UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	C27A7.6	C27A7.6	0	chrV 12,126,221	contains similarity to Interpro domain IPR016196 (MFS general substrate transporter)
2	gei-12	F52D2.4	n/a	chrX 1,988,059	gei-12 encodes a novel protein that affects embryonic viability and development of the hypodermis; interacts with GEX-3 in yeast two-hybrid assays, and is expressed in all somatic cells.
3	R10D12.12	R10D12.12	n/a	chrV 13,961,624	contains similarity to Pfam domain PF04101 Glycosyltransferase family 28 C-terminal domain contains similarity to Interpro domain IPR007235 (Glycosyl transferase, family 28, C-terminal)
4	B0304.2	B0304.2	n/a	chrII 4,524,073
5	daf-18	T07A9.6	n/a	chrIV 422,580	daf-18 encodes a lipid phosphatase homologous to the human PTEN tumor suppresor (OMIM:601728, mutated in Cowden disease and several cancers); DAF-18 negatively regulates insulin-like signaling mediated by DAF-2/IR and AGE-1/PI3K and thus plays a role in metabolism, development, and longevity; based on sequence and genetic analysis, DAF-18 is predicted to dephosphorylate AGE-1-generated PIP3 in order to limit activation of the downstream AKT-1 and AKT-2 kinases that negatively regulate DAF-16.
6	try-1	ZK546.15	n/a	chrII 4,948,807	C. elegans TRY-1 protein; contains similarity to Pfam domain PF00089 Trypsin contains similarity to Interpro domains IPR001314 (Peptidase S1A, chymotrypsin), IPR001254 (Peptidase S1 and S6, chymotrypsin/Hap), IPR009003 (Peptidase, trypsin-like serine and cysteine), IPR008256 (Peptidase S1B, glutamyl endopeptidase I)
7	F30A10.3	F30A10.3	n/a	chrI 9,493,712	contains similarity to Pfam domain PF03770 Inositol polyphosphate kinase contains similarity to Interpro domain IPR005522 (Inositol polyphosphate kinase)
8	T09A5.8	T09A5.8	n/a	chrII 7,856,638	contains similarity to Pfam domain PF00385 'chromo' (CHRromatin Organisation MOdifier) domain contains similarity to Interpro domains IPR000953 (Chromo domain), IPR016197 (Chromo domain-like), IPR001525 (C-5 cytosine-specific DNA methylase)
9	C39E9.11	C39E9.11	n/a	chrIV 13,092,485	C39E9.11 is orthologous to the human gene PAPILLARY RENAL CELL CARCINOMA (TRANSLOCATION-ASSOCIATED) (PRCC; OMIM:179755), which when mutated leads to disease.
10	mel-47	EEED8.1	n/a	chrII 5,421,944	C. elegans MEL-47 protein; contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
11	pie-1	Y49E10.14	n/a	chrIII 12,427,870	pie-1 encodes a C-x8-C-x5-C-x3-H-type zinc-finger protein; maternally provided PIE-1 is essential for germline cell fate determination, as it functions as a repressor of RNA polymerase II-dependent gene expression in the developing germ line; PIE-1 localization, initially uniform and then concentrated in the posterior germ cell lineages, is regulated by other maternally supplied gene products including PAR-1, MEX-5, and MEX-6.
12	M151.4	M151.4	n/a	chrII 3,625,534	contains similarity to Interpro domain IPR000533 (Tropomyosin)
13	C05C8.6	C05C8.6	n/a	chrV 7,236,014	contains similarity to Pfam domains PF07707 (BTB And C-terminal Kelch) , PF00651 (BTB/POZ domain) contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR008979 (Galactose-binding like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ), IPR011705 (BTB/Kelch-associated), IPR013089 (Kelch related)
