UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	C25A1.4	C25A1.4	0	chrI 10,171,209	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	F47C12.1	F47C12.1	n/a	chrIV 4,001,937	contains similarity to Pfam domains PF00008 (EGF-like domain) (4), PF00754 (F5/8 type C domain) , PF07645 (Calcium binding EGF domain) (2), PF07699 (GCC2 and GCC3) (3), PF00431 (CUB domain) , PF07974 (EGF-like domain) , PF02494 (HYR domain) (2), PF00084 (Sushi domain (SCR repeat)) (6)contains similarity to Interpro domains IPR001438 (EGF-like, type 2), IPR000742 (EGF-like, type 3), IPR003410 (Hyalin), IPR000436 (Sushi/SCR/CCP), IPR006209 (EGF-like), IPR000152 (Aspartic acid and asparagine hydroxylation site), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR008979 (Galactose-binding like), IPR000859 (CUB), IPR011641 (GCC2 and GCC3), IPR001881 (EGF-like calcium-binding), IPR016060 (Complement control module), IPR009030 (Growth factor, receptor), IPR013032 (EGF-like region, conserved site), IPR000421 (Coagulation factor 5/8 type, C-terminal), IPR013111 (EGF, extracellular), IPR013091 (EGF calcium-binding)
4	Y8A9A.3	Y8A9A.3	n/a	chrII 3,791,812	contains similarity to Interpro domain IPR009071 (High mobility group box, HMG)
5	dpy-26	C25G4.5	n/a	chrIV 12,448,610	dpy-26 encodes a novel, acidic protein that is highly conserved in other Caenorhabditis species; during development, dpy-26 activity is required for both dosage compensation and meiotic chromosome segregation; DPY-26 localizes to all meiotic chromosomes in the germline and to the hermaphrodite X chromosomes in somatic cells; SDC-1, SDC-2, and SDC-3 proteins form a complex and these three proteins, in turn, colocalize with DPY-26, DPY-27, and MIX-1 proteins both on the X chromosome and on a transgenic her-1(+) array.
6	srw-95	H06H21.2	n/a	chrIV 4,813,069	C. elegans SRW-95 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
7	psa-4	F01G4.1	n/a	chrIV 11,128,568	The psa-4 (phasmid socket absent) gene encodes an ortholog of SWI2/SNF2, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; psa-4 is probably required during mitosis of the T cells for asymmetric cell division.
8	F16B12.6	F16B12.6	n/a	chrX 14,105,057	contains similarity to Mus musculus Neurofilament triplet H protein (200 kDa neurofilament protein)s(Neurofilament heavy polypeptide) (NF-H).; SW:NFH_MOUSE
9	rnp-2	K08D10.4	n/a	chrIV 4,173,038	rnp-2 encodes the small nuclear ribonucleoprotein (snRNP)-associated protein RNP-2/U1A, which associates with U1 snRNPs; rnp-2 is coexpressed with rnp-3, dnj-15, and K08D10.12 in an operon; RNP-2 and RNP-3 are paralogs with ~50% identity that are more closely related to one another than to non-nematode orthologs; despite their association with distinct snRNPs, RNP-2 and RNP-3 are functionally interchangeable in vivo; either rnp-2(RNAi) or rnp-3(ok1424) animals are viable, with only rpn-2(RNAi) rpn-3(ok1424) animals showing lethality; moreover, RNAi against only RNP-3 causes RNP-2 to associate with RNP-3's normal U2 snRNP partners.
10	C41H7.5	C41H7.5	n/a	chrII 3,003,154	contains similarity to Pfam domain PF03353 DUF278 contains similarity to Interpro domain IPR005020 (Protein of unknown function DUF278)
11	Y45F10D.7	Y45F10D.7	n/a	chrIV 13,792,547	Y45F10D.7 encodes a WD40 repeat-containing protein that is the C. elegans ortholog of human WDR36, mutations in which cause primary open angle glaucoma type 1G (GLC1G, OMIM:609887); large-scale RNAi experiments indicate that Y45F10D.7 activity is required for embryonic and larval development; the Saccharomyces cerevisiae homolog of WDR36, Utp21, is a component of the small-subunit (SSU) processome required for formation of 18S rRNA.
