UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	B0280.2	B0280.2	0	chrIII 7,126,452	contains similarity to Interpro domain IPR000697 (EVH1)
2	F43C1.1	F43C1.1	n/a	chrIII 4,213,606	contains similarity to Pfam domains PF00481 (Protein phosphatase 2C) , PF00560 (Leucine Rich Repeat) (11)contains similarity to Interpro domains IPR001932 (Protein phosphatase 2C-related), IPR001611 (Leucine-rich repeat), IPR000694 (Proline-rich region), IPR003591 (Leucine-rich repeat, typical subtype), IPR014045 (Protein phosphatase 2C, N-terminal)
3	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
4	F25C8.4	F25C8.4	n/a	chrV 20,901,062	contains similarity to Pfam domain PF00501 AMP-binding enzyme contains similarity to Interpro domain IPR000873 (AMP-dependent synthetase and ligase)
5	T07D10.2	T07D10.2	n/a	chrI 12,622,116	T07D10.2 is orthologous to the human gene VASOPRESSIN RECEPTOR TYPE 2 (AVPR2; OMIM:304800), which when mutated leads to nephrogenic diabetes insipidus.
6	ubh-1	F46E10.8	n/a	chrV 6,510,664	ubh-1 encodes a putative ubiquitin C-terminal hydrolase orthologous to human UCHL1 (OMIM:191342, mutated in Parkinson disease).
7	F19C7.2	F19C7.2	n/a	chrIV 4,601,343	contains similarity to Pfam domain PF05577 Serine carboxypeptidase S28 contains similarity to Interpro domain IPR008758 (Peptidase S28)
8	B0035.13	B0035.13	n/a	chrIV 11,305,691	contains similarity to Pfam domain PF01764 Lipase (class 3) contains similarity to Interpro domains IPR002921 (Lipase, class 3), IPR008262 (Lipase, active site)
9	Y40B1B.5	Y40B1B.5	n/a	chrI 13,436,717	contains similarity to Homo sapiens Retinoblastoma binding protein 6 isoform 1; ENSEMBL:ENSP00000317872
10	gtl-2	F54D1.5	n/a	chrIV 11,277,712	gtl-2 encodes a predicted receptor-activated calcium channel and represents a family of calcium channels, the other two family members being gtl-1 and gon-2.
11	fbxa-60	T12B5.10	n/a	chrIII 945,562	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
12	F38A1.9	F38A1.9	n/a	chrIV 1,244,866
13	Y11D7A.8	Y11D7A.8	n/a	chrIV 9,252,608	contains similarity to Pfam domains PF02958 (Domain of unknown function (DUF227)) , PF07914 (Protein of unknown function (DUF1679)) contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR012877 (Protein of unknown function DUF1679, Caenorhabditis species), IPR004119 (Protein of unknown function DUF227), IPR015897 (CHK kinase-like)
14	T27C4.2	T27C4.2	n/a	chrV 3,729,612
15	Y49E10.16	Y49E10.16	n/a	chrIII 12,432,047	contains similarity to Pfam domain PF01764 Lipase (class 3) contains similarity to Interpro domains IPR002921 (Lipase, class 3), IPR008262 (Lipase, active site)
16	F31A3.3	F31A3.3	n/a	chrX 17,533,568
17	R07B7.5	R07B7.5	n/a	chrV 12,069,626	contains similarity to Pfam domain PF01494 FAD binding domain contains similarity to Interpro domains IPR003042 (Aromatic-ring hydroxylase), IPR002938 (Monooxygenase, FAD-binding)
18	C26D10.4	C26D10.4	n/a	chrII 8,331,544	contains similarity to Pfam domains PF08544 (GHMP kinases C terminal) , PF00288 (GHMP kinases N terminal domain) contains similarity to Interpro domains IPR006206 (Mevalonate and galactokinase), IPR001174 (Galactokinase/homoserine kinase), IPR006204 (GHMP kinase), IPR014721 (Ribosomal protein S5 domain 2-type fold), IPR013750 (GHMP kinase, C-terminal)
19	T05E12.3	T05E12.3	n/a	chrV 17,077,410	contains similarity to Pfam domain PF02214 K+ channel tetramerisation domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR003131 (Potassium channel, voltage dependent, Kv, tetramerisation)
20	srxa-2	F56D5.10	n/a	chrIV 9,423,882	C. elegans SRXA-2 protein; contains similarity to Pfam domain PF03383 Caenorhabditis serpentine receptor-like protein, class xa contains similarity to Interpro domain IPR005047 (Protein of unknown function DUF286, G protein-coupled receptor-like putative Caenorhabditis species)
