UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	C29F5.1	C29F5.1	0	chrII 6,304,849
2	cyp-33A1	C12D5.7	n/a	chrV 7,680,386	C. elegans CYP-33A1 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV)
3	M03F8.1	M03F8.1	n/a	chrV 5,952,583
4	wrt-6	ZK377.1	n/a	chrX 3,481,938	wrt-6 encodes a hedgehog-like protein, with (from N- to C-terminus) a signal sequence, a Wart domain, an short region of low-complexity sequence, and a Hint/Hog domain; WRT-6 is expressed in sheath and socket cells of anterior sensilla, seam cells, and hypodermis; the Hint/Hog domain is predicted to cut WRT-6 into two halves and then covalently link cholesterol to the C-terminus of the Wart domain; the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; WRT-6 is weakly required for normal molting; WRT-6 is also required for normal growth to full size and locomotion; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
5	T07C12.9	T07C12.9	n/a	chrV 9,957,579	contains similarity to Pfam domain PF01234 NNMT/PNMT/TEMT family contains similarity to Interpro domain IPR000940 (Methyltransferase, NNMT/PNMT/TEMT)
6	col-68	C50D2.4	n/a	chrII 105,181	C. elegans COL-68 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002952 (Eggshell protein), IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR008160 (Collagen triple helix repeat)
7	T20B3.1	T20B3.1	n/a	chrV 16,818,064	contains similarity to Pfam domain PF00755 Choline/Carnitine o-acyltransferase contains similarity to Interpro domain IPR000542 (Acyltransferase ChoActase/COT/CPT)
8	ZK899.2	ZK899.2	n/a	chrX 9,451,048	contains similarity to Aedes aegypti Putative uncharacterized protein.; TR:Q16QQ2
9	hsp-4	F43E2.8	n/a	chrII 7,351,305	hsp-4 encodes a predicted homolog of the mammalian ER chaperone BiP that affects embryonic and larval viability; expression is most prominent in the spermatheca and transcription of hsp-4 is induced in the gut and in the hypodermis upon ER stress.
10	R08C7.5	R08C7.5	n/a	chrIV 4,431,281	contains similarity to Pfam domain PF03941 Inner centromere protein, ARK binding region contains similarity to Interpro domains IPR005819 (Histone H5), IPR005635 (Inner centromere protein, ARK binding region)
11	his-7	F45F2.4	n/a	chrV 8,533,548	his-7 encodes an H2A histone.
12	T14D7.1	T14D7.1	n/a	chrII 8,847,171	T14D7.1 is orthologous to the human gene ALANINE-GLYOXYLATE AMINOTRANSFERASE HOMOLOG (AGXT; OMIM:604285), which when mutated leads to disease.
13	pqn-5	C03A7.4	n/a	chrV 5,159,245	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
14	let-721	C05D11.12	n/a	chrIII 6,445,833	The let-721 gene encodes an ortholog of the human gene SIMILAR TO ELECTRON-TRANSFERRING-FLAVOPROTEIN DEHYDROGENASE (ETFDH), which when mutated leads to glutaricaciduria type IIC (OMIM:231675).
