UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	crn-5	C14A4.5	2e-123	chrII 10,593,065	C. elegans CRN-5 protein; contains similarity to Pfam domain PF01138 3' exoribonuclease family, domain 1 contains similarity to Interpro domain IPR001247 (Exoribonuclease, phosphorolytic domain 1)
2	sra-25	T26E3.9	n/a	chrI 12,687,150	C. elegans SRA-25 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domains IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR000344 (Nematode chemoreceptor, Sra)
3	T19H12.6	T19H12.6	n/a	chrV 4,877,093	contains similarity to Pfam domains PF04942 (CC domain) (2), PF01019 (Gamma-glutamyltranspeptidase) contains similarity to Interpro domains IPR007026 (Domian of unknown function, DUF-CC), IPR000101 (Gamma-glutamyltranspeptidase)
4	T01D1.4	T01D1.4	n/a	chrII 178,045	contains similarity to Pfam domain PF03079 ARD/ARD' family contains similarity to Interpro domains IPR011051 (Cupin, RmlC-type), IPR004313 (Acireductone dioxygenase, ARD), IPR014710 (RmlC-like jelly roll fold)
5	F55D12.2	F55D12.2	n/a	chrI 7,892,099	contains similarity to Interpro domains IPR002017 (Spectrin repeat), IPR001251 (Cellular retinaldehyde-binding/triple function, C-terminal)
6	adr-2	T20H4.4	n/a	chrIII 7,231,956	adr-2 encodes an adenosine deaminase that acts on RNA (ADAR); ADARs are RNA-editing enzymes that deaminate adenosines to create inosines in double-stranded RNA (dsRNA); adr-2 is expressed ubiquitously in early embryos, as well as in the germline of early adults; ADR-2 is required for ADAR activity in vivo, and for normal chemotaxis.
7	set-25	Y43F4B.3	n/a	chrIII 13,288,364	set-25 encodes a putative histone H3 lysine-9 methyltransferase, with a C-terminal SET domain but no obvious non-nematode orthologs; SET-25 is required both for normal axonal guidance during development, and for a normally low somatic mutation rate; set-25(RNAi) animals have defective DD/VD motoneuron commissures, and also display an elevated somatic mutation rate, but are otherwise normal.
8	W02D7.6	W02D7.6	n/a	chrV 8,300,526	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
9	K01A2.4	K01A2.4	n/a	chrII 310,134	contains similarity to Interpro domain IPR000814 (TATA-box binding)
10	H43I07.2	H43I07.2	n/a	chrV 4,201,565	contains similarity to Pfam domains PF01000 (RNA polymerase Rpb3/RpoA insert domain) , PF01193 (RNA polymerase Rpb3/Rpb11 dimerisation domain) contains similarity to Interpro domains IPR011263 (DNA-directed RNA polymerase, RpoA/D/Rpb3-type), IPR011262 (DNA-directed RNA polymerase, insert), IPR011261 (DNA-directed RNA polymerase, dimerisation)
11	ZK632.12	ZK632.12	n/a	chrIII 9,831,513	ZK632.12 encodes one of 12 C. elegans FYVE-domain containing proteins and is orthologous to mammalian Phafin2; as loss of ZK632.12 activity via RNAi screens results in no obvious defects, the precise role of ZK632.12 in C. elegans development and/or behavior is not yet known.
