UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	his-46	B0035.9	1e-41	chrIV 11,326,144	his-46 encodes an H4 histone.
2	syn-4	T01B11.3	n/a	chrIV 8,458,062	syn-4 encodes a Type-I transmembrane protein that is orthologous to mammalian Syntaxin 1, a t-SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor); by homology, SYN-4 is predicted to function as a receptor for intracellular transport vesicles during membrane fusion reactions; in C. elegans, SYN-4 activity is essential for three aspects of early embryogenesis: polar body extrusion, cytokinesis, and nuclear envelope reassembly following mitosis; in addition, SYN-4 may also play a role in formation of the vitelline membrane and/or eggshell; SYN-4 is expressed in the outer membrane of the early embryo, in a punctate pattern around reforming nuclear envelopes, and at the cleavage furrow during ingression; in L1 larvae, SYN-4 is expressed at high levels in lateral seam cells, and in adult hermaphrodites SYN-4 localizes to the incomplete membranes that separate germline nuclei in the gonad.
3	F19D8.2	F19D8.2	n/a	chrX 13,835,397	contains similarity to Homo sapiens Splice isoform 1 of Q9UMN6 Myeloid/lymphoid or mixed-lineage leukemia protein 4; ENSEMBL:ENSP00000222270
4	fipr-8	C12D8.6	n/a	chrV 10,240,388	C. elegans FIPR-8 protein ; contains similarity to Homo sapiens Keratin-associated protein 19-8; ENSEMBL:ENSP00000372272
5	C56E6.2	C56E6.2	n/a	chrII 6,525,580	contains similarity to Pfam domains PF00071 (Ras family) , PF08477 (Miro-like protein) contains similarity to Interpro domains IPR002041 (Ran GTPase), IPR003577 (Ras small GTPase, Ras type), IPR013684 (Miro-like), IPR003578 (Ras small GTPase, Rho type), IPR005225 (Small GTP-binding protein), IPR001806 (Ras GTPase), IPR003579 (Ras small GTPase, Rab type), IPR006688 (ADP-ribosylation factor), IPR013753 (Ras), IPR006036 (Potassium uptake protein TrkA), IPR002078 (RNA polymerase sigma factor 54, interaction)
6	R107.2	R107.2	n/a	chrIII 9,044,850	contains similarity to Pfam domain PF01256 Carbohydrate kinase contains similarity to Interpro domain IPR000631 (Carbohydrate kinase)
7	ZK218.1	ZK218.1	n/a	chrV 17,092,954	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
8	C48B6.3	C48B6.3	n/a	chrI 6,915,508	contains similarity to Homo sapiens UPF0472 protein C16orf72; ENSEMBL:ENSP00000331720
9	T15D6.5	T15D6.5	n/a	chrI 12,382,523	contains similarity to Pfam domain PF01762 Galactosyltransferase contains similarity to Interpro domain IPR002659 (Glycosyl transferase, family 31)
10	F08B6.1	F08B6.1	n/a	chrI 6,760,893	contains similarity to Interpro domain IPR010916 (TonB box, conserved site)
11	grd-10	F09D12.1	n/a	chrIV 3,441,427	grd-10 encodes a hedgehog-like protein, with an N-terminal signal sequence and a C-terminal Ground domain; GRD-10 is expressed in seam cells; the Ground domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-10 is weakly required for normal molting; GRD-10 is also required for normal growth to full size and locomotion; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
12	Y56A3A.31	Y56A3A.31	n/a	chrIII 11,986,100	contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)
13	abce-1	Y39E4B.1	n/a	chrIII 13,156,917	C. elegans ABCE-1 protein; contains similarity to Pfam domains PF04068 (Possible metal-binding domain in RNase L inhibitor, RLI) , PF00037 (4Fe-4S binding domain) , PF00005 (ABC transporter) (2)contains similarity to Interpro domains IPR003439 (ABC transporter-like), IPR001450 (4Fe-4S ferredoxin, iron-sulphur binding), IPR013283 (ABC transporter, ABCE), IPR007209 (Possible metal-binding region in RNase L inhibitor, RLI), IPR003593 (AAA+ ATPase, core)
14	F53F8.5	F53F8.5	n/a	chrV 20,697,686	contains similarity to Pfam domain PF00536 SAM domain (Sterile alpha motif) contains similarity to Interpro domains IPR010993 (Sterile alpha motif homology), IPR013761 (Sterile alpha motif-type), IPR001660 (Sterile alpha motif SAM)
