UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	C27D9.1	C27D9.1	0	chrII 4,754,512	contains similarity to Pfam domain PF06542 Protein of unknown function (DUF1114) contains similarity to Interpro domain IPR009497 (Protein of unknown function DUF1114)
2	fem-3	C01F6.4	n/a	chrIV 9,106,267	fem-3 encodes a novel protein that promotes male development in all tissues.
3	C27C12.3	C27C12.3	n/a	chrX 14,864,682	C27C12.3 encodes a novel protein that is conserved in C. elegans; three other genes related to C27C12.3 are present in tandem on the X chromosome; in situ hybridization studies indicate that C27C12.3 mRNA is expressed in the proximal germline.
4	R02F2.4	R02F2.4	n/a	chrIII 5,485,028	R02F2.4 encodes a protein with six chitin-binding peritrophin-A domains; R02F2.4 transcripts are enriched during oogenesis; like CEJ-1 and CPG-2, R02F2.4 might participate in eggshell synthesis and early embryonic development, and R02F2.4's multiple peritrophin-A domains might enable mechanical cross-linking of chitin; however, R02F2.4 has no obvious function in mass RNAi assays; while R02F2.4 is more closely similar to CPG-2 than CEJ-1, it may be less strongly expressed (since it has substantially fewer ESTs) and thus be less important in development.
5	C50E3.13	C50E3.13	n/a	chrV 7,623,254
6	C08F8.3	C08F8.3	n/a	chrIV 11,155,803	contains similarity to Gallus gallus Dosal neuron-tube nuclear protein.; TR:Q8QHJ7
7	F17C11.10	F17C11.10	n/a	chrV 10,963,667	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR009071 (High mobility group box, HMG), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
8	T04A8.8	T04A8.8	n/a	chrIII 4,694,596	contains similarity to Homo sapiens;Mus musculus;Rattus norvegicus;Bos taurus;Sus scrofa Ubiquitin-like protein SMT3B (Sentrin 2) (HSMT3).; SW:SM32_HUMAN
9	zif-1	F59B2.6	n/a	chrIII 9,003,725	zif-1 encodes a SOCS-box protein that promotes establishment of the germ line by targetting germline proteins for cullin-dependent degradation in non-germline (somatic) cells; ZIF-1 binds germline CCCH-(zinc)-finger proteins and the E3 ubiquitin ligase subunit elongin C (ELC-1); while ZIF-1 has no obvious homologs, it may be analogous to the Drosophila SOCS-box protein GUSTAVUS, which is required for VASA localization to the germline and which does have mammalian homologs.
10	T28A8.4	T28A8.4	n/a	chrIII 13,504,444	contains similarity to Pfam domain PF04435 Domain of unknown function (DUF545) contains similarity to Interpro domain IPR006570 (SPK)
11	F54F7.2	F54F7.2	n/a	chrX 11,844,424
12	ZC477.5	ZC477.5	n/a	chrIV 7,102,332
13	F32D1.6	F32D1.6	n/a	chrV 4,374,245
14	zyg-11	C08B11.1	n/a	chrII 8,019,153	zyg-11 encodes a protein containing four diverged leucine-rich repeats and an armadillo-like helical domain and is conserved in metazoa, but not found in Drosophila; during development, ZYG-11 functions as the substrate-recognition subunit for a CUL-2-based ubiquitin-ligase complex that is required for a number of biological processes including progression through meiotic anaphase II, mitotic chromosome condensation, and establishment of anterior/posterior polarity in the early embryo; ZYG-11 interacts with CUL-2 in vivo and with ELC-1/elongin C in vitro.
15	C31H1.8	C31H1.8	n/a	chrIV 5,812,882	contains similarity to Homo sapiens Protocadherin 15; ENSEMBL:ENSP00000378832
16	W03C9.2	W03C9.2	n/a	chrII 11,963,758	contains similarity to Schizosaccharomyces pombe Transcription elongation factor S-II (TFIIS).; SW:TFS2_SCHPO
17	C17F4.5	C17F4.5	n/a	chrII 3,247,215	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
18	let-99	K08E7.3	n/a	chrIV 12,569,200	let-99 encodes a protein with a DEP domain (Domain found in Dishevelled, Egl-10, and Pleckstrin); LET-99 has no obvious homologs in non-nematodes, but has a truncated paralog (LRG-1) in C. elegans; LET-99 is required for the mitotic spindle to be properly oriented with respect to the axis of cellular polarity, both during anterior migration and rotation of the nuclear-centrosome complex and during anaphase; let-99 mutants exhibit hyperactive nuclear movement and abnormal anaphase spindle pole behavior; LET-99 is mislocalized in par-2 and par-3 mutants; like other proteins containing DEP domains, LET-99 may act as part of a G protein signalling pathway (e.g., the one controlling spindle position).
