UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	C29F4.2	C29F4.2	0	chrIV 11,228,390	contains similarity to Pfam domain PF01062 Bestrophin contains similarity to Interpro domain IPR000615 (Bestrophin)
2	col-98	F14F7.1	n/a	chrIII 13,019,448	C. elegans COL-98 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (2)contains similarity to Interpro domains IPR000596 (Cholecystokinin receptor, type A), IPR002952 (Eggshell protein), IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR009143 (Wnt-6 protein), IPR008160 (Collagen triple helix repeat), IPR013286 (Annexin, type VII)
3	F26E4.6	F26E4.6	n/a	chrI 9,773,519	contains similarity to Pfam domain PF02935 Cytochrome c oxidase subunit VIIc contains similarity to Interpro domain IPR004202 (Cytochrome c oxidase subunit VIIc)
4	tag-290	F35B12.6	n/a	chrV 11,614,053	C. elegans TAG-290 protein; contains similarity to Pfam domain PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain contains similarity to Interpro domains IPR002223 (Proteinase inhibitor I2, Kunitz metazoa), IPR006150 (Cysteine-rich repeat)
5	R09F10.1	R09F10.1	n/a	chrX 8,324,257	contains similarity to Pfam domains PF08246 (Cathepsin propeptide inhibitor domain (I29)) , PF00112 (Papain family cysteine protease) contains similarity to Interpro domains IPR013128 (Peptidase C1A, papain), IPR000169 (Peptidase, cysteine peptidase active site), IPR013201 (Proteinase inhibitor I29, cathepsin propeptide), IPR000668 (Peptidase C1A, papain C-terminal)
6	col-103	F56B3.1	n/a	chrIV 763,047	C. elegans COL-103 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002952 (Eggshell protein), IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR000817 (Prion protein), IPR008160 (Collagen triple helix repeat), IPR013286 (Annexin, type VII)
7	col-141	T15B7.5	n/a	chrV 6,830,181	C. elegans COL-141 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR008160 (Collagen triple helix repeat)
8	C50F7.4	C50F7.4	n/a	chrIV 7,729,765	contains similarity to Pfam domains PF08442 (ATP-grasp domain) , PF00549 (CoA-ligase) contains similarity to Interpro domains IPR013650 (ATP-grasp fold, succinyl-CoA synthetase-type), IPR005811 (ATP-citrate lyase/succinyl-CoA ligase), IPR005809 (Succinyl-CoA synthetase, beta subunit), IPR013815 (ATP-grasp fold, subdomain 1), IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR013816 (ATP-grasp fold, subdomain 2), IPR016102 (Succinyl-CoA synthetase-like)
9	F20A1.9	F20A1.9	n/a	chrV 7,050,345	contains similarity to Pfam domains PF04326 (Divergent AAA domain) , PF00622 (SPRY domain) contains similarity to Interpro domains IPR001870 (B302, (SPRY)-like), IPR003877 (SPla/RYanodine receptor SPRY), IPR007421 (ATPase associated with various cellular activities, AAA-4)
10	T11G6.3	T11G6.3	n/a	chrIV 10,853,967	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
11	ZK1193.2	ZK1193.2	n/a	chrX 411,499	contains similarity to Pfam domains PF00092 (von Willebrand factor type A domain) , PF00059 (Lectin C-type domain) contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR002049 (EGF-like, laminin), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR013032 (EGF-like region, conserved site), IPR001304 (C-type lectin), IPR006582 (Region of unknown fuction MD, Caenorhabditis elegans), IPR002035 (von Willebrand factor, type A)
12	F52B5.3	F52B5.3	n/a	chrI 8,321,160	The F52B5.3 gene encodes a DEAH helicase orthologous to the Drosophila SpindleE protein.
