UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	C07H6.2	C07H6.2	3e-34	chrIII 7,521,145	contains similarity to Pfam domain PF07491 Protein phosphatase inhibitor contains similarity to Interpro domain IPR011107 (Protein phosphatase inhibitor)
2	hsp-6	C37H5.8	n/a	chrV 4,825,414	hsp-6 encodes a mitochondrial-specific chaperone that is a member of the DnaK/Hsp70 superfamily of molecular chaperones; hsp-6 is believed to be involved in the mitochondrial unfolded protein response, as hsp-6 expression, normally broadly detected from the L1 larval through adult stages of development, is greatly increased in response to treatments that disrupt mitochondrial protein handling; loss of hsp-6 activity via RNAi results in severe growth defects with arrest at embryonic and early larval stages of development.
3	nhr-253	ZK6.4	n/a	chrV 397,792	C. elegans NHR-253 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000679 (Zinc finger, GATA-type), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
4	C06E1.9	C06E1.9	n/a	chrIII 8,608,051	contains similarity to Interpro domain IPR001680 (WD40 repeat)
5	W07E6.3	W07E6.3	n/a	chrII 496,617	contains similarity to Interpro domain IPR000326 (Phosphatidic acid phosphatase type 2/haloperoxidase)
6	H16D19.4	H16D19.4	n/a	chrI 12,642,571	contains similarity to Dictyostelium discoideum Rep protein.; TR:O15924
7	C40A11.3	C40A11.3	n/a	chrII 2,142,086	contains similarity to Pfam domain PF02214 K+ channel tetramerisation domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR003131 (Potassium channel, voltage dependent, Kv, tetramerisation)
8	clec-187	ZK896.6	n/a	chrIV 12,870,360	C. elegans CLEC-187 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR003990 (Pancreatitis-associated protein), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
9	vha-1	R10E11.8	n/a	chrIII 9,781,407	vha-1 encodes an ortholog of subunit c of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-1 is a predicted V-ATPase transmembrane rotor component; VHA-1 and VHA-2/3 comprise a closely related family of subunit c co-orthologs, predicted to carry protons from the cytosol to a-subunits (VHA-5, VHA-6, VHA-7, or UNC-32) for transmembrane export; VHA-1, like VHA-12 and VHA-17, antagonizes EFF-1-mediated cell fusion in hypodermal cells; VHA-1 is required for ovulation and embryogenesis, since vha-1(RNAi) animals are sterile with polyploid, unmatured oocytes and dead progeny; VHA-1 is required for alae formation, like the V0 subunits VHA-4 and VHA-5, but not like the V1 subunits VHA-8 or VHA-13; vha-1 shares an operon with vha-2 and R10E11.6; both vha-1 and vha-2 are expressed in the excretory cell, the rectum, and a pair of cells near the anus.
10	T03G6.3	T03G6.3	n/a	chrX 2,613,474	contains similarity to Pfam domain PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase contains similarity to Interpro domains IPR017849 (Alkaline phosphatase-like, alpha/beta/alpha), IPR002591 (Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase), IPR017850 (Alkaline-phosphatase-like, core domain)
11	R09D1.2	R09D1.2	n/a	chrII 9,441,109	contains similarity to Pfam domain PF00704 Glycosyl hydrolases family 18 contains similarity to Interpro domains IPR011583 (Chitinase II), IPR017853 (Glycoside hydrolase, catalytic core), IPR001223 (Glycoside hydrolase, family 18, catalytic domain), IPR013781 (Glycoside hydrolase, subgroup, catalytic core)
12	F14F8.8	F14F8.8	n/a	chrV 16,671,873	contains similarity to Saccharomyces cerevisiae Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP; SGD:YHR143W
13	clec-218	W02D7.2	n/a	chrV 8,309,344	C. elegans CLEC-218 protein; contains similarity to Pfam domains PF00092 (von Willebrand factor type A domain) , PF00059 (Lectin C-type domain) contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin), IPR002035 (von Willebrand factor, type A)