19	C29A12.1	C29A12.1	n/a	chrV 10,812,876	contains similarity to Mesocricetus auratus Synaptonemal complex protein 1 (SCP-1 protein) (Meiotic chromosomessynaptic protein) (Fragment).; SW:SCP1_MESAU
20	try-1	ZK546.15	n/a	chrII 4,948,807	C. elegans TRY-1 protein; contains similarity to Pfam domain PF00089 Trypsin contains similarity to Interpro domains IPR001314 (Peptidase S1A, chymotrypsin), IPR001254 (Peptidase S1 and S6, chymotrypsin/Hap), IPR009003 (Peptidase, trypsin-like serine and cysteine), IPR008256 (Peptidase S1B, glutamyl endopeptidase I)
21	T05B9.1	T05B9.1	n/a	chrII 11,260,588	contains similarity to Saccharomyces cerevisiae Mlp proteins restrict telomere length by influencing the Rif1-Tel1 pathway of telomerase regulation; also involved in the translocation of macromolecules between the nucleoplasm and the NPC; SGD:YKR095W
22	C29G2.1	C29G2.1	n/a	chrV 2,591,466
23	F11C1.2	F11C1.2	n/a	chrX 12,986,446	contains similarity to Lactococcus lactis Rgg protein, putative.; TR:O87251
24	T09B4.1	T09B4.1	n/a	chrI 6,186,762	contains similarity to Pfam domain PF04188 Mannosyltransferase (PIG-V)) contains similarity to Interpro domain IPR007315 (Mannosyltransferase, PIG-V)
25	C36C9.1	C36C9.1	n/a	chrX 1,684,665	contains similarity to Dictyostelium discoideum Similar to Homo sapiens (Human). Dentin sialophosphoprotein [Contains:sDentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentinssialoprotein (DSP)].; TR:Q869X8
26	W01A8.5	W01A8.5	n/a	chrI 7,070,051	contains similarity to Interpro domain IPR009057 (Homeodomain-like)
27	F31B9.3	F31B9.3	n/a	chrX 15,924,034	contains similarity to Homo sapiens Similar to polymerase (RNA) III; ENSEMBL:ENSP00000334758
28	C04B4.2	C04B4.2	n/a	chrX 12,284,223	contains similarity to Interpro domain IPR002048 (Calcium-binding EF-hand)
29	bath-41	F37A4.9	n/a	chrIII 6,721,274	The F37A4.9 gene encodes a protein with a meprin-associated Traf homology (MATH) domain that may be involved in apoptosis.
30	nos-1	R03D7.7	n/a	chrII 10,952,444	nos-1 encodes an putative RNA-binding protein that contains a zinc-binding motif homologous to that of Drosophila Nanos, a posterior-group protein required for embryonic patterning and primordial germ cell development; in C. elegans, NOS-1 is required redundantly with NOS-2, a second Nanos homolog, for maintenance of germ cell viability during postembryonic development and for preventing primordial germ cells from dividing in the absence of food; nos-1 mRNA is expressed dynamically in the embryo, with early expression seen throughout the embryo and later expression restricted solely to germline blastomeres; nos-1 mRNA becomes undetectable after the 200-cell stage, but reappears later at the 550-cell stage; NOS-1 protein is not detectable in germline blastomeres until the 550-cell stage, suggesting that NOS-1 might actually function zygotically in germline specification.
31	F54D10.5	F54D10.5	n/a	chrII 3,807,652
32	fut-3	F59E12.13	n/a	chrII 5,658,783	C. elegans FUT-3 protein; contains similarity to Pfam domain PF00852 Glycosyltransferase family 10 (fucosyltransferase) contains similarity to Interpro domain IPR001503 (Glycosyl transferase, family 10)
33	B0393.3	B0393.3	n/a	chrIII 4,758,450	contains similarity to Pfam domains PF00560 (Leucine Rich Repeat) , PF00646 (F-box domain) contains similarity to Interpro domains IPR001810 (Cyclin-like F-box), IPR006553 (Leucine-rich repeat, cysteine-containing subtype)
34	zim-1	T07G12.6	n/a	chrIV 10,551,197	zim-1 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include HIM-8, ZIM-2/-3, and C02F5.12; ZIM-1 specifically required for homolog pairing, synapsis, and segregation of chromosomes II and III during meiosis; zim-1(tm1813) oocytes ending prophase have ~4 bivalents and ~4 univalents, the latter of which are consistently chromosomes II and III; ZIM-1 associates with the left ends of chromosomes II and III, which may indicate an association with their pairing centers; while the C-terminal region of ZIM-1 most closely resembles those of its orthologs in other Caenorhabditis species, its N-terminal region instead most closely resembles those of its paralogs in C. elegans, indicating coevolving, species-specific functions; ZIM-1 foci, like HIM-8 foci, associate with the nuclear envelope during meiotic prophase; zim-1 mutants also have some defective segregation of the X chromosome (yielding a Him phenotype), but this may be an indirect effect of autosomal asynapsis.
