-carboxylate reductase), IPR011128 (NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal), IPR016040 (NAD(P)-binding)
49	arr-1	F53H8.2	n/a	chrX 952,505	arr-1 encodes the C. elegans beta-arrestin ortholog (OMIM:107940, 107941, mice lacking beta-arrestin family members display defects in G protein-coupled receptor desensitization); by homology, ARR-1 is predicted to be a multifunctional adaptor protein that interacts with intracellular signaling molecules as well as activated and phosphorylated G protein-coupled and TGF-beta receptors to: 1) downregulate receptor signaling, 2) promote receptor endocytosis, and 3) activate MAP kinase- and Src-dependent signaling pathways; in vivo, arr-1 activity is required for normal egg laying and for proper olfactory adaptation and recovery to volatile odorants; in addition, animals doubly mutant for arr-1 and grk-2, which encodes a G protein-coupled receptor kinase, are sick and slow growing; ARR-1 is detected throughout the nervous system and is highly expressed in the amphid chemosensory neurons; in neuronal cells, ARR-1 appears to be largely cytoplasmic; ARR-1 interacts physically with clathrin and beta2-adaptin, two proteins involved in receptor endocytosis.
50	C34C12.1	C34C12.1	n/a	chrIII 3,455,082	contains similarity to Pfam domain PF06918 Protein of unknown function (DUF1280) contains similarity to Interpro domain IPR009689 (Protein of unknown function DUF1280)