UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	C04E6.11	C04E6.11	0	chrV 5,915,960	contains similarity to Homo sapiens Leucine-rich PPR motif-containing protein, mitochondrial precursor; ENSEMBL:ENSP00000260665
2	sra-25	T26E3.9	n/a	chrI 12,687,150	C. elegans SRA-25 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domains IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR000344 (Nematode chemoreceptor, Sra)
3	W02B12.4	W02B12.4	n/a	chrII 11,457,473	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
4	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
5	F47B8.6	F47B8.6	n/a	chrV 14,329,569	contains similarity to Drosophila heteroneura Aminopeptidase N (Fragment).; TR:O61534
6	srbc-29	C02A12.2	n/a	chrV 3,470,161	C. elegans SRBC-29 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
7	mat-2	W10C6.1	n/a	chrII 11,116,985	mat-2 encodes a subunit of the anaphase-promoting complex or cyclosome (APCC) which is a multi-subunit E3 ubiquitin ligase that targets proteins for degradation during the metaphase-to-anaphase transition of the cell cycle; mat-2 is required for chromosome segregation during meiosis I and is involved in polarity specification of the anterior/posterior axis in the developing embryo.
8	thoc-3	F32H2.4	n/a	chrI 8,972,046	C. elegans THOC-3 protein; contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR015943 (WD40/YVTN repeat-like)
9	F35C11.5	F35C11.5	n/a	chrII 8,254,199	contains similarity to Interpro domains IPR016090 (Phospholipase A2), IPR013090 (Phospholipase A2, active site)
10	syp-3	F39H2.4	n/a	chrI 8,663,589	syp-3 encodes a coiled-coil protein; SYP-3 activity is required during meiosis for chromosome synapsis and chiasma formation, specifically for proper assembly of the central region of the synaptonemal complex; thus, SYP-3 is essential activity is essential for normal embryonic development; immunolocalization studies indicate that SYP-3 is likely a structural component of the central element of the synaptonemal complex.
11	bra-2	F23H11.1	n/a	chrIII 911,744	The bra-2 gene encodes a homolog of the human BMP receptor-associated molecule (BRAM1), paralogous to bra-1, that may act upon the SMA-6 TGF-beta signalling pathway
12	C34G6.5	C34G6.5	n/a	chrI 5,873,231	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
13	C36B1.11	C36B1.11	n/a	chrI 8,756,734	contains similarity to Interpro domain IPR001576 (Phosphoglycerate kinase)
14	srj-25	C05E4.10	n/a	chrV 735,347	C. elegans SRJ-25 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR001991 (Sodium:dicarboxylate symporter)
15	mex-5	W02A2.7	n/a	chrIV 13,354,881	mex-5 encodes a novel protein that contains two CCCH zinc finger motifs; maternally provided MEX-5, which functions partly redundantly with the highly similar CCCH finger protein MEX-6, is essential for transducing polarity cues and establishing soma/germline asymmetry in the early embryo; in regulating soma/germline asymmetry, MEX-5 interacts with, and activates, the SOCS-box protein ZIF-1, which functions as part of an E3 ubiquitin ligase complex that degrades germ plasm proteins in somatic blastomeres; accordingly, ectopic expression of MEX-5 throughout the early embryo results in reduced expression of germline proteins in germline blastomeres; MEX-5 is a cytoplasmic protein expressed at uniform levels in oocytes and newly fertilized eggs; from the 1-cell to 4-cell stages of embryogenesis, MEX-5 expression is dynamic, with highest levels seen in the anterior AB blastomere and, for a time, its daughters, the anterior portion of the P1 blastomere, P1 centrosomes (both, then posterior only), and the EMS and C blastomeres; the asymmetric distribution of MEX-5 in early embryos depends upon wild-type activity of the PAR and OMA-1 proteins.
