UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	ugt-1	AC3.7	0	chrV 10,396,677	C. elegans UGT-1 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
2	K04A8.1	K04A8.1	n/a	chrV 6,567,604	contains similarity to Pfam domain PF03269 Caenorhabditis protein of unknown function, DUF268 contains similarity to Interpro domain IPR004951 (Protein of unknown function DUF268, Caenorhabditis species)
3	hmit-1.1	Y51A2D.4	n/a	chrV 18,520,286	hmit-1.1 encodes one of three C. elegans proton (H+)-dependent myo-inositol transporters; loss of hmit-1.1 activity via large-scale RNAi result in no obvious abnormalities but by homology, HMIT-1.1 is predicted to function as a plasma membrane protein required for the regulated uptake of myo-inositol and thus potentially for regulation of cell signaling and intracellular osmolarity.
4	hum-5	T02C12.1	n/a	chrIII 4,032,950	C. elegans HUM-5 protein; contains similarity to Pfam domains PF00612 (IQ calmodulin-binding motif) , PF06017 (Myosin tail) , PF00063 (Myosin head (motor domain)) contains similarity to Interpro domains IPR010926 (Myosin tail 2), IPR000048 (IQ calmodulin-binding region), IPR001609 (Myosin head, motor region)
5	irs-1	R11A8.6	n/a	chrIV 10,370,700	irs-1 encodes a predicted cytoplasmic isoleucyl-tRNA synthetase (IleRS), an aminoacyl-tRNA synthetase that catalyzes the attachment of isoleucine to its cognate tRNA and is thus required for protein biosynthesis; loss of irs-1 activity via RNA-mediated interference (RNAi) results in sterility, embryonic lethality, and slower rates of growth, indicating that IRS-1 is essential for development.
6	F25B4.1	F25B4.1	n/a	chrV 5,713,763	F25B4.1 is orthologous to the human gene GLYCINE CLEAVAGE SYSTEM T-PROTEIN (AMT; OMIM:238310), which when mutated leads to glycine encephalopathy.
7	F13B12.2	F13B12.2	n/a	chrIV 10,427,657	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR001991 (Sodium:dicarboxylate symporter), IPR001411 (Tetracycline resistance protein, TetB), IPR011701 (Major facilitator superfamily MFS-1), IPR005829 (Sugar transporter, conserved site), IPR005828 (General substrate transporter), IPR003663 (Sugar transporter), IPR008075 (Lipocalin-1 receptor), IPR016196 (MFS general substrate transporter)
8	kqt-2	M60.5	n/a	chrX 8,244,691	kqt-2 encodes one of three C. elegans KCNQ-like potassium channel subunits for which mutations in humans are associated with heredity diseases that affect epithelial cells, cardiac muscle and neurons; a KQT-2::GFP fusion protein is expressed exclusively in the intestine.
9	F52D1.1	F52D1.1	n/a	chrX 463,783	contains similarity to Pfam domain PF01055 Glycosyl hydrolases family 31 contains similarity to Interpro domains IPR017853 (Glycoside hydrolase, catalytic core), IPR000322 (Glycoside hydrolase, family 31)
10	cyp-35A2	C03G6.15	n/a	chrV 7,363,242	C. elegans CYP-35A2 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV)
11	K11G9.2	K11G9.2	n/a	chrV 6,675,280	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
12	pmp-4	T02D1.5	n/a	chrIV 17,404,001	The pmp-4 gene encodes a homolog of human ALD, which when mutated leads to X-linked adrenoleukodystrophy (OMIM:300100).
13	ZK1307.8	ZK1307.8	n/a	chrII 9,625,448	contains similarity to Pfam domains PF07915 (Glucosidase II beta subunit-like protein) , PF00036 (EF hand) contains similarity to Interpro domains IPR011992 (EF-Hand type), IPR002048 (Calcium-binding EF-hand), IPR001907 (Peptidase S14, ClpP), IPR002172 (Low density lipoprotein-receptor, class A, cysteine-rich), IPR009011 (Mannose-6-phosphate receptor, binding), IPR000886 (Endoplasmic reticulum, targeting sequence), IPR012913 (Glucosidase II beta subunit-like)
14	cdr-2	C54D10.1	n/a	chrV 12,415,171	C. elegans CDR-2 protein; contains similarity to Pfam domain PF00043 Glutathione S-transferase, C-terminal domain contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004046 (Glutathione S-transferase, C-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
15	B0286.3	B0286.3	n/a	chrII 4,371,091	contains similarity to Pfam domains PF01259 (SAICAR synthetase) , PF00731 (AIR carboxylase) contains similarity to Interpro domains IPR001636 (SAICAR synthetase), IPR000031 (1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase), IPR013816 (ATP-grasp fold, subdomain 2)
16	his-7	F45F2.4	n/a	chrV 8,533,548	his-7 encodes an H2A histone.
