UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	fkb-3	C05C8.3	2e-136	chrV 7,225,808	fkb-3 encodes a peptidylprolyl cis/trans isomerase homologous to mammalian FK506 immunosuppressant-binding protein 9; FKB-3 expression is positively regulated by signaling through the DAF-2 insulin receptor-like pathway and the activity of the DAF-16 fork-head transcription factor suggesting that FKB-3 could play a role in metabolism and longevity; however, as loss of FKB-3 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of FKB-3 in C. elegans development and/or behavior is not yet known; FKB-3 contains a predicted endoplasmic reticulum (ER) retention sequence and is thus proposed to localize to the ER.
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	dpy-18	Y47D3B.10	n/a	chrIII 11,375,393	An alpha subunit of prolyl-4-hydroxylase which is a procollagen modifying enzyme required for exoskeleton formation, morphogenesis and maintenance of body shape; it is expressed throughout the hypodermis and certain head and posterior neurons.
4	T19B10.2	T19B10.2	n/a	chrV 11,222,045
5	ZK1025.2	ZK1025.2	n/a	chrI 11,450,904	contains similarity to Pfam domain PF04590 Protein of unknown function, DUF595 contains similarity to Interpro domain IPR007669 (Protein of unknown function DUF595)
6	ZK662.2	ZK662.2	n/a	chrX 15,697,316	contains similarity to Homo sapiens Metallothionein-IL; ENSEMBL:ENSP00000290704
7	ZK1025.8	ZK1025.8	n/a	chrI 11,470,513	contains similarity to Pfam domain PF04590 Protein of unknown function, DUF595 contains similarity to Interpro domain IPR007669 (Protein of unknown function DUF595)
8	lon-3	ZK836.1	n/a	chrV 12,198,007	lon-3 encodes a cuticle collagen; during development, lon-3 acts downstream of the TGF-beta signaling pathway to specify body length; lon-3 reporter fusions are expressed in hypodermal cells and LON-3 appears to localize to the surface of the animal, consistent with a role in cuticle formation.
9	C05G5.4	C05G5.4	n/a	chrX 14,755,163	contains similarity to Pfam domains PF00549 (CoA-ligase) , PF02629 (CoA binding domain) contains similarity to Interpro domains IPR005811 (ATP-citrate lyase/succinyl-CoA ligase), IPR005810 (Succinyl-CoA ligase, alpha subunit), IPR016040 (NAD(P)-binding), IPR017440 (ATP-citrate lyase/succinyl-CoA ligase, active site), IPR003781 (CoA-binding), IPR016102 (Succinyl-CoA synthetase-like)
10	hke-4.2	H13N06.5	n/a	chrX 15,506,879	C. elegans HKE-4.2 protein; contains similarity to Pfam domain PF02535 ZIP Zinc transporter contains similarity to Interpro domains IPR002395 (HMW kininogen), IPR003689 (Zinc/iron permease)
11	erd-2	F09B9.3	n/a	chrX 10,158,581	erd-2 encodes a protein with homology to human ER lumen protein retaining receptor 1.
12	set-15	R11E3.4	n/a	chrIV 4,777,653	set-15 encodes a SET domain-containing protein required for normally short lifespan; SET-15 has no non-nematode orthologs, but several paralogs (SET-6, SET-13, SET-19, SET-20, SET-21, and SET-32); other than extending lifespan, set-15(RNAi) has no obvious phenotype.
13	F53F1.4	F53F1.4	n/a	chrV 13,411,377	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR013286 (Annexin, type VII)
14	tfg-1	Y63D3A.5	n/a	chrI 14,103,115	C. elegans TFG-1 protein; contains similarity to Pfam domain PF00564 PB1 domain contains similarity to Interpro domains IPR006030 (Molluscan rhodopsin C-terminal tail), IPR000694 (Proline-rich region), IPR000270 (Octicosapeptide/Phox/Bem1p)
15	fasn-1	F32H2.5	n/a	chrI 8,980,067	fasn-1 encodes a putative fatty acid synthase, orthologous to human FASN (OMIM:600212); CEP-1 is required for fully normal fasn-1 expression in vivo; CEP-1 drives transcription of luciferase reporters whose promoters contains either of two putative CEP-1 binding sites (FAS-T1 and FAS-T2) found in the fasn-1 gene, and this activity is partially lost by mutation of conserved CEP-1 residues (R298 or H310); in humans, the CEP-1 ortholog isoforms TAp73alpha and deltaNp63alpha bind the human FASN gene, suggesting that FASN genes might be a conserved direct target of p53-like proteins in metazoa; fasn-1 transcription is moderately activated (2 to 4-fold) in L1 or L2 larvae starved for 12 hours, but is not so activated in later larvae or adults.
16	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
17	tni-1	F42E11.4	n/a	chrX 11,376,606	tni-1 encodes a member of the troponin family that affects body morphology, locomotion, egg laying, and epithelial morphogenesis in a large-scale RNAi analysis.