13	F55G1.9	F55G1.9	n/a	chrIV 7,476,741	contains similarity to Pfam domain PF03807 NADP oxidoreductase coenzyme F420-dependent contains similarity to Interpro domains IPR004455 (NADP oxidoreductase, coenzyme F420-dependent), IPR000304 (Delta 1-pyrroline-5-carboxylate reductase), IPR016040 (NAD(P)-binding)
14	Y37A1B.5	Y37A1B.5	n/a	chrIV 14,053,897	contains similarity to Pfam domain PF05694 56kDa selenium binding protein (SBP56) contains similarity to Interpro domains IPR008826 (Selenium-binding protein), IPR015943 (WD40/YVTN repeat-like)
15	C07D8.6	C07D8.6	n/a	chrX 7,342,092	contains similarity to Pfam domain PF00248 Aldo/keto reductase family contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)
16	spr-1	D1014.8	n/a	chrV 8,128,020	spr-1 encodes the C. elegans ortholog of the human corepressor CoREST that functions in HDAC-containing complexes to mediate transcriptional repression; in C. elegans, spr-1 was first identified in screens for genetic suppressors of the egg-laying defective phenotype of sel-12/presenilin mutants; subsequent genetic analyses showed that spr-1 likely functions as a negative regulator of LIN-12/Notch signaling in multiple cells, including those of the somatic gonad, vulva, and early embryo; spr-1 also interacts genetically with sem-5 to regulate postembryonic growth rates and lin-35Rb to regulate vulval morphogenesis and germline proliferation; in binding assays and yeast two-hybrid experiments, SPR-1 interacts with SPR-5, the C. elegans ortholog of the LSD1 histone demethylase; an SPR-1::MYC fusion protein expressed under the control of the cog-2 promoter localizes to the nucleus and shows increased staining in nuclear speckles and what appears to be the nucleolus.
17	B0495.2	B0495.2	n/a	chrII 7,700,550	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR008351 (JNK MAP kinase), IPR002290 (Serine/threonine protein kinase), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core)
18	C26E1.2	C26E1.2	n/a	chrV 13,306,168	contains similarity to Interpro domain IPR000169 (Eukaryotic thiol (cysteine) protease)
19	ddb-1	M18.5	n/a	chrIV 12,117,957	M18.5 is orthologous to the human gene DAMAGE-SPECIFIC DNA BINDING PROTEIN 1 (127KD) (DDB1; OMIM:600045), which when mutated leads to disease.
20	T01G1.3	T01G1.3	n/a	chrIV 11,368,676	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR000694 (Proline-rich region), IPR002110 (Ankyrin), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
21	C32D5.3	C32D5.3	n/a	chrII 6,319,574	C32D5.3 encodes an ortholog of ROLLING BLACKOUT (RBO; also called CMP44E or STAMPHA), a eukaryotic protein required for sustained phospholipase C activity during Drosophila phototransduction; RBO homologs have two predicted transmembrane helices, are significantly similar to several acylglycerol lipases, and share motifs characteristic of carboxyesterases and lipases.
22	cid-1	K10D2.3	n/a	chrIII 5,177,184	cid-1 (also known as pup-1) encodes a template-independent poly(U) polymerase with 3'' end RNA substrates, orthologous to human ZCCHC6 and ZCCHC11, and paralogous to PUP-2; CID-1 prevents larvae from growing to adulthood in media containing hydroxyurea (HU, a drug that stalls replication forks) and represses HSP-4 expression; CID-1 is required for gonadogenesis, embryonic and vulval development, normally rapid growth, and normally short lifespan; CID-1, like HSP-4, is expressed in postmitotic intestinal cells; by orthology with Cid1p in fission yeast, CID-1 is predicted to act in a DNA synthesis-to-mitosis checkpoint; in cid-1(rf35::Tc4) mutants or cid-1(RNAi) animals grow from L1 larvae to adulthood despite the presence of HU, are abnormally resistant to lethal heat shock, overexpress hsp-4::GFP, have protruding vulvae, have abnormally short and thick gonads with fewer germ cells than normal, produce disorganized embryos, grow slowly, and have abnormally long lifespans; CID-1 and its eukaryotic homologs are distantly related to the GLD-2 family of poly(A) polymerases.
23	D2085.6	D2085.6	n/a	chrII 8,660,679	D2085.6 is orthologous to the human gene CLASS A GLCNAC-INOSITOL PHOSPHOLIPID ASSEMBLY PROTEIN (PIGA; OMIM:311770), which when mutated leads to paroxysmal nocturnal hemoglobinuria.