17	C06G8.1	C06G8.1	n/a	chrIV 10,779,821	contains similarity to Pfam domain PF03083 MtN3/saliva family contains similarity to Interpro domains IPR004316 (MtN3 and saliva related transmembrane protein), IPR003091 (Voltage-dependent potassium channel)
18	nhr-68	H12C20.3	n/a	chrV 11,574,552	C. elegans NHR-68 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
19	T20D4.6	T20D4.6	n/a	chrV 3,411,676	contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF02752 (Arrestin (or S-antigen), C-terminal domain) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011022 (Arrestin-like, C-terminal), IPR014752 (Arrestin, C-terminal), IPR011021 (Arrestin-like, N-terminal)
20	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
21	K02G10.3	K02G10.3	n/a	chrX 4,675,475	contains similarity to Rattus norvegicus Transmembrane protein 135.; SW:Q5U4F4
22	H03A11.2	H03A11.2	n/a	chrX 15,228,166	contains similarity to Trypanosoma brucei Putative uncharacterized protein.; TR:Q57WE8
23	F55E10.6	F55E10.6	n/a	chrX 8,345,470	contains similarity to Pfam domain PF00106 short chain dehydrogenase contains similarity to Interpro domains IPR003560 (2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase), IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016040 (NAD(P)-binding)
24	Y43C5A.2	Y43C5A.2	n/a	chrIV 10,271,258	contains similarity to Pfam domain PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain contains similarity to Interpro domains IPR013048 (Meiotic recombination Spo11), IPR014716 (Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1), IPR002181 (Fibrinogen, alpha/beta/gamma chain, C-terminal globular)
25	grd-6	T18H9.1	n/a	chrV 9,223,090	grd-6 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central low-complexity proline-rich domain, and a C-terminal Ground domain; GRD-6 is expressed in hypodermis and in various neurons, in both head and tail, and the PVT interneuron; the Ground domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-6 has no obvious function in RNAi assays.
26	Y56A3A.19	Y56A3A.19	n/a	chrIII 11,915,313	contains similarity to Pfam domain PF00550 Phosphopantetheine attachment site contains similarity to Interpro domains IPR006163 (Phosphopantetheine-binding), IPR009081 (Acyl carrier protein-like), IPR003231 (Acyl carrier protein (ACP))
27	pcp-2	F23B2.12	n/a	chrIV 9,162,862	C. elegans PCP-2 protein; contains similarity to Pfam domain PF05577 Serine carboxypeptidase S28 contains similarity to Interpro domains IPR008758 (Peptidase S28), IPR000258 (Bacterial ice-nucleation proteins octamer repeat)
28	cnx-1	ZK632.6	n/a	chrIII 9,815,658	cnx-1 encodes the C. elegans ortholog of calnexin, a type I Ca2+-binding integral membrane protein of the endoplasmic reticulum (ER); CNX-1 binds calcium and is predicted to function as a molecular chaperone required for glycoprotein folding and maturation as well as regulation of intracellular calcium homeostasis; in C. elegans, cnx-1 activity is required at 25 degrees C for wild-type levels of fertility and normal embryonic and larval development; cnx-1 activity is also required for maintaining viability in response to ER stress; in addition, cnx-1(RNAi) can suppress necrotic-like cell death induced by hyperactivated MEC-4 and DEG-1 ion channels, suggesting that CNX-1 also plays a role in regulating necrotic cell death; CNX-1 expression is first detected ubiquitously in the early embryo, with expression then becoming restricted to embryonic head and tail regions; post-embryonic expression is seen in the excretory cell, head and tail neurons, spermatheca, intestine, germ cells, and spicules in the male tail; antibody staining of early embryos indicates that CNX-1 localizes to the endoplasmic reticulum; in regulating reproduction at 25 degrees C, cnx-1 functions redundantly with crt-1, which encodes calreticulin, an additional Ca2+-binding ER chaperone protein.