12	ZK686.4	ZK686.4	n/a	chrIII 7,769,518	contains similarity to Interpro domains IPR003604 (Zinc finger, U1-type), IPR007087 (Zinc finger, C2H2-type)
13	K02B7.1	K02B7.1	n/a	chrII 14,689,509	contains similarity to Pfam domains PF00628 (PHD-finger) (2), PF00439 (Bromodomain) contains similarity to Interpro domains IPR001965 (Zinc finger, PHD-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR001487 (Bromodomain), IPR013032 (EGF-like region, conserved site), IPR011011 (Zinc finger, FYVE/PHD-type)
14	taf-11.1	F48D6.1	n/a	chrX 4,255,964	C. elegans TAF-11.1 protein; contains similarity to Pfam domain PF04719 hTAFII28-like protein conserved region contains similarity to Interpro domains IPR006809 (TAFII28-like protein), IPR000104 (Antifreeze protein, type I), IPR009072 (Histone-fold)
15	tag-175	D2013.10	n/a	chrII 9,324,253	tag-175 encodes an ortholog of human TMEM41B, whose protein family is ancient (conserved in both animals and plants) but functionally uncharacterized; TAG-175 is broadly expressed (in hypodermis, muscle, neurons, intestine, spermetheca, and vulva); TAG-175 has no known function in vivo, since neither tag-175(RNAi) nor tag-175(gk278) has obvious phenotypes.
16	B0285.1	B0285.1	n/a	chrIII 4,336,901	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR000694 (Proline-rich region)
17	dep-1	F44G4.8	n/a	chrII 9,012,700	dep-1 encodes a class III receptor protein tyrosine phosphatase (R-PTP) orthologous to human R-PTPs such as PTPRJ/Dep-1 (mutated in epithelial cancers; OMIM:600925); DEP-1 is required, redundantly with LIP-1 and LET-60, and downstream of LIN-12, to promote secondary over primary vulval fate in the P5.p and P7.p lineages; DEP-1 is expressed in P5.p and P7.p lineages, and dep-1 acts cell-autonomously in these lineages; DEP-1 colocalizes with LET-23 in punctae, and binds LET-23 in vitro; DEP-1, with LIP-1, is also required for normal duct cell and excretory pore development; dep-1 mutations are wild-type in isolation, but have vulval phenotypes with added mutations in lin-15, lip-1, or let-60; DEP-1 laterally inhibits secondary vulval fates in parallel with LIN-12/Notch signalling; in primary (P5.p) vulval cells, LET-60/RAS-activated SUR-2 inhibits dep-1 and lin-12 expression; since RNAi of 125 out of 165 predicted C. elegans protein phosphatase genes fails to enhance lip-1 mutations, the LIP-1/DEP-1 interaction is likely to be highly specific.
18	C44C1.1	C44C1.1	n/a	chrX 981,899
19	gta-1	K04D7.3	n/a	chrIV 10,182,270	The gta-1 gene encodes an ortholog of the human gene GABAT, which when mutated leads to GABA-transaminase deficiency (OMIM:137150).
20	ger-1	R01H2.5	n/a	chrIII 7,066,371	C. elegans GER-1 protein; contains similarity to Pfam domain PF01370 NAD dependent epimerase/dehydratase family contains similarity to Interpro domains IPR001509 (NAD-dependent epimerase/dehydratase), IPR002347 (Glucose/ribitol dehydrogenase), IPR016040 (NAD(P)-binding)
21	F11C1.1	F11C1.1	n/a	chrX 12,988,210	contains similarity to Pfam domain PF06747 CHCH domain contains similarity to Interpro domain IPR010625 (CHCH)
22	C01A2.5	C01A2.5	n/a	chrI 13,385,906	contains similarity to Pfam domain PF04641 Protein of unknown function, DUF602 contains similarity to Interpro domain IPR006735 (Protein of unknown function DUF602)
23	T07A9.1	T07A9.1	n/a	chrIV 384,318	contains similarity to Homo sapiens Protein; VG:OTTHUMP00000025811
24	eif-3.H	C41D11.2	n/a	chrI 4,445,653	C. elegans EIF-3.H protein; contains similarity to Pfam domain PF01398 Mov34/MPN/PAD-1 family contains similarity to Interpro domains IPR000555 (Mov34/MPN/PAD-1), IPR003639 (Mov34-1)
25	clh-5	C07H4.2	n/a	chrII 9,096,575	The clh-5 gene encodes a chloride channel, whose human homologs include CLC1 and CLCN5; the latter homolog is imvolved in receptor-mediated endocytosis.