12	ZC513.5	ZC513.5	n/a	chrV 8,037,288	contains similarity to Pfam domain PF03901 Alg9-like mannosyltransferase family contains similarity to Interpro domain IPR005599 (Alg9-like mannosyltransferase)
13	fbxa-43	T20H9.2	n/a	chrIII 2,258,234	C. elegans FBXA-43 protein; contains similarity to Pfam domains PF01827 (FTH domain) , PF00646 (F-box domain) contains similarity to Interpro domains IPR002900 (Protein of unknown function DUF38, Caenorhabditis species), IPR001810 (Cyclin-like F-box)
14	C46F11.3	C46F11.3	n/a	chrIII 3,649,797	contains similarity to Interpro domain IPR006578 (MADF)
15	rpb-3	C36B1.3	n/a	chrI 8,729,359	C. elegans RPB-3 protein; contains similarity to Pfam domains PF01000 (RNA polymerase Rpb3/RpoA insert domain) , PF01193 (RNA polymerase Rpb3/Rpb11 dimerisation domain) contains similarity to Interpro domains IPR011263 (DNA-directed RNA polymerase, RpoA/D/Rpb3-type), IPR011262 (DNA-directed RNA polymerase, insert), IPR011261 (DNA-directed RNA polymerase, dimerisation)
16	Y106G6H.14	Y106G6H.14	n/a	chrI 10,472,796	contains similarity to Pfam domains PF07653 (Variant SH3 domain) , PF00018 (SH3 domain) , PF00023 (Ankyrin repeat) (3)contains similarity to Interpro domains IPR001452 (Src homology-3), IPR000108 (Neutrophil cytosol factor 2), IPR002110 (Ankyrin), IPR013315 (Spectrin alpha chain), IPR011511 (Variant SH3)
17	brf-1	F45E12.2	n/a	chrII 7,307,210	brf-1 encodes an ortholog of mammalian B-RELATED FACTOR (also known as BRF, TDS4, PCF4, or hTFIIIB90); BRF is thought to act as a molecular bridge between TATA-binding protein (TBP) associated factors that functions in TFIIIB (RNA polymerase III associated transcription factors).
18	F19D8.2	F19D8.2	n/a	chrX 13,835,397	contains similarity to Homo sapiens Splice isoform 1 of Q9UMN6 Myeloid/lymphoid or mixed-lineage leukemia protein 4; ENSEMBL:ENSP00000222270
19	R151.8	R151.8	n/a	chrIII 7,228,224	contains similarity to Interpro domains IPR001005 (SANT, DNA-binding), IPR009057 (Homeodomain-like)
20	D2030.3	D2030.3	n/a	chrI 7,579,667	contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
21	ZK856.4	ZK856.4	n/a	chrV 10,183,835	contains similarity to Interpro domain IPR011001 (Saposin-like)
22	R09F10.5	R09F10.5	n/a	chrX 8,307,016
23	tag-298	C01H6.7	n/a	chrI 7,226,247	C. elegans TAG-298 protein; contains similarity to Pfam domain PF00439 Bromodomain contains similarity to Interpro domain IPR001487 (Bromodomain)
24	K09E9.3	K09E9.3	n/a	chrX 15,612,740	contains similarity to Interpro domain IPR000533 (Tropomyosin)
25	ZC239.16	ZC239.16	n/a	chrII 3,225,022	contains similarity to Pfam domain PF02214 K+ channel tetramerisation domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR003131 (Potassium channel, voltage dependent, Kv, tetramerisation)
26	K04G7.1	K04G7.1	n/a	chrIII 7,163,752
27	T21D12.7	T21D12.7	n/a	chrIV 290,077	contains similarity to Pfam domain PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain contains similarity to Interpro domains IPR002223 (Proteinase inhibitor I2, Kunitz metazoa), IPR013090 (Phospholipase A2, active site), IPR006150 (Cysteine-rich repeat)
28	W04A4.6	W04A4.6	n/a	chrI 13,686,458	contains similarity to Oryza sativa P0005A05.15 protein.; TR:Q9FTN4
29	F28D1.1	F28D1.1	n/a	chrIV 12,373,435	contains similarity to Pfam domains PF08149 (BING4CT (NUC141) domain) , PF00400 (WD domain, G-beta repeat) contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR012952 (BING4, C-terminal), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