29	C03H12.1	C03H12.1	n/a	chrX 15,692,830	contains similarity to Interpro domain IPR012336 (Thioredoxin-like fold)
30	coq-8	C35D10.4	n/a	chrIII 4,865,152	coq-8 encodes a putative protein kinase orthologous to ABC1 (COQ8) from S. cerevisiae and UbiB from E. coli, and paralogous to C. elegans D2023.6 and its (uncharacterized) eukaryotic orthologs; COQ-8 is required for ubiquinone (coenzyme Q9) biosynthesis and for normally short lifespan; alternative hypotheses for COQ-8's biochemical function are that it is a 2-polyprenylphenol 6-hydroxylase, or that it may activate proteins necessary for monooxygenase activity via phosphorylation; coq-8 is expressed in several tissues during larval development, but in later adult life its expression is restricted to neurons; coq-8 mutants have slowed pharyngeal pumping, and eventually arrest as paralysed larvae before dying; coq-8(RNAi) animals have reduced levels of coenzyme Q9 and superoxide, and have abnormally long lifespans; coq-8 mutants are not rescued by dietary coenzyme Q.
31	H03A11.1	H03A11.1	n/a	chrX 15,211,201	H03A11.1 encodes an FAM20 ortholog; murine FAM20A is a secreted protein expressed in hematopoietic cells.
32	math-8	C16C4.13	n/a	chrII 1,888,192	C. elegans MATH-8 protein; contains similarity to Pfam domain PF00917 MATH domain contains similarity to Interpro domains IPR008974 (TRAF-like), IPR002083 (MATH)
33	tag-257	F46G11.3	n/a	chrX 5,784,865	C. elegans TAG-257 protein; contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
34	B0272.3	B0272.3	n/a	chrX 9,432,002	contains similarity to Pfam domains PF00725 (3-hydroxyacyl-CoA dehydrogenase, C-terminal domain) , PF02737 (3-hydroxyacyl-CoA dehydrogenase, NAD binding domain) contains similarity to Interpro domains IPR013328 (Dehydrogenase, multihelical), IPR008927 (6-phosphogluconate dehydrogenase, C-terminal-like), IPR006176 (3-hydroxyacyl-CoA dehydrogenase, NAD binding), IPR006168 (NAD-dependent glycerol-3-phosphate dehydrogenase), IPR006108 (3-hydroxyacyl-CoA dehydrogenase, C-terminal), IPR006180 (3-hydroxyacyl-CoA dehydrogenase, conserved site), IPR016040 (NAD(P)-binding), IPR006036 (Potassium uptake protein TrkA)
35	pcca-1	F27D9.5	n/a	chrX 7,659,204	The F27D9.5 gene encodes an ortholog of the human gene PROPIONYL-COA CARBOXYLASE ALPHA SUBUNIT (PCCA), which when mutated leads to propionicaciduria, type I (OMIM:232000).
36	T01E8.5	T01E8.5	n/a	chrII 10,245,041	contains similarity to Pfam domain PF08424 Protein of unknown function (DUF1740) contains similarity to Interpro domain IPR013633 (Protein of unknown function DUF1740)
37	gly-3	ZK688.8	n/a	chrIII 7,916,183	gly-3 encodes an N-acetylgalactosaminyltransferase that is functional in vitro.
38	R05F9.12	R05F9.12	n/a	chrII 4,919,859	contains similarity to Pfam domains PF01055 (Glycosyl hydrolases family 31) , PF00088 (Trefoil (P-type) domain) contains similarity to Interpro domains IPR000519 (P-type trefoil), IPR017853 (Glycoside hydrolase, catalytic core), IPR000322 (Glycoside hydrolase, family 31)
39	C25F9.4	C25F9.4	n/a	chrV 19,412,581	contains similarity to Arabidopsis thaliana Putative SWI/SNF-related matrix-associated actin-dependent regulatorsof chromatin subfamily A member 3-like 3 (EC 3.6.1.-) (SMARCA3-likesprotein 3).; SW:Q9FIY7
40	F08A8.3	F08A8.3	n/a	chrI 12,948,957	contains similarity to Pfam domains PF01756 (Acyl-CoA oxidase) , PF02770 (Acyl-CoA dehydrogenase, middle domain) contains similarity to Interpro domains IPR013786 (Acyl-CoA dehydrogenase/oxidase, N-terminal), IPR006091 (Acyl-CoA dehydrogenase/oxidase, central region), IPR013764 (Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal), IPR012258 (Acyl-CoA oxidase), IPR009100 (Acyl-CoA dehydrogenase/oxidase, middle and N-terminal), IPR002655 (Acyl-CoA oxidase, C-terminal), IPR009075 (Acyl-CoA dehydrogenase/oxidase C-terminal)