14	F09A5.2	F09A5.2	n/a	chrX 13,137,360	contains similarity to Pfam domains PF07714 (Protein tyrosine kinase) , PF00069 (Protein kinase domain) contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR008266 (Tyrosine protein kinase, active site)
15	egg-4	T21E3.1	n/a	chrI 3,933,502	C. elegans EGG-4 protein; contains similarity to Pfam domain PF00102 Protein-tyrosine phosphatase contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type), IPR000387 (Protein-tyrosine phosphatase), IPR000340 (Protein-tyrosine phosphatase, dual specificity)
16	nhr-166	C49D10.2	n/a	chrII 3,881,165	C. elegans NHR-166 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
17	F54E2.5	F54E2.5	n/a	chrV 2,814,230	contains similarity to Pfam domain PF04789 Protein of unknown function (DUF621) contains similarity to Interpro domains IPR006874 (Protein of unknown function DUF621), IPR003091 (Voltage-dependent potassium channel)
18	T22F7.1	T22F7.1	n/a	chrIII 544,286	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR006655 (Molybdopterin oxidoreductase, prokaryotic, conserved site), IPR001991 (Sodium:dicarboxylate symporter), IPR011701 (Major facilitator superfamily MFS-1), IPR005828 (General substrate transporter), IPR016196 (MFS general substrate transporter)
19	T07D3.3	T07D3.3	n/a	chrII 895,627	contains similarity to Homo sapiens CGI16-iso; ENSEMBL:ENSP00000368599
20	ZK1307.4	ZK1307.4	n/a	chrII 9,651,306	contains similarity to Pfam domain PF00635 MSP (Major sperm protein) domain contains similarity to Interpro domains IPR008962 (PapD-like), IPR000535 (Major sperm protein)
21	B0361.6	B0361.6	n/a	chrIII 7,276,316	contains similarity to Pfam domain PF02598 Uncharacterized ACR, COG2106 contains similarity to Interpro domain IPR003750 (Protein of unknown function DUF171)
22	tag-77	C28C12.10	n/a	chrIV 8,506,971	C. elegans TAG-77 protein; contains similarity to Pfam domains PF00169 (PH domain) , PF01363 (FYVE zinc finger) contains similarity to Interpro domains IPR000219 (Dbl homology (DH) domain), IPR001849 (Pleckstrin-like), IPR000306 (Zinc finger, FYVE-type), IPR000694 (Proline-rich region), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR011993 (Pleckstrin homology-type), IPR017455 (Zinc finger, FYVE-related), IPR011011 (Zinc finger, FYVE/PHD-type)
23	F31A9.4	F31A9.4	n/a	chrX 1,779,978
24	T24F1.2	T24F1.2	n/a	chrII 11,304,196	contains similarity to Drosophila melanogaster Flybase gene name is CG7744-PA;; FLYBASE:CG7744
25	lgc-5	F17E9.7	n/a	chrIV 8,343,385	C. elegans LGC-5 protein; contains similarity to Pfam domain PF02931 Neurotransmitter-gated ion-channel ligand binding domain contains similarity to Interpro domains IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding)
26	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
27	T16A9.4	T16A9.4	n/a	chrV 14,218,017	T16A9.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; while T16A9.4 has no clear orthologs in other organisms, it falls into a group of proteins that includes the classical neprilysins found in mammals (e.g., PEX [OMIM:307800] and the enkephalin cleaving enzymes).
28	R02E12.4	R02E12.4	n/a	chrX 4,005,562	contains similarity to Pfam domains PF03148 (Tektin family) , PF00097 (Zinc finger, C3HC4 type (RING finger)) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR000435 (Tektin), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
29	K01A12.2	K01A12.2	n/a	chrX 8,618,599
30	T14B4.2	T14B4.2	n/a	chrII 6,736,402	contains similarity to Pfam domain PF01084 Ribosomal protein S18 contains similarity to Interpro domain IPR001648 (Ribosomal protein S18)
31	pgp-7	T21E8.2	n/a	chrX 10,867,530	pgp-7 encodes an ATP-binding protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; PGP-7 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-7 activity via RNAi results in no obvious defects, the precise role of PGP-7 in C. elegans development and/or behavior is not yet known; pgp-7 promoter-gfp fusion proteins are expressed in the rays of the adult male tail.