15	F26F12.2	F26F12.2	n/a	chrV 5,838,075
16	Y52B11A.8	Y52B11A.8	n/a	chrI 11,033,190	contains similarity to Interpro domains IPR016090 (Phospholipase A2), IPR013090 (Phospholipase A2, active site)
17	Y18D10A.16	Y18D10A.16	n/a	chrI 12,903,539	contains similarity to Homo sapiens Uncharacterized protein C2orf64; ENSEMBL:ENSP00000330730
18	T20D3.8	T20D3.8	n/a	chrIV 9,342,540	contains similarity to Pfam domain PF06432 Phosphatidylinositol N-acetylglucosaminyltransferase contains similarity to Interpro domain IPR009450 (Phosphatidylinositol N-acetylglucosaminyltransferase)
19	ZK1307.2	ZK1307.2	n/a	chrII 9,653,433	contains similarity to Dictyostelium discoideum Hypothetical protein.; TR:Q8T1G2
20	M02B7.4	M02B7.4	n/a	chrIV 3,802,482	contains similarity to Pfam domain PF08660 Oligosaccharide biosynthesis protein Alg14 like contains similarity to Interpro domain IPR013969 (Oligosaccharide biosynthesis protein Alg14 like)
21	M110.3	M110.3	n/a	chrII 8,215,496	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR011016 (Zinc finger, variant RING-type)
22	mxl-2	F40G9.11	n/a	chrIII 187,571	C. elegans MXL-2 protein; contains similarity to Pfam domain PF00010 Helix-loop-helix DNA-binding domain contains similarity to Interpro domains IPR001092 (Basic helix-loop-helix dimerisation region bHLH), IPR011598 (Helix-loop-helix DNA-binding)
23	cyn-12	C34D4.12	n/a	chrIV 7,132,656	cyn-12 encodes a member of the cyclophilin family that is related to human PPIL1 (CGI-124); based upon its sequence similarity, CYN-12 is predicted to be a cytoplasmic protein potentially involved in a wide range of signal transduction pathways.
24	F18E9.3	F18E9.3	n/a	chrX 8,588,029	contains similarity to Drosophila melanogaster Flybase gene name is Sgs1-PA;; FLYBASE:CG3047
25	set-5	C47E8.8	n/a	chrV 14,702,283	set-5 encodes a large (1,675-residue) protein with an N-terminal SET domain and a C-terminal SPK domain; SET-5 has no non-nematode orthologs, but is paralogous to Y57A10A.1; SET-5's domain organization resembles that of SET-24; neither set-5(ok1568) nor set-5(RNAi) have any obvious phenotypes.
26	spat-1	F57C2.6	n/a	chrII 14,531,337	spat-1 encodes a divergent ortholog of Drosophila melanogaster AURORA BOREALIS (BORA) and human BORA (OMIM:610510); SPAT-1 is specifically required for PAR protein-dependent cell-polarity; RNAi of spat-1 weakly suppresses the embryonic lethality of par-2(it5ts) at restrictive temperature.
27	F48G7.9	F48G7.9	n/a	chrV 628,338	contains similarity to Pfam domain PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) contains similarity to Interpro domains IPR015727 (Protein kinase C mu-related), IPR002219 (Protein kinase C, phorbol ester/diacylglycerol binding)
28	F42A6.5	F42A6.5	n/a	chrIV 3,331,304	contains similarity to Interpro domain IPR001357 (BRCT)
29	Y49E10.21	Y49E10.21	n/a	chrIII 12,458,332	contains similarity to Nanoarchaeum equitans DNA double-strand break repair rad50 ATPase.; SW:P62135
30	zim-1	T07G12.6	n/a	chrIV 10,551,197	zim-1 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include HIM-8, ZIM-2/-3, and C02F5.12; ZIM-1 specifically required for homolog pairing, synapsis, and segregation of chromosomes II and III during meiosis; zim-1(tm1813) oocytes ending prophase have ~4 bivalents and ~4 univalents, the latter of which are consistently chromosomes II and III; ZIM-1 associates with the left ends of chromosomes II and III, which may indicate an association with their pairing centers; while the C-terminal region of ZIM-1 most closely resembles those of its orthologs in other Caenorhabditis species, its N-terminal region instead most closely resembles those of its paralogs in C. elegans, indicating coevolving, species-specific functions; ZIM-1 foci, like HIM-8 foci, associate with the nuclear envelope during meiotic prophase; zim-1 mutants also have some defective segregation of the X chromosome (yielding a Him phenotype), but this may be an indirect effect of autosomal asynapsis.