30	R06F6.2	R06F6.2	n/a	chrII 10,790,634	contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR016528 (Vacuolar protein sorting-associated protein 11), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR000547 (Clathrin, heavy chain/VPS, 7-fold repeat), IPR016024 (Armadillo-type fold), IPR011044 (Quinoprotein amine dehydrogenase, beta chain-like)
31	W03C9.6	W03C9.6	n/a	chrII 11,957,465	contains similarity to Interpro domains IPR006052 (Tumor Necrosis Factor), IPR016196 (MFS general substrate transporter)
32	brc-1	C36A4.8	n/a	chrIII 3,858,030	brc-1 encodes an ortholog of human BRCA1 (OMIM:113705, mutated in early onset breast and ovarian cancer) required for double-strand break repair via inter-sister recombination during meiosis; BRC-1 forms a heterodimer with BRD-1, which constitutes an E3 ubiquitin ligase; after irradiation, the DNA checkpoint proteins ATL-1 and MRE-11 are required for BRC-1/BRD-1 heterodimers to associate with RAD-51 and LET-70/Ubc5, and to ubiquitylate damaged chromatin; brc-1(RNAi) animals have excess chromosomal nondisjunction, abnormally high levels of CEP-1-dependent germ cell apoptosis (both with and without gamma-irradiation) and hypersensitivity to gamma-irradiation (e.g., abnormal sterility after irradiation); BRC-1 and BRD-1 bind one another, probably through their N-terminal RING domains, in yeast two-hybrid experiments and pull-down assays; BRC-1/BRD-1 heterodimers may interact with RAD-51 and other proteins via mutual binding to UBC-9; brc-1 is genetically dispensable for the induction of nuclear ATL-1 foci by gamma-irradiation or hydroxyurea.
33	R05D11.7	R05D11.7	n/a	chrI 8,601,675	contains similarity to Pfam domain PF08648 Protein of unknown function (DUF1777) contains similarity to Interpro domain IPR013957 (Protein of unknown function DUF1777)
34	T05C1.3	T05C1.3	n/a	chrII 4,488,577
35	F01G10.10	F01G10.10	n/a	chrIV 10,247,944	contains similarity to Pfam domains PF02886 (LBP / BPI / CETP family, C-terminal domain) , PF01273 (LBP / BPI / CETP family, N-terminal domain) contains similarity to Interpro domain IPR001124 (Lipid-binding serum glycoprotein)
36	pfd-5	R151.9	n/a	chrIII 7,198,447	pfd-5 encodes a putative prefoldin 5 subunit, orthologous to human PFDN5 (OMIM:604899), that is required for normal microtubule growth, embryonic and larval viability, fertility, vulval development, and locomotion; PFD-5 is expressed in most, if not all, tissues; pfd-5(RNAi) animals show sterile progeny, larval arrest or lethality, uncoordination, and abnormal body shapes, and pfd-5(RNAi) embryos show a reduced microtubule growth rate.
37	tag-125	C14B1.4	n/a	chrIII 3,706,004	tag-125/C14B1.4 encodes an ortholog of the histone methyltransferase subunit WDR5 (OMIM:609012) that antagonizes SynMuv transcriptional repressors.
38	ztf-4	T10B11.3	n/a	chrI 6,927,973	C. elegans ZTF-4 protein; contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1), IPR007087 (Zinc finger, C2H2-type)
39	C05E7.2	C05E7.2	n/a	chrX 12,939,625
40	F16H6.9	F16H6.9	n/a	chrV 18,219,656	contains similarity to Mus musculus Calpain 6.; SW:CAN6_MOUSE
41	rap-1	C27B7.8	n/a	chrIV 8,917,869	rap-1 encodes a member of the Ras superfamily of small GTPases; the activated protein interacts with W05B10.4 and T14G10.2 in yeast two-hybrid assays and rap-1 is expressed in some neurons in the head and tail, the rectal epithelial cells, body muscle, hypodermis, and in the somatic cells of the gonad.