24	F02D8.4	F02D8.4	n/a	chrV 14,986,177	contains similarity to Pfam domain PF00246 Zinc carboxypeptidase contains similarity to Interpro domains IPR000834 (Peptidase M14, carboxypeptidase A), IPR009020 (Proteinase inhibitor, propeptide)
25	math-8	C16C4.13	n/a	chrII 1,888,192	C. elegans MATH-8 protein; contains similarity to Pfam domain PF00917 MATH domain contains similarity to Interpro domains IPR008974 (TRAF-like), IPR002083 (MATH)
26	CD4.8	CD4.8	n/a	chrV 5,600,286	contains similarity to Pfam domain PF04435 Domain of unknown function (DUF545) contains similarity to Interpro domain IPR006570 (SPK)
27	D2007.4	D2007.4	n/a	chrIII 8,145,419	contains similarity to Drosophila melanogaster Flybase gene name is mRpL18-PA;; FLYBASE:CG12373
28	ZC376.2	ZC376.2	n/a	chrV 14,173,463	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domains IPR002018 (Carboxylesterase, type B), IPR002000 (Lysosome-associated membrane glycoprotein (Lamp)/CD68)
29	W07G4.4	W07G4.4	n/a	chrV 13,045,013	contains similarity to Pfam domain PF00883 Cytosol aminopeptidase family, catalytic domain contains similarity to Interpro domain IPR000819 (Peptidase M17, leucyl aminopeptidase, C-terminal)
30	coq-8	C35D10.4	n/a	chrIII 4,865,152	coq-8 encodes a putative protein kinase orthologous to ABC1 (COQ8) from S. cerevisiae and UbiB from E. coli, and paralogous to C. elegans D2023.6 and its (uncharacterized) eukaryotic orthologs; COQ-8 is required for ubiquinone (coenzyme Q9) biosynthesis and for normally short lifespan; alternative hypotheses for COQ-8's biochemical function are that it is a 2-polyprenylphenol 6-hydroxylase, or that it may activate proteins necessary for monooxygenase activity via phosphorylation; coq-8 is expressed in several tissues during larval development, but in later adult life its expression is restricted to neurons; coq-8 mutants have slowed pharyngeal pumping, and eventually arrest as paralysed larvae before dying; coq-8(RNAi) animals have reduced levels of coenzyme Q9 and superoxide, and have abnormally long lifespans; coq-8 mutants are not rescued by dietary coenzyme Q.
31	cya-2	F59H6.7	n/a	chrII 2,023,091	C. elegans CYA-2 protein; contains similarity to Pfam domain PF00134 Cyclin, N-terminal domain contains similarity to Interpro domains IPR006670 (Cyclin), IPR011028 (Cyclin-like), IPR013763 (Cyclin-related), IPR006671 (Cyclin, N-terminal)
32	F10F2.2	F10F2.2	n/a	chrIII 4,631,042	contains similarity to Pfam domains PF02769 (AIR synthase related protein, C-terminal domain) (2), PF00586 (AIR synthase related protein, N-terminal domain) contains similarity to Interpro domains IPR016188 (PurM, N-terminal-like), IPR001220 (Legume lectin, beta domain), IPR000728 (AIR synthase related protein), IPR010073 (Phosphoribosylformylglycinamidine synthase, eukaryotes and proteobacteria), IPR010918 (AIR synthase related protein, C-terminal), IPR002016 (Haem peroxidase, plant/fungal/bacterial)
33	ugt-19	K08B4.3	n/a	chrIV 6,078,341	C. elegans UGT-19 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
34	F07A11.5	F07A11.5	n/a	chrII 11,613,153	contains similarity to Pfam domain PF00294 pfkB family carbohydrate kinase contains similarity to Interpro domains IPR011611 (Carbohydrate/purine kinase), IPR011877 (Ribokinase, bacterial), IPR002139 (Ribokinase)
35	T19C9.8	T19C9.8	n/a	chrV 17,239,506	contains similarity to Amsacta moorei entomopoxvirus AMV141.; TR:Q9EMQ8
