UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	C07A9.9	C07A9.9	1e-92	chrIII 9,665,312	contains similarity to Guillardia theta RNA polymerase sigma factor.; TR:Q8S9D0
2	clc-2	C01C10.1	n/a	chrX 7,432,451	clc-2 encodes a claudin homolog, closely similar to CLC-1, that is required for normal cohesion of apical junctions in epithelia; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water; CLC-2 maintains the impermeability ('barrier function') of epithelia, since clc-1(RNAi) animals have abnormal permeability of the hypodermis to dyes; clc-2 is expressed in hypodermal seam cells, with two diffuse lines of CLC-2 protein.
3	F46F5.14	F46F5.14	n/a	chrII 800,774	contains similarity to Pfam domain PF03314 Protein of unknown function, DUF273 contains similarity to Interpro domain IPR004988 (Protein of unknown function DUF273)
4	T23C6.4	T23C6.4	n/a	chrX 17,148,667	contains similarity to Lactobacillus plantarum Translation initiation factor IF-2.; SW:Q88VK7
5	nhr-67	C08F8.8	n/a	chrIV 11,172,266	nhr-67 encodes a nuclear receptor that is orthologous to Drosophila and vertebrate tailless hormone receptors; during development, nhr-67 plays an essential role in larval development and also functions as part of a complex regulatory network that regulates vulval patterning and differentiation and thus, egg laying; specifically, nhr-67 functions to positively regulate gene expression in the vulA, vulD, and vulF cells and negatively regulate gene expression in vulE and vulF; in regulating vulval gene expression, nhr-67 functions together with other transcription factors, including egl-38, lin-11, and cog-1; nhr-67 reporter fusion constructs are expressed dynamically in multiple vulval cell types as well as in head neurons, the hyp7 syncytium, late-stage embryos, the male tail, the anchor cell, and the linker cell.
6	C16C10.9	C16C10.9	n/a	chrIII 4,156,357	contains similarity to Bacillus anthracis MutS2 family protein.; TR:Q81L40
7	R02F2.2	R02F2.2	n/a	chrIII 5,493,250	contains similarity to Pfam domain PF00621 RhoGEF domain contains similarity to Interpro domains IPR000219 (Dbl homology (DH) domain), IPR011046 (WD40 repeat-like), IPR001331 (Guanine-nucleotide dissociation stimulator, CDC24, conserved site)
8	sdz-19	F45E6.6	n/a	chrX 12,502,884	C. elegans SDZ-19 protein ;
9	M28.4	M28.4	n/a	chrII 10,645,246	contains similarity to Homo sapiens Kinesin-like protein 2; ENSEMBL:ENSP00000324020
10	rab-14	K09A9.2	n/a	chrX 15,605,871	rab-14 encodes a member of the Rab GTPase family.
11	set-19	W01C8.3	n/a	chrX 5,677,695	set-19 encodes a SET domain-containing protein; SET-19 has no non-nematode orthologs, but several paralogs (SET-6, SET-13, SET-15, SET-20, SET-21, and SET-32); neither set-19(ok1813) nor set-19(RNAi) have any obvious phenotypes.
12	F57A8.1	F57A8.1	n/a	chrV 10,045,776	contains similarity to Interpro domain IPR009058 ()
13	valv-1	B0496.7	n/a	chrIV 7,444,987	B0496.7 encodes a LIM domain-containing protein.
14	M03C11.1	M03C11.1	n/a	chrIII 10,394,622	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
15	sdz-3	C29F5.2	n/a	chrII 6,300,414	C. elegans SDZ-3 protein ;
16	pag-3	F45B8.4	n/a	chrX 14,952,780	pag-3 encodes a C2H2 zinc-finger protein orthologous to Drosophila SENSELESS, and to human GFI1 (OMIM:600871, mutated in neutropenia) and GFI1B (OMIM:604383); pag-3 is expressed in neurons (touch receptors, BDU interneurons, ventral cord motor neurons, and others); PAG-3 is required to repress the touch neuron-specific genes mec-4 and mec-7 in BDU neurons, but since this repression does not occur in touch neurons (which also have PAG-3), PAG-3 may require another protein or proteins for repression (such as PRK-1 or PRK-2, the C. elegans orthologs of human PIM-1); PAG-3 is also needed for normal neuroblast lineages in the ventral nerve cord, and for normal locomotion; pag-3 mutants have a reverse kinker uncoordinated phenotype, and occasional axonal guidance errors in the PLM and BDU neurons; PAG-3's similarity to GFI1 and GFIB falls mainly within residues 159-261, but within these residues (which overlap PAG-3's five zinc-finger domains in residues 126-265) the amino acid identity is 87%; pag-3 transcript quantities are doubled in pag-3 mutants, suggesting that PAG-3 inhibits its own gene.