26	F22E5.11	F22E5.11	n/a	chrII 2,644,695	contains similarity to Pfam domain PF02214 K+ channel tetramerisation domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR003131 (Potassium channel, voltage dependent, Kv, tetramerisation)
27	npp-11	F53F10.5	n/a	chrI 3,819,703	C. elegans NPP-11 protein; contains similarity to Interpro domains IPR003072 (Orphan nuclear receptor, NOR1 type), IPR000104 (Antifreeze protein, type I), IPR001778 (Pollen allergen Poa pIX/Phl pVI, C-terminal), IPR007758 (Nucleoporin, Nsp1-like, C-terminal)
28	F23C8.9	F23C8.9	n/a	chrI 2,433,103	contains similarity to Pfam domain PF07962 Replication Fork Protection Component Swi3 contains similarity to Interpro domain IPR012923 (Replication fork protection component Swi3)
29	cpf-2	F56A8.6	0.00006	chrIII 13,267,824	C. elegans CPF-2 protein; contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR012677 (Nucleotide-binding, alpha-beta plait), IPR003954 (RNA recognition, region 1), IPR000504 (RNA recognition motif, RNP-1)
30	mdt-29	K08E3.8	n/a	chrIII 13,776,056	mdt-29 encodes a putative mediator subunit with a prion-like (asparagine- or glutamine-rich) domain; note that K08E3.8 is allegedly an ortholog of Drosophila INTERSEX/IX, but the actual C. elegans IX ortholog appears to be PQN-15); in yeast two-hybrid screens, MDT-29 interacts with SEL-7 and SEL-8; MDT-29 protein also self-associates; RNAi of K08E3.8 weakly enhances the two-anchor-cell phenotype of lin-12(ar170), roughly as much as sel-7 RNAi; since SEL-7 is a novel nuclear protein, MDT-29/SEL-7/SEL-8 is likely to form a nuclear complex formed in response to LIN-12 activation.
31	R03C1.1	R03C1.1	n/a	chrII 14,908,902	contains similarity to Homo sapiens Mucin-5AC precursor (Fragment); ENSEMBL:ENSP00000351148
32	ZK632.7	ZK632.7	n/a	chrIII 9,821,105	contains similarity to Interpro domain IPR011009 (Protein kinase-like)
33	glt-6	R05G6.6	n/a	chrIV 7,505,011	glt-6 encodes an ortholog of glutamate/aspartate and neutral amino acid transporters.
34	F33H2.5	F33H2.5	n/a	chrI 15,009,733	contains similarity to Pfam domains PF00136 (DNA polymerase family B) , PF03104 (DNA polymerase family B, exonuclease domain) , PF08490 (Domain of unknown function (DUF1744)) contains similarity to Interpro domains IPR006055 (Exonuclease), IPR006172 (DNA-directed DNA polymerase, family B), IPR006133 (DNA-directed DNA polymerase, family B, exonuclease), IPR006134 (DNA-directed DNA polymerase, family B, conserved region), IPR013697 (Region of unknown function DUF1744), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
35	fipr-15	F13E9.3	n/a	chrIV 10,880,611	C. elegans FIPR-15 protein; contains similarity to Interpro domain IPR005137 (Photosystem I assembly BtpA)
36	F55H12.2	F55H12.2	n/a	chrI 8,868,112	contains similarity to Interpro domain IPR000242 (Tyrosine specific protein phosphatase)
37	K02F3.2	K02F3.2	n/a	chrIII 848,051	The K02F3.2 gene encodes a homolog of human SLC25A13, which when mutated leads to adult onset type II citrullinaemia (OMIM:603471).