21	T19D12.6	T19D12.6	n/a	chrII 6,640,052	contains similarity to Pfam domains PF00008 (EGF-like domain) , PF02210 (Laminin G domain) (3), PF00054 (Laminin G domain) (2)contains similarity to Interpro domains IPR013320 (Concanavalin A-like lectin/glucanase, subgroup), IPR001791 (Laminin G), IPR006209 (EGF-like), IPR006210 (EGF), IPR001881 (EGF-like calcium-binding), IPR013032 (EGF-like region, conserved site), IPR012680 (Laminin G, subdomain 2), IPR008985 (Concanavalin A-like lectin/glucanase), IPR012679 (Laminin G, subdomain 1)
22	acl-3	ZK809.2	n/a	chrIV 11,651,359	acl-3 encodes a phosphate acyltransferase that is orthologous to human tafazzin (TAZ; OMIM:300394, mutated in Barth syndrome); by homology, ACL-3 is predicted to be a mitochondrial protein that plays a role in phospholipid metabolism, although loss of acl-3 activity via large-scale RNAi screens results in no obvious defects.
23	B0222.9	B0222.9	n/a	chrV 9,170,672	contains similarity to Pfam domains PF00941 (FAD binding domain in molybdopterin dehydrogenase) , PF02738 (Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding domain) , PF00111 (2Fe-2S iron-sulfur cluster binding domain) , PF01799 ([2Fe-2S] binding domain) , PF01315 (Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain) contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR001041 (Ferredoxin), IPR002346 (Molybdopterin dehydrogenase, FAD-binding), IPR012675 (Beta-grasp fold, ferredoxin-type), IPR002888 ([2Fe-2S]-binding), IPR016166 (FAD-binding, type 2), IPR006058 (2Fe-2S ferredoxin, iron-sulphur binding site), IPR016169 (CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2), IPR000674 (Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead), IPR008274 (Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding)
24	C06A12.3	C06A12.3	n/a	chrIV 17,428,622	contains similarity to Pfam domain PF05303 Protein of unknown function (DUF727) contains similarity to Interpro domain IPR007967 (Protein of unknown function DUF727)
25	sre-55	C50E10.7	n/a	chrII 12,330,123	C. elegans SRE-55 protein; contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domain IPR004151 (C. elegans Sre G protein-coupled chemoreceptor)
26	let-70	M7.1	n/a	chrIV 11,081,640	let-70 encodes a class I E2 ubiquitin conjugating enzyme; let-70 was identified in screens for essential genes and phenotypic analyses indicate that loss of let-70 activity results in embryonic and larval lethality with defects in sarcomere assembly; purified LET-70 can stimulate the self-ubiquitylation activities of CHN-1 and UFD-2, E4 ubiquitin conjugation factors and, in addition, can stimulate the CHN-1- and UFD-2-dependent multiubiquitylation of UNC-45, a myosin-directed chaperone; in this manner, LET-70 may regulate UNC-45 degradation and myosin assembly; RNA blot analyses and a let-70-lacZ reporter fusion reveal that let-70 is abundantly expressed at all stages of development, including the dauer larval stage; strong staining is observed in most somatic tissues until adult stages, when expression generally becomes restricted to the nervous system.
27	C33G3.4	C33G3.4	n/a	chrX 14,073,660	C33G3.4 is orthologous to the human gene BETA-MANNOSIDASE (MANBA; OMIM:248510), which when mutated leads to disease.
28	F53G2.3	F53G2.3	n/a	chrII 2,480,856
29	H37A05.1	H37A05.1	n/a	chrV 13,652,199	H37A05.1 encodes a putative phosphatidic acid phosphatase orthologous to budding yeast PAH1 and human LPIN1 (OMIM:605518), LPIN2 (OMIM:605519, mutated in Majeed syndrome), and LPIN3 (OMIM:605520); H37A05.1 is expressed in vulval muscle; in mass RNAi assays, H37A05.1 is required for the osmotic integrity of eggs and for normal larval growth, body thickness, locomotion, and fertility; by orthology, H37A05.1 is expected to be dephosphorylated by SCPL-2.
