UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	hil-5	B0414.3	1e-44	chrI 5,775,100	C. elegans HIL-5 protein; contains similarity to Pfam domain PF00538 linker histone H1 and H5 family contains similarity to Interpro domains IPR011991 (Winged helix repressor DNA-binding), IPR005819 (Histone H5), IPR000104 (Antifreeze protein, type I), IPR005818 (Histone H1/H5), IPR003216 (Linker histone, N-terminal)
2	sra-25	T26E3.9	n/a	chrI 12,687,150	C. elegans SRA-25 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domains IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR000344 (Nematode chemoreceptor, Sra)
3	Y23H5A.3	Y23H5A.3	n/a	chrI 2,621,258
4	B0304.2	B0304.2	n/a	chrII 4,524,073
5	T19H12.2	T19H12.2	n/a	chrV 4,890,911	contains similarity to Pfam domains PF00560 (Leucine Rich Repeat) (2), PF07723 (Leucine Rich Repeat) contains similarity to Interpro domains IPR001611 (Leucine-rich repeat), IPR003603 (U2A'/phosphoprotein 32 family A, C-terminal)
6	F33H1.4	F33H1.4	n/a	chrII 10,177,309	contains similarity to Pfam domain PF02178 (AT hook motif)
7	F28D1.9	F28D1.9	n/a	chrIV 12,395,382	contains similarity to Pfam domain PF00501 AMP-binding enzyme contains similarity to Interpro domain IPR000873 (AMP-dependent synthetase and ligase)
8	dsh-2	C27A2.6	n/a	chrII 5,079,682	dsh-2 encodes a protein containing a DIX domain, a DEP domain, and a PDZ domain that is required for embryonic viability and functions in Wnt pathway signaling between the embryonic blastomeres P2 and EMS with respect to endoderm specification and to orient the division axis of the EMS cell; expressed from the four-cell embryo stage, and is primarily associated with membranes.
9	nhr-211	T01G6.5	n/a	chrV 488,034	C. elegans NHR-211 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
10	T03F6.3	T03F6.3	n/a	chrIII 13,390,012	contains similarity to Pfam domain PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase contains similarity to Interpro domains IPR006148 (Glucosamine/galactosamine-6-phosphate isomerase), IPR004547 (Glucosamine-6-phosphate isomerase)
11	ugt-58	F35H8.6	n/a	chrII 9,585,502	C. elegans UGT-58 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
12	sdz-26	R06A4.6	n/a	chrII 14,382,371	C. elegans SDZ-26 protein; contains similarity to Pfam domain PF07149 Pes-10 contains similarity to Interpro domain IPR009819 (Pes-10)
13	F30A10.3	F30A10.3	n/a	chrI 9,493,712	contains similarity to Pfam domain PF03770 Inositol polyphosphate kinase contains similarity to Interpro domain IPR005522 (Inositol polyphosphate kinase)
14	fbxb-119	B0462.3	n/a	chrV 18,319,134	C. elegans FBXB-119 protein; contains similarity to Pfam domain PF07735 F-box associated contains similarity to Interpro domain IPR012885 (F-box associated type 2)
15	R09B3.2	R09B3.2	n/a	chrI 11,909,721	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR003954 (RNA recognition, region 1), IPR000504 (RNA recognition motif, RNP-1)
16	ZK632.11	ZK632.11	n/a	chrIII 9,828,713	contains similarity to Pfam domain PF04046 PSP contains similarity to Interpro domains IPR006568 (PSP, proline-rich), IPR001878 (Zinc finger, CCHC-type)
17	F31F6.1	F31F6.1	n/a	chrX 14,867,621	F31F6.1 encodes a novel protein that is conserved in C. elegans; three other genes related to F31F6.1 are present in tandem on the X chromosome.
18	C41D11.5	C41D11.5	n/a	chrI 4,450,433
19	nasp-1	C09H10.6	n/a	chrII 11,107,270	C. elegans NASP-1 protein; contains similarity to Interpro domain IPR013026 (Tetratricopeptide region)
20	nasp-2	C50B6.2	n/a	chrV 13,311,278	C. elegans NASP-2 protein ; contains similarity to Halocynthia roretzi Protein HGV2.; SW:Q02508
21	T05B11.4	T05B11.4	n/a	chrV 7,753,022	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
22	Y14H12B.2	Y14H12B.2	n/a	chrII 3,932,952	contains similarity to Pfam domain PF04435 Domain of unknown function (DUF545) contains similarity to Interpro domain IPR006570 (SPK)
23	msh-5	F09E8.3	n/a	chrIV 13,159,611	msh-5 encodes a germline-specific homolog of the yeast and mammalian DNA mismatch repair protein MSH5 (MutS-family) that is required for crossing over and chiasma formation during Caenorhabditis elegans meiosis; inactivation of both rad-51 and msh-5 induces chromosome fragmentation, not seen with inactivation of either gene alone.