32	nhr-125	R02D1.1	n/a	chrV 4,322,934	C. elegans NHR-125 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
33	W09G10.3	W09G10.3	n/a	chrII 3,526,838	contains similarity to Interpro domains IPR011992 (EF-Hand type), IPR002048 (Calcium-binding EF-hand)
34	D1005.1	D1005.1	n/a	chrX 1,481,966	contains similarity to Pfam domains PF08442 (ATP-grasp domain) , PF00549 (CoA-ligase) , PF02629 (CoA binding domain) contains similarity to Interpro domains IPR013650 (ATP-grasp fold, succinyl-CoA synthetase-type), IPR014608 (ATP-citrate synthase), IPR016142 (Citrate synthase-like, large alpha subdomain), IPR005811 (ATP-citrate lyase/succinyl-CoA ligase), IPR016141 (Citrate synthase-like, core), IPR005809 (Succinyl-CoA synthetase, beta subunit), IPR016143 (Citrate synthase-like, small alpha subdomain), IPR005810 (Succinyl-CoA ligase, alpha subunit), IPR016040 (NAD(P)-binding), IPR013816 (ATP-grasp fold, subdomain 2), IPR017440 (ATP-citrate lyase/succinyl-CoA ligase, active site), IPR003781 (CoA-binding), IPR016102 (Succinyl-CoA synthetase-like)
35	C01B7.5	C01B7.5	n/a	chrV 8,800,549	contains similarity to Pfam domain PF00595 PDZ domain (Also known as DHR or GLGF) contains similarity to Interpro domain IPR001478 (PDZ/DHR/GLGF)
36	K08F4.5	K08F4.5	n/a	chrIV 10,135,380	contains similarity to Paramecium tetraurelia Chromosome undetermined scaffold_96, whole genome shotgun sequence.; TR:A0EH68
37	F49E8.6	F49E8.6	n/a	chrIV 7,553,994	contains similarity to Interpro domain IPR000694 (Proline-rich region)
38	F54D10.8	F54D10.8	n/a	chrII 3,826,789	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
39	aco-1	ZK455.1	n/a	chrX 11,341,447	aco-1 encodes an aconitase that is homologous to mammalian iron regulatory protein-1 (IRP1); aco-1 activity is required for normal brood sizes and, under iron stress conditions, for normal lifespan and L4-to-adult growth rates; ACO-1 physically interacts with GEX-3; like IRP1, ACO-1 has aconitase activity and is post-translationally regulated by iron, but, unlike IRP1, it lacks RNA-binding activity; ACO-1 is predicted to be mitochondrial, and its mRNA levels appear to decrease in response to iron treatment.
40	C55A1.1	C55A1.1	n/a	chrV 15,622,421	contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
41	C34C6.2	C34C6.2	n/a	chrII 8,681,696	contains similarity to Homo sapiens KIAA1219; ENSEMBL:ENSP00000302059
42	str-56	T06C12.3	n/a	chrV 15,873,145	C. elegans STR-56 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR003569 (Cytochrome c-type biogenesis protein CcbS)
43	F52B11.2	F52B11.2	n/a	chrIV 14,084,140	F52B11.2 is orthologous to the human gene PHOSPHOMANNOMUTASE 2 (PMS2; OMIM:601785), which when mutated leads to congenital disorder of glycosylation, type Ia.
44	C11D9.1	C11D9.1	n/a	chrI 4,424,085	contains similarity to Pfam domain PF00621 RhoGEF domain contains similarity to Interpro domains IPR000219 (Dbl homology (DH) domain), IPR001478 (PDZ/DHR/GLGF)
45	pqn-27	E01G4.4	n/a	chrII 13,454,655	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
46	F42C5.6	F42C5.6	n/a	chrIV 7,308,755
47	Y48B6A.1	Y48B6A.1	n/a	chrII 14,152,681	Y48B6A.1 encodes an ortholog of human BOP1 (OMIM:610596, overexpressed in colon cancer) and S. cerevisiae ERB1; Y48B6A.1 may suppress tumorous growth in the germline; like PRO-1, -2, and -3, Y48B6A.1 is probably required for ribosome biogenesis, suggesting a link between biogenesis in the distal sheath and control of cell division in the germline; however, BOP1 is also a phosphoprotein in mitotic spindles and required for normal chromosomal segregation, raising the possibility that Y48B6A.1 is multifunctional.
48	Y57G11B.2	Y57G11B.2	n/a	chrIV 14,566,202	contains similarity to Guillardia theta Hypothetical protein orf176 from chromosome 3.; TR:Q98SC3
49	C46A5.2	C46A5.2	n/a	chrIV 7,761,432	contains similarity to Pfam domain PF00858 Amiloride-sensitive sodium channel contains similarity to Interpro domain IPR001873 (Na+ channel, amiloride-sensitive)
50	T05E8.3	T05E8.3	n/a	chrI 5,475,882	The T05E8.3 gene encodes a divergent DEAH helicase that is (apparently) unique to Caenorhabditis; it has no well-characterized orthologs in the complete Drosophila or S. cerevisiae genomes, and no obvious orthologs in the draft human genome sequence either.