36	6R55.2	6R55.2	n/a	chrX 17,713,765
37	fbxa-58	C29F9.11	n/a	chrIII 110,182	C. elegans FBXA-58 protein; contains similarity to Pfam domains PF01827 (FTH domain) , PF00646 (F-box domain) contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
38	W01A11.1	W01A11.1	n/a	chrV 6,500,809	contains similarity to Pfam domains PF06441 (Epoxide hydrolase N terminus) , PF00561 (alpha/beta hydrolase fold) contains similarity to Interpro domains IPR016292 (Epoxide hydrolase), IPR000073 (Alpha/beta hydrolase fold-1), IPR000639 (Epoxide hydrolase-like), IPR010497 (Epoxide hydrolase, N-terminal)
39	C26E1.3	C26E1.3	n/a	chrV 13,303,181	contains similarity to Interpro domains IPR001356 (Homeobox), IPR009057 (Homeodomain-like)
40	fbxa-51	T12B5.1	n/a	chrIII 962,902	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
41	hrd-1	F55A11.3	n/a	chrV 11,768,584	C. elegans HRD-1 protein; contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR000694 (Proline-rich region), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR011016 (Zinc finger, variant RING-type)
42	C30H6.7	C30H6.7	n/a	chrIV 17,381,384	contains similarity to Pfam domains PF00198 (2-oxoacid dehydrogenases acyltransferase (catalytic domain)) , PF02817 (e3 binding domain) contains similarity to Interpro domains IPR004167 (E3 binding), IPR001078 (Catalytic domain of components of various dehydrogenase complexes)
43	T20F5.3	T20F5.3	n/a	chrI 3,910,087	contains similarity to Pfam domain PF01765 Ribosome recycling factor contains similarity to Interpro domains IPR002661 (Ribosome recycling factor), IPR001669 (Arginine repressor)
44	F19F10.9	F19F10.9	n/a	chrV 7,573,793	The F19F10.9 gene encodes a homolog of the human SART1 gene, which encodes a protein recognised by IgE that may be involved in atopic disease.
45	nas-38	F57C12.1	n/a	chrX 560,901	C. elegans NAS-38 protein; contains similarity to Pfam domains PF00431 (CUB domain) , PF00090 (Thrombospondin type 1 domain) , PF01400 (Astacin (Peptidase family M12A)) contains similarity to Interpro domains IPR000884 (Thrombospondin, type I), IPR006025 (Peptidase M, neutral zinc metallopeptidases, zinc-binding site), IPR001506 (Peptidase M12A, astacin), IPR006026 (Peptidase, metallopeptidases), IPR000859 (CUB), IPR013032 (EGF-like region, conserved site)
46	cul-6	K08E7.7	n/a	chrIV 12,588,438	cul-6 encodes a member of the cullin family that may physically interact with SKR-3.
47	lpd-2	C48E7.3	n/a	chrI 6,254,291	C. elegans LPD-2 protein; contains similarity to Interpro domain IPR010916 (TonB box, conserved site)
48	F55A3.6	F55A3.6	n/a	chrI 10,784,384	contains similarity to Pfam domain PF00334 Nucleoside diphosphate kinase contains similarity to Interpro domain IPR001564 (Nucleoside diphosphate kinase, core)
49	Y57G11C.4	Y57G11C.4	n/a	chrIV 14,766,103	contains similarity to Pfam domain PF05008 Vesicle transport v-SNARE protein contains similarity to Interpro domains IPR000727 (Target SNARE coiled-coil region), IPR007705 (Vesicle transport v-SNARE)
50	acl-3	ZK809.2	n/a	chrIV 11,651,359	acl-3 encodes a phosphate acyltransferase that is orthologous to human tafazzin (TAZ; OMIM:300394, mutated in Barth syndrome); by homology, ACL-3 is predicted to be a mitochondrial protein that plays a role in phospholipid metabolism, although loss of acl-3 activity via large-scale RNAi screens results in no obvious defects.