24	F56C9.3	F56C9.3	n/a	chrIII 7,312,130	contains similarity to Pfam domain PF01545 Cation efflux family contains similarity to Interpro domain IPR002524 (Cation efflux protein)
25	C05C8.5	C05C8.5	n/a	chrV 7,233,733	contains similarity to Pfam domain PF00929 Exonuclease contains similarity to Interpro domains IPR013520 (Exonuclease, RNase T and DNA polymerase III), IPR006055 (Exonuclease), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
26	F31F6.2	F31F6.2	n/a	chrX 14,870,061	F31F6.2 encodes a novel protein that is conserved in C. elegans; three other genes related to F31F6.2 are present in tandem on the X chromosome; loss of F31F6.2 function via large-scale RNAi results in increased fat content.
27	K07F5.12	K07F5.12	n/a	chrIV 9,856,975	contains similarity to Pfam domain PF07857 CEO family (DUF1632) contains similarity to Interpro domain IPR012435 (Protein of unknown function DUF1632)
28	pch-2	F10B5.5	n/a	chrII 8,159,065	pch-2 encodes a putative AAA+-type ATPase orthologous to budding yeast PCH2 and human TRIP13 (OMIM:604507); PCH-2 is required for the apoptosis of pachytene cells induced by unsynapsed chromosomal pairing centers, but is dispensable for meiotic apoptosis induced by DNA damage; PCH-2-mediated apoptosis is inhibited by SYP-1 and SYP-2, while it requires HIM-8 (and probably HIM-8's paralogs, ZIM-1/-3 and C02F5.12); however, PCH-2-mediated apoptosis does not require SPO-11; pch-2 transcripts are enriched during oogenesis; the excess germline apoptosis of syp-1(me17) mutants is partially suppressed by pch-2(tm1458), and fully suppressed by pch-2(tm1458);spo-11(ok79).
29	T28A8.5	T28A8.5	n/a	chrIII 13,502,424	contains similarity to Pfam domain PF04435 Domain of unknown function (DUF545) contains similarity to Interpro domain IPR006570 (SPK)
30	T01C3.9	T01C3.9	n/a	chrV 15,005,731	contains similarity to Foot-and-mouth disease virus O Polyprotein.; TR:Q80B22
31	R05D11.5	R05D11.5	n/a	chrI 8,592,502	contains similarity to Pfam domain PF05620 Protein of unknown function (DUF788) contains similarity to Interpro domain IPR008506 (Protein of unknown function DUF788)
32	B0511.7	B0511.7	n/a	chrI 10,632,437	contains similarity to Pfam domain PF00498 FHA domain contains similarity to Interpro domains IPR008984 (SMAD/FHA domain), IPR000253 (Forkhead-associated)
33	aph-1	VF36H2L.1	n/a	chrI 9,232,806	aph-1 encodes an unfamiliar protein predicted to have seven transmembrane domains; APH-1 is a component of the GLP-1/LIN-12 (Notch) pathway, is required maternally for embryonic viability, and also affects morphogenesis, egg laying, germ line proliferation, and translocation of APH-2 to the cell surface; with PEN-2, APH-1 is required for Notch pathway signaling, gamma-secretase cleavage of beta-amyloid precursor protein, and presenilin protein accumulation.
34	F45F2.11	F45F2.11	n/a	chrV 8,520,032	contains similarity to Interpro domain IPR000694 (Proline-rich region)
35	C01G6.3	C01G6.3	n/a	chrII 9,270,502	contains similarity to Pichia etchellsii Hypothetical protein.; TR:Q9HFH3
36	F57B10.4	F57B10.4	n/a	chrI 6,567,540	contains similarity to Trichomonas vaginalis G3 Viral A-type inclusion protein, putative.; TR:A2E8Z5
37	him-17	T09E8.2	n/a	chrV 13,178,423	him-17 encodes a protein with no obvious non-nematode homologs that localizes to chromatin in germline nuclei, and that is required for double-stranded break (DSB) formation, chiasmata, crossovers, and genetic recombination during meiosis, but is dispensable for homolog pairing and synapsis, spo-11 germline transcription, or the conversion of DSBs into chiasmata; HIM-17 is also required for normal organization of meiotic stages in the germline, and to promote its orderly transistion from (potentially tumorous) mitosis to meiosis; moreover, HIM-17 is required for normal dimethylation of lysine 9 residues on H3 histones in meiotic prophase chromosomes from early pachytene onward, with null him-17(ok424) mutants showing greatly reduced or delayed dimethylation in both hermaphrodite and male germlines; HIM-17 cooperates with GLP-1 to promote meiotic entry, and with EGO-1 to promote germline viability; HIM-17 has six THAP and THAP-like domains, a domain type also found in CDC-14B, CTB-1, GON-14, LIN-15A, LIN-15B, and LIN-36, along with ~100 other proteins such as Drosophila P element transposase and human nuclear proapoptotic factor THAP1; missense or truncating mutations of HIM-17's THAP and THAP-like domains cause partial loss of function, implying that the domains collectively and partially contribute to HIM-17 activity; of the C. elegans genes encoding THAP or THAP-like domains, at least four (lin-15A, lin-15B, lin-36, and him-17) interact genetically with lin-35/Rb.
