UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	lip-1	C05B10.1	0	chrIV 6,843,879	lip-1 encodes a mitogen-activated protein (MAP) kinase phosphatase homologous to the vertebrate dual specificity phosphatase MKP-3; during development, LIP-1 negatively regulates MAP kinase activity to control the extent of germline proliferation and oocyte meiotic cell cycle progression; lip-1 activity is also required redundantly with dep-1 to negatively regulate MAPK signaling during vulval induction; in addition, lip-1 is required for normal embryonic development; lip-1 expression begins during embryogenesis and continues through adulthood; expression is seen in most somatic cells and in germ cells of the pachytene region, transition zone and proximal-most region of the mitotic zone; in the pachytene region, LIP-1 is associated with the plasma membrane; in early L3 larvae, LIP-1 expression increases in secondary vulval precursor cells in a lin-12/Notch-dependent manner, suggesting that lip-1 may be a direct downstream target of lin-12-mediated signaling; interaction with the Notch pathway is further demonstrated by chromatin immunoprecipitation experiments showing that, in the germline, the lip-1 promoter region coprecipitates with LAG-3; germline lip-1 mRNA accumulation is negatively regulated by the FBF proteins (FBF-1 and FBF-2) that bind to the lip-1 3'UTR.
2	F54C9.9	F54C9.9	n/a	chrII 8,579,712	contains similarity to Pfam domain PF05178 Krr1 family contains similarity to Interpro domain IPR007851 (Kri1)
3	C36E8.1	C36E8.1	n/a	chrIII 4,001,753	contains similarity to Pfam domain PF05327 RNA polymerase I specific transcription initiation factor RRN3 contains similarity to Interpro domain IPR007991 (RNA polymerase I specific transcription initiation factor RRN3)
4	ruvb-2	T22D1.10	n/a	chrIV 6,918,257	C. elegans RUVB-2 protein; contains similarity to Pfam domains PF00004 (ATPase family associated with various cellular activities (AAA)) , PF06068 (TIP49 C-terminus) contains similarity to Interpro domains IPR003959 (AAA ATPase, core), IPR010339 (TIP49, C-terminal), IPR003593 (AAA+ ATPase, core)
5	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
6	F56A11.5	F56A11.5	n/a	chrIV 569,608	contains similarity to Pfam domains PF03473 (MOSC domain) , PF03476 (MOSC N-terminal beta barrel domain) contains similarity to Interpro domains IPR005303 (MOSC, N-terminal beta barrel), IPR005302 (Molybdenum cofactor sulphurase, C-terminal), IPR001484 (Pyrokinin, conserved site), IPR011037 (Pyruvate kinase, beta-barrel-like)
7	R17.2	R17.2	n/a	chrIII 10,842,361	contains similarity to Pfam domain PF03372 Endonuclease/Exonuclease/phosphatase family contains similarity to Interpro domain IPR005135 (Endonuclease/exonuclease/phosphatase)
8	F52H2.5	F52H2.5	n/a	chrX 2,558,768
9	F09E5.12	F09E5.12	n/a	chrII 5,368,494	contains similarity to Pfam domain PF05001 RNA polymerase Rpb1 C-terminal repeat
10	D1081.8	D1081.8	n/a	chrI 8,493,557	contains similarity to Pfam domain PF00249 Myb-like DNA-binding domain contains similarity to Interpro domains IPR001005 (SANT, DNA-binding), IPR012287 (Homeodomain-related), IPR014778 (Myb, DNA-binding), IPR009057 (Homeodomain-like), IPR015495 (Myb transcription factor)
11	gly-19	F22D6.12	n/a	chrI 7,113,932	gly-19 encodes a protein similar to 2/I N-acetylglucosaminyltransferase; it is probably coexpressed with gly-18 in the anal sphincter muscle.
12	adm-4	ZK154.7	n/a	chrX 7,796,626	adm-4 encodes a member of the ADAM (disintegrin plus metalloprotease) family; ADM-4 is highly expressed in most post-embryonic tissues.
13	scpl-2	F45E12.1	n/a	chrII 7,312,591	scpl-2 encodes a putative serine/threonine phosphatase, orthologous to budding yeast Nem1p and human DULLARD; SCPL-2 is expressed in pharynx and intestine; SCPL-2 is distantly similar to FCP-1 and SCPL-1, -3, and -4; by orthology, SCPL-2 is expected to localize to the nuclear envelope, to regulate nuclear membrane biogenesis, and to dephosphorylate the phosphatidic acid phosphatase ortholog H37A05.1.