14	T01E8.4	T01E8.4	n/a	chrII 10,238,236	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains WD repeats.
15	ZK1320.7	ZK1320.7	n/a	chrII 9,672,350	contains similarity to Pfam domains PF00023 (Ankyrin repeat) , PF01585 (G-patch domain) contains similarity to Interpro domains IPR003604 (Zinc finger, U1-type), IPR002110 (Ankyrin), IPR000467 (D111/G-patch)
16	E02H9.7	E02H9.7	n/a	chrIII 2,445,442	contains similarity to Homo sapiens Uncharacterized protein MUC17 (Fragment); ENSEMBL:ENSP00000368750
17	rgs-10	F45B8.2	n/a	chrX 14,963,378	C. elegans RGS-10 protein; contains similarity to Pfam domain PF00615 Regulator of G protein signaling domain contains similarity to Interpro domains IPR016137 (Regulator of G protein signalling superfamily), IPR000342 (Regulator of G protein signalling)
18	ZC168.3	ZC168.3	n/a	chrIV 10,733,704	contains similarity to Homo sapiens Origin recognition complex subunit 5; ENSEMBL:ENSP00000297431
19	srg-4	T12A2.12	n/a	chrIII 6,261,094	C. elegans SRG-4 protein; contains similarity to Pfam domain PF02118 C.elegans Srg family integral membrane protein contains similarity to Interpro domain IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
20	T12F5.2	T12F5.2	n/a	chrI 3,732,139
21	pch-2	F10B5.5	n/a	chrII 8,159,065	pch-2 encodes a putative AAA+-type ATPase orthologous to budding yeast PCH2 and human TRIP13 (OMIM:604507); PCH-2 is required for the apoptosis of pachytene cells induced by unsynapsed chromosomal pairing centers, but is dispensable for meiotic apoptosis induced by DNA damage; PCH-2-mediated apoptosis is inhibited by SYP-1 and SYP-2, while it requires HIM-8 (and probably HIM-8's paralogs, ZIM-1/-3 and C02F5.12); however, PCH-2-mediated apoptosis does not require SPO-11; pch-2 transcripts are enriched during oogenesis; the excess germline apoptosis of syp-1(me17) mutants is partially suppressed by pch-2(tm1458), and fully suppressed by pch-2(tm1458);spo-11(ok79).
22	F10D11.2	F10D11.2	n/a	chrI 8,437,292	contains similarity to Bacillus thuringiensis Pesticidial crystal protein cry8Ca (Insecticidal delta-endotoxinsCryVIIIC(a)) (Crystaline entomocidal protoxin) (130 kDa crystalsprotein).; SW:C8CA_BACTP
23	let-99	K08E7.3	n/a	chrIV 12,569,200	let-99 encodes a protein with a DEP domain (Domain found in Dishevelled, Egl-10, and Pleckstrin); LET-99 has no obvious homologs in non-nematodes, but has a truncated paralog (LRG-1) in C. elegans; LET-99 is required for the mitotic spindle to be properly oriented with respect to the axis of cellular polarity, both during anterior migration and rotation of the nuclear-centrosome complex and during anaphase; let-99 mutants exhibit hyperactive nuclear movement and abnormal anaphase spindle pole behavior; LET-99 is mislocalized in par-2 and par-3 mutants; like other proteins containing DEP domains, LET-99 may act as part of a G protein signalling pathway (e.g., the one controlling spindle position).
24	C52B11.4	C52B11.4	n/a	chrX 1,285,532
25	F42A6.5	F42A6.5	n/a	chrIV 3,331,304	contains similarity to Interpro domain IPR001357 (BRCT)
26	C15C6.4	C15C6.4	n/a	chrI 12,214,144	C15C6.4 encodes an ortholog of Pop4 (Rpp29), a protein subunit of the endoribonuclease RNAse P, which cleaves tRNA precursors to produce their mature 5' end; C15C6.4 is evolutionarily ubiquitous among eukaryotes.
27	F43D2.1	F43D2.1	n/a	chrV 14,613,051	contains similarity to Pfam domain PF00134 Cyclin, N-terminal domain contains similarity to Interpro domains IPR006670 (Cyclin), IPR011028 (Cyclin-like), IPR013763 (Cyclin-related), IPR006671 (Cyclin, N-terminal), IPR015429 (Transcription regulator cyclin)
28	C08F8.3	C08F8.3	n/a	chrIV 11,155,803	contains similarity to Gallus gallus Dosal neuron-tube nuclear protein.; TR:Q8QHJ7
29	zfp-2	F35H8.3	n/a	chrII 9,558,501	zfp-2 encodes a zinc-finger transcription factor; loss of zfp-2 and lin-35/Rb results in almost complete sterility accompanied by defects in somatic gonad development and vulval morphology, as well as polyploidization of somatic cell nuclei; loss of zfp-2 activity by itself reveals that zfp-2 is also required for cosuppression, inhibition of RNAi of some genes, and wild-type levels of expression of a rol-6 extrachromosomal array; a zfp-2::GFP promoter fusion construct is expressed in vulval cells and all somatic gonad structures, such as the spermatheca, sheath cells, uterine cells and distal tip cells (DTCs).