16	C04E7.3	C04E7.3	n/a	chrX 345,208	contains similarity to Homo sapiens inner centromere protein antigens 135/155kDa isoform 2; ENSEMBL:ENSP00000278849
17	clec-38	T25E12.10	n/a	chrV 16,734,718	C. elegans CLEC-38 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
18	T25C8.1	T25C8.1	n/a	chrIII 13,611,268	contains similarity to Interpro domains IPR002345 (Lipocalin), IPR000577 (Carbohydrate kinase, FGGY)
19	C06A5.6	C06A5.6	n/a	chrI 5,984,551
20	him-17	T09E8.2	n/a	chrV 13,178,423	him-17 encodes a protein with no obvious non-nematode homologs that localizes to chromatin in germline nuclei, and that is required for double-stranded break (DSB) formation, chiasmata, crossovers, and genetic recombination during meiosis, but is dispensable for homolog pairing and synapsis, spo-11 germline transcription, or the conversion of DSBs into chiasmata; HIM-17 is also required for normal organization of meiotic stages in the germline, and to promote its orderly transistion from (potentially tumorous) mitosis to meiosis; moreover, HIM-17 is required for normal dimethylation of lysine 9 residues on H3 histones in meiotic prophase chromosomes from early pachytene onward, with null him-17(ok424) mutants showing greatly reduced or delayed dimethylation in both hermaphrodite and male germlines; HIM-17 cooperates with GLP-1 to promote meiotic entry, and with EGO-1 to promote germline viability; HIM-17 has six THAP and THAP-like domains, a domain type also found in CDC-14B, CTB-1, GON-14, LIN-15A, LIN-15B, and LIN-36, along with ~100 other proteins such as Drosophila P element transposase and human nuclear proapoptotic factor THAP1; missense or truncating mutations of HIM-17's THAP and THAP-like domains cause partial loss of function, implying that the domains collectively and partially contribute to HIM-17 activity; of the C. elegans genes encoding THAP or THAP-like domains, at least four (lin-15A, lin-15B, lin-36, and him-17) interact genetically with lin-35/Rb.
21	btb-7	F45C12.12	n/a	chrII 1,713,745	C. elegans BTB-7 protein; contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
22	srsx-26	C51E3.1	n/a	chrV 10,149,791	C. elegans SRSX-26 protein; contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
23	Y43E12A.3	Y43E12A.3	n/a	chrIV 10,988,514	contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
24	F46B6.8	F46B6.8	n/a	chrV 9,792,368	contains similarity to Pfam domains PF04083 (ab-hydrolase associated lipase region) , PF00561 (alpha/beta hydrolase fold) contains similarity to Interpro domains IPR006693 (AB-hydrolase associated lipase region), IPR000073 (Alpha/beta hydrolase fold-1), IPR008262 (Lipase, active site)
25	ZK792.5	ZK792.5	n/a	chrIV 11,686,516	contains similarity to Pfam domain PF00806 Pumilio-family RNA binding repeat contains similarity to Interpro domains IPR011989 (Armadillo-like helical), IPR002952 (Eggshell protein), IPR001313 (Pumilio RNA-binding region), IPR016024 (Armadillo-type fold)
26	gln-6	C28D4.3	n/a	chrIV 9,740,184	C. elegans GLN-6 protein; contains similarity to Pfam domains PF03951 (Glutamine synthetase, beta-Grasp domain) , PF00120 (Glutamine synthetase, catalytic domain) contains similarity to Interpro domains IPR008147 (Glutamine synthetase, beta-Grasp), IPR014746 (Glutamine synthetase/guanido kinase, catalytic region), IPR008146 (Glutamine synthetase, catalytic region)
27	VC27A7L.1	VC27A7L.1	n/a	chrV 12,165,914	contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
28	mex-6	AH6.5	n/a	chrII 9,525,192	mex-6 encodes a CCCH zinc-finger protein highly similar to MEX-5 that functions with MEX-5 to affect embryonic viability, establish soma germline asymmetry in embryos and establish PIE-1, MEX-1, and POS-1 asymmetry in embryos, and also affects formation of intestinal cells; MEX-6 and MEX-5 may act downstream of the PAR proteins.
29	ZK1128.4	ZK1128.4	n/a	chrIII 10,119,727	contains similarity to Pfam domain PF03850 Transcription factor Tfb4 contains similarity to Interpro domain IPR004600 (Transcription factor Tfb4)
30	rev-1	ZK675.2	n/a	chrII 7,902,571	C. elegans REV-1 protein; contains similarity to Pfam domains PF00817 (impB/mucB/samB family) , PF00533 (BRCA1 C Terminus (BRCT) domain) contains similarity to Interpro domains IPR001126 (UMUC-like DNA-repair protein), IPR012112 (DNA repair protein, Rev1), IPR001357 (BRCT)
31	vha-18	F52E1.10	n/a	chrV 8,412,615	vha-18 encodes an an ortholog of subunit H of the cytoplasmic (V1) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-18 and VHA-15 are co-orthologs; VHA-18 is a predicted cytosolic stator (stalk) component.