14	F17A9.4	F17A9.4	n/a	chrV 6,109,818	contains similarity to Pfam domain PF00724 NADH:flavin oxidoreductase / NADH oxidase family contains similarity to Interpro domains IPR013785 (Aldolase-type TIM barrel), IPR001155 (NADH:flavin oxidoreductase/NADH oxidase, N-terminal), IPR002343 (Paraneoplastic encephalomyelitis antigen)
15	T12G3.5	T12G3.5	n/a	chrIV 12,031,705	contains similarity to Drosophila melanogaster Flybase gene name is mRpL51-PA;; FLYBASE:CG13098
16	T03G11.4	T03G11.4	n/a	chrX 5,167,050	contains similarity to Pfam domain PF01532 Glycosyl hydrolase family 47 contains similarity to Interpro domain IPR001382 (Glycoside hydrolase, family 47)
17	C05D11.10	C05D11.10	n/a	chrIII 6,431,356	contains similarity to Interpro domain IPR016027 (Nucleic acid-binding, OB-fold-like)
18	pssy-2	T27E9.5	n/a	chrIII 13,473,420	C. elegans PSSY-2 protein; contains similarity to Pfam domain PF03034 Phosphatidyl serine synthase contains similarity to Interpro domain IPR004277 (Phosphatidyl serine synthase)
19	ifa-4	K05B2.3	n/a	chrX 4,914,125	IFA-4 encodes a nonessential intermediate filament protein that is coexpressed with the essential IF protein IFB-1; IFA-4 binds IFB-1 in blot overlay assays; ifa-4 is expressed in larvae in the pharyngeal-intestinal valve, the rectum, some neurons of the tail, the excretory cell, and the intestine of dauer (but not nondauer) larvae; IFA-4 has no function in RNAi assays.
20	F22B8.6	F22B8.6	n/a	chrV 16,101,647	F22B8.6 encodes a putative cystathionine gamma-lyase; F22B8.6 is orthologous to human CTH (OMIM:607657, mutated in cystathioninuria), extremely similar to its paralog ZK1127.10, and also paralogous to C12C8.2; either F22B8.6, or ZK1236.10, or both proteins weakly inhibit DHC-1 in vivo; otherwise, F22B8.6 has no obvious function in mass RNAi assays, perhaps because of genetic redundancy with ZK1127.10.
21	F20H11.1	F20H11.1	n/a	chrIII 6,590,715	contains similarity to Pfam domain PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR002219 (Protein kinase C, phorbol ester/diacylglycerol binding)
22	C50E3.5	C50E3.5	n/a	chrV 7,591,348	contains similarity to Interpro domain IPR008108 (Type III secretion system outer membrane, B protein)
23	F56E10.1	F56E10.1	n/a	chrV 105,397	contains similarity to Neurospora crassa Protein bfr-2.; SW:Q7S6P8
24	C25F9.9	C25F9.9	n/a	chrV 19,417,227	contains similarity to Plasmodium falciparum Hypothetical protein.; TR:Q8IE25
25	sec-3	F52E4.7	n/a	chrX 3,097,634	C. elegans SEC-3 protein ; contains similarity to Danio rerio Exocyst complex component 1.; TR:Q7T2A6
26	F46F5.12	F46F5.12	n/a	chrII 807,746	contains similarity to Pfam domain PF03269 Caenorhabditis protein of unknown function, DUF268 contains similarity to Interpro domain IPR004951 (Protein of unknown function DUF268, Caenorhabditis species)
27	F25H8.2	F25H8.2	n/a	chrIV 9,933,029	contains similarity to Pfam domain PF05492 NAF1 domain contains similarity to Interpro domain IPR008696 (NAF1)
28	npp-4	Y54E5A.4	n/a	chrI 14,703,902	C. elegans NPP-4 protein; contains similarity to Interpro domains IPR001778 (Pollen allergen Poa pIX/Phl pVI, C-terminal), IPR007758 (Nucleoporin, Nsp1-like, C-terminal)
29	C01B10.4	C01B10.4	n/a	chrIV 6,630,045	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
30	R09A8.1	R09A8.1	n/a	chrX 12,615,226	contains similarity to Homo sapiens FLASH; ENSEMBL:ENSP00000237177
31	F55H12.2	F55H12.2	n/a	chrI 8,868,112	contains similarity to Interpro domain IPR000242 (Tyrosine specific protein phosphatase)
32	T19D12.9	T19D12.9	n/a	chrII 6,653,312	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
33	Y18D10A.9	Y18D10A.9	n/a	chrI 12,855,664	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR015943 (WD40/YVTN repeat-like)
34	Y47D3B.9	Y47D3B.9	n/a	chrIII 11,467,116	contains similarity to Pfam domain PF02892 BED zinc finger contains similarity to Interpro domain IPR003656 (Zinc finger, BED-type predicted)
35	C34B2.5	C34B2.5	n/a	chrI 10,675,986	contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR013026 (Tetratricopeptide region)
36	C32D5.10	C32D5.10	n/a	chrII 6,350,550	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
37	F28C6.8	F28C6.8	0.000004	chrII 8,607,222	contains similarity to Pfam domain PF00782 Dual specificity phosphatase, catalytic domain contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR016130 (Protein-tyrosine phosphatase, active site), IPR000387 (Protein-tyrosine phosphatase), IPR000340 (Protein-tyrosine phosphatase, dual specificity)
38	ttll-5	C55A6.2	n/a	chrV 11,510,749	ttll-5 encodes a putative tubulin polyglutamylase orthologous to human TTLL5; TTLL-5 is required for embryonic development and fertility; by orthology, TTLL-5 is expected to initiate glutamyl chains rather than elongating them, to prefer alpha-tubulin over beta-tubulin as a substrate, and to have non-tubulin substrates.
