UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	nuo-1	C09H10.3	0	chrII 11,099,005	nuo-1 encodes a encodes a 51 kDa subunit of mitochondrial complex I that is required for oxidative phosphorylation, resistance to volatile anesthetics, and progression through development; nuo-1 is orthologous to human NDUFV1 (OMIM:161015, mutated in Leigh syndrome); nuo-1(ua1) induces a developmental arrest at the third larval (L3) stage that blocks reproduction, and thus is lethal to a population homozygous for nuo-1(ua1); yet arrested L3 nuo-1(ua1) animals have an individual lifespan significantly longer than normal.
2	tufm-2	C43E11.4	n/a	chrI 4,248,543	C. elegans TUFM-2 protein; contains similarity to Pfam domains PF03143 (Elongation factor Tu C-terminal domain) , PF03144 (Elongation factor Tu domain 2) , PF00009 (Elongation factor Tu GTP binding domain) contains similarity to Interpro domains IPR000795 (Protein synthesis factor, GTP-binding), IPR005225 (Small GTP-binding protein), IPR004160 (Translation elongation factor EFTu/EF1A, C-terminal), IPR004161 (Translation elongation factor EFTu/EF1A, domain 2), IPR009001 (Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)
3	F25E5.1	F25E5.1	n/a	chrV 7,468,526	contains similarity to Interpro domain IPR009091 (Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)
4	E02A10.1	E02A10.1	n/a	chrV 12,564,567	contains similarity to Pfam domains PF00333 (Ribosomal protein S5, N-terminal domain) , PF03719 (Ribosomal protein S5, C-terminal domain) contains similarity to Interpro domains IPR014720 (Double-stranded RNA-binding-like), IPR013810 (Ribosomal protein S5, N-terminal), IPR005324 (Ribosomal protein S5, C-terminal), IPR000851 (Ribosomal protein S5), IPR014721 (Ribosomal protein S5 domain 2-type fold)
5	ugt-21	C33A12.6	n/a	chrIV 9,501,385	C. elegans UGT-21 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
6	ubh-4	C08B11.7	n/a	chrII 8,038,864	C. elegans UBH-4 protein; contains similarity to Pfam domain PF01088 Ubiquitin carboxyl-terminal hydrolase, family 1 contains similarity to Interpro domains IPR001578 (Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1), IPR017390 (Ubiquitinyl hydrolase, UCH37 type)
7	tag-257	F46G11.3	n/a	chrX 5,784,865	C. elegans TAG-257 protein; contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
8	C29F7.2	C29F7.2	n/a	chrX 13,417,071	contains similarity to Pfam domains PF02958 (Domain of unknown function (DUF227)) , PF07914 (Protein of unknown function (DUF1679)) contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR012877 (Protein of unknown function DUF1679, Caenorhabditis species), IPR004119 (Protein of unknown function DUF227), IPR015897 (CHK kinase-like)
9	ppk-1	F55A12.3	n/a	chrI 5,361,848	ppk-1 encodes a putative phosphatidylinositol-4-phosphate 5' kinase that is essential for ovulation, intense gonad sheath contraction and dilation of the spermathecal valve during oocyte maturation, and UNC-54 filament organization; more generally, PPK-1 is required for fertility, progression through larval development, normal locomotion and defecation, and overall health; defects of ppk-1(RNAi) animals in sterility, ovulation, and UNC-54 filaments are suppressed by the gain-of-function itr-1(sy290) allele, presumably through increased IP(3) signalling; PPK-1 is expressed in gonad sheath, spermatheca, uterine and vulva muscles, distal tip cells, intestine, head mesodermal cell, and many neurons (e.g., in the ventral nerve cord, near the nerve ring, and in tail); PPK-1 may be activated by VAV-1; PPK-1 is orthologous to five human proteins (e.g., PIP5K1B, OMIM:602745), and distantly paralogous to PPK-2.