32	rnh-1.2	ZK938.7	n/a	chrII 9,840,817	C. elegans RNH-1.2 protein; contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF00075 (RNase H) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011021 (Arrestin-like, N-terminal), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold), IPR002156 (Ribonuclease H)
33	C03G6.5	C03G6.5	n/a	chrV 7,365,571	contains similarity to Pfam domain PF01579 Domain of unknown function DUF19 contains similarity to Interpro domains IPR016638 (Uncharacterised conserved protein UPF0376), IPR002542 (Protein of unknown function DUF19)
34	K08F4.3	K08F4.3	n/a	chrIV 10,129,732	contains similarity to Pfam domain PF05753 Translocon-associated protein beta (TRAPB) contains similarity to Interpro domain IPR008856 (Translocon-associated beta)
35	ZK856.12	ZK856.12	n/a	chrV 10,214,597	contains similarity to Homo sapiens similar to hypothetical protein FLJ12851; ENSEMBL:ENSP00000301962
36	pqn-73	W01C9.3	n/a	chrII 8,543,297	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
37	vps-16	C05D11.2	n/a	chrIII 6,434,734	vps-16 encodes the C. elegans homolog of the Saccharomyces cerevisiae vacuolar sorting protein Vps16p; in C. elegans, vps-16 activity is required for biogenesis of the lysosome-related gut granules and for embryonic development; in addition, vps-16 is required for normal body morphology and regulation of germline apoptosis.
38	ric-3	T14A8.1	n/a	chrIV 7,819,689	The ric-3 gene encodes a novel, highly charged protein with two transmembrane domains and extensive coiled-coil domains; it is necessary for the function of at least four nicotinic acetylcholine receptors; specifically, it is needed for assembly or trafficking of the DEG-3 nicotinic acetylcholine receptor.
39	btb-20	F57C2.1	n/a	chrII 14,522,887	C. elegans BTB-20 protein; contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
40	K07A1.1	K07A1.1	n/a	chrI 9,583,089	contains similarity to Plasmodium falciparum Hypothetical protein.; TR:Q8IBJ6
41	C14B1.9	C14B1.9	n/a	chrIII 3,725,339	contains similarity to Homo sapiens Hypothetical protein; ENSEMBL:ENSP00000307805
42	cdc-6	C43E11.10	n/a	chrI 4,269,180	cdc-6 encodes a homolog of an origin complex component (CDC6) which in yeast controls the start of DNA replication, and also has a distant paralog (Y39A1A.12) within the C. elegans genome; CDC-6 is superficially dispensable for embryonic viability, perhaps because of redundancy with Y39A1A.12.
43	F31F6.2	F31F6.2	n/a	chrX 14,870,061	F31F6.2 encodes a novel protein that is conserved in C. elegans; three other genes related to F31F6.2 are present in tandem on the X chromosome; loss of F31F6.2 function via large-scale RNAi results in increased fat content.
44	syp-2	C24G6.1	n/a	chrV 5,537,191	C. elegans SYP-2 protein ;
45	C17E4.4	C17E4.4	n/a	chrI 9,419,701	contains similarity to Thermoplasma acidophilum Hypothetical membrane protein.; TR:Q9HLF7
46	C16C8.12	C16C8.12	n/a	chrII 3,453,161
47	W06D4.4	W06D4.4	n/a	chrI 9,061,846	contains similarity to Interpro domain IPR014644 (Protein arginine N-methyltransferase)
48	F08F1.3	F08F1.3	n/a	chrX 8,430,035
49	B0244.9	B0244.9	n/a	chrIII 5,730,515	contains similarity to Interpro domains IPR005838 (Type III secretion system inner membrane P protein), IPR001865 (Ribosomal protein S2)
50	F32D8.4	F32D8.4	n/a	chrV 10,892,425	F32D8.4 is homologous to Yip1p, an essential Golgi membrane protein in S. cerevisiae that specifically binds the transport GTPases Ypt1p and Ypt31p, as well as Yop1p (the yeast homolog of human ADENOMATOUS POLYPOSIS COLI 1); F32D8.4 is also homologous to the Golgi membrane protein SB140 of H. sapiens, and contains a glutamine/asparagine-rich domain.