30	F22E5.9	F22E5.9	n/a	chrII 2,638,698
31	F21D5.2	F21D5.2	n/a	chrIV 8,729,166	contains similarity to Pfam domain PF02338 OTU-like cysteine protease contains similarity to Interpro domain IPR003323 (Ovarian tumour, otubain)
32	F35H10.5	F35H10.5	n/a	chrIV 8,300,920
33	T24C2.2	T24C2.2	n/a	chrX 14,546,208	contains similarity to Fusobacterium nucleatum Hypothetical protein FN0465.; TR:Q8RG53
34	F21F8.2	F21F8.2	n/a	chrV 8,275,167	contains similarity to Pfam domain PF00026 Eukaryotic aspartyl protease contains similarity to Interpro domains IPR009007 (Peptidase aspartic, catalytic), IPR001461 (Peptidase A1)
35	C27C12.1	C27C12.1	n/a	chrX 14,853,081	contains similarity to Homo sapiens 10 kDa protein; VG:OTTHUMP00000170593
36	fbxb-67	F49B2.2	n/a	chrI 14,297,764	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
37	T04H1.5	T04H1.5	n/a	chrV 12,251,820	contains similarity to Pfam domain PF01585 G-patch domain contains similarity to Interpro domains IPR000467 (D111/G-patch), IPR007087 (Zinc finger, C2H2-type)
38	msh-5	F09E8.3	n/a	chrIV 13,159,611	msh-5 encodes a germline-specific homolog of the yeast and mammalian DNA mismatch repair protein MSH5 (MutS-family) that is required for crossing over and chiasma formation during Caenorhabditis elegans meiosis; inactivation of both rad-51 and msh-5 induces chromosome fragmentation, not seen with inactivation of either gene alone.
39	srd-18	F53F1.10	n/a	chrV 13,426,143	C. elegans SRD-18 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR000276 (GPCR, rhodopsin-like)
40	K08F9.4	K08F9.4	n/a	chrV 15,145,223	contains similarity to Saccharomyces cerevisiae Essential protein with a highly acidic N-terminal domain; IFH1 exhibits genetic interactions with FHL1, overexpression interferes with silencing at telomeres and HM loci; potential Cdc28p substrate; SGD:YLR223C
41	nhr-192	F57A8.5	n/a	chrV 10,069,976	C. elegans NHR-192 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
42	C27C12.3	C27C12.3	n/a	chrX 14,864,682	C27C12.3 encodes a novel protein that is conserved in C. elegans; three other genes related to C27C12.3 are present in tandem on the X chromosome; in situ hybridization studies indicate that C27C12.3 mRNA is expressed in the proximal germline.
43	pfn-1	Y18D10A.20	n/a	chrI 12,922,763	C. elegans PFN-1 protein; contains similarity to Pfam domain PF00235 Profilin contains similarity to Interpro domains IPR002097 (Profilin/allergen), IPR005455 (Profilin, plant)
44	his-74	W05B10.1	n/a	chrV 12,659,997	C. elegans HIS-74 protein; contains similarity to Pfam domain PF00125 Core histone H2A/H2B/H3/H4 contains similarity to Interpro domains IPR000164 (Histone H3), IPR009072 (Histone-fold), IPR007125 (Histone core)
45	H21P03.2	H21P03.2	n/a	chrIV 11,481,604	contains similarity to Pfam domain PF08743 Nse4 contains similarity to Interpro domain IPR014854 (Nse4)
46	mes-1	F54F7.5	n/a	chrX 11,859,856	The mes-1 gene encodes a receptor tyrosine kinase-like protein that is required for unequal cell divisions in the early embryonic germline; during embryonic cell divisions, mes-1 is involved in positioning of the early mitotic spindle and of associated P granules.
47	fsn-1	C26E6.5	n/a	chrIII 4,938,358	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins
48	W02D7.5	W02D7.5	n/a	chrV 8,298,506	contains similarity to Interpro domain IPR016181 (Acyl-CoA N-acyltransferase)
49	bath-27	F14D2.1	n/a	chrII 3,360,782	C. elegans BATH-27 protein; contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
50	uri-1	C55B7.5	n/a	chrI 6,495,201	uri-1 encodes a molecular chaperone orthologous to the unconventional prefoldin RPB5 (RNA polymerase subunit 5) interactor, URI; in C.elegans, URI-1 activity is required for suppressing endogenous genotoxic DNA damage and thus, is essential for maintenance of genome integrity (DNA stability) and progression through the mitotic and meiotic cell cycles, particularly during germ cell development; URI-1 activity is also required for development of some somatic structures, such as the vulva, and for RNA interference; uri-1 mRNA is germline-enriched.