31	btb-3	B0047.2	n/a	chrII 2,043,575	C. elegans BTB-3 protein; contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ), IPR000210 (BTB/POZ-like)
32	B0564.2	B0564.2	n/a	chrIV 13,107,893	contains similarity to Pfam domain PF03171 2OG-Fe(II) oxygenase superfamily contains similarity to Interpro domain IPR005123 (2OG-Fe(II) oxygenase)
33	C49F5.3	C49F5.3	n/a	chrX 11,983,268	contains similarity to Phytophthora infestans SECY-independent transporter protein.; TR:Q9T238
34	kup-1	F10C2.2	n/a	chrV 12,036,541	kup-1 encodes a novel protein that is conserved in C. briggsae, but contains no other known homologs; kup-1 is the upstream gene in an operon with pkc-1, which encodes two protein kinase C isoforms of the nPKC isotype; the polycistronic kup-1/pkc-1 mRNA is detected at low levels in embryos and larvae, but its expression greatly increases in adults; as loss of kup-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of kup-1 in C. elegans development and/or behavior is not yet known.
35	K11B4.2	K11B4.2	n/a	chrI 14,798,156	contains similarity to Tetraodon nigroviridis UPF0402 protein.; SW:Q4S3C1
36	W02D7.5	W02D7.5	n/a	chrV 8,298,506	contains similarity to Interpro domain IPR016181 (Acyl-CoA N-acyltransferase)
37	srx-1	F59E11.1	n/a	chrV 9,004,313	C. elegans SRX-1 protein; contains similarity to Interpro domains IPR000366 (Fungal pheromone mating factor STE2 GPCR), IPR000276 (GPCR, rhodopsin-like)
38	his-60	F55G1.11	1e-41	chrIV 7,487,766	his-60 encodes an H4 histone; by homology, HIS-60 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-60 expression is detected in early embryos, beginning at the 28-cell stage and continuing through the comma stage (early morphogenesis); his-60 is a replication-dependent histone locus that resides in a histone gene-rich region on chromosome IV.
39	srxa-9	ZK678.4	n/a	chrX 15,749,493	C. elegans SRXA-9 protein; contains similarity to Pfam domain PF03383 Caenorhabditis serpentine receptor-like protein, class xa contains similarity to Interpro domain IPR005047 (Protein of unknown function DUF286, G protein-coupled receptor-like putative Caenorhabditis species)
40	C36F7.2	C36F7.2	n/a	chrI 9,551,413	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domain IPR002110 (Ankyrin)
41	C13F10.5	C13F10.5	n/a	chrV 7,217,043	contains similarity to Homo sapiens Isoform 2 of Uncharacterized protein C6orf64; ENSEMBL:ENSP00000362346
42	F56H6.4	F56H6.4	n/a	chrI 12,291,320	contains similarity to Pfam domain PF04590 Protein of unknown function, DUF595 contains similarity to Interpro domain IPR007669 (Protein of unknown function DUF595)
43	C05E4.7	C05E4.7	n/a	chrV 742,319
44	F17A2.13	F17A2.13	n/a	chrX 12,322,252	contains similarity to Mus musculus X-linked retinitis pigmentosa GTPase regulator-interacting protein 1s(RPGR-interacting protein 1).; SW:Q9EPQ2
45	Y57G7A.8	Y57G7A.8	n/a	chrII 1,291,464
46	W06A11.2	W06A11.2	n/a	chrII 4,060,321
47	F56A8.4	F56A8.4	n/a	chrIII 13,264,008	contains similarity to Pfam domain PF00646 F-box domain contains similarity to Interpro domain IPR001810 (Cyclin-like F-box)
48	T09B4.2	T09B4.2	n/a	chrI 6,184,694
49	D2092.5	D2092.5	n/a	chrI 6,603,752	contains similarity to Interpro domains IPR002713 (FF), IPR000533 (Tropomyosin)
50	F35H10.6	F35H10.6	n/a	chrIV 8,300,273	contains similarity to Pfam domain PF02996 Prefoldin subunit contains similarity to Interpro domains IPR004127 (Prefoldin alpha-like), IPR009053 (Prefoldin)