10	F55E10.6	F55E10.6	n/a	chrX 8,345,470	contains similarity to Pfam domain PF00106 short chain dehydrogenase contains similarity to Interpro domains IPR003560 (2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase), IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016040 (NAD(P)-binding)
11	F08A8.3	F08A8.3	n/a	chrI 12,948,957	contains similarity to Pfam domains PF01756 (Acyl-CoA oxidase) , PF02770 (Acyl-CoA dehydrogenase, middle domain) contains similarity to Interpro domains IPR013786 (Acyl-CoA dehydrogenase/oxidase, N-terminal), IPR006091 (Acyl-CoA dehydrogenase/oxidase, central region), IPR013764 (Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal), IPR012258 (Acyl-CoA oxidase), IPR009100 (Acyl-CoA dehydrogenase/oxidase, middle and N-terminal), IPR002655 (Acyl-CoA oxidase, C-terminal), IPR009075 (Acyl-CoA dehydrogenase/oxidase C-terminal)
12	tag-264	B0511.8	n/a	chrI 10,637,866	C. elegans TAG-264 protein; contains similarity to Pfam domain PF07147 Mitochondrial 28S ribosomal protein S30 (PDCD9) contains similarity to Interpro domain IPR010793 (Ribosomal protein S30, mitochondrial)
13	C47C12.4	C47C12.4	n/a	chrX 7,757,369	contains similarity to Pfam domains PF08355 (EF hand associated) , PF00071 (Ras family) , PF00036 (EF hand) , PF08477 (Miro-like protein) contains similarity to Interpro domains IPR013566 (EF hand associated, type-1), IPR011992 (EF-Hand type), IPR002048 (Calcium-binding EF-hand), IPR003577 (Ras small GTPase, Ras type), IPR013684 (Miro-like), IPR003578 (Ras small GTPase, Rho type), IPR001806 (Ras GTPase), IPR003579 (Ras small GTPase, Rab type), IPR013753 (Ras)
14	K10D11.6	K10D11.6	n/a	chrIV 12,988,061	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
15	gly-13	B0416.6	n/a	chrX 9,295,081	gly-13 encodes an experimentally verified UDP-N-acetylglucosamine alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GnT I), that is the primary GnT I enzyme in vivo, and that can act on unusual substrates; gly-13 is expressed throughout development in many cell types; gly-13 has no obvious function in vivo, since a deletion allele of gly-13 is phenotypically normal even as a double or triple mutant with gly-12 and gly-14.
16	oxi-1	Y39A1C.2	n/a	chrIII 10,862,495	C. elegans OXI-1 protein; contains similarity to Pfam domain PF00632 HECT-domain (ubiquitin-transferase) contains similarity to Interpro domain IPR000569 (HECT)
17	acl-8	T05H4.1	n/a	chrV 6,451,547	C. elegans ACL-8 protein; contains similarity to Pfam domain PF01553 Acyltransferase contains similarity to Interpro domain IPR002123 (Phospholipid/glycerol acyltransferase)
18	dpyd-1	C25F6.3	n/a	chrX 5,470,240	The C25F6.3 gene encodes an ortholog of the human gene DIHYDROPYRIMIDINE DEHYDROGENASE (DPYD), which when mutated leads to thymine-uraciluria (OMIM:274270).
19	H19N07.1	H19N07.1	n/a	chrV 11,111,736	contains similarity to Pfam domains PF03143 (Elongation factor Tu C-terminal domain) , PF03144 (Elongation factor Tu domain 2) , PF00009 (Elongation factor Tu GTP binding domain) contains similarity to Interpro domains IPR000795 (Protein synthesis factor, GTP-binding), IPR004160 (Translation elongation factor EFTu/EF1A, C-terminal), IPR004161 (Translation elongation factor EFTu/EF1A, domain 2), IPR009001 (Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)
20	fbxa-64	T28A11.21	n/a	chrV 3,277,607	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
21	his-3	T10C6.12	n/a	chrV 16,040,965	his-3 encodes an H2A histone; by homology, HIS-3 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-3 is a replication-dependent histone locus that resides in the HIS1 cluster on chromosome V.
22	nud-1	F53A2.4	n/a	chrIII 13,341,947	nud-1 encodes the C. elegans ortholog of the Aspergillus nidulans nudC, which mediates nuclear migration along Aspergillus hyphae.
23	pcca-1	F27D9.5	n/a	chrX 7,659,204	The F27D9.5 gene encodes an ortholog of the human gene PROPIONYL-COA CARBOXYLASE ALPHA SUBUNIT (PCCA), which when mutated leads to propionicaciduria, type I (OMIM:232000).