41	H23N18.4	H23N18.4	5.000000000000001e-106	chrV 4,902,178	contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
42	R05F9.6	R05F9.6	n/a	chrII 4,890,420	contains similarity to Pfam domains PF02879 (Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II) , PF02878 (Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I) , PF02880 (Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III) , PF00408 (Phosphoglucomutase/phosphomannomutase, C-terminal domain) contains similarity to Interpro domains IPR016066 (Alpha-D-phosphohexomutase, conserved site), IPR005843 (Alpha-D-phosphohexomutase, C-terminal), IPR016055 (Alpha-D-phosphohexomutase, alpha/beta/alpha I, II and III), IPR005841 (Alpha-D-phosphohexomutase, N-terminal), IPR005844 (Alpha-D-phosphohexomutase, alpha/beta/alpha domain I), IPR005846 (Alpha-D-phosphohexomutase, alpha/beta/alpha domain III), IPR005845 (Alpha-D-phosphohexomutase, alpha/beta/alpha domain II)
43	Y70C5A.2	Y70C5A.2	n/a	chrV 16,622,275	contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
44	R07E3.4	R07E3.4	n/a	chrX 10,331,226	contains similarity to Pfam domain PF00153 Mitochondrial carrier protein contains similarity to Interpro domains IPR002067 (Mitochondrial carrier protein), IPR001993 (Mitochondrial substrate carrier), IPR002113 (Adenine nucleotide translocator 1)
45	pgp-13	F22E10.2	n/a	chrX 12,741,422	pgp-13 encodes a member of the ABC transporter family with high similarity to the vertebrate MDR (multidrug resistance) family; PGP-13 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-13 activity via large-scale RNAi screens does not result in any obvious defects, the precise role of pgp-13 in C. elegans development and/or behavior is not yet known; pgp-13 promoter-gfp fusion proteins are expressed in larvae and adults in the posterior intestine and the amphids.
46	pxn-1	ZK994.3	n/a	chrV 8,498,505	C. elegans PXN-1 protein; contains similarity to Pfam domains PF07686 (Immunoglobulin V-set domain) , PF00047 (Immunoglobulin domain) (2), PF00560 (Leucine Rich Repeat) (4), PF01462 (Leucine rich repeat N-terminal domain) , PF07679 (Immunoglobulin I-set domain) (2), PF03098 (Animal haem peroxidase) contains similarity to Interpro domains IPR003598 (Immunoglobulin subtype 2), IPR000483 (Cysteine-rich flanking region, C-terminal), IPR001611 (Leucine-rich repeat), IPR013098 (Immunoglobulin I-set), IPR010255 (Haem peroxidase), IPR003596 (Immunoglobulin V-set, subgroup), IPR013783 (Immunoglobulin-like fold), IPR003591 (Leucine-rich repeat, typical subtype), IPR013106 (Immunoglobulin V-set), IPR007110 (Immunoglobulin-like), IPR002007 (Haem peroxidase, animal), IPR000372 (Leucine-rich repeat, cysteine-rich flanking region, N-terminal), IPR003599 (Immunoglobulin subtype), IPR013151 (Immunoglobulin)
47	C05D12.2	C05D12.2	n/a	chrII 11,420,763	contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR013032 (EGF-like region, conserved site), IPR006582 (Region of unknown fuction MD, Caenorhabditis elegans)
48	K08E3.4	K08E3.4	n/a	chrIII 13,760,645	contains similarity to Pfam domains PF07653 (Variant SH3 domain) , PF00018 (SH3 domain) , PF00241 (Cofilin/tropomyosin-type actin-binding protein) contains similarity to Interpro domains IPR002108 (Actin-binding, cofilin/tropomyosin type), IPR001452 (Src homology-3), IPR000108 (Neutrophil cytosol factor 2), IPR000694 (Proline-rich region), IPR013315 (Spectrin alpha chain), IPR011511 (Variant SH3)
49	amx-3	F25C8.2	n/a	chrV 20,896,026	C. elegans AMX-3 protein; contains similarity to Pfam domain PF01593 Flavin containing amine oxidoreductase contains similarity to Interpro domains IPR000759 (Adrenodoxin reductase), IPR001613 (Flavin-containing amine oxidase), IPR002937 (Amine oxidase), IPR016040 (NAD(P)-binding)
50	col-111	F29B9.9	n/a	chrIV 4,656,697	C. elegans COL-111 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR008160 (Collagen triple helix repeat)