UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	lin-24	B0001.1	5e-138	chrIV 12,132,269	lin-24 was identified in screens for mutations that result in altered vulval cell lineages; lin-24 is defined by two alleles, the first of which, a partially dominant mutation, generally results in vulvaless animals, while the second, a non-null amber mutation that is also partially dominant, results in wild-type animals when homozygous, but vulvaless animals when heterozygous with a wild-type allele; morphological examination of lin-24 animals indicates that some of the Pn.p cells that normally make up the vulva undergo inappropriate cell death that is dependent upon the ced-2, ced-5, and ced-10 engulfment genes, but not on the ced-3 and ced-4 killing genes; the precise molecular identity of lin-24 has not yet been reported.
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	nhr-273	T12C9.1	n/a	chrII 4,436,140	C. elegans NHR-273 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
4	nhr-264	F14A5.1	n/a	chrIV 9,293,087	C. elegans NHR-264 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
5	T09E11.1	T09E11.1	n/a	chrI 12,338,593	contains similarity to Pfam domain PF03360 Glycosyltransferase family 43 contains similarity to Interpro domain IPR005027 (Glycosyl transferase, family 43)
6	polq-1	W03A3.2	n/a	chrIII 5,797,057	C. elegans POLQ-1 protein; contains similarity to Pfam domains PF00270 (DEAD/DEAH box helicase) , PF00476 (DNA polymerase family A) , PF00271 (Helicase conserved C-terminal domain) contains similarity to Interpro domains IPR011545 (DNA/RNA helicase, DEAD/DEAH box type, N-terminal), IPR001098 (DNA-directed DNA polymerase, family A), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR002298 (DNA polymerase A), IPR003593 (AAA+ ATPase, core), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
7	Y116A8C.40	Y116A8C.40	n/a	chrIV 17,147,619	contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
8	ZC317.1	ZC317.1	n/a	chrV 5,472,445	contains similarity to Pfam domains PF00270 (DEAD/DEAH box helicase) , PF00271 (Helicase conserved C-terminal domain) contains similarity to Interpro domains IPR011545 (DNA/RNA helicase, DEAD/DEAH box type, N-terminal), IPR000629 (RNA helicase, ATP-dependent, DEAD-box, conserved site), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
9	R10H10.6	R10H10.6	n/a	chrIV 10,409,131	contains similarity to Pfam domain PF01687 Riboflavin kinase contains similarity to Interpro domain IPR015865 (Riboflavin kinase)
10	srt-70	B0238.6	n/a	chrV 5,258,776	C. elegans SRT-70 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
11	F41G4.5	F41G4.5	n/a	chrX 16,831,782
12	C24H12.2	C24H12.2	n/a	chrII 437,796
13	W06D11.4	W06D11.4	n/a	chrX 12,302,364	contains similarity to Pfam domain PF08123 Histone methylation protein DOT1 contains similarity to Interpro domain IPR013110 (Histone methylation DOT1)
14	str-193	C50C10.6	n/a	chrV 9,821,161	C. elegans STR-193 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
15	Y17G7B.4	Y17G7B.4	n/a	chrII 11,995,419	contains similarity to Pfam domain PF01916 Deoxyhypusine synthase contains similarity to Interpro domain IPR002773 (Deoxyhypusine synthase)
16	sra-31	C56C10.5	n/a	chrII 6,577,792	C. elegans SRA-31 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domain IPR000344 (Nematode chemoreceptor, Sra)
17	srbc-70	F30B5.6	n/a	chrIV 4,227,430	C. elegans SRBC-70 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
18	nhr-102	T06C12.6	n/a	chrV 15,875,252	nhr-102 encodes a nuclear receptor that is most highly conserved amongst nematode species.
19	hsf-1	Y53C10A.12	n/a	chrI 11,957,869	hsf-1 encodes the C. elegans heat-shock transcription factor ortholog; HSF-1 functions as a transcriptional regulator of stress-induced gene expression whose activity is required for heat-shock and proteotoxicity response, larval development, innate immunity, and regulation of adult lifespan.
20	srbc-45	ZC455.11	n/a	chrV 12,804,041	C. elegans SRBC-45 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
21	C08G5.1	C08G5.1	n/a	chrII 736,664	contains similarity to Pfam domain PF02206 Domain of unknown function contains similarity to Interpro domain IPR003125 (Protein of unknown function WSN)
22	gpa-8	F56H9.3	n/a	chrV 12,639,639	gpa-8 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; expressed in URX, AQR, and PQR sensory cells.