15	F21C10.7	F21C10.7	n/a	chrV 9,117,429	contains similarity to Pfam domains PF07686 (Immunoglobulin V-set domain) (2), PF00047 (Immunoglobulin domain) (3), PF07679 (Immunoglobulin I-set domain) (6)contains similarity to Interpro domains IPR003598 (Immunoglobulin subtype 2), IPR002017 (Spectrin repeat), IPR013098 (Immunoglobulin I-set), IPR013783 (Immunoglobulin-like fold), IPR013106 (Immunoglobulin V-set), IPR007110 (Immunoglobulin-like), IPR003599 (Immunoglobulin subtype), IPR013151 (Immunoglobulin)
16	B0416.1	B0416.1	n/a	chrX 9,307,010	contains similarity to Pfam domain PF07810 TMC domain contains similarity to Interpro domain IPR012496 (TMC)
17	imp-2	T05E11.5	n/a	chrIV 11,117,784	C. elegans IMP-2 protein; contains similarity to Pfam domain PF04258 Signal peptide peptidase contains similarity to Interpro domains IPR006639 (Peptidase A22, presenilin signal peptide), IPR007369 (Peptidase A22B, signal peptide peptidase)
18	R06B10.1	R06B10.1	n/a	chrIII 969,326	contains similarity to Pfam domains PF02206 (Domain of unknown function) , PF00102 (Protein-tyrosine phosphatase) contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR016130 (Protein-tyrosine phosphatase, active site), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type), IPR000387 (Protein-tyrosine phosphatase), IPR003125 (Protein of unknown function WSN)
19	K09E10.2	K09E10.2	n/a	chrIV 12,309,919	contains similarity to Pfam domain PF01757 Acyltransferase family contains similarity to Interpro domain IPR002656 (Acyltransferase 3)
20	T01E8.5	T01E8.5	n/a	chrII 10,245,041	contains similarity to Pfam domain PF08424 Protein of unknown function (DUF1740) contains similarity to Interpro domain IPR013633 (Protein of unknown function DUF1740)
21	col-79	C09G5.3	n/a	chrII 10,703,993	C. elegans COL-79 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR008160 (Collagen triple helix repeat)
22	B0393.5	B0393.5	n/a	chrIII 4,772,641	contains similarity to Pfam domains PF00008 (EGF-like domain) (2), PF07645 (Calcium binding EGF domain) (6), PF06119 (Nidogen-like) (2)contains similarity to Interpro domains IPR003886 (Nidogen, extracellular region), IPR001438 (EGF-like, type 2), IPR001881 (EGF-like calcium-binding), IPR000742 (EGF-like, type 3), IPR013032 (EGF-like region, conserved site), IPR006209 (EGF-like), IPR000152 (Aspartic acid and asparagine hydroxylation site), IPR013091 (EGF calcium-binding), IPR006210 (EGF)
23	itx-1	W03D8.6	n/a	chrI 2,809,305	itx-1 encodes one of two Caspr orthologues found in the C. elegans genome; Caspr proteins belong to the Neurexin superfamily and are involved in mediating cell-cell contacts and in the formation of specialized membrane-domains in polarized epithelial and nerve cells; RNA interference of itx-1 suggests that itx-1 is involved in the correct positioning and maintenance of apical junctions and in maintaining epithelial integrity in the gut; gfp-reporter studies indicate that ITX-1 is expressed in intestinal cell epithelia and in the socket cells of the inner and outer labial sensilla; immunofluorescence studies indicate that ITX-1 localizes to the baso-lateral membranes of intestinal epithelia.
24	ptr-1	C24B5.3	n/a	chrV 9,179,855	ptr-1 encodes an ortholog of Drosophila and human PTCHD3, which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; individually, PTR-1 is weakly required for normal molting from L4 to adult stages; however, PTR-1, in conjunction with either PTR-16 alone or with PTR-6 and PTR-10, is strongly required for both molting and viability, with double ptr-1/-16 or triple ptr-1/-6/-10 RNAi animals showing pronounced molting defects and lethality; PTR-1 is also required for normal adult alae formation, growth to full size, locomotion, and male tail development.
25	T05B4.12	T05B4.12	n/a	chrV 4,124,080	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
26	kcc-1	R13A1.2	n/a	chrIV 7,215,841	C. elegans KCC-1 protein; contains similarity to Pfam domain PF00324 Amino acid permease contains similarity to Interpro domains IPR000076 (K-Cl co-transporter), IPR004841 (Amino acid permease-associated region), IPR006029 (Neurotransmitter-gated ion-channel transmembrane region)
27	col-182	R09A8.4	n/a	chrX 12,636,305	C. elegans COL-182 protein; contains similarity to Pfam domain PF01391 Collagen triple helix repeat (20 copies) contains similarity to Interpro domain IPR008160 (Collagen triple helix repeat)
28	atf-5	T04C10.4	n/a	chrX 14,809,925	atf-5 encodes a homolog of the mammalian bZIP transcription factors ATF4 and ATF5, analogous to GCN4 in S. cerevisiae; like like ATF4 and GCN4, atf-5 has an extensive 5' UTR with one 37-residue uORF; ATF4 is poorly translated in unstressed cells but well-translated during ER stress, amino acid starvation, or arsenite treatment; possibly atf-5 is also translationally regulated in a way similar to ATF4.