24	tag-231	ZK430.2	n/a	chrII 4,421,285	C. elegans TAG-231 protein; contains similarity to Pfam domain PF00459 Inositol monophosphatase family contains similarity to Interpro domains IPR000760 (Inositol monophosphatase), IPR000146 (Inositol phosphatase/fructose-1,6-bisphosphatase)
25	clec-26	T20B3.12	n/a	chrV 16,849,392	C. elegans CLEC-26 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
26	Y56A3A.19	Y56A3A.19	n/a	chrIII 11,915,313	contains similarity to Pfam domain PF00550 Phosphopantetheine attachment site contains similarity to Interpro domains IPR006163 (Phosphopantetheine-binding), IPR009081 (Acyl carrier protein-like), IPR003231 (Acyl carrier protein (ACP))
27	glrx-5	Y49E10.2	n/a	chrIII 12,373,098	C. elegans GLRX-5 protein; contains similarity to Pfam domain PF00462 Glutaredoxin contains similarity to Interpro domains IPR002109 (Glutaredoxin), IPR014025 (Glutaredoxin subgroup), IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004480 (Glutaredoxin-related protein)
28	K02B12.3	K02B12.3	n/a	chrI 8,510,282	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
29	lgc-50	T20B12.9	n/a	chrIII 7,393,409	C. elegans LGC-50 protein; contains similarity to Pfam domains PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) , PF02932 (Neurotransmitter-gated ion-channel transmembrane region) contains similarity to Interpro domains IPR002289 (Gamma-aminobutyric-acid A receptor, beta subunit), IPR006028 (Gamma-aminobutyric acid A receptor), IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding), IPR006029 (Neurotransmitter-gated ion-channel transmembrane region)
30	ptr-14	R09H10.4	n/a	chrIV 10,618,200	ptr-14 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-14 is weakly required for normal molting from L4 to adult stages; PTR-14 is also required for normal growth to full size and locomotion.
31	F26H9.5	F26H9.5	n/a	chrI 9,313,557	contains similarity to Pfam domain PF00266 Aminotransferase class-V contains similarity to Interpro domains IPR015422 (Pyridoxal phosphate-dependent transferase, major region, subdomain 2), IPR015424 (Pyridoxal phosphate-dependent transferase, major region), IPR000192 (Aminotransferase, class V/Cysteine desulphurase), IPR003248 (Phosphoserine aminotransferase), IPR015421 (Pyridoxal phosphate-dependent transferase, major region, subdomain 1)
32	vpr-1	F33D11.11	n/a	chrI 5,869,119	C. elegans VPR-1 protein; contains similarity to Pfam domain PF00635 MSP (Major sperm protein) domain contains similarity to Interpro domains IPR008962 (PapD-like), IPR000535 (Major sperm protein), IPR016763 (Vesicle-associated membrane protein)
33	F28A10.10	F28A10.10	n/a	chrII 831,531	contains similarity to Pfam domain PF01467 Cytidylyltransferase contains similarity to Interpro domains IPR004821 (Cytidyltransferase-related), IPR014729 (Rossmann-like alpha/beta/alpha sandwich fold), IPR004820 (Cytidylyltransferase)
34	K06A5.6	K06A5.6	n/a	chrI 6,465,004	contains similarity to Pfam domains PF08028 (Acyl-CoA dehydrogenase, C-terminal domain) , PF02770 (Acyl-CoA dehydrogenase, middle domain) , PF00441 (Acyl-CoA dehydrogenase, C-terminal domain) , PF02771 (Acyl-CoA dehydrogenase, N-terminal domain) contains similarity to Interpro domains IPR013107 (Acyl-CoA dehydrogenase, type 2, C-terminal), IPR006090 (Acyl-CoA oxidase/dehydrogenase, type 1), IPR013786 (Acyl-CoA dehydrogenase/oxidase, N-terminal), IPR006091 (Acyl-CoA dehydrogenase/oxidase, central region), IPR006089 (Acyl-CoA dehydrogenase, conserved site), IPR013764 (Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal), IPR009100 (Acyl-CoA dehydrogenase/oxidase, middle and N-terminal), IPR006092 (Acyl-CoA dehydrogenase, N-terminal)
35	scpl-4	T21C9.12	n/a	chrV 10,600,600	scpl-4 encodes an ortholog of budding yeast TIM50 and human TIMM50 (OMIM:607381); by orthology, SCPL-4 is expected to be part of the mitochondrial inner membrane protein translocase; SCPL-4 is required for embryonic development and fertility in mass RNAi assays; SCPL-4 is distantly similar to FCP-1 and SCPL-1, -2, and -3.
