UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	stdh-1	C06B3.4	5e-180	chrV 13,907,215	stdh-1 encodes a putative steroid dehydrogenase required for normally short lifespan; STDH-1 is orthologous to human HSD17B3 (OMIM:605573, mutated in pseudohermaphroditism), HSD17B12 (OMIM:609574), and HSDL1, and paralogous to LET-767 and STDH-2/-4; STDH-1 is expressed in larval intestine, and in both larval and adult body wall muscle and neurons.
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	col-132	C39E9.9	n/a	chrIV 13,090,324	C. elegans COL-132 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (2)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR008160 (Collagen triple helix repeat)
4	T11F1.2	T11F1.2	n/a	chrII 2,957,123	contains similarity to Pfam domain PF01030 Receptor L domain contains similarity to Interpro domain IPR000494 (EGF receptor, L domain)
5	hlh-4	T05G5.2	n/a	chrIII 9,738,064	C. elegans HLH-4 protein; contains similarity to Pfam domain PF00010 Helix-loop-helix DNA-binding domain contains similarity to Interpro domains IPR015660 (Achaete-scute transcription factor related), IPR001092 (Basic helix-loop-helix dimerisation region bHLH), IPR000694 (Proline-rich region), IPR011598 (Helix-loop-helix DNA-binding)
6	nhr-169	C54C8.1	n/a	chrI 12,443,002	C. elegans NHR-169 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
7	tbx-41	T26C11.1	n/a	chrX 1,865,937	C. elegans TBX-41 protein; contains similarity to Pfam domain PF00907 T-box contains similarity to Interpro domains IPR008967 (p53-like transcription factor, DNA-binding), IPR001699 (Transcription factor, T-box)
8	grd-8	C37C3.4	n/a	chrV 7,843,402	grd-8 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central low-complexity proline-rich domain, and a C-terminal Ground domain; GRD-8 is expressed in larval intestine and neurons; the grd-8 gene is directly bound by DAF-12 and requires DAF-12 for full transcription; GRD-8's Ground domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-8 is weakly required for normal molting; GRD-8 is also required for normal adult alae formation, growth to full size, locomotion, and male tail development; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
9	clec-156	F26A1.11	n/a	chrIII 4,842,010	C. elegans CLEC-156 protein; contains similarity to Interpro domains IPR006077 (Vinculin/alpha-catenin), IPR000694 (Proline-rich region), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
10	F18A12.6	F18A12.6	n/a	chrII 3,401,335	F18A12.6 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F18A12.6 has no clear orthologs in other organisms.
11	C40D2.4	C40D2.4	n/a	chrII 2,000,282	contains similarity to Pfam domain PF00046 Homeobox domain contains similarity to Interpro domains IPR012287 (Homeodomain-related), IPR001356 (Homeobox), IPR009057 (Homeodomain-like)
12	Y38F1A.2	Y38F1A.2	n/a	chrII 12,956,401	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
13	H40L08.3	H40L08.3	n/a	chrX 15,073,031	contains similarity to Trichomonas vaginalis G3 Viral A-type inclusion protein, putative.; TR:A2EJ43
14	C45G9.8	C45G9.8	n/a	chrIII 5,052,953
15	try-6	F48A9.3	n/a	chrI 6,586,594	C. elegans TRY-6 protein; contains similarity to Pfam domains PF00089 (Trypsin) , PF03761 (Domain of unknown function (DUF316)) contains similarity to Interpro domains IPR001314 (Peptidase S1A, chymotrypsin), IPR001254 (Peptidase S1 and S6, chymotrypsin/Hap), IPR005514 (Protein of unknown function DUF316), IPR009003 (Peptidase, trypsin-like serine and cysteine)
16	F27C8.5	F27C8.5	n/a	chrIV 9,591,134	contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
17	F46F5.10	F46F5.10	n/a	chrII 824,543	contains similarity to Pfam domain PF07801 Protein of unknown function (DUF1647) contains similarity to Interpro domain IPR012444 (Protein of unknown function DUF1647)
18	M163.7	M163.7	n/a	chrX 14,466,135	contains similarity to Reclinomonas americana Ribosomal protein L31.; TR:O21296
19	F15D3.8	F15D3.8	n/a	chrI 11,580,950	contains similarity to Methanocaldococcus jannaschii Chromosome partition protein smc homolog.; SW:Q59037
20	srg-13	T23F11.5	n/a	chrIII 4,673,171	C. elegans SRG-13 protein; contains similarity to Pfam domain PF02118 C.elegans Srg family integral membrane protein contains similarity to Interpro domains IPR001411 (Tetracycline resistance protein, TetB), IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
21	C18F10.2	C18F10.2	n/a	chrIII 6,274,532	contains similarity to Schizosaccharomyces pombe Sporulation-specific protein 15.; SW:Q10411
22	F31B9.2	F31B9.2	n/a	chrX 15,919,200	contains similarity to Mus musculus Radixin (ESP10).; SW:RADI_MOUSE
23	F02E11.3	F02E11.3	n/a	chrII 3,273,416	contains similarity to Interpro domain IPR010993 (Sterile alpha motif homology)
24	F37C4.1	F37C4.1	n/a	chrIV 3,890,907	contains similarity to Pfam domain PF01757 Acyltransferase family contains similarity to Interpro domain IPR002656 (Acyltransferase 3)
25	srb-19	C54F6.11	n/a	chrV 7,518,912	C. elegans SRB-19 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domain IPR000344 (Nematode chemoreceptor, Sra)
26	fbxa-30	ZC47.4	n/a	chrIII 1,275,041	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
27	F59H6.2	F59H6.2	n/a	chrII 2,021,048
28	R07C3.10	R07C3.10	n/a	chrII 910,744
29	R07H5.10	R07H5.10	n/a	chrIV 11,214,469	contains similarity to Pfam domain PF07716 Basic region leucine zipper contains similarity to Interpro domains IPR011700 (Basic leucine zipper), IPR004827 (Basic-leucine zipper (bZIP) transcription factor)
30	sru-35	C33D9.4	n/a	chrIV 8,789,328	C. elegans SRU-35 protein; contains similarity to Pfam domain PF02688 Domain of unknown function DUF215 contains similarity to Interpro domain IPR003839 (Protein of unknown function DUF215)
31	B0041.1	B0041.1	n/a	chrI 4,665,314
32	ZK1290.10	ZK1290.10	n/a	chrII 7,552,859	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR003582 (Metridin-like ShK toxin)
33	acr-21	F27B3.2	n/a	chrIII 6,584,504	acr-21 encodes an alpha subunit of nicotinic acetylcholine receptor (nAChR); ACR-21 is a highly divergent member of the 'ACR-16' class of nAChR subunits, which includes ACR-7, ACR-9, ACR-10, ACR-11, ACR-14, ACR-15, ACR-16, and ACR-19, and is most closely related to the alpha-7 subunits of vertebrate nAChRs.
