UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	tbb-4	B0272.1	0	chrX 9,435,612	C. elegans TBB-4 protein; contains similarity to Pfam domains PF00091 (Tubulin/FtsZ family, GTPase domain) , PF03953 (Tubulin/FtsZ family, C-terminal domain) contains similarity to Interpro domains IPR002454 (Gamma tubulin), IPR002452 (Alpha tubulin), IPR002453 (Beta tubulin), IPR000158 (Cell division protein FtsZ, N-terminal), IPR000217 (Tubulin), IPR003008 (Tubulin/FtsZ, GTPase), IPR008280 (Tubulin/FtsZ, C-terminal), IPR013838 (Beta tubulin, autoregulation binding site), IPR004057 (Epsilon tubulin), IPR002967 (Delta tubulin)
2	R06A10.1	R06A10.1	n/a	chrI 1,087,211	contains similarity to Interpro domain IPR016196 (MFS general substrate transporter)
3	acr-2	K11G12.2	n/a	chrX 6,705,942	A homolog of a non-alpha type nicotinic acetylcholine receptor subunit that forms a functional channel when co-expressed with the unc-38 alpha subunit.
4	ssr-2	C14A11.7	n/a	chrX 2,825,197	C. elegans SSR-2 protein; contains similarity to Pfam domains PF00071 (Ras family) , PF08477 (Miro-like protein) contains similarity to Interpro domains IPR002041 (Ran GTPase), IPR003577 (Ras small GTPase, Ras type), IPR013684 (Miro-like), IPR003578 (Ras small GTPase, Rho type), IPR005225 (Small GTP-binding protein), IPR001806 (Ras GTPase), IPR003579 (Ras small GTPase, Rab type), IPR013753 (Ras), IPR006689 (ARF/SAR superfamily)
5	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
6	ift-74	C18H9.8	n/a	chrII 6,681,205	C. elegans IFT-74 protein; contains similarity to Interpro domains IPR010989 (t-SNARE), IPR000694 (Proline-rich region)
7	F13A7.7	F13A7.7	n/a	chrV 16,382,944	contains similarity to Saccharomyces cerevisiae Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis; SGD:YGR159C
8	T05A7.3	T05A7.3	n/a	chrII 4,676,002	contains similarity to Pfam domain PF00431 CUB domain contains similarity to Interpro domain IPR000859 (CUB)
9	C33D9.8	C33D9.8	n/a	chrIV 8,784,995	contains similarity to Interpro domains IPR000533 (Tropomyosin), IPR009053 (Prefoldin)
10	clec-263	F26F2.6	n/a	chrV 20,571,518	C. elegans CLEC-263 protein; contains similarity to Pfam domains PF08277 (PAN-like domain) (2), PF00024 (PAN domain) contains similarity to Interpro domains IPR006583 (CW), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
11	M03F8.6	M03F8.6	n/a	chrV 5,954,355	contains similarity to Interpro domains IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding)
12	srg-67	ZC317.4	n/a	chrV 5,462,245	C. elegans SRG-67 protein; contains similarity to Interpro domain IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
13	W05H9.3	W05H9.3	n/a	chrX 6,252,987
14	rhgf-1	F13E6.6	n/a	chrX 10,704,787	rhgf-1 encodes an RGS RhoGEF (Regulator of G-protein Signaling Rho Guanine Nucleotide Exchange Factor); RHGF-1 functions within cholingergic motor neurons in one of four G-protein-mediated signaling pathways that control locomotion via regulation of acetylcholine (ACh) release at neuromuscular junctions; in regulating ACh release, RHGF-1 functions downstream of the C. elegans Galpha12 ortholog, GPA-12, and upstream of the Rho GTPase ortholog, RHO-1; additionally, rhgf-1 activity is required for normal mechanosensory behavior, egg laying, and embryonic development; an rhgf-1 reporter fusion is expressed in ventral cord motor neurons as well as several head neurons.
15	glb-14	F21A3.6	n/a	chrV 15,543,990	glb-14 encodes a globin with no obvious function in mass RNAi assays; glb-14 expression is induced by anoxia in a HIF-1 dependent manner, although it is also paradoxically upregulated in a hif-1 mutant background; glb-14 is downregulated in a daf-2(e1370) mutant background under normoxic conditions.
16	gur-3	ZC504.5	n/a	chrX 10,404,346	gur-3 encodes a predicted seven-transmembrane protein related to the gustatory class of receptors in Drosophila.