23	Y41C4A.9	Y41C4A.9	n/a	chrIII 11,714,688	contains similarity to Pfam domain PF06862 Protein of unknown function (DUF1253) contains similarity to Interpro domain IPR010678 (Protein of unknown function DUF1253)
24	aat-4	T13A10.10	n/a	chrIV 6,274,136	aat-4 encodes a predicted amino acid transporter catalytic subunit; unlike catalytic subunits in other organisms, however, AAT-4 does not contain the highly conserved cysteine residue known to facilitate covalent interaction with a glycoprotein subunit, suggesting that AAT-4 does not require this residue for heterodimer formation or, alternatively, does not require the glycoprotein subunit for function.
25	F54B11.7	F54B11.7	n/a	chrX 13,600,836	contains similarity to Neurospora crassa GTP cyclohydrolase I (EC 3.5.4.16) (GTP-CH-I).; SW:GCH1_NEUCR
26	str-228	C07G3.5	n/a	chrV 3,511,106	C. elegans STR-228 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
27	F41C6.2	F41C6.2	n/a	chrX 6,870,966
28	srw-59	H24D24.1	n/a	chrV 15,950,332	C. elegans SRW-59 protein; contains similarity to Pfam domain PF06976 Protein of unknown function (DUF1300) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR010726 (Protein of unknown function DUF1300), IPR000276 (GPCR, rhodopsin-like)
29	F36F12.4	F36F12.4	n/a	chrV 2,089,002	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
30	nhr-231	Y17D7B.1	n/a	chrV 18,792,886	C. elegans NHR-231 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
31	itsn-1	Y116A8C.36	n/a	chrIV 17,122,917	tag-11/Y116A8C.36 encodes a homolog of human NCF1, which when mutated leads to chronic granulomatous disease (OMIM:306400).
32	srbc-76	M01B2.4	n/a	chrV 15,252,812	C. elegans SRBC-76 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
33	eif-3.C	T23D8.4	n/a	chrI 9,978,188	eif-3.C encodes a putative c subunit of translation initiation factor 3 that is required for fertility and for embryonic osmotic integrity; eif-3.C is orthologous to human EIF3S8 (OMIM:603916) and budding yeast NIP1.
34	mvb-12	C06A6.3	n/a	chrIV 7,831,453	C. elegans MVB-12 protein ; contains similarity to Homo sapiens Isoform 1 of Protein FAM125B; ENSEMBL:ENSP00000354772
35	aps-1	F29G9.3	n/a	chrV 6,018,404	aps-1 encodes an adaptin: specifically, it encodes an ortholog of the sigma1 subunit of adaptor protein complex 1 (AP-1).
36	B0432.9	B0432.9	n/a	chrII 283,160	contains similarity to Pfam domain PF00753 Metallo-beta-lactamase superfamily contains similarity to Interpro domain IPR001279 (Beta-lactamase-like)
37	T08D2.2	T08D2.2	n/a	chrX 167,955	contains similarity to Pfam domains PF00953 (Glycosyl transferase family 4) , PF00646 (F-box domain) contains similarity to Interpro domain IPR000715 (Glycosyl transferase, family 4)
38	ina-1	F54G8.3	n/a	chrIII 9,170,331	ina-1 encodes one of two C. elegans alpha integrin subunits; during development, ina-1 activity is required for migration of a number of cell types, including neurons, coelomocyte precursors, and the distal tip cells of the somatic gonad; in addition, ina-1 is required for axon fasciculation and morphogenesis of structures such as the head, pharynx, egg-laying apparatus, and male tail; INA-1 coimmunoprecipitates with the PAT-3 beta integrin subunit suggesting that, in vivo, INA-1 and PAT-3 function as a heterodimer to regulate cell migration and tissue morphogenesis; INA-1 is expressed in many tissues, including neurons, the gonad, and the pharyngeal basement membrane; expression begins during gastrulation and continues through to adulthood.
