UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	HTB1	YDR224C	487	n/a	chrIV 914,514	Histone H2B, core histone protein required for chromatin assembly and chromosome function nearly identical to HTB2 Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
2	SPT15	YER148W	487	n/a	chrV 465,664	TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
3	PET18	YCR020C	487	n/a	chrIII 154,335	Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism expression is induced in the absence of thiamin
4	SEC65	YML105C	487	n/a	chrXIII 58,276	Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER interacts with Srp54p homolog of mammalian SRP19
5	SSS1	YDR086C	487	n/a	chrIV 617,049	Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p) interacts with Ost4p and Wbp1p
6	TOM20	YGR082W	487	n/a	chrVII 644,319	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins acts as a receptor for incoming precursor proteins
7	SWD3	YBR175W	487	n/a	chrII 582,881	Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres WD40 beta propeller superfamily member and ortholog of mammalian WDR5
8	LSM2	YBL026W	487	n/a	chrII 170,830	Lsm (Like Sm) protein part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
9	YSY6	YBR162W-A	487	n/a	chrII 565,329	Protein whose expression suppresses a secretory pathway mutation in E. coli has similarity to the mammalian RAMP4 protein involved in secretion
10	MGE1	YOR232W	487	n/a	chrXV 774,916	Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins homolog of E. coli GrpE
11	INM1	YHR046C	487	n/a	chrVIII 197,841	Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
12	PAN5	YHR063C	487	n/a	chrVIII 224,599	2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE
13	YHR162W	YHR162W	487	n/a	chrVIII 423,266	Putative protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
14	VMA7	YGR020C	487	n/a	chrVII 527,151	Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system required for the V1 domain to assemble onto the vacuolar membrane
15	VTC1	YER072W	487	n/a	chrV 303,000	Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion also has mRNA binding activity
16	CCS1	YMR038C	487	n/a	chrXIII 347,885	Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation
17	SFH5	YJL145W	487	n/a	chrX 145,602	Non-classical phosphatidylinositol transfer protein (PITP) exhibits PI- but not PC-transfer activity localizes to the peripheral endoplasmic reticulum, cytosol and microsomes similar to Sec14p
18	YJR054W	YJR054W	487	n/a	chrX 536,802	Vacuolar protein of unknown function potential Cdc28p substrate
19	PGA2	YNL149C	487	n/a	chrXIV 349,561	Essential protein required for maturation of Gas1p and Pho8p involved in protein trafficking GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network null mutants have a cell separation defect
20	HHT1	YBR010W	487	n/a	chrII 256,536	Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing one of two identical histone H3 proteins (see HHT2) regulated by acetylation, methylation, and phosphorylation
21	TIM10	YHR005C-A	487	n/a	chrVIII 115,760	Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane
22	RHO3	YIL118W	487	n/a	chrIX 140,099	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
23	AAT1	YKL106W	487	n/a	chrXI 238,213	Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis
24	MMT1	YMR177W	487	n/a	chrXIII 617,332	Putative metal transporter involved in mitochondrial iron accumulation closely related to Mmt2p
25	YMR010W	YMR010W	487	n/a	chrXIII 285,708	Putative protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm YMR010W is not an essential gene YMR010W mRNA is transcribed with ADI1
26	YHP1	YDR451C	487	n/a	chrIV 1,361,650	One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval
27	SMP3	YOR149C	487	n/a	chrXV 610,613	Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis required for addition of the fourth, side branching mannose to the GPI core structure
28	HLR1	YDR528W	487	n/a	chrIV 1,495,221	Protein involved in regulation of cell wall composition and integrity and response to osmotic stress overproduction suppresses a lysis sensitive PKC mutation similar to Lre1p, which functions antagonistically to protein kinase A
29	NNT1	YLR285W	487	3e-131	chrXII 707,752	Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination
30	YCS4	YLR272C	487	n/a	chrXII 685,437	Subunit of the condensin complex required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus
31	YLH47	YPR125W	487	n/a	chrXVI 788,643	Mitochondrial inner membrane protein exposed to the mitochondrial matrix, associates with mitochondrial ribosomes, NOT required for respiratory growth homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome
32	PLP2	YOR281C	487	n/a	chrXV 846,699	Essential protein that interacts with the CCT (chaperonin containing TCP-1) complex to stimulate actin folding has similarity to phosducins null mutant lethality is complemented by mouse phosducin-like protein MgcPhLP
33	TAH18	YPR048W	487	n/a	chrXVI 660,117	Conserved NAPDH-dependent diflavin reductase, component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery transfers electrons from NADPH to the Fe-S cluster of Dre2p plays a pro-death role under oxidative stress
34	YLL054C	YLL054C	487	n/a	chrXII 33,938	Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation YLL054C is not an essential gene
35	PGA3	YML125C	487	n/a	chrXIII 21,230	Putative cytochrome b5 reductase, localized to the plasma membrane may be involved in regulation of lifespan required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking