UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	npp-14	C03D6.4	0	chrI 9,662,535	npp-14 is orthologous to the human gene NUCLEOPORIN, 214-KD (NUP214; OMIM:114350), which encodes part of the nucleopore complex mediating nucleocytoplasmic transport; NUP214, as a fusion gene with DEK (OMIM:125264), is found in a subset of acute myeloid leukemia.
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	D1043.1	D1043.1	n/a	chrII 11,585,601	contains similarity to Pfam domain PF02985 HEAT repeat contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
4	F33H2.2	F33H2.2	n/a	chrI 15,025,433	contains similarity to Homo sapiens Protein FAM91A1; ENSEMBL:ENSP00000335082
5	T05E7.1	T05E7.1	n/a	chrI 6,205,413	contains similarity to Pfam domains PF08840 (BAAT / Acyl-CoA thioester hydrolase C terminal) , PF04775 (Acyl-CoA thioester hydrolase / Bile acid-CoA amino acid N-acetyltransferase) contains similarity to Interpro domains IPR006862 (Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase), IPR014940 (BAAT/Acyl-CoA thioester hydrolase C-terminal), IPR016662 (Acyl-CoA thioesterase, long chain)
6	vps-54	T21C9.2	n/a	chrV 10,571,379	The vps-54 gene encodes an ortholog of VPS54 in S. cerevisiae, a protein involved in vacuolar trafficking.
7	C08B11.8	C08B11.8	n/a	chrII 8,040,793	contains similarity to Pfam domain PF03155 ALG6, ALG8 glycosyltransferase family contains similarity to Interpro domain IPR004856 (ALG6, ALG8 glycosyltransferase)
8	mrs-1	F58B3.5	n/a	chrIV 11,633,685	mrs-1 encodes a predicted cytoplasmic methionyl-tRNA synthetase (MetRS), a class I aminoacyl-tRNA synthetase that catalyzes the attachment of methionine to its cognate tRNA and is thus required for protein biosynthesis; MRS-1 is essential for embryogenesis and required also for a normal rate of postembryonic growth.
9	adm-4	ZK154.7	n/a	chrX 7,796,626	adm-4 encodes a member of the ADAM (disintegrin plus metalloprotease) family; ADM-4 is highly expressed in most post-embryonic tissues.
10	cyn-7	Y75B12B.2	n/a	chrV 15,186,997	cyn-7 encodes a cyclophilin A isoform; while not tested for peptidyl-prolyl isomerase activity in vitro, it is very similar to CYN-3 and closely resembles the prototypical CypA, and is therefore likely to be a member of the cytosolic CsA-binding cyclophilin subfamily; CYN-7 was required for embryonic viability in one set of mass RNAi assays.
11	T01B7.6	T01B7.6	n/a	chrII 8,723,943	contains similarity to Interpro domain IPR000694 (Proline-rich region)
12	stl-1	F30A10.5	n/a	chrI 9,487,412	C. elegans STL-1 protein; contains similarity to Pfam domain PF01145 SPFH domain / Band 7 family contains similarity to Interpro domains IPR001107 (Band 7 protein), IPR001972 (Stomatin)
13	K04G2.6	K04G2.6	n/a	chrI 8,041,954	contains similarity to Pfam domain PF02985 HEAT repeat contains similarity to Interpro domains IPR011989 (Armadillo-like helical), IPR000357 (HEAT), IPR016024 (Armadillo-type fold)
14	C24D10.6	C24D10.6	n/a	chrIV 5,159,856	contains similarity to Homo sapiens Coiled-coil-helix-coiled-coil-helix domain-containing protein 1; ENSEMBL:ENSP00000361923
15	T03G11.6	T03G11.6	n/a	chrX 5,178,330	contains similarity to Pfam domains PF05219 (DREV methyltransferase) , PF08242 (Methyltransferase domain) contains similarity to Interpro domains IPR013217 (Methyltransferase type 12), IPR007884 (DREV methyltransferase)
16	C24F3.4	C24F3.4	n/a	chrIV 10,217,118	contains similarity to Pfam domains PF00795 (Carbon-nitrogen hydrolase) , PF02540 (NAD synthase) contains similarity to Interpro domains IPR003010 (Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase), IPR014729 (Rossmann-like alpha/beta/alpha sandwich fold), IPR003694 (NAD+ synthase), IPR014445 (Glutamine-dependent NAD(+) synthetase, GAT region)