38	amx-1	R13G10.2	n/a	chrIII 3,824,311	C. elegans AMX-1 protein; contains similarity to Pfam domains PF01593 (Flavin containing amine oxidoreductase) , PF01266 (FAD dependent oxidoreductase) contains similarity to Interpro domains IPR006076 (FAD dependent oxidoreductase), IPR001613 (Flavin-containing amine oxidase), IPR000960 (Flavin-containing monooxygenase FMO), IPR002937 (Amine oxidase), IPR016040 (NAD(P)-binding), IPR007526 (SWIRM)
39	T03D3.5	T03D3.5	n/a	chrV 2,825,328
40	T22C1.6	T22C1.6	n/a	chrI 7,944,147	contains similarity to Homo sapiens Alpha-taxilin; ENSEMBL:ENSP00000362711
41	srx-105	F40H7.8	n/a	chrII 3,700,613	C. elegans SRX-105 protein ;
42	rnp-5	K02F3.11	n/a	chrIII 853,412	rnp-5 encodes a putative member of the exon-exon junction complex, orthologous to human RNPS1 (OMIM:606447); RNP-5 is dispensable for embryonic viability.
43	srm-2	T28H11.3	n/a	chrIV 5,009,723	C. elegans SRM-2 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
44	pqn-38	F44B9.7	n/a	chrIII 8,026,555	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
45	sedl-1	W05H7.3	n/a	chrX 1,439,758	C. elegans SEDL-1 protein; contains similarity to Pfam domain PF04628 Sedlin, N-terminal conserved region contains similarity to Interpro domains IPR011012 (Longin-like), IPR006722 (Sedlin)
46	F21G4.6	F21G4.6	n/a	chrX 9,913,063	F21G4.6 is orthologous to the human gene HUNTINGTIN (HD; OMIM:143100), which when mutated leads to disease.
47	ver-3	F59F3.1	n/a	chrX 10,995,095	C. elegans VER-3 protein; contains similarity to Pfam domains PF07686 (Immunoglobulin V-set domain) (2), PF00047 (Immunoglobulin domain) (4), PF07714 (Protein tyrosine kinase) , PF00069 (Protein kinase domain) , PF07679 (Immunoglobulin I-set domain) contains similarity to Interpro domains IPR003598 (Immunoglobulin subtype 2), IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR013098 (Immunoglobulin I-set), IPR011009 (Protein kinase-like), IPR003596 (Immunoglobulin V-set, subgroup), IPR013783 (Immunoglobulin-like fold), IPR000719 (Protein kinase, core), IPR013106 (Immunoglobulin V-set), IPR007110 (Immunoglobulin-like), IPR003599 (Immunoglobulin subtype), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR008266 (Tyrosine protein kinase, active site), IPR013151 (Immunoglobulin)
48	F12F6.8	F12F6.8	n/a	chrIV 11,556,346	contains similarity to Schizosaccharomyces pombe Adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylylscyclase).; SW:CYAA_SCHPO
49	Y53C12B.6	Y53C12B.6	n/a	chrII 9,723,099	contains similarity to Pfam domain PF00100 Zona pellucida-like domain contains similarity to Interpro domain IPR001507 (Endoglin/CD105 antigen)
50	sdc-3	C25D7.3	n/a	chrV 15,043,550	sdc-3 encodes a protein that contains two mutationally separable domains: a zinc finger motif required for dosage compensation and a myosin- like putative ATP- binding region required for her-1 regulation of sex determination; SDC-3 activates dosage compensation by directing the dosage compensation protein complex to the hermaphrodite X chromosomes, and is functionally redundant with SDC-2 with respect to dosage compensation; SDC-1, SDC-2, and SDC-3 proteins form a complex.