34	srd-49	R04B5.8	n/a	chrV 10,095,486	C. elegans SRD-49 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR003002 (7TM chemoreceptor, subfamily 1)
35	C56G2.5	C56G2.5	n/a	chrIII 6,323,209	contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR008973 (C2 calcium/lipid-binding region, CaLB)
36	F18A12.4	F18A12.4	n/a	chrII 3,405,348	F18A12.4 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; F18A12.4 has no clear orthologs in other organisms.
37	F47G6.2	F47G6.2	n/a	chrI 1,475,611	contains similarity to Pfam domain PF00501 AMP-binding enzyme contains similarity to Interpro domain IPR000873 (AMP-dependent synthetase and ligase)
38	C27C7.5	C27C7.5	n/a	chrI 11,425,014	contains similarity to Pfam domains PF00337 (Galactoside-binding lectin) , PF08277 (PAN-like domain) contains similarity to Interpro domains IPR006583 (CW), IPR001079 (Galectin, galactose-binding lectin), IPR013320 (Concanavalin A-like lectin/glucanase, subgroup), IPR008985 (Concanavalin A-like lectin/glucanase)
39	ZK402.2	ZK402.2	n/a	chrX 1,403,926	contains similarity to Pfam domain PF04435 Domain of unknown function (DUF545) contains similarity to Interpro domain IPR006570 (SPK)
40	M04D8.5	M04D8.5	n/a	chrIII 10,032,724	contains similarity to Periplaneta americana Large conductance calcium activated potassium channel pSlo spliceforms1-5A.; TR:Q8I9V1
41	sru-22	F36G9.5	n/a	chrV 15,973,922	C. elegans SRU-22 protein; contains similarity to Pfam domain PF02688 Domain of unknown function DUF215 contains similarity to Interpro domain IPR003839 (Protein of unknown function DUF215)
42	Y113G7A.12	Y113G7A.12	n/a	chrV 20,140,914
43	Y37D8A.22	Y37D8A.22	n/a	chrIII 12,937,773	contains similarity to Danio rerio Transmembrane protein 49.; SW:Q6NYY9
44	F53H4.4	F53H4.4	n/a	chrX 15,867,475	contains similarity to Salmonella typhi Hypothetical protein STY0658.; TR:Q8Z8J9
45	T27E7.4	T27E7.4	n/a	chrIV 14,534,258	contains similarity to Pelomedusa subrufa NADH-ubiquinone oxidoreductase chain 5 (EC 1.6.5.3).; SW:NU5M_PELSU
46	T02G6.2	T02G6.2	n/a	chrI 11,801,906	contains similarity to Arabidopsis thaliana Hypothetical protein.; TR:Q9C9Y9
47	ndx-2	W02G9.1	n/a	chrV 2,664,041	ndx-2 encodes a NUDIX hydrolase; by sequence comparison, NDX-2 is predicted to be orthologous to human NUDT5 which, in vitro, possesses ADP-sugar diphosphatase activity; in C. elegans, loss of ndx-2 activity via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, consistent with the proposed nonessential roles for Nudix proteins in eliminating potentially toxic nucleotide metabolites from cells and modulating levels of metabolic intermediates by shuttling them into alternative biochemical pathways.
48	F55F1.1	F55F1.1	n/a	chrX 2,779,060	contains similarity to Homo sapiens Rho family guanine-nucleotide exchange factor; ENSEMBL:ENSP00000328118
49	ins-37	F08G2.6	n/a	chrII 13,835,294	ins-37 encodes an insulin-like peptide.
50	irk-1	R03E9.4	n/a	chrX 6,769,400	C. elegans IRK-1 protein; contains similarity to Pfam domain PF01007 Inward rectifier potassium channel contains similarity to Interpro domains IPR013521 (Potassium channel, inwardly rectifying, Kir, conserved region 2), IPR014756 (Immunoglobulin E-set), IPR013518 (Potassium channel, inwardly rectifying, Kir, cytoplasmic), IPR001838 (Potassium channel, inwardly rectifying, Kir-like)