17	fbxb-14	W08F4.9	n/a	chrII 582,428	C. elegans FBXB-14 protein; contains similarity to Pfam domain PF07735 F-box associated contains similarity to Interpro domain IPR012885 (F-box associated type 2)
18	T05H4.10	T05H4.10	n/a	chrV 6,420,809	contains similarity to Pfam domain PF02985 HEAT repeat contains similarity to Interpro domains IPR000357 (HEAT), IPR016024 (Armadillo-type fold)
19	lin-66	B0513.1	n/a	chrIV 13,891,003	lin-66 encodes an unfamiliar protein, with visible homologs only in nematodes, that was identified in screens for molecules that interact with GEX-3, a homolog of mammalian protein ligands of the small GTPase Rac1, that is essential for ventral enclosure during embryonic development; LIN-66 is expressed in body wall and vulval muscles, and is also detected in the intestine, neurons, and probably the hypodermis.
20	T04C9.3	T04C9.3	n/a	chrIII 5,985,695
21	C06E2.2	C06E2.2	n/a	chrX 8,879,967
22	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
23	unc-108	F53F10.4	n/a	chrI 3,825,732	unc-108 encodes a small GTPase homologous to the Rab GTPases that function in endocytosis, membrane fusion, and vesicular trafficking events.
24	col-105	F58F6.2	n/a	chrIV 1,358,519	C. elegans COL-105 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (2)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR003979 (Tropoelastin), IPR000694 (Proline-rich region), IPR008161 (Collagen helix repeat), IPR008160 (Collagen triple helix repeat)
25	dpy-22	F47A4.2	n/a	chrX 9,816,134	dpy-22 encodes a broadly expressed protein, homologous to the human transcriptional mediator protein TRAP230, which is involved in WNT and RAS signaling, as well as in dosage compensation; DPY-22 has a C-terminal glutamine-rich domain that is dispensable for inhibition of RAS-dependent cell differentiation, but is required for inhibition of BAR-1-dependent gene expression.
26	dpy-28	Y39A1B.3	n/a	chrIII 10,770,127	dpy-28 encodes a non-SMC condensin subunit homolog, similar to XCAP-D2 in Xenopus, Cnd1 in S. pombe, and Ycs4p in S. cerevisiae, that is required for negative, chromosome-wide regulation of X-chromosomal genes in XX but not XO animals (dosage compensation), and for some undetermined aspect of body morphogenesis; DPY-28 is part of a multiprotein 'dosage compensation' complex with DPY-26, DPY-27 and MIX-1.
27	F22E5.1	F22E5.1	n/a	chrII 2,676,663	contains similarity to Pfam domain PF07801 Protein of unknown function (DUF1647) contains similarity to Interpro domain IPR012444 (Protein of unknown function DUF1647)
28	C50F2.8	C50F2.8	n/a	chrI 3,903,318	contains similarity to Pfam domains PF00018 (SH3 domain) , PF00625 (Guanylate kinase) contains similarity to Interpro domains IPR008144 (Guanylate kinase), IPR008145 (Guanylate kinase/L-type calcium channel region), IPR001452 (Src homology-3), IPR001478 (PDZ/DHR/GLGF)
29	tag-304	F53E2.1	n/a	chrV 1,469,424	C. elegans TAG-304 protein; contains similarity to Pfam domain PF08513 LisH contains similarity to Interpro domains IPR006594 (LisH dimerisation motif), IPR013144 (CT11-RanBPM), IPR013720 (LisH dimerisation motif, subgroup), IPR006595 (CTLH, C-terminal to LisH motif)
30	F53B3.3	F53B3.3	n/a	chrX 2,868,560
31	R13D11.3	R13D11.3	n/a	chrV 815,301	contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
32	fbxb-85	R17.1	n/a	chrIII 10,848,088	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
33	gpa-7	R10H10.5	n/a	chrIV 10,406,114	gpa-7 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that affects egg laying and response to water- soluble odorants; it is expressed in excitable cells.
34	M01G4.1	M01G4.1	n/a	chrIII 6,665,107
35	cwn-2	W01B6.1	n/a	chrIV 10,069,006	cwn-2 encodes a member of the WNT family; expressed at highest levels in embryos and expression declines and is almost absent by the third larval stage.