18	R11A5.7	R11A5.7	n/a	chrI 7,873,884	contains similarity to Pfam domains PF00246 (Zinc carboxypeptidase) , PF01549 (ShK domain-like) , PF02244 (Carboxypeptidase activation peptide) contains similarity to Interpro domains IPR003146 (Proteinase inhibitor, carboxypeptidase propeptide), IPR000834 (Peptidase M14, carboxypeptidase A), IPR009020 (Proteinase inhibitor, propeptide), IPR003582 (Metridin-like ShK toxin)
19	F49E12.6	F49E12.6	n/a	chrII 8,414,691	The F49E12.6 gene encodes a protein with two E2F domains that may be involved in apoptosis.
20	C15C7.5	C15C7.5	n/a	chrX 3,151,795	contains similarity to Oryctolagus cuniculus Trichohyalin.; SW:P37709
21	H03E18.1	H03E18.1	n/a	chrX 8,510,941	contains similarity to Pfam domain PF00024 PAN domain contains similarity to Interpro domains IPR003609 (Apple-like), IPR003014 (N/apple PAN)
22	K01A2.5	K01A2.5	n/a	chrII 303,020	contains similarity to Pfam domain PF00561 alpha/beta hydrolase fold contains similarity to Interpro domains IPR000073 (Alpha/beta hydrolase fold-1), IPR003089 (Alpha/beta hydrolase)
23	cyn-6	F42G9.2	n/a	chrIII 773,770	cyn-6 encodes a cyclophilin most similar to human secreted cyclophilin type B isoforms that is functional when expressed in E. coli; it is expressed in the intestine.
24	nrs-2	F25G6.6	n/a	chrV 8,547,557	nrs-2 encodes a predicted asparaginyl-tRNA synthetase (AsnRS), a class II aminoacyl-tRNA synthetase that catalyzes the attachment of asparagine to its cognate tRNA and is thus required for protein biosynthesis; loss of nrs-2 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities.
25	pyr-1	D2085.1	n/a	chrII 8,654,903	pyr-1 is orthologous to the human gene CARBAMYL PHOSPHATE SYNTHETASE I (CPS1, which when mutated leads to hyperammonemia (OMIM:237300); PYR-1 protein is predicted to be mitochondrial with 68% accuracy.
26	col-65	K08C9.4	n/a	chrI 11,489,885	C. elegans COL-65 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (2)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR008160 (Collagen triple helix repeat)
27	col-182	R09A8.4	n/a	chrX 12,636,305	C. elegans COL-182 protein; contains similarity to Pfam domain PF01391 Collagen triple helix repeat (20 copies) contains similarity to Interpro domain IPR008160 (Collagen triple helix repeat)
28	sft-4	C54H2.5	n/a	chrX 5,779,970	sft-4 encodes a member of the SURF family highly conserved with the mouse Surf-4 gene, and conservation includes an encoded dilysine motif that is implicated in endoplasmic reticulum localization of the mouse protein.
29	F40E10.5	F40E10.5	n/a	chrX 14,702,656	contains similarity to Onchocerca volvulus OV39 antigen (Fragment).; SW:P31730
30	Y47D3B.6	Y47D3B.6	n/a	chrIII 11,427,622	contains similarity to Pfam domain PF01683 EB module contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR000480 (Glutelin), IPR006149 (Nematode-specific EB region)
31	odc-1	K11C4.4	n/a	chrV 6,899,252	odc-1 encodes ornithine decarboxylase, the first enzyme of polyamine biosynthesis that catalyzes the conversion of ornithine to putrescine; ODC-1 is required for development when animals are deprived of exogenous polyamines, which are required for oogenesis and completion of embryogenesis; in addition,ODC-1 may contribute to male fertility; ODC-1 activity is detectable at all developmental stages, with highest levels observed in adults and L4 larvae.
32	lpr-3	W04G3.8	n/a	chrX 11,058,541	W04G3.8 encodes a novel protein, conserved amongst nematodes; large-scale RNAi experiments indicate that W04G3.8 activity is required for normal growth rates, early larval development, and coordinated locomotion.
33	C02E7.7	C02E7.7	n/a	chrV 4,918,355	contains similarity to Homo sapiens Isoform 3 of AMME syndrome candidate gene 1 protein; ENSEMBL:ENSP00000361129
34	acbp-3	F47B10.7	n/a	chrX 10,904,105	acbp-3 encodes an Acyl-CoA-binding protein; a deletion mutation, tm2924, that overlaps with the 5' region of acbp-3 has been reported to result in lethality and sterility.