39	K01C8.6	K01C8.6	n/a	chrII 8,278,000	contains similarity to Drosophila pseudoobscura 39S ribosomal protein L10, mitochondrial precursor (L10mt) (MRP-L10).; SW:Q29NV5
40	Y26D4A.8	Y26D4A.8	n/a	chrI 13,084,164	contains similarity to Bos taurus Myosin-10 (Myosin heavy chain 10) (Myosin heavy chain, non-muscle IIb)s(Non-muscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellularsmyosin heavy chain, type B) (Non-muscle myosin heavy chain-B) (NMMHC-sB).; SW:Q27991
41	T01D1.5	T01D1.5	n/a	chrII 188,286
42	mtss-1	PAR2.1	n/a	chrIII 8,768,640	C. elegans MTSS-1 protein; contains similarity to Pfam domain PF00436 Single-strand binding protein family contains similarity to Interpro domains IPR000424 (Primosome PriB/single-strand DNA-binding), IPR016027 (Nucleic acid-binding, OB-fold-like), IPR012340 (Nucleic acid-binding, OB-fold), IPR011344 (Single-strand DNA-binding)
43	ucp-4	K07B1.3	n/a	chrV 9,335,690	C. elegans UCP-4 protein; contains similarity to Pfam domain PF00153 Mitochondrial carrier protein contains similarity to Interpro domains IPR002067 (Mitochondrial carrier protein), IPR002030 (Mitochondrial brown fat uncoupling protein), IPR001993 (Mitochondrial substrate carrier), IPR002113 (Adenine nucleotide translocator 1)
44	srt-69	B0238.8	n/a	chrV 5,264,800	C. elegans SRT-69 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
45	R12C12.5	R12C12.5	n/a	chrII 6,044,615	contains similarity to Pfam domain PF03357 Snf7 contains similarity to Interpro domain IPR005024 (Snf7)
46	ZK593.1	ZK593.1	n/a	chrIV 10,911,466	contains similarity to Pfam domains PF02887 (Pyruvate kinase, alpha/beta domain) , PF00224 (Pyruvate kinase, barrel domain) contains similarity to Interpro domains IPR015806 (Pyruvate kinase, beta-barrel), IPR015794 (Pyruvate kinase, alpha/beta), IPR015795 (Pyruvate kinase, C-terminal-like), IPR015813 (Pyruvate/Phosphoenolpyruvate kinase, catalytic core), IPR001697 (Pyruvate kinase), IPR015793 (Pyruvate kinase, barrel)
47	C30H6.7	C30H6.7	n/a	chrIV 17,381,384	contains similarity to Pfam domains PF00198 (2-oxoacid dehydrogenases acyltransferase (catalytic domain)) , PF02817 (e3 binding domain) contains similarity to Interpro domains IPR004167 (E3 binding), IPR001078 (Catalytic domain of components of various dehydrogenase complexes)
48	cif-1	K08F11.3	n/a	chrIV 4,708,690	C. elegans CIF-1 protein; contains similarity to Pfam domain PF01399 PCI domain contains similarity to Interpro domain IPR000717 (Proteasome component region PCI)
49	srt-33	F40G12.8	n/a	chrV 14,279,072	C. elegans SRT-33 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
50	smp-2	D1037.2	n/a	chrI 3,669,414	C. elegans SMP-2 protein; contains similarity to Pfam domain PF01403 Sema domain contains similarity to Interpro domains IPR001627 (Semaphorin/CD100 antigen), IPR003659 (Plexin/semaphorin/integrin), IPR016201 (Plexin-like fold), IPR015943 (WD40/YVTN repeat-like)