17	F31F4.11	F31F4.11	n/a	chrV 663,441	contains similarity to Pfam domains PF00788 (Ras association (RalGDS/AF-6) domain) , PF02204 (Vacuolar sorting protein 9 (VPS9) domain) contains similarity to Interpro domains IPR013995 (Vacuolar sorting protein 9, subgroup), IPR003123 (Vacuolar sorting protein 9), IPR000159 (Ras-association)
18	flp-32	R03A10.2	n/a	chrX 15,434,497	C. elegans FLP-32 protein ;
19	C01B12.2	C01B12.2	n/a	chrII 20,848	contains similarity to Pfam domain PF01342 SAND domain contains similarity to Interpro domains IPR010919 (SAND-like), IPR000770 (SAND)
20	R04B3.1	R04B3.1	n/a	chrX 2,468,815	contains similarity to Interpro domain IPR000998 (MAM)
21	unc-75	C17D12.2	n/a	chrI 11,596,943	unc-75 encodes an RNA-binding protein with two N-terminal RNA recognition motifs (RRMs), a glutamine/asparagine-rich linker domain, and a third C-terminal RRM; UNC-75 is orthologous to mammalian CELF/BrunoL proteins that control pre-mRNA splicing; unc-75 is expressed in all neurons and in neurosecretory gland cells, and is required for normal modulation of GABA- and acetylcholine-mediated neurotransmission; UNC-75 protein is found with other RRM proteins in dynamic nuclear speckles, consistent with a role in alternative mRNA splicing; unc-75 mutations can be rescued in vivo by a human unc-75 transgene, but not by exc-7 or W02D3.11, indicating that UNC-75 acts on evolutionarily conserved but highly specific pre-mRNA substrates; both UNC-75 and EXC-7 are required in parallel for normal cholinergic neurotransmission.
22	ctbp-1	F49E10.5	n/a	chrX 5,867,998	tag-45 encodes a D-isomer specific 2-hydroxyacid dehydrogenase.
23	mif-3	F13G3.9	n/a	chrI 7,313,193	C. elegans MIF-3 protein; contains similarity to Pfam domain PF01187 Macrophage migration inhibitory factor (MIF) contains similarity to Interpro domains IPR014347 (Tautomerase), IPR001398 (Macrophage migration inhibitory factor)
24	M28.1	M28.1	n/a	chrII 10,624,279	contains similarity to Pfam domain PF00100 Zona pellucida-like domain contains similarity to Interpro domain IPR001507 (Endoglin/CD105 antigen)
25	srj-50	T03D3.2	n/a	chrV 2,833,942	C. elegans SRJ-50 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
26	F32D1.3	F32D1.3	n/a	chrV 4,355,654	contains similarity to Pfam domains PF07719 (Tetratricopeptide repeat) (3), PF08409 (Domain of unknown function (DUF1736)) , PF00515 (Tetratricopeptide repeat) (6)contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR013618 (Region of unknown function DUF1736), IPR008940 (Protein prenyltransferase), IPR001440 (Tetratricopeptide TPR-1), IPR013105 (Tetratricopeptide TPR2), IPR013026 (Tetratricopeptide region)
27	F55E10.2	F55E10.2	n/a	chrX 8,340,780
28	lim-4	ZC64.4	n/a	chrX 3,871,505	lim-4 encodes a LIM homeodomain protein homologous to murine Lhx6 and L3/Lhx7, and to Drosophila ARROWHEAD; LIM-4 is required for differentiation of AWB chemosensory neurons, for several but not all aspects of RID motor neuron differentiation, expression of ser-2, repulsion from chemosensory repellants, SAA neurite outgrowth, and normal locomotion and head foraging; lim-4 is expressed in AWB, RID, RIV, RMDL, RMDR, RMEV, four SAA neurons, and four SIA neurons.
29	R02C2.1	R02C2.1	n/a	chrV 237,472	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
30	tkr-1	C38C10.1	n/a	chrIII 9,386,535	tkr-1 encodes a G protein-coupled receptor that is the C. elegans tachykinin-like neuropeptide receptor homolog; by homology, TKR-1 is predicted to function in modulation of excitatory neurotransmission; as loss of tkr-1 activity via RNAi results in moderate reduction of fat content, TKR-1 may play a specific role in regulating lipid metabolism; a tkr-1 reporter gene fusion is reportedly expressed in the socket cells of the deirid and post-deirid sensilla from the L2 larval stage through adulthood.
