UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	CDC9	YDL164C	385	n/a	chrIV 166,120	DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication also acts in nucleotide excision repair, base excision repair, and recombination
2	UNG1	YML021C	385	n/a	chrXIII 230,273	Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
3	ERD1	YDR414C	385	n/a	chrIV 1,296,142	Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins mutants secrete the endogenous ER protein, BiP (Kar2p)
4	CDC43	YGL155W	385	n/a	chrVII 214,646	Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe has substrates important for morphogenesis
5	CDC42	YLR229C	385	n/a	chrXII 604,499	Small rho-like GTPase, essential for establishment and maintenance of cell polarity mutants have defects in the organization of actin and septins
6	CCA1	YER168C	385	n/a	chrV 521,849	ATP (CTP):tRNA-specific tRNA nucleotidyltransferase different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites
7	CLB4	YLR210W	385	n/a	chrXII 562,699	B-type cyclin involved in cell cycle progression activates Cdc28p to promote the G2/M transition may be involved in DNA replication and spindle assembly accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
8	PRR1	YKL116C	385	n/a	chrXI 222,122	Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
9	DEG1	YFL001W	385	n/a	chrVI 147,795	tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm non-essential for viability
10	MTC7	YEL033W	385	n/a	chrV 86,388	Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites null mutant is sensitive to temperature oscillation in a cdc13-1 mutant
11	GCS1	YDL226C	385	n/a	chrIV 51,644	ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport shares functional similarity with Glo3p
12	PPS1	YBR276C	385	n/a	chrII 758,831	Protein phosphatase with specificity for serine, threonine, and tyrosine residues has a role in the DNA synthesis phase of the cell cycle
13	SLI15	YBR156C	385	n/a	chrII 552,152	Subunit of the conserved chromosomal passenger complex (CPC Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly
14	YPT31	YER031C	385	n/a	chrV 214,411	Rab family GTPase, very similar to Ypt32p involved in the exocytic pathway mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi
15	SRP72	YPL210C	385	n/a	chrXVI 155,251	Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
16	PPX1	YHR201C	385	n/a	chrVIII 500,546	Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues located in the cytosol, plasma membrane, and mitochondrial matrix
17	MNN9	YPL050C	385	n/a	chrXVI 461,372	Subunit of Golgi mannosyltransferase complex also containing Anp1p, Mnn10p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone forms a separate complex with Van1p that is also involved in backbone elongation
18	PRP39	YML046W	385	n/a	chrXIII 182,418	U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
19	NUP60	YAR002W	385	n/a	chrI 153,066	Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP involved in nuclear export and cytoplasmic localization of specific mRNAs such as ASH1
20	PAC1	YOR269W	385	n/a	chrXV 827,127	Protein involved in nuclear migration, part of the dynein/dynactin pathway targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex synthetic lethal with bni1 homolog of human LIS1
21	FIR1	YER032W	385	0	chrV 216,378	Protein involved in 3' mRNA processing, interacts with Ref2p potential Cdc28p substrate
22	SHO1	YER118C	385	n/a	chrV 398,503	Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway phosphorylated by Hog1p interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
23	KTR7	YIL085C	385	n/a	chrIX 201,266	Putative mannosyltransferase involved in protein glycosylation member of the KRE2/MNT1 mannosyltransferase family
24	SAD1	YFR005C	385	n/a	chrVI 155,200	Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle
25	ARC1	YGL105W	385	n/a	chrVII 308,002	Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm also binds quadruplex nucleic acids
26	LSM1	YJL124C	385	n/a	chrX 187,385	Lsm (Like Sm) protein forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs
27	CCT8	YJL008C	385	n/a	chrX 420,810	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
28	CPR7	YJR032W	385	n/a	chrX 491,671	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues binds to Hsp82p and contributes to chaperone activity
29	HAM1	YJR069C	385	n/a	chrX 569,102	Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools mutant is sensitive to the base analog 6-N-hydroxylaminopurine
30	GPI8	YDR331W	385	n/a	chrIV 1,130,205	ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins human PIG-K protein is a functional homolog
31	MNT2	YGL257C	385	n/a	chrVII 13,319	Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans
32	RAI1	YGL246C	385	n/a	chrVII 38,198	Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures binds to and stabilizes the exoribonuclease Rat1p required for pre-rRNA processing homologous to human DOM3Z
33	TUB4	YLR212C	385	n/a	chrXII 565,570	Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body
34	YNL108C	YNL108C	385	n/a	chrXIV 419,420	Putative protein of unknown function with similarity to Tfc7p and prokaryotic phosphotransfer enzymes null mutant shows alterations in glucose metabolism GFP-fusion protein localizes to the cytoplasm and nucleus
35	TMA20	YER007C-A	385	n/a	chrV 166,561	Protein of unknown function that associates with ribosomes and has a putative RNA binding domain interacts with Tma22p null mutant exhibits translation defects has homology to human oncogene MCT-1
36	SMD1	YGR074W	385	n/a	chrVII 635,932	Core Sm protein Sm D1 part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs homolog of human Sm D1
37	TFB2	YPL122C	385	n/a	chrXVI 319,996	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH
38	YMD8	YML038C	385	n/a	chrXIII 203,439	Putative nucleotide sugar transporter, has similarity to Vrg4p
39	YMR130W	YMR130W	385	n/a	chrXIII 532,573	Putative protein of unknown function YMR130W is not an essential gene
40	GIM5	YML094W	385	n/a	chrXIII 82,562	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
41	YMR221C	YMR221C	385	n/a	chrXIII 714,688	Putative protein of unknown function the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies physical interaction with Atg27p suggests a possible role in autophagy
42	ARP9	YMR033W	385	n/a	chrXIII 338,532	Component of both the SWI/SNF and RSC chromatin remodeling complexes actin-related protein involved in transcriptional regulation
43	RBS1	YDL189W	385	n/a	chrIV 122,902	Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization proposed to bind single-stranded nucleic acids via its R3H domain
44	CSR1	YLR380W	385	n/a	chrXII 878,895	Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions interacts specifically with thioredoxin peroxidase may have a role in oxidative stress resistance
45	DTD1	YDL219W	385	n/a	chrIV 65,503	D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery ubiquitous among eukaryotes
46	PAM18	YLR008C	385	n/a	chrXII 165,830	Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex) essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import inhibited by Pam16p
47	YEH2	YLR020C	385	n/a	chrXII 182,597	Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane involved in sterol metabolism
48	YPL199C	YPL199C	385	n/a	chrXVI 172,394	Putative protein of unknown function, predicted to be palmitoylated
49	SUT2	YPR009W	385	n/a	chrXVI 576,955	Putative transcription factor multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway highly similar to Sut1p
50	SME1	YOR159C	385	n/a	chrXV 633,424	Core Sm protein Sm E part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs homolog of human Sm E