35	C48B4.9	C48B4.9	n/a	chrIII 9,562,829	contains similarity to Arabidopsis thaliana Hypothetical protein (At1g32400/F5D14_22) (Tobamovirus multiplications2A).; TR:Q9C5W7
36	tag-319	C30B5.1	n/a	chrII 6,200,135	C. elegans TAG-319 protein ;
37	F01F1.11	F01F1.11	n/a	chrIII 5,870,989
38	pie-1	Y49E10.14	n/a	chrIII 12,427,870	pie-1 encodes a C-x8-C-x5-C-x3-H-type zinc-finger protein; maternally provided PIE-1 is essential for germline cell fate determination, as it functions as a repressor of RNA polymerase II-dependent gene expression in the developing germ line; PIE-1 localization, initially uniform and then concentrated in the posterior germ cell lineages, is regulated by other maternally supplied gene products including PAR-1, MEX-5, and MEX-6.
39	hop-1	C18E3.8	n/a	chrI 4,209,468	hop-1 encodes one of three C. elegans presenilins (the other two presenilins are encoded by sel-12 and spe-4); originally identified on the basis of its sequence similarity to SEL-12 and the human PS1 and PS2 presenilins, HOP-1 has been shown to function redundantly with SEL-12 in embryonic, larval, and germline development and thus, to likely function by regulating LIN-12/GLP-1 signaling; in addition, hop-1 can functionally substitute for sel-12 by rescuing the egg-laying and vulval development defects of sel-12 mutants; hop-1 transcription appears to be regulated, at least in part, by the C. elegans spr genes, some of which encode orthologs of the mammalian CoREST repressor complex.
40	T24C4.5	T24C4.5	n/a	chrIII 878,584	contains similarity to Pfam domain PF01896 Eukaryotic and archaeal DNA primase small subunit contains similarity to Interpro domains IPR014052 (DNA primase, small subunit, eukaryotic and archaeal), IPR002755 (DNA primase, small subunit)
41	F26H11.4	F26H11.4	n/a	chrII 14,410,374	contains similarity to Saccharomyces cerevisiae Mitochondrial ATPase (similar to E. coli FtsH protein) that resides in the innner mitochondrial membrane; SGD:YMR089C
42	C50B6.3	C50B6.3	n/a	chrV 13,314,685	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
43	F52C6.3	F52C6.3	n/a	chrII 1,925,233	contains similarity to Interpro domain IPR000626 (Ubiquitin)
44	F36A4.5	F36A4.5	n/a	chrIV 4,266,416	contains similarity to Pfam domain PF05912 Caenorhabditis elegans protein of unknown function (DUF870) contains similarity to Interpro domain IPR008588 (Protein of unknown function DUF870, Caenorhabditis species)
45	W06D11.5	W06D11.5	n/a	chrX 12,300,631	contains similarity to Homo sapiens Hypothetical protein KIAA1801; ENSEMBL:ENSP00000256007
46	C52B11.4	C52B11.4	n/a	chrX 1,285,532
47	W07E6.5	W07E6.5	n/a	chrII 477,174
48	C17H11.4	C17H11.4	n/a	chrX 8,181,277	contains similarity to Drosophila melanogaster Flybase gene name is ari-1-PC;; FLYBASE:CG5659
49	C02B10.2	C02B10.2	n/a	chrIV 5,090,651	contains similarity to Homo sapiens SNARE-associated protein Snapin; ENSEMBL:ENSP00000357674
50	zhp-3	K02B12.8	n/a	chrI 8,530,344	zhp-3 encodes a RING finger protein orthologous to budding yeast Cst9p (meiotically expressed) and human RNF212 (associated with varying recombination rate); ZHP-3 activity is required during meiosis for crossover recombination and chiasma formation; ZHP-3 activity is thus essential for proper chromosome segregation and normal levels of fertility; a ZHP-3::GFP fusion protein localizes along synapsed chromosomes in a manner that is dependent upon the presence of mature synaptonemal complexes; ZHP-3 is paralogous to D1081.9, F55A12.10, and Y39B6A.16.