36	K11G9.1	K11G9.1	n/a	chrV 6,677,918	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
37	srg-37	K04C1.1	n/a	chrX 14,234,536	C. elegans SRG-37 protein; contains similarity to Interpro domain IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
38	arr-1	F53H8.2	n/a	chrX 952,505	arr-1 encodes the C. elegans beta-arrestin ortholog (OMIM:107940, 107941, mice lacking beta-arrestin family members display defects in G protein-coupled receptor desensitization); by homology, ARR-1 is predicted to be a multifunctional adaptor protein that interacts with intracellular signaling molecules as well as activated and phosphorylated G protein-coupled and TGF-beta receptors to: 1) downregulate receptor signaling, 2) promote receptor endocytosis, and 3) activate MAP kinase- and Src-dependent signaling pathways; in vivo, arr-1 activity is required for normal egg laying and for proper olfactory adaptation and recovery to volatile odorants; in addition, animals doubly mutant for arr-1 and grk-2, which encodes a G protein-coupled receptor kinase, are sick and slow growing; ARR-1 is detected throughout the nervous system and is highly expressed in the amphid chemosensory neurons; in neuronal cells, ARR-1 appears to be largely cytoplasmic; ARR-1 interacts physically with clathrin and beta2-adaptin, two proteins involved in receptor endocytosis.
39	rsr-1	F28D9.1	n/a	chrI 11,179,945	C. elegans RSR-1 protein; contains similarity to Pfam domain PF01480 PWI domain contains similarity to Interpro domains IPR002483 (Splicing factor PWI), IPR000694 (Proline-rich region), IPR005819 (Histone H5), IPR002185 (Dopamine D4 receptor)
40	set-30	ZC8.3	n/a	chrX 5,001,358	set-30 encodes a divergent ortholog of human SMYD1 (OMIM:606846), SMYD2 (OMIM:610663), and SYMD3 (OMIM:608783); SET-30 is paralogous to SET-10, SET-14, and SET-18; neither set-30(gk314) nor set-30(RNAi) have any obvious phenotypes.
41	T02G5.3	T02G5.3	n/a	chrII 7,094,691
42	zig-1	K10C3.3	n/a	chrI 9,848,900	zig-1 encodes a predicted transmembrane protein that is a member of the immunoglobulin superfamily of proteins; a zig-1::gfp reporter fusion is expressed in most neurons, including the PVT interneuron, as well as in body wall muscle; zig-1::gfp expression begins during the L1 larval stage of development.
43	C36A4.10	C36A4.10	n/a	chrIII 3,830,011
44	F40H3.3	F40H3.3	n/a	chrII 6,172,163
45	C39F7.5	C39F7.5	n/a	chrV 1,267,440	contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold)
46	C23H4.2	C23H4.2	n/a	chrX 12,221,143	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domains IPR008262 (Lipase, active site), IPR002018 (Carboxylesterase, type B)
47	C34D4.14	C34D4.14	n/a	chrIV 7,139,438	contains similarity to Pfam domains PF06701 (Mib_herc2) , PF07738 (Sad1 / UNC-like C-terminal) , PF02985 (HEAT repeat) , PF00023 (Ankyrin repeat) (2), PF00632 (HECT-domain (ubiquitin-transferase)) contains similarity to Interpro domains IPR012919 (Sad1/UNC-like, C-terminal), IPR011989 (Armadillo-like helical), IPR000569 (HECT), IPR008979 (Galactose-binding like), IPR002110 (Ankyrin), IPR010606 (Mib-herc2), IPR016024 (Armadillo-type fold)
48	ceh-10	W03A3.1	n/a	chrIII 5,800,012	ceh-10 encodes a member of the Paired-like class of homeodomain proteins; the CEH-10 homeodomain is closely related to the homeodomains of two vertebrate retina proteins (Chx10 from mice and Vsx-1 from goldfish); ceh-10 is required for CAN cell fate specification and migration, complete loss of ceh-10 function results in failure of CAN cell migration and loss of expression of CEH-23 and CEH-10 itself in the CAN and AIY interneurons; CEH-10, along with TTX-3 and CEH-23, constitutes a regulatory cascade of transcription factors that controls all sub-type specific features of the AIY interneurons.
49	gcy-11	C30G4.3	n/a	chrX 17,049,964	C. elegans GCY-11 protein; contains similarity to Pfam domains PF00069 (Protein kinase domain) , PF00211 (Adenylate and Guanylate cyclase catalytic domain) contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001054 (Adenylyl cyclase class-3/4/guanylyl cyclase), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
50	col-75	K03H9.2	n/a	chrII 6,426,809	C. elegans COL-75 protein; contains similarity to Pfam domain PF01391 Collagen triple helix repeat (20 copies) contains similarity to Interpro domains IPR008161 (Collagen helix repeat), IPR008160 (Collagen triple helix repeat)