30	F38B6.4	F38B6.4	n/a	chrX 6,677,310	contains similarity to Pfam domains PF02844 (Phosphoribosylglycinamide synthetase, N domain) , PF02769 (AIR synthase related protein, C-terminal domain) , PF02843 (Phosphoribosylglycinamide synthetase, C domain) , PF01071 (Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain) , PF00551 (Formyl transferase) , PF00586 (AIR synthase related protein, N-terminal domain) contains similarity to Interpro domains IPR016185 (PreATP-grasp-like fold), IPR011761 (ATP-grasp fold), IPR004733 (Phosphoribosylformylglycinamidine cyclo-ligase), IPR002376 (Formyl transferase, N-terminal), IPR016188 (PurM, N-terminal-like), IPR000728 (AIR synthase related protein), IPR004607 (Phosphoribosylglycinamide formyltransferase), IPR013815 (ATP-grasp fold, subdomain 1), IPR010918 (AIR synthase related protein, C-terminal), IPR013816 (ATP-grasp fold, subdomain 2), IPR013817 (Pre-ATP-grasp fold), IPR011054 (Rudiment single hybrid motif), IPR000115 (Phosphoribosylglycinamide synthetase)
31	wts-1	T20F10.1	n/a	chrI 10,294,898	C. elegans WTS-1 protein; contains similarity to Pfam domains PF00069 (Protein kinase domain) , PF00433 (Protein kinase C terminal domain) contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR000694 (Proline-rich region), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR000961 (Protein kinase, C-terminal)
32	nhr-210	R11G11.12	n/a	chrV 518,366	C. elegans NHR-210 protein; contains similarity to Pfam domain PF00105 Zinc finger, C4 type (two domains) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
33	clk-2	C07H6.6	n/a	chrIII 7,516,797	The clk-2 gene encodes an ortholog of the S. cerevisiae telomere length-regulating protein Tel2p that has been shown to bind a number of DNA structures in vitro, including single-, double- and four-stranded DNA; in C. elegans, CLK-2 activity is required for the DNA damage and S phase replication checkpoints, for embryonic development, and for normal biological rhythms and life span; a functional CLK-2::GFP fusion protein is detected exclusively in the cytoplasm of somatic tissues.
34	ZK673.1	ZK673.1	n/a	chrII 10,444,162	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domains IPR000104 (Antifreeze protein, type I), IPR001778 (Pollen allergen Poa pIX/Phl pVI, C-terminal), IPR003582 (Metridin-like ShK toxin)
35	fbxa-111	Y102A5C.14	n/a	chrV 16,949,135	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
36	pkc-1	F57F5.5	n/a	chrV 12,019,252	pkc-1 encodes a serine/threonine protein kinase that is orthologous to mammalian protein kinase C epsilon (PRKCE), a member of the nPKC subgroup of the protein kinase C superfamily; together with UNC-13, PKC-1 may act downstream of goa-1 to modulate phorbol ester-induced stimulation of acetylcholine release at NMJs; PKC-1 positively regulates locomotion, and affects thermotaxis and chemotaxis together with kin-11; PKC-1 is required for regulating several behaviors including sensation of volatile and soluble compounds, osmolarity, and temperature (thermosensation); PKC-1 is also required for phorbolester-induced stimulation of acetylcholine release at neuromuscular junctions; PKC-1 localizes to the processes and cell bodies of approximately 75 sensory neurons and interneurons, and pkc-1 mRNA is detectable at varying levels during larval and adult stages.
37	dhs-30	T25G12.7	n/a	chrX 17,233,193	dhs-30 encodes a member of the short-chain dehydrogenases/reductases family (SDR) homologous to HSD, which when mutated leads to cortisol 11-beta ketoreductase deficiency (OMIM:218030).