36	str-32	T19H12.7	n/a	chrV 4,880,697	C. elegans STR-32 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
37	M03B6.1	M03B6.1	n/a	chrX 13,842,218
38	cyp-35A2	C03G6.15	n/a	chrV 7,363,242	C. elegans CYP-35A2 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV)
39	F43E2.9	F43E2.9	n/a	chrII 7,359,080
40	ars-2	F28H1.3	n/a	chrI 3,984,796	ars-2 encodes a predicted cytoplasmic alanyl-tRNA synthetase (AlaRS), a class II aminoacyl-tRNA synthetase that catalyzes the attachment of alanine to its cognate tRNA and is thus required for protein biosynthesis; ARS-2 is essential for embryogenesis, and is required for fertility and a normal rate of postembryonic development; ARS-2 expression is likely ubiquitous and detected in hypodermis, intestine, neurons, and the pharynx from late embryogenesis through the adult stage of development.
41	mif-2	C52E4.2	n/a	chrV 11,977,505	C. elegans MIF-2 protein; contains similarity to Pfam domain PF01187 Macrophage migration inhibitory factor (MIF) contains similarity to Interpro domains IPR014347 (Tautomerase), IPR001398 (Macrophage migration inhibitory factor)
42	F53F1.2	F53F1.2	n/a	chrV 13,407,532	contains similarity to Pfam domain PF00248 Aldo/keto reductase family contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)
43	vha-2	R10E11.2	n/a	chrIII 9,782,355	vha-2 and vha-3 encode an ortholog of subunit c of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); the protein encoded by vha-2 and vha-3 (VHA-2/3) is identical; VHA-2/3 is a predicted V-ATPase transmembrane rotor component, whose polypeptide sequence is identical to that of VHA-3; VHA-1 and VHA-2/3 comprise a closely related family of subunit c co-orthologs, predicted to carry protons from the cytosol to a-subunits (VHA-5, VHA-6, VHA-7, or UNC-32) for transmembrane export; VHA-2/3 is dispensable for viability, since vha-2/3(RNAi) animals have mostly healthy progeny; however, VHA-2 is required for ovulation and embryogenesis, since vha-2(RNAi) animals are sterile with polyploid, unmatured oocytes; VHA-2, along with VHA-15 and probably all V-ATPase subunits, is required for systemic RNAi, probably during endocytotic RNAi uptake; VHA-2 is required for necrosis, since vha-2(RNAi) suppresses necrotic neurodegeneration; vha-2 shares an operon with vha-1 and R10E11.6; both vha-2 and vha-1 are expressed in the excretory cell, the rectum, and a pair of cells posterior to the anus.
44	gly-3	ZK688.8	n/a	chrIII 7,916,183	gly-3 encodes an N-acetylgalactosaminyltransferase that is functional in vitro.
45	K04A8.10	K04A8.10	n/a	chrV 6,569,901	contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
46	H23N18.4	H23N18.4	n/a	chrV 4,902,178	contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
47	T24C12.3	T24C12.3	n/a	chrX 2,200,203	contains similarity to Pfam domains PF00294 (pfkB family carbohydrate kinase) , PF04227 (Indigoidine synthase A like protein) contains similarity to Interpro domains IPR011611 (Carbohydrate/purine kinase), IPR002139 (Ribokinase), IPR007342 (Indigoidine synthase A like protein), IPR002173 (Carbohydrate/puine kinase, PfkB, conserved site)
48	ZK370.8	ZK370.8	n/a	chrIII 8,753,333	contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR013026 (Tetratricopeptide region)
49	K03C7.3	K03C7.3	n/a	chrX 3,828,246
50	lst-2	R160.7	n/a	chrX 4,380,673	C. elegans LST-2 protein; contains similarity to Pfam domain PF01363 FYVE zinc finger contains similarity to Interpro domains IPR000306 (Zinc finger, FYVE-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR017455 (Zinc finger, FYVE-related), IPR011011 (Zinc finger, FYVE/PHD-type)