31	C10A4.3	C10A4.3	n/a	chrX 7,408,027
32	F32H2.6	F32H2.6	n/a	chrI 8,999,077	contains similarity to Pfam domain PF00109 Beta-ketoacyl synthase, N-terminal domain contains similarity to Interpro domains IPR016038 (Thiolase-like, subgroup), IPR000794 (Beta-ketoacyl synthase), IPR014030 (Beta-ketoacyl synthase, N-terminal), IPR016039 (Thiolase-like)
33	F56F11.5	F56F11.5	n/a	chrIII 2,853,197
34	fbxb-71	F40F4.1	n/a	chrX 3,263,537	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
35	dkf-1	W09C5.5	n/a	chrI 13,644,346	C. elegans DKF-1 protein; contains similarity to Pfam domains PF00069 (Protein kinase domain) , PF00130 (Phorbol esters/diacylglycerol binding domain (C1 domain)) (2)contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR001849 (Pleckstrin-like), IPR000719 (Protein kinase, core), IPR015727 (Protein kinase C mu-related), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR002219 (Protein kinase C, phorbol ester/diacylglycerol binding)
36	glf-1	H04M03.4	n/a	chrIV 5,887,804	H04M03.4 encodes a UDP-galactopyranose mutase predicted to synthesize galactofuranose (Gal(f)) as a nucleotide sugar (UDP-Gal(f)); recombinant H04M03.4 has biochemical activity either in vivo (expressed in E. coli) or in vitro; orthologs of H04M03.4 are found in the urochordates Halocynthia and Ciona.
37	str-143	C09H5.4	n/a	chrV 8,068,920	C. elegans STR-143 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
38	srbc-10	C18B10.2	n/a	chrV 7,492,430	C. elegans SRBC-10 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
39	unc-29	T08G11.5	n/a	chrI 8,899,525	unc-29 encodes an non-alpha subunit of the nicotinic acetylcholine receptor (nAChR) superfamily; UNC-29 is required for normal locomotion and egg-laying, and functions as a subunit of a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with LEV-1, a non-alpha nAChR subunit, and UNC-38 or UNC-63, alpha AChR subunits, the resulting multimer can form levamisole-gated channels; UNC-29 is expressed in body wall muscle.
40	F35F10.12	F35F10.12	n/a	chrV 3,314,352	contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF02752 (Arrestin (or S-antigen), C-terminal domain) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011022 (Arrestin-like, C-terminal), IPR000694 (Proline-rich region), IPR000698 (Arrestin), IPR014752 (Arrestin, C-terminal), IPR011021 (Arrestin-like, N-terminal)
41	C15B12.3	C15B12.3	n/a	chrX 6,467,380
42	F39C12.1	F39C12.1	n/a	chrX 4,843,950	contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR000694 (Proline-rich region), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
43	T09E8.4	T09E8.4	n/a	chrV 13,182,889	contains similarity to Pfam domain PF02460 Patched family contains similarity to Interpro domains IPR003392 (Patched), IPR000731 (Sterol-sensing 5TM box)
44	str-13	C24B9.8	n/a	chrV 2,726,550	C. elegans STR-13 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
45	F53F4.2	F53F4.2	n/a	chrV 13,589,230	contains similarity to Hordeum vulgare Glycine-rich cell wall structural protein precursor.; SW:P17816
46	T20B6.1	T20B6.1	n/a	chrIII 2,898,031	contains similarity to Pfam domain PF00102 Protein-tyrosine phosphatase contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR016130 (Protein-tyrosine phosphatase, active site), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type), IPR000387 (Protein-tyrosine phosphatase)
47	clec-146	Y48E1B.9	n/a	chrII 13,592,126	C. elegans CLEC-146 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
48	C06E1.1	C06E1.1	n/a	chrIII 8,606,076	contains similarity to Pfam domain PF03134 TB2/DP1, HVA22 family contains similarity to Interpro domain IPR004345 (TB2/DP1 and HVA22 related protein)
49	clec-141	EEED8.11	n/a	chrII 5,406,695	C. elegans CLEC-141 protein; contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR001304 (C-type lectin)
50	F11G11.4	F11G11.4	n/a	chrII 4,861,326