29	C03H12.1	C03H12.1	n/a	chrX 15,692,830	contains similarity to Interpro domain IPR012336 (Thioredoxin-like fold)
30	gbf-1	C24H11.7	n/a	chrIII 11,762,525	C. elegans GBF-1 protein; contains similarity to Pfam domain PF01369 Sec7 domain contains similarity to Interpro domains IPR008979 (Galactose-binding like), IPR000904 (SEC7-like)
31	ZK180.6	ZK180.6	n/a	chrIV 4,522,552	contains similarity to Interpro domain IPR000694 (Proline-rich region)
32	chc-1	T20G5.1	n/a	chrIII 10,206,656	chc-1 encodes the C. elegans clathrin heavy chain ortholog; loss of chc-1 activity via RNAi results in defects in receptor-mediated yolk endocytosis and thus, embryonic lethality.
33	sec-23	Y113G7A.3	n/a	chrV 20,093,804	C. elegans SEC-23 protein; contains similarity to Pfam domains PF04811 (Sec23/Sec24 trunk domain) , PF04815 (Sec23/Sec24 helical domain) , PF04810 (Sec23/Sec24 zinc finger) , PF00626 (Gelsolin repeat) , PF08033 (Sec23/Sec24 beta-sandwich domain) contains similarity to Interpro domains IPR006900 (Sec23/Sec24 helical region), IPR012990 (Sec23/Sec24 beta-sandwich), IPR006896 (Sec23/Sec24 trunk region), IPR006895 (Zinc finger, Sec23/Sec24-type), IPR007123 (Gelsolin region)
34	ZK84.1	ZK84.1	n/a	chrII 6,021,961	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR003980 (Histamine H3 receptor)
35	gex-2	F56A11.1	n/a	chrIV 578,227	The gex-2 gene encodes a homolog of p140/Sra-1, a mammalian protein ligand of the small GTPase Rac1; gex-2 is required for tissue morphogenesis and cell migrations.
36	T06E4.9	T06E4.9	n/a	chrV 9,620,523	contains similarity to Interpro domain IPR000694 (Proline-rich region)
37	Y75B8A.4	Y75B8A.4	n/a	chrIII 12,110,492	contains similarity to Pfam domains PF07726 (ATPase family associated with various cellular activities (AAA)) , PF00004 (ATPase family associated with various cellular activities (AAA)) , PF05362 (Lon protease (S16) C-terminal proteolytic domain) , PF07728 (ATPase family associated with various cellular activities (AAA)) contains similarity to Interpro domains IPR003959 (AAA ATPase, core), IPR000767 (Disease resistance protein), IPR011704 (ATPase associated with various cellular activities, AAA-5), IPR011703 (ATPase associated with various cellular activities, AAA-3), IPR004815 (Peptidase S16, ATP-dependent protease La), IPR008269 (Peptidase S16, lon C-terminal), IPR003111 (Peptidase S16, lon N-terminal), IPR003593 (AAA+ ATPase, core), IPR001984 (Peptidase S16, Lon protease)
38	cogc-6	K07C11.9	n/a	chrV 8,219,777	cogc-6 encodes an ortholog of mammalian COG-6, a subunit of lobe B of the conserved oligomeric Golgi complex (COGC); COGC-6 is weakly required for normal gonadal distal tip cell migration, a process that also requires seven other orthologs of COGC subunits; like other lobe B subunits in both C. elegans and S. cerevisiae, COGC-6 is only partially required for normal function, while lobe A subunits are strongly required in either worms or yeast.