17	C14B1.6	C14B1.6	n/a	chrIII 3,716,084	contains similarity to Interpro domain IPR008162 (Inorganic pyrophosphatase)
18	ZK856.10	ZK856.10	n/a	chrV 10,206,112	contains similarity to Pfam domains PF08292 (RNA polymerase III subunit Rpc25) , PF03876 (RNA polymerase Rpb7-like, N-terminal domain) contains similarity to Interpro domains IPR003029 (S1, RNA binding), IPR005576 (RNA polymerase Rpb7, N-terminal), IPR013238 (RNA polymerase III, subunit Rpc25)
19	sna-2	T13F2.7	n/a	chrIV 9,776,092	sna-2 encodes an snRNP-binding protein (SNA-2/SL75p) homologous to Ascaris SL95p (SL 175kd); SNA-2 is found in at least two Sm snRNPs, SL1 and Y, but not in SL2; in snRNP SL1, SNA-2 associates with the SNA-1/SL21p protein, while associating with SUT-1/SL26p (a paralog of SNA-1) in snRNP Y; sna-2(RNAi) is lethal; SNA-2 can bind either SNA-1 or SUT-1 even in the absence of RNA.
20	C27A12.9	C27A12.9	n/a	chrI 6,064,908	contains similarity to Pfam domain PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase contains similarity to Interpro domains IPR017849 (Alkaline phosphatase-like, alpha/beta/alpha), IPR002591 (Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase), IPR017850 (Alkaline-phosphatase-like, core domain)
21	ucp-4	K07B1.3	n/a	chrV 9,335,690	C. elegans UCP-4 protein; contains similarity to Pfam domain PF00153 Mitochondrial carrier protein contains similarity to Interpro domains IPR002067 (Mitochondrial carrier protein), IPR002030 (Mitochondrial brown fat uncoupling protein), IPR001993 (Mitochondrial substrate carrier), IPR002113 (Adenine nucleotide translocator 1)
22	F52C12.1	F52C12.1	n/a	chrIV 1,961,538	contains similarity to Pfam domain PF06087 Tyrosyl-DNA phosphodiesterase contains similarity to Interpro domains IPR001736 (Phospholipase D/Transphosphatidylase), IPR010347 (Tyrosyl-DNA phosphodiesterase)
23	smp-2	D1037.2	n/a	chrI 3,669,414	C. elegans SMP-2 protein; contains similarity to Pfam domain PF01403 Sema domain contains similarity to Interpro domains IPR001627 (Semaphorin/CD100 antigen), IPR003659 (Plexin/semaphorin/integrin), IPR016201 (Plexin-like fold), IPR015943 (WD40/YVTN repeat-like)
24	F40G9.2	F40G9.2	n/a	chrIII 191,482	contains similarity to Pfam domain PF05051 Cytochrome C oxidase copper chaperone (COX17) contains similarity to Interpro domain IPR007745 (Cytochrome C oxidase copper chaperone)
25	T12E12.2	T12E12.2	n/a	chrIV 5,546,641	contains similarity to Pfam domain PF00385 'chromo' (CHRromatin Organisation MOdifier) domain contains similarity to Interpro domains IPR000953 (Chromo domain), IPR016197 (Chromo domain-like)
26	R08D7.1	R08D7.1	n/a	chrIII 8,966,795	contains similarity to Drosophila pseudoobscura GA12417-PA (Fragment).; TR:Q293H8
27	K06H7.7	K06H7.7	n/a	chrIII 8,084,529
28	K02B2.1	K02B2.1	n/a	chrIV 5,942,943	contains similarity to Pfam domains PF01591 (6-phosphofructo-2-kinase) , PF00300 (Phosphoglycerate mutase family) contains similarity to Interpro domains IPR016260 (Bifunctional 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphate 2-phosphatase), IPR001345 (Phosphoglycerate/bisphosphoglycerate mutase), IPR003094 (Fructose-2,6-bisphosphatase), IPR013079 (6-phosphofructo-2-kinase), IPR013078 (Phosphoglycerate mutase)
29	rpa-1	F18A1.5	n/a	chrII 7,665,772	rpa-1 encodes the C. elegans ortholog of the replication protein A (RPA) large subunit; by homology, RPA-1 is predicted to function as a DNA-binding and oligonucleotide oligosaccharide-binding (OB) protein that is required for DNA replication, repair, and recombination; large-scale RNAi screens indicate that rpa-1 is essential for embryonic development, and that in yeast two-hybrid assays interacts with the product of M04F3.1, the RPA medium subunit; in situ hybridization studies indicate that rpa-1 transcripts are expressed in germ cells.
30	nhl-2	F26F4.7	n/a	chrIII 4,896,829	C. elegans NHL-2 protein; contains similarity to Pfam domains PF00097 (Zinc finger, C3HC4 type (RING finger)) , PF00643 (B-box zinc finger) (2), PF01436 (NHL repeat) (4)contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR003649 (B-box, C-terminal), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR000315 (Zinc finger, B-box), IPR001258 (NHL repeat)
31	tag-229	W09G3.3	n/a	chrI 13,804,628	C. elegans TAG-229 protein; contains similarity to Pfam domain PF08755 Hemimethylated DNA-binding protein YccV like contains similarity to Interpro domain IPR011722 (Hemimethylated DNA-binding region)
32	mrp-4	F21G4.2	n/a	chrX 9,886,947	mrp-4 encodes a putative member of subfamily C of the ATP-binding cassette transporters; MRP-4 is required, redundantly with its paralog WHT-2, for sperm to normally migrate towards a PUFA-based signal exuded by oocytes; hermaphrodites subjected to double wht-2(RNAi) mrp-4(RNAi) are infertile, both through aberrant loss of their own sperm and through failure of males to effectively inseminate them; in mammalian eicosanoid signalling, subfamily C ABC transporters are required for PUFA and eicosanoid transport.
33	plc-4	R05G6.8	n/a	chrIV 7,511,060	C. elegans PLC-4 protein; contains similarity to Pfam domains PF00168 (C2 domain) , PF00387 (Phosphatidylinositol-specific phospholipase C, Y domain) , PF09279 (Phosphoinositide-specific phospholipase C, efhand-like) , PF00036 (EF hand) , PF00388 (Phosphatidylinositol-specific phospholipase C, X domain) contains similarity to Interpro domains IPR015359 (Phospholipase C, phosphoinositol-specific, EF-hand-like), IPR011992 (EF-Hand type), IPR002048 (Calcium-binding EF-hand), IPR001192 (Phospholipase C, phosphoinositol-specific, C-terminal (PLC)), IPR001849 (Pleckstrin-like), IPR011993 (Pleckstrin homology-type), IPR000909 (Phospholipase C, phosphatidylinositol-specific , X region), IPR001711 (Phospholipase C, phosphatidylinositol-specific, Y domain), IPR013841 (Phospholipase C, phosphatidylinositol-specific , X and Y boxes), IPR000008 (C2 calcium-dependent membrane targeting)
34	CD4.8	CD4.8	n/a	chrV 5,600,286	contains similarity to Pfam domain PF04435 Domain of unknown function (DUF545) contains similarity to Interpro domain IPR006570 (SPK)
35	C48B4.10	C48B4.10	n/a	chrIII 9,563,945	contains similarity to Homo sapiens Transmembrane 9 superfamily protein member 2 precursor; ENSEMBL:ENSP00000245361
36	ZK1067.3	ZK1067.3	n/a	chrII 9,224,144	contains similarity to Mus musculus Serine/threonine-protein kinase Nek9 (EC 2.7.1.37) (NimA-relatedsprotein kinase 9).; SW:NEK9_MOUSE
37	pqn-96	ZK1236.6	n/a	chrIII 8,438,835	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
38	W02G9.4	W02G9.4	n/a	chrV 2,668,540	contains similarity to Pfam domain PF00431 CUB domain contains similarity to Interpro domain IPR000859 (CUB)
39	qdpr-1	T03F6.1	n/a	chrIII 13,394,312	The T03F6.1 gene encodes an ortholog of the human gene QUINOID DIHYDROPTERIDINE REDUCTASE (QDPR; DHPR), which when mutated leads to phenylketonuria II (OMIM:261630).
