UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	T26E3.7	T26E3.7	8e-58	chrI 12,655,698	contains similarity to Pfam domain PF00006 ATP synthase alpha/beta family, nucleotide-binding domain contains similarity to Interpro domain IPR000194 (ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)
2	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
3	K08E3.4	K08E3.4	n/a	chrIII 13,760,645	contains similarity to Pfam domains PF07653 (Variant SH3 domain) , PF00018 (SH3 domain) , PF00241 (Cofilin/tropomyosin-type actin-binding protein) contains similarity to Interpro domains IPR002108 (Actin-binding, cofilin/tropomyosin type), IPR001452 (Src homology-3), IPR000108 (Neutrophil cytosol factor 2), IPR000694 (Proline-rich region), IPR013315 (Spectrin alpha chain), IPR011511 (Variant SH3)
4	H03A11.1	H03A11.1	n/a	chrX 15,211,201	H03A11.1 encodes an FAM20 ortholog; murine FAM20A is a secreted protein expressed in hematopoietic cells.
5	dhs-7	E04F6.7	n/a	chrII 7,207,642	dhs-7 encodes a short-chain dehydrogenase predicted to be mitochondrial.
6	cdr-2	C54D10.1	n/a	chrV 12,415,171	C. elegans CDR-2 protein; contains similarity to Pfam domain PF00043 Glutathione S-transferase, C-terminal domain contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004046 (Glutathione S-transferase, C-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
7	T04F3.1	T04F3.1	n/a	chrV 11,747,105	contains similarity to Pfam domain PF00155 Aminotransferase class I and II contains similarity to Interpro domains IPR001176 (1-aminocyclopropane-1-carboxylate synthase), IPR015422 (Pyridoxal phosphate-dependent transferase, major region, subdomain 2), IPR015424 (Pyridoxal phosphate-dependent transferase, major region), IPR004839 (Aminotransferase, class I and II), IPR015421 (Pyridoxal phosphate-dependent transferase, major region, subdomain 1)
8	Y49G5A.1	Y49G5A.1	n/a	chrV 5,286,867	contains similarity to Pfam domain PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain contains similarity to Interpro domain IPR002223 (Proteinase inhibitor I2, Kunitz metazoa)
9	ZC376.2	ZC376.2	n/a	chrV 14,173,463	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domains IPR002018 (Carboxylesterase, type B), IPR002000 (Lysosome-associated membrane glycoprotein (Lamp)/CD68)
10	K07H8.3	K07H8.3	n/a	chrIV 8,290,863	contains similarity to Pfam domain PF00583 Acetyltransferase (GNAT) family contains similarity to Interpro domains IPR000182 (GCN5-related N-acetyltransferase), IPR016181 (Acyl-CoA N-acyltransferase)
11	hum-5	T02C12.1	n/a	chrIII 4,032,950	C. elegans HUM-5 protein; contains similarity to Pfam domains PF00612 (IQ calmodulin-binding motif) , PF06017 (Myosin tail) , PF00063 (Myosin head (motor domain)) contains similarity to Interpro domains IPR010926 (Myosin tail 2), IPR000048 (IQ calmodulin-binding region), IPR001609 (Myosin head, motor region)
12	C34C6.4	C34C6.4	n/a	chrII 8,697,694	contains similarity to Pfam domains PF00732 (GMC oxidoreductase) , PF05199 (GMC oxidoreductase) contains similarity to Interpro domains IPR013027 (FAD-dependent pyridine nucleotide-disulphide oxidoreductase), IPR012132 (Glucose-methanol-choline oxidoreductase), IPR007867 (Glucose-methanol-choline oxidoreductase, C-terminal), IPR000172 (Glucose-methanol-choline oxidoreductase, N-terminal), IPR001100 (Pyridine nucleotide-disulphide oxidoreductase, class I)
13	C15H9.7	C15H9.7	n/a	chrX 6,108,092	contains similarity to Interpro domains IPR015422 (Pyridoxal phosphate-dependent transferase, major region, subdomain 2), IPR015424 (Pyridoxal phosphate-dependent transferase, major region), IPR010111 (Kynureninase), IPR015421 (Pyridoxal phosphate-dependent transferase, major region, subdomain 1)
14	C17H12.4	C17H12.4	n/a	chrIV 6,800,609	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
15	ZK370.8	ZK370.8	n/a	chrIII 8,753,333	contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR013026 (Tetratricopeptide region)
16	K10C2.4	K10C2.4	n/a	chrX 6,447,827	K10C2.4 encodes a putative fumarylacetoacetate hydrolase, orthologous to human FAH (OMIM:276700, mutated in type I tyrosinemia), that is required for tyrosine metabolism, resistance to oxidative and protein-folding stresses, and more generally for normally rapid growth, normal locomotion, fertility, and viability; K10C2.4 is expressed in hypodermis and intestine; the intestines of K10C2.4(RNAi) animals atrophy rapidly, and show an abnormally active oxidative stress response (seen via gst-4::GFP) and ER stress response (seen via hsp-4::GFP); while RNAi against enzymes upstream of K10C2.4 suppresses the K10C2.4(RNAi) phenotype, excess dietary tyrosine or homogentisic acid enhances it, and exogenous succinylacetone (SA) mimics it, consistent with the hypothesis that blocked SA metabolism is toxic in K10C2.4(RNAi) animals.