35	F22F4.1	F22F4.1	n/a	chrX 6,005,723
36	T03G6.1	T03G6.1	n/a	chrX 2,609,102
37	grl-10	C26F1.5	n/a	chrV 7,775,086	grl-10 encodes a hedgehog-like protein, with an N-terminal signal sequence and a C-terminal Ground-like (Grl) domain; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
38	C15C6.1	C15C6.1	n/a	chrI 12,202,933	contains similarity to Caulobacter crescentus Hypothetical protein CC0499.; TR:Q9AAU5
39	F08A8.2	F08A8.2	n/a	chrI 12,944,409	contains similarity to Pfam domains PF01756 (Acyl-CoA oxidase) , PF02770 (Acyl-CoA dehydrogenase, middle domain) contains similarity to Interpro domains IPR013786 (Acyl-CoA dehydrogenase/oxidase, N-terminal), IPR006091 (Acyl-CoA dehydrogenase/oxidase, central region), IPR013764 (Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal), IPR012258 (Acyl-CoA oxidase), IPR009100 (Acyl-CoA dehydrogenase/oxidase, middle and N-terminal), IPR002655 (Acyl-CoA oxidase, C-terminal), IPR009075 (Acyl-CoA dehydrogenase/oxidase C-terminal)
40	M03B6.3	M03B6.3	n/a	chrX 13,862,714	contains similarity to Interpro domain IPR000694 (Proline-rich region)
41	T25B6.2	T25B6.2	n/a	chrX 9,036,480	T25B6.2 encodes two isoforms of a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; T25B6.2 is orthologous to Ac-mep-1, a gut luminal neprilysin which is specifically expressed in the adult life stage of Ancylostoma caninum hookworms, and whose protein product is localized to the microvilli of the gastrointestinal tract, suggesting a role in digestion.
42	ptr-1	C24B5.3	n/a	chrV 9,179,855	ptr-1 encodes an ortholog of Drosophila and human PTCHD3, which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; individually, PTR-1 is weakly required for normal molting from L4 to adult stages; however, PTR-1, in conjunction with either PTR-16 alone or with PTR-6 and PTR-10, is strongly required for both molting and viability, with double ptr-1/-16 or triple ptr-1/-6/-10 RNAi animals showing pronounced molting defects and lethality; PTR-1 is also required for normal adult alae formation, growth to full size, locomotion, and male tail development.
43	F53B1.4	F53B1.4	n/a	chrX 2,112,426	contains similarity to Pfam domains PF07993 (Male sterility protein) , PF01370 (NAD dependent epimerase/dehydratase family) , PF04321 (RmlD substrate binding domain) , PF01073 (3-beta hydroxysteroid dehydrogenase/isomerase family) , PF02719 (Polysaccharide biosynthesis protein) contains similarity to Interpro domains IPR003869 (Polysaccharide biosynthesis protein CapD), IPR002225 (3-beta hydroxysteroid dehydrogenase/isomerase), IPR005913 (dTDP-4-dehydrorhamnose reductase), IPR001509 (NAD-dependent epimerase/dehydratase), IPR002347 (Glucose/ribitol dehydrogenase), IPR016040 (NAD(P)-binding), IPR013120 (Male sterility, NAD-binding)
44	col-76	M110.1	n/a	chrII 8,205,836	C. elegans COL-76 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR008161 (Collagen helix repeat), IPR008160 (Collagen triple helix repeat)
45	gana-1	R07B7.11	n/a	chrV 12,088,053	gana-1 encodes a protein with homology to both human alpha-galactosidase (alpha-GAL) and alpha-N-acetylgalactosaminidase (alpha-NAGA) enzymes; these dual enzymatic activities were detected in mixed culture homogenates; immunofluorescence studies show cytoplasmic expression of GANA-1 in body wall muscle and intestinal cells and in coelomocytes; the human gene alpha-galactosidase B (GALB; OMIM:104170), when mutated leads to Schindler disease, Kanzaki disease, or NAGA deficiency.
46	F19H8.4	F19H8.4	n/a	chrII 14,619,275	contains similarity to Pfam domain PF04870 Protein of unknown function, DUF644 contains similarity to Interpro domain IPR006954 (Protein of unknown function DUF644)
47	dsc-4	K02D7.4	n/a	chrIV 317,817	dsc-4 encodes the C. elegans ortholog of the large subunit of the microsomal triglyceride transfer protein; dsc-4 affects the length of the defecation cycle and genetically interacts with clk-1 with respect to defecation cycle length, and also with respect to the clk-1- dependent adjustment of defecation cycle length to temperature; a DSC-4::GFP fusion protein is expressed in the intestine beginning during embryonic elongation and continuing on through adulthood.
48	ZK682.5	ZK682.5	n/a	chrV 9,285,827	contains similarity to Pfam domain PF00560 Leucine Rich Repeat contains similarity to Interpro domains IPR000483 (Cysteine-rich flanking region, C-terminal), IPR001611 (Leucine-rich repeat), IPR003591 (Leucine-rich repeat, typical subtype), IPR000480 (Glutelin)
49	B0395.2	B0395.2	n/a	chrX 16,032,720	contains similarity to Pfam domain PF03062 MBOAT family contains similarity to Interpro domain IPR004299 (Membrane bound O-acyl transferase, MBOAT)
50	ugt-46	B0310.5	n/a	chrX 528,055	C. elegans UGT-46 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)