40	W02D9.3	W02D9.3	n/a	chrI 12,536,484	contains similarity to Pfam domain PF00505 HMG (high mobility group) box contains similarity to Interpro domains IPR000910 (High mobility group box, HMG1/HMG2), IPR009071 (High mobility group box, HMG)
41	lap-1	ZK353.6	n/a	chrIII 8,400,522	The lap-1 gene encodes a homolog of the zinc metalloprotease leucine aminopeptidase LAP that is predicted to be mitochondrial.
42	Y23H5A.2	Y23H5A.2	n/a	chrI 2,622,537	Y23H5A.2 encodes a Caenorhabditis-specific protein, without obvious similarities or motifs; Y23H5A.2 inhibits CEP-1- and HUS-1-dependent germline apoptosis, as do BMK-1, RAD-50, and RAD-51.
43	npp-5	F07A11.3	n/a	chrII 11,598,202	C. elegans NPP-5 protein; contains similarity to Interpro domain IPR007252 (Nuclear pore protein 84/107)
44	C47E12.3	C47E12.3	n/a	chrIV 10,000,452	contains similarity to Pfam domain PF01532 Glycosyl hydrolase family 47 contains similarity to Interpro domain IPR001382 (Glycoside hydrolase, family 47)
45	C50F2.3	C50F2.3	n/a	chrI 3,878,907	contains similarity to Pfam domain PF02184 HAT (Half-A-TPR) repeat contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR013212 (Mad3/BUB1 homology region 1), IPR003107 (RNA-processing protein, HAT helix)
46	cash-1	K07C5.8	n/a	chrV 10,364,141	cash-1 encodes an ortholog of Drosophila CKA and the human striatins STRN, STRN3, and STRN4 that is required for vulval development; CASH-1 has an N-terminal region which may bind caveolin or calmodulin, and a C-terminal region with five tandem WD domains; by its orthology with CKA and striatins, CASH-1 is predicted to act as a scaffold linking signal transduction proteins (such as JKK-1 and JNK-1) to transcription factors (such as JUN-1 or FOS-1); CASH-1 is expressed broadly, in both larval and adult pharynx, intestine, rectal epithelium, hypodermis, and neurons, as well as the developing vulva and the adult reproductive system.
47	T01D1.5	T01D1.5	n/a	chrII 188,286
48	K08F4.1	K08F4.1	n/a	chrIV 10,124,631	contains similarity to Pfam domain PF00004 ATPase family associated with various cellular activities (AAA) contains similarity to Interpro domains IPR003959 (AAA ATPase, core), IPR001199 (Cytochrome b5), IPR003593 (AAA+ ATPase, core)
49	lpd-9	T21C9.5	n/a	chrV 10,579,970	lpd-9 encodes a novel protein conserved amongst C. elegans, C. briggsae, and C. remanei; loss of lpd-9 activity via RNAi indicates that LPD-9 is required for fat storage and for larval growth and development.
50	ifa-4	K05B2.3	n/a	chrX 4,914,125	IFA-4 encodes a nonessential intermediate filament protein that is coexpressed with the essential IF protein IFB-1; IFA-4 binds IFB-1 in blot overlay assays; ifa-4 is expressed in larvae in the pharyngeal-intestinal valve, the rectum, some neurons of the tail, the excretory cell, and the intestine of dauer (but not nondauer) larvae; IFA-4 has no function in RNAi assays.