17	K02C4.2	K02C4.2	n/a	chrII 8,076,226	contains similarity to Brugia pahangi Alt-1 protein.; TR:O96781
18	col-69	K01A2.7	n/a	chrII 304,726	C. elegans COL-69 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR008160 (Collagen triple helix repeat)
19	F48C1.6	F48C1.6	n/a	chrI 5,318,763
20	M04F3.3	M04F3.3	n/a	chrI 4,764,191	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
21	fbxa-58	C29F9.11	n/a	chrIII 110,182	C. elegans FBXA-58 protein; contains similarity to Pfam domains PF01827 (FTH domain) , PF00646 (F-box domain) contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
22	H03A11.2	H03A11.2	n/a	chrX 15,228,166	contains similarity to Trypanosoma brucei Putative uncharacterized protein.; TR:Q57WE8
23	B0416.1	B0416.1	n/a	chrX 9,307,010	contains similarity to Pfam domain PF07810 TMC domain contains similarity to Interpro domain IPR012496 (TMC)
24	col-110	F19C7.7	n/a	chrIV 4,608,935	C. elegans COL-110 protein; contains similarity to Pfam domain PF01391 Collagen triple helix repeat (20 copies) contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR008161 (Collagen helix repeat), IPR008160 (Collagen triple helix repeat)
25	T08D10.3	T08D10.3	n/a	chrX 11,956,831	contains similarity to Homo sapiens Hypothetical protein KIAA1681; ENSEMBL:ENSP00000316543
26	F15E11.2	F15E11.2	n/a	chrV 2,335,582	contains similarity to Pfam domain PF01030 Receptor L domain contains similarity to Interpro domain IPR000494 (EGF receptor, L domain)
27	ZK328.6	ZK328.6	n/a	chrIII 6,029,645	contains similarity to Pfam domains PF02818 (PPAK motif) , PF00646 (F-box domain) contains similarity to Interpro domain IPR001810 (Cyclin-like F-box)
28	pmp-4	T02D1.5	n/a	chrIV 17,404,001	The pmp-4 gene encodes a homolog of human ALD, which when mutated leads to X-linked adrenoleukodystrophy (OMIM:300100).
29	asg-2	C53B7.4	n/a	chrX 6,841,624	asg-2 encodes a homolog of subunit G of the membrane-bound F0 proton channel portion of ATP synthase (mitochondrial respiratory chain [MRC] complex V); asg-2 activity is required for growth at a normally high rate and for normal osmoregulation; in addition, asg-2 activity is required for response to hermaphrodite contact, the first step in a series of stereotypical male mating behaviors; an ASG-2::GFP fusion localizes to mitochondria and to cilia of the male-specific CEM neurons.
30	clec-67	F56D6.2	n/a	chrIV 3,923,599	C. elegans CLEC-67 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
31	T20D4.6	T20D4.6	n/a	chrV 3,411,676	contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF02752 (Arrestin (or S-antigen), C-terminal domain) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011022 (Arrestin-like, C-terminal), IPR014752 (Arrestin, C-terminal), IPR011021 (Arrestin-like, N-terminal)
32	vpr-1	F33D11.11	n/a	chrI 5,869,119	C. elegans VPR-1 protein; contains similarity to Pfam domain PF00635 MSP (Major sperm protein) domain contains similarity to Interpro domains IPR008962 (PapD-like), IPR000535 (Major sperm protein), IPR016763 (Vesicle-associated membrane protein)
33	F55A3.6	F55A3.6	n/a	chrI 10,784,384	contains similarity to Pfam domain PF00334 Nucleoside diphosphate kinase contains similarity to Interpro domain IPR001564 (Nucleoside diphosphate kinase, core)
34	pgp-3	ZK455.7	n/a	chrX 11,354,551	pgp-3 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; with PGP-1, PGP-3 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-3 is also required for resistance to colchicine and chloroquine; PGP-3 is expressed in the apical membranes of the excretory cell and the intestinal cells; loss of pgp-3 activity via large-scale RNAi screens does not result in any obvious abnormalities.
35	mdh-1	F20H11.3	n/a	chrIII 6,607,404	mdh-1 encodes a homolog of malate dehydrogenase that is predicted to be mitochondrial.