39	taf-9	T12D8.7	n/a	chrIII 13,624,992	C. elegans TAF-9 protein; contains similarity to Pfam domain PF02291 Transcription initiation factor IID, 31kD subunit contains similarity to Interpro domains IPR003162 (Transcription factor TAFII-31), IPR009072 (Histone-fold)
40	W08D2.5	W08D2.5	n/a	chrIV 9,821,001	contains similarity to Pfam domains PF00122 (E1-E2 ATPase) , PF00702 (haloacid dehalogenase-like hydrolase) contains similarity to Interpro domains IPR008250 (E1-E2 ATPase-associated region), IPR006544 (P-type ATPase of unknown pump specificity (type V)), IPR001757 (ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter), IPR000150 (Cof protein), IPR005834 (Haloacid dehalogenase-like hydrolase)
41	C41A3.1	C41A3.1	n/a	chrX 5,427,831	contains similarity to Pfam domains PF02801 (Beta-ketoacyl synthase, C-terminal domain) (5), PF01370 (NAD dependent epimerase/dehydratase family) , PF08659 (KR domain) (2), PF00501 (AMP-binding enzyme) , PF00668 (Condensation domain) , PF00106 (short chain dehydrogenase) , PF00109 (Beta-ketoacyl synthase, N-terminal domain) (5), PF00550 (Phosphopantetheine attachment site) (8), PF00698 (Acyl transferase domain) (2)contains similarity to Interpro domains IPR016035 (Acyl transferase/acyl hydrolase/lysophospholipase), IPR006163 (Phosphopantetheine-binding), IPR001242 (Condensation domain), IPR016038 (Thiolase-like, subgroup), IPR013968 (Polyketide synthase, KR), IPR000794 (Beta-ketoacyl synthase), IPR001509 (NAD-dependent epimerase/dehydratase), IPR014031 (Beta-ketoacyl synthase, C-terminal), IPR014043 (Acyl transferase), IPR014030 (Beta-ketoacyl synthase, N-terminal), IPR008262 (Lipase, active site), IPR006162 (Phosphopantetheine attachment site), IPR000873 (AMP-dependent synthetase and ligase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016039 (Thiolase-like), IPR016040 (NAD(P)-binding), IPR009081 (Acyl carrier protein-like), IPR001227 (Acyl transferase region)
42	aqp-7	M02F4.8	n/a	chrX 3,026,113	aqp-7 encodes an aquaglyceroporin whose expression in Xenopus oocytes increases either water or glycerol permeability five- to seven-fold; AQP-7 has no function in mass RNAi assays, perhaps reflecting genetic redundancy with its several paralogs; AQP-7 is expressed in muscle punctae (perhaps focal adhesions).
43	F26F2.3	F26F2.3	n/a	chrV 20,561,363	contains similarity to Saccharomyces cerevisiae Profilin synthetic lethal protein, has region of coiled-coil structure; subunit of the Exocyst complex--the Exocyst complex contains the gene products encoded by SEC3, SEC5, SEC6, SEC8, SEC10, SEC15 and EXO70 and is required for exocytosis; SGD:YER008C
44	M01E5.1	M01E5.1	n/a	chrI 13,275,251	contains similarity to Ichthyophthirius multifiliis Immobilization antigen isoform.; TR:Q9BMH3
45	C52B11.5	C52B11.5	n/a	chrX 1,274,112	contains similarity to Pfam domains PF00071 (Ras family) , PF08477 (Miro-like protein) contains similarity to Interpro domains IPR003577 (Ras small GTPase, Ras type), IPR013684 (Miro-like), IPR003578 (Ras small GTPase, Rho type), IPR005225 (Small GTP-binding protein), IPR001806 (Ras GTPase), IPR003579 (Ras small GTPase, Rab type), IPR013753 (Ras)
46	T12G3.4	T12G3.4	n/a	chrIV 12,049,069	contains similarity to Pfam domain PF03088 Strictosidine synthase contains similarity to Interpro domains IPR004141 (Strictosidine synthase), IPR011042 (Six-bladed beta-propeller, TolB-like)
47	alr-1	R08B4.2	n/a	chrX 11,123,705	C. elegans ALR-1 protein; contains similarity to Pfam domain PF00046 Homeobox domain contains similarity to Interpro domains IPR012287 (Homeodomain-related), IPR000047 (Helix-turn-helix motif, lambda-like repressor), IPR013847 (POU), IPR001356 (Homeobox), IPR009057 (Homeodomain-like)
48	C06E4.4	C06E4.4	n/a	chrIV 7,259,079	contains similarity to Interpro domains IPR002424 (Insect alcohol dehydrogenase family), IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016040 (NAD(P)-binding)
49	emb-27	F10B5.6	n/a	chrII 8,160,979	emb-27 encodes a tetratricopeptide repeat (TPR)-containing protein that is the C. elegans ortholog of the anaphase-promoting complex (APC) subunit APC-6 (CDC16); required maternally and paternally, EMB-27 activity is essential for proper execution of the metaphase-to-anaphase transition during meiosis (both oogenesis and spermatogenesis) and mitosis (during germline proliferation); EMB-27 activity is also critical for embryonic anterior-posterior (A-P) axis formation, production of the secreted eggshell, and normal vulval development; in establishing the embryonic A-P axis, EMB-27 likely acts upstream of the separin protease to ensure proper localization of PAR-3 and PAR-2 to the anterior and posterior cortices, respectively.
50	C04G6.7	C04G6.7	n/a	chrII 5,101,080	contains similarity to Interpro domains IPR006081 (Alpha defensin), IPR001778 (Pollen allergen Poa pIX/Phl pVI, C-terminal), IPR001008 (Mollusc metallothionein, family 2)