39	col-113	C34D4.15	n/a	chrIV 7,151,565	C. elegans COL-113 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR009143 (Wnt-6 protein), IPR008161 (Collagen helix repeat), IPR008160 (Collagen triple helix repeat)
40	dre-1	K04A8.6	n/a	chrV 6,535,821	dre-1 encodes an ortholog of human FBXO11/PRMT9 (OMIM:607871, associated with vitiligo and otitis media) that is required, in conjunction with DAF-12 and its partners, for global developmental timing of the transistion from larval to adult cell fates; DRE-1 has an N-terminal F-box domain, three central tandem C-terminal CASH domains, and a C-terminal zinc finger; hypomorphic dre-1 mutations are synthetically heterochronic with loss-of-function daf-12 alleles, inducing defective distal tip cell migration and precocious fusion of seam cells; five different hypomorphic dre-1 alleles alter conserved glycine residues in the CASH domain region, whereas the null dre-1(hd60) allele is lethal at the three-fold embryo stage; DRE-1 is expressed in many tissues, including epidermal and distal tip cells, and localizes to both nucleus and cytoplasm; strong loss-of-function of dre-1 (the dh99 mutant fed RNAi) induces defects at all four molts; dre-1 also has synthetic phenotypes with daf-9(k182), daf-36(k114), and lin-29(n546); dre-1-like enhancement of daf-12 is also seen in skr-1(RNAi), cul-1(RNAi), or rbx-1/2(RNAi) animals; DRE-1 and SKR-1 bind one another, as do their human orthologs; DRE-1 affects lin-29 expression, and is suppressed by lin-42(RNAi); DRE-1 is paralogous to C. elegans BE0003N10.3.
41	erv-46	K09E9.2	n/a	chrX 15,615,388	C. elegans ERV-46 protein; contains similarity to Pfam domain PF07970 Protein of unknown function (DUF1692) contains similarity to Interpro domain IPR012936 (Protein of unknown function DUF1692)
42	K07H8.3	K07H8.3	n/a	chrIV 8,290,863	contains similarity to Pfam domain PF00583 Acetyltransferase (GNAT) family contains similarity to Interpro domains IPR000182 (GCN5-related N-acetyltransferase), IPR016181 (Acyl-CoA N-acyltransferase)
43	F40E10.5	F40E10.5	n/a	chrX 14,702,656	contains similarity to Onchocerca volvulus OV39 antigen (Fragment).; SW:P31730
44	hum-5	T02C12.1	n/a	chrIII 4,032,950	C. elegans HUM-5 protein; contains similarity to Pfam domains PF00612 (IQ calmodulin-binding motif) , PF06017 (Myosin tail) , PF00063 (Myosin head (motor domain)) contains similarity to Interpro domains IPR010926 (Myosin tail 2), IPR000048 (IQ calmodulin-binding region), IPR001609 (Myosin head, motor region)
45	Y113G7B.16	Y113G7B.16	n/a	chrV 20,268,307	contains similarity to Pfam domain PF05600 Protein of unknown function (DUF773) contains similarity to Interpro domain IPR008491 (Protein of unknown function DUF773)
46	clec-186	ZK896.7	n/a	chrIV 12,867,615	C. elegans CLEC-186 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
47	ost-1	C44B12.2	n/a	chrIV 1,109,128	ost-1 encodes the C. elegans ortholog of the conserved basement membrane glycoprotein component osteonectin/SPARC/BM-40; loss of ost-1 function via RNAi indicates that ost-1 activity is required for embryonic and larval development, as well as for normal gut development, body size, and fecundity; an OST-1::GFP reporter fusion protein localizes to the basement membranes along body wall and sex muscles, as well as around the pharynx and gonad, with particular concentration at the spermatheca and distal tip cells.
48	F47F6.3	F47F6.3	n/a	chrII 1,264,985	contains similarity to Pfam domain PF01757 Acyltransferase family contains similarity to Interpro domain IPR002656 (Acyltransferase 3)
49	Y32F6B.1	Y32F6B.1	n/a	chrV 10,482,818	contains similarity to Pfam domain PF03137 Organic Anion Transporter Polypeptide (OATP) family contains similarity to Interpro domains IPR004156 (Organic anion transporter polypeptide OATP), IPR016196 (MFS general substrate transporter)
50	F42A10.3	F42A10.3	n/a	chrIII 6,156,244	contains similarity to Pfam domain PF01234 NNMT/PNMT/TEMT family contains similarity to Interpro domain IPR000940 (Methyltransferase, NNMT/PNMT/TEMT)