38	pink-1	EEED8.9	n/a	chrII 5,394,469	pink-1 encodes a predicted serine/threonine protein kinase that is most similar to the Drosophila and human PINK1 (PTEN-induced kinase) protein kinases, the latter of which has been implicated in familial forms of Parkinson's disease; although loss of C. elegans pink-1 activity via large-scale RNAi screens results in no obvious abnormalities, studies in Drosophila indicate that Drosophila PINK1 is a mitochondrial protein that genetically interacts with Drosophila parkin and is essential for maintaining mitochondrial function and integrity in several tissues, including flight muscles and dopaminergic neurons.
39	ZK1290.5	ZK1290.5	n/a	chrII 7,530,168	contains similarity to Pfam domain PF00248 Aldo/keto reductase family contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)
40	K09C4.2	K09C4.2	n/a	chrX 3,297,833
41	F56F10.3	F56F10.3	n/a	chrX 863,092	F56F10.3 encodes the C. elegans cysteine dioxygenase ortholog; by homology to mammalian enzymes, the product of F56F10.3 is predicted to function in cysteine catabolism by catalyzing the oxidation of cysteine to cysteine sulfanate.
42	clec-21	T07H3.4	n/a	chrII 1,583,563	C. elegans CLEC-21 protein; contains similarity to Pfam domains PF00431 (CUB domain) , PF00059 (Lectin C-type domain) (2)contains similarity to Interpro domains IPR000859 (CUB), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
43	mab-10	R166.1	n/a	chrII 10,532,058	C. elegans MAB-10 protein; contains similarity to Pfam domains PF04905 (NAB conserved region 2 (NCD2)) , PF04904 (NAB conserved region 1 (NCD1)) contains similarity to Interpro domains IPR010993 (Sterile alpha motif homology), IPR006988 (Nab, N-terminal), IPR006989 (Nab, central region)
44	hlh-15	C43H6.8	n/a	chrX 2,413,123	C. elegans HLH-15 protein; contains similarity to Pfam domain PF00010 Helix-loop-helix DNA-binding domain contains similarity to Interpro domains IPR001092 (Basic helix-loop-helix dimerisation region bHLH), IPR011598 (Helix-loop-helix DNA-binding)
45	lin-48	F34D10.5	n/a	chrIII 3,746,355	lin-48 encodes a C2H2-type zinc-finger transcription factor that is orthologous to Drosophila OVO and mouse OVO1; LIN-48 is required for development of the hindgut, the male tail, and the excretory duct cell; in hindgut and male tail development, LIN-48 activity is essential for proper fate specification of the U, F, and K' blast cells and B blast cell descendants, and in excretory duct cell development, for normal duct cell morphogenesis; a LIN-48 translational reporter is expressed in the nuclei of the U, F, K, and K' blast cells, the excretory duct cell, and up to 10 cells in the head region beginning in late embryogenesis and continuing through adulthood; in addition, expression is detected in the neuronal support cells of the phasmid and labial sensory structures beginning at the late L1 larval stage; in hindgut cell specification, LIN-48 functions with EGL-38/Pax, which appears to be a direct transcriptional regulator of LIN-48 expression, and in excretory duct cell development, LIN-48 is likely under the control of the CES-2 bZip transcription factor
46	D1022.4	D1022.4	n/a	chrII 7,456,724	contains similarity to Pfam domain PF01738 Dienelactone hydrolase family contains similarity to Interpro domain IPR002925 (Dienelactone hydrolase)
47	C38D9.2	C38D9.2	n/a	chrV 17,568,988	contains similarity to Interpro domain IPR001878 (Zinc finger, CCHC-type)
48	C49A9.6	C49A9.6	n/a	chrIV 6,212,029	contains similarity to Pfam domain PF03312 Protein of unknown function, DUF272 contains similarity to Interpro domain IPR004987 (Protein of unknown function DUF272)
49	F28C1.1	F28C1.1	n/a	chrV 12,452,041	contains similarity to Drosophila melanogaster Flybase gene name is CG6695-PA;; FLYBASE:CG6695
50	D1081.3	D1081.3	n/a	chrI 8,466,325	contains similarity to Pfam domain PF03761 Domain of unknown function (DUF316) contains similarity to Interpro domains IPR005514 (Protein of unknown function DUF316), IPR009003 (Peptidase, trypsin-like serine and cysteine)