38	aly-2	F23B2.6	n/a	chrIV 9,148,006	aly-2 encodes an RRM motif-containing protein required for normal export of TRA-1/tra-2 mRNA complexes, and thus for normal hermaphroditism; ALY-2 is orthologous to human THOC4 (OMIM:604171), and paralogous to ALY-1 and ALY-3; in the absence of TRA-1, and in conjunction with NXF-1, ALY-2 and its paralog ALY-1 are required to bind the TRE 3' UTR element of tra-2 mRNA, and block tra-2 mRNA's export from the nucleus; aly-2(RNAi) animals have abnormal female (as opposed to hermaphrodite) sexual phenotypes; by orthology, ALY-2 is thought to promote recruitment of mRNA export factor to mRNAs; other than these sex-determination phenotypes, ALY-2 has no grossly obvious function in four-way RNAi assays of ALY-1/-3 and W04D2.6.
39	klc-1	M7.2	n/a	chrIV 11,085,048	klc-1 encodes one of two C. elegans kinesin light chains; by homology, KLC-1 is predicted to function, along with kinesin-like heavy chains, as part of a multimeric kinesin complex involved in intracellular transport; consistent with this, KLC-1 has been shown to interact with UNC-116/kinesin, KCA-1/kinesin cargo adaptor, and the ARX-2/Arp2/3 complex component in yeast two-hybrid assays; RNAi experiments indicate that klc-1 activity is required for normal embryonic development.
40	W04A8.6	W04A8.6	n/a	chrI 13,856,302	contains similarity to Interpro domain IPR011598 (Helix-loop-helix DNA-binding)
41	set-17	T21B10.5	n/a	chrII 8,939,689	set-17 encodes a SET domain-containing protein orthologous to human PRDM11 and PRDM7 (Q9NQW5-2; OMIM:609759); SET-17 is expressed in many or all cells of embryo, and several postembryonic tissues (hypodermis, muscle, and excretory cell); neither set-17(n5017) nor set-17(RNAi) have any obvious phenotypes.
42	C42D4.13	C42D4.13	n/a	chrIV 7,187,729	contains similarity to Interpro domain IPR004052 (Potassium channel, voltage dependent, Kv1.5)
43	T21B10.4	T21B10.4	n/a	chrII 8,941,726
44	F29C4.6	F29C4.6	n/a	chrIV 120,551	contains similarity to Pfam domain PF01171 PP-loop family contains similarity to Interpro domains IPR011063 (PP-loop), IPR012089 (PP-loop ATPase, YdaO-related), IPR000541 (Protein of unknown function UPF0021), IPR014729 (Rossmann-like alpha/beta/alpha sandwich fold)
45	ZK643.5	ZK643.5	n/a	chrIII 8,954,457	contains similarity to Homo sapiens RNA binding motif protein 25; ENSEMBL:ENSP00000261973
46	T05H10.4	T05H10.4	n/a	chrII 8,053,981	contains similarity to Saccharomyces cerevisiae Involved in cell-type-specific transcription and pheromone response; SGD:YMR043W
47	C27C12.1	C27C12.1	n/a	chrX 14,853,081	contains similarity to Homo sapiens 10 kDa protein; VG:OTTHUMP00000170593
48	asfl-1	C03D6.5	n/a	chrI 9,659,163	C. elegans ASFL-1 protein; contains similarity to Pfam domain PF04729 Anti-silencing protein, ASF1-like contains similarity to Interpro domains IPR006818 (Anti-silencing protein, ASF1-like), IPR017282 (Histone deposition protein Asf1)
49	F18C12.3	F18C12.3	n/a	chrI 8,097,075	contains similarity to Dictyostelium discoideum Putative uncharacterized protein.; TR:Q54H40
50	nhr-273	T12C9.1	n/a	chrII 4,436,140	C. elegans NHR-273 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)