42	spe-42	B0240.2	n/a	chrV 11,735,328	C. elegans SPE-42 protein; contains similarity to Pfam domain PF07782 DC-STAMP-like protein contains similarity to Interpro domain IPR012858 (DC-STAMP-like)
43	mau-2	C09H6.3	n/a	chrI 8,127,936	mau-2 encodes an ortholog of budding yeast Scc4p, Drosophila CG4203, and human KIAA0892; MAU-2 is required (with PQN-85 and SCC-3) for normal mitotic chromosome segregation, and for cellular (e.g., neuronal) or axonal migration; MAU-2 is required for migration both embryonically and postembryonically, along both dorsoventral and longitudinal body axes; MAU-2 guides the axonal projection of AVM (and probably other neurons) by some cell-autonomous mechanism independent of SLT-1; MAU-2 is also required for normal larval development, locomotion, excretory canals and osmoregulation, phasmid morphology, and egg-laying; the primary sequences of MAU-2 and its Scc4-like orthologs are composed of tetratricopeptide repeats, and are highly divergent between yeast and metazoa; MAU-2 is expressed ubiquitously in embryos during late gastrulation, subsequently becoming restricted to neurons; mau-2 transcripts are abundant in oocytes, and maternal transcripts alone can support normal MAU-2 protein synthesis through the L3 larval stage (but not in L4 larvae or adults); MAU-2's N-terminal 371 residues of MAU-2 are its most conserved domain, and are sufficient to transgenically rescue mau-2 mutants; despite its behavioral phenotype, MAU-2 is thought to act early in development, since the uncoordinated phenotype of mau-2 mutants is maternal; while the uncoordinated phenotype of mau-2 mutants can be rescued either maternally or zygotically, the egg-laying phenotype of mau-2 mutants is purely zygotic; partially penetrant mau-2 dye-filling phenotypes occur on one side of the body, suggesting that MAU-2 acts on a whole side of an embryo at a time; while mau-2(RNAi) has no obvious early embryonic phenotype, joint mau-2/scc-3(RNAi) grossly deranges chromosomal segregation in early embryos, and mau-2(RNAi) enhances the lagging of anaphase chromosomes induced by pqn-85(RNAi).
44	F48E3.2	F48E3.2	n/a	chrX 7,491,715	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR005829 (Sugar transporter, conserved site), IPR005828 (General substrate transporter), IPR003663 (Sugar transporter), IPR016196 (MFS general substrate transporter)
45	xpg-1	F57B10.6	n/a	chrI 6,560,500	F57B10.6 is orthologous to the human gene EXCISION REPAIR CROSS-COMPLEMENTING RODENT REPAIR DEFICIENCY, COMPLEMENTATION GROUP 5 (XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP G (COCKAYNE SYNDROME)) (ERCC5; OMIM:133530), which when mutated leads to disease.
46	tag-170	C05D11.3	n/a	chrIII 6,432,606	C05D11.3/tag-170 encodes a thioredoxin domain-containing protein orthologous to human TXNDC9 and ENSG00000145268; in one-cell embryos, C05D11.3/TAG-170 is required for normal nuclear-centrosome rotation, male pronuclear migration, cytokinesis, and mitotic spindles, and for normally long astral microtubules; in early embryos, C05D11.3/TAG-170 is also required for normally rapid microtubule elongation; C05D11.3/tag-170 is expressed in larval and adult neurons and pharynx, and in vulva, with its strongest transcription in adults; like its mammalian ortholog, C05D11.3/TAG-170 protein is both nuclear and cytoplasmic.
47	tag-322	C33H5.10	n/a	chrIV 7,784,751	C. elegans TAG-322 protein ; contains similarity to Drosophila melanogaster Flybase gene name is CG5913-PA;; FLYBASE:CG5913
48	C36B1.7	C36B1.7	n/a	chrI 8,736,564	contains similarity to Pfam domain PF00186 Dihydrofolate reductase contains similarity to Interpro domain IPR001796 (Dihydrofolate reductase region)
49	W04D2.4	W04D2.4	n/a	chrV 12,496,219	contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
50	ZK218.1	ZK218.1	n/a	chrV 17,092,954	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)