36	tre-4	F15A2.2	n/a	chrX 13,473,950	C. elegans TRE-4 protein; contains similarity to Pfam domain PF01204 Trehalase contains similarity to Interpro domains IPR001661 (Glycoside hydrolase, family 37), IPR000886 (Endoplasmic reticulum, targeting sequence), IPR008928 (Six-hairpin glycosidase-like)
37	T21C9.6	T21C9.6	n/a	chrV 10,584,474	contains similarity to Pfam domains PF00391 (PEP-utilising enzyme, mobile domain) , PF01326 (Pyruvate phosphate dikinase, PEP/pyruvate binding domain) contains similarity to Interpro domains IPR008279 (PEP-utilising enzyme, mobile region), IPR013815 (ATP-grasp fold, subdomain 1), IPR002192 (Pyruvate phosphate dikinase, PEP/pyruvate-binding), IPR013816 (ATP-grasp fold, subdomain 2)
38	tli-1	F25H2.1	n/a	chrI 10,536,634	C. elegans TLI-1 protein; contains similarity to Pfam domains PF00168 (C2 domain) , PF02845 (CUE domain) contains similarity to Interpro domains IPR003892 (Ubiquitin system component Cue), IPR009060 (UBA-like), IPR008973 (C2 calcium/lipid-binding region, CaLB), IPR000008 (C2 calcium-dependent membrane targeting)
39	tre-1	F57B10.7	n/a	chrI 6,556,662	C. elegans TRE-1 protein; contains similarity to Pfam domain PF01204 Trehalase contains similarity to Interpro domains IPR001661 (Glycoside hydrolase, family 37), IPR008928 (Six-hairpin glycosidase-like)
40	coq-8	C35D10.4	n/a	chrIII 4,865,152	coq-8 encodes a putative protein kinase orthologous to ABC1 (COQ8) from S. cerevisiae and UbiB from E. coli, and paralogous to C. elegans D2023.6 and its (uncharacterized) eukaryotic orthologs; COQ-8 is required for ubiquinone (coenzyme Q9) biosynthesis and for normally short lifespan; alternative hypotheses for COQ-8's biochemical function are that it is a 2-polyprenylphenol 6-hydroxylase, or that it may activate proteins necessary for monooxygenase activity via phosphorylation; coq-8 is expressed in several tissues during larval development, but in later adult life its expression is restricted to neurons; coq-8 mutants have slowed pharyngeal pumping, and eventually arrest as paralysed larvae before dying; coq-8(RNAi) animals have reduced levels of coenzyme Q9 and superoxide, and have abnormally long lifespans; coq-8 mutants are not rescued by dietary coenzyme Q.
41	M03B6.2	M03B6.2	n/a	chrX 13,855,038	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR002455 (GPCR, family 3, gamma-aminobutyric acid receptor, type B), IPR016196 (MFS general substrate transporter)
42	ptr-24	F46G10.5	n/a	chrX 13,345,071	ptr-24 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-24 has no known function in vivo.
43	ZK1058.9	ZK1058.9	n/a	chrIII 3,924,612	contains similarity to Borrelia burgdorferi Probable O-sialoglycoprotein endopeptidase (EC 3.4.24.57)s(Glycoprotease).; SW:GCP_BORBU
44	maoc-1	E04F6.3	n/a	chrII 7,196,834	maoc-1 encodes an ortholog of human HSD17B4 (OMIM:601860, mutated in D-bifunctional protein deficiency); MAOC-1 contains a MaoC-like domain found in diverse enzymes (HSD17B4, peroxisomal hydratase-dehydrogenase-epimerase, and the fatty acid synthase beta subunit) and by homology, is predicted to function in peroxisomal fatty acid beta-oxidation; loss of maoc-1 activity via RNAi results in lifespan extension, increased fat content, and an increased susceptibility to pathogens.
45	T11G6.3	T11G6.3	n/a	chrIV 10,853,967	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
46	K08D10.10	K08D10.10	n/a	chrIV 4,155,758
47	F42E8.1	F42E8.1	n/a	chrV 13,063,254	contains similarity to Campylobacter jejuni DNA polymerase III alpha subunit (EC 2.7.7.7).; SW:DP3A_CAMJE
48	K02B12.7	K02B12.7	n/a	chrI 8,528,009	contains similarity to Pfam domain PF01412 Putative GTPase activating protein for Arf contains similarity to Interpro domain IPR001164 (Arf GTPase activating protein)
49	mrp-3	E03G2.2	n/a	chrX 15,934,560	C. elegans MRP-3 protein; contains similarity to Pfam domains PF00664 (ABC transporter transmembrane region) (2), PF00005 (ABC transporter) (2)contains similarity to Interpro domains IPR003439 (ABC transporter-like), IPR011527 (ABC transporter, transmembrane region, type 1), IPR001140 (ABC transporter, transmembrane region), IPR003593 (AAA+ ATPase, core)
50	C27A2.4	C27A2.4	n/a	chrII 5,058,455	contains similarity to Pfam domain PF00328 Histidine acid phosphatase contains similarity to Interpro domain IPR000560 (Histidine acid phosphatase)