UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	TPK1	YJL164C	505	n/a	chrX 110,562	cAMP-dependent protein kinase catalytic subunit promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway inhibited by regulatory subunit Bcy1p in the absence of cAMP partially redundant with Tpk2p and Tpk3p
2	YOL162W	YOL162W	505	n/a	chrXV 10,442	Putative protein of unknown function member of the Dal5p subfamily of the major facilitator family
3	GPA2	YER020W	505	n/a	chrV 195,842	Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
4	YPK2	YMR104C	505	n/a	chrXIII 474,436	Protein kinase with similarity to serine/threonine protein kinase Ypk1p functionally redundant with YPK1 at the genetic level participates in a signaling pathway required for optimal cell wall integrity homolog of mammalian kinase SGK
5	YSP3	YOR003W	505	n/a	chrXV 332,173	Putative precursor to the subtilisin-like protease III
6	KIN82	YCR091W	505	n/a	chrIII 275,485	Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p similar to Fpk1p
7	FUN19	YAL034C	505	n/a	chrI 81,330	Non-essential protein of unknown function expression induced in response to heat stress
8	GUT2	YIL155C	505	n/a	chrIX 52,733	Mitochondrial glycerol-3-phosphate dehydrogenase expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
9	YEF1	YEL041W	505	n/a	chrV 76,687	ATP-NADH kinase phosphorylates both NAD and NADH homooctameric structure consisting of 60-kDa subunits sequence similarity to Utr1p and Pos5p overexpression complements certain pos5 phenotypes
10	UGX2	YDL169C	505	n/a	chrIV 158,399	Protein of unknown function, transcript accumulates in response to any combination of stress conditions
11	REC114	YMR133W	505	0	chrXIII 536,908	Protein involved in early stages of meiotic recombination possibly involved in the coordination of recombination and meiotic division mutations lead to premature initiation of the first meiotic division
12	ATO2	YNR002C	505	n/a	chrXIV 633,432	Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies phosphorylated in mitochondria member of the TC 9.B.33 YaaH family homolog of Ady2p and Y. lipolytica Gpr1p
13	GDH2	YDL215C	505	n/a	chrIV 72,279	NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
14	TOR1	YJR066W	505	n/a	chrX 563,122	PIK-related protein kinase and rapamycin target subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy involved in meiosis
15	YPT53	YNL093W	505	n/a	chrXIV 450,199	Rab family GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5 required for vacuolar protein sorting and endocytosis
16	PET10	YKR046C	505	n/a	chrXI 524,648	Protein of unknown function that co-purifies with lipid particles expression pattern suggests a role in respiratory growth computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange
17	YBR241C	YBR241C	505	n/a	chrII 703,322	Putative transporter, member of the sugar porter family green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane YBR241C is not an essential gene
18	VID24	YBR105C	505	n/a	chrII 451,425	Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole promotes proteasome-dependent catabolite degradation of FBPase
19	COS111	YBR203W	505	n/a	chrII 630,555	Protein required for resistance to the antifungal drug ciclopirox olamine not related to the subtelomerically-encoded COS family the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
20	SAF1	YBR280C	505	n/a	chrII 763,740	F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence interacts with Skp1
21	RIM4	YHL024W	505	n/a	chrVIII 57,719	Putative RNA-binding protein required for the expression of early and middle sporulation genes
22	GAT2	YMR136W	505	n/a	chrXIII 542,040	Protein containing GATA family zinc finger motifs similar to Gln3p and Dal80p expression repressed by leucine
23	SDP1	YIL113W	505	n/a	chrIX 150,873	Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
24	AIM19	YIL087C	505	n/a	chrIX 199,882	Putative protein of unknown function the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies null mutant displays reduced respiratory growth
25	YIL077C	YIL077C	505	n/a	chrIX 215,472	Putative protein of unknown function the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
26	YIR016W	YIR016W	505	n/a	chrIX 383,026	Putative protein of unknown function expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p overexpression causes a cell cycle delay or arrest YIR016W is a non-essential gene
27	GSC2	YGR032W	505	n/a	chrVII 551,107	Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall activity positively regulated by Rho1p and negatively by Smk1p has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
28	GSM1	YJL103C	505	n/a	chrX 229,953	Putative zinc cluster protein of unknown function proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
29	YJL045W	YJL045W	505	n/a	chrX 356,976	Minor succinate dehydrogenase isozyme homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone induced during the diauxic shift in a Cat8p-dependent manner
30	BNA2	YJR078W	505	n/a	chrX 579,540	Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine interacts genetically with telomere capping gene CDC13 regulated by Hst1p and Aftp
31	RMR1	YGL250W	505	n/a	chrVII 32,272	Protein required for meiotic recombination and gene conversion null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media GFP-fusion protein localizes to both cytoplasm and nucleus
32	TOS8	YGL096W	505	n/a	chrVII 325,746	Homeodomain-containing protein and putative transcription factor found associated with chromatin target of SBF transcription factor induced during meiosis and under cell-damaging conditions similar to Cup9p transcription factor
33	YGR053C	YGR053C	505	n/a	chrVII 595,411	Putative protein of unknown function
34	YGR066C	YGR066C	505	n/a	chrVII 621,360	Putative protein of unknown function
35	YTP1	YNL237W	505	n/a	chrXIV 205,877	Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins
36	MDG1	YNL173C	505	n/a	chrXIV 309,507	Plasma membrane protein involved in G-protein mediated pheromone signaling pathway overproduction suppresses bem1 mutations
37	YNL092W	YNL092W	505	n/a	chrXIV 451,472	Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family YNL092W is not an essential gene
38	TGL2	YDR058C	505	n/a	chrIV 568,213	Triacylglycerol lipase that is localized to the mitochondria has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli
39	NRG1	YDR043C	505	n/a	chrIV 543,021	Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
40	NGL3	YML118W	505	n/a	chrXIII 33,092	Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p similar to Ngl1p and Ngl2p
41	ICY1	YMR195W	505	n/a	chrXIII 654,225	Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA mutants have an invasive growth defect with elongated morphology induced by amino acid starvation
42	COX20	YDR231C	505	n/a	chrIV 926,601	Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
43	SOM1	YEL059C-A	505	n/a	chrV 42,512	Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space Som1p facilitates cleavage of a subset of substrates contains twin cysteine-x9-cysteine motifs
44	ECI1	YLR284C	505	n/a	chrXII 706,619	Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced
45	YLR297W	YLR297W	505	n/a	chrXII 724,238	Putative protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the vacuole YLR297W is not an essential gene induced by treatment with 8-methoxypsoralen and UVA irradiation
46	PIG1	YLR273C	505	n/a	chrXII 690,056	Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase
47	YPR127W	YPR127W	505	n/a	chrXVI 790,601	Protein of unknown function, differentially expressed during alcoholic fermentation expression activated by transcription factor YRM1/YOR172W green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
48	HBT1	YDL223C	505	n/a	chrIV 58,835	Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection) mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
49	ICL2	YPR006C	505	n/a	chrXVI 568,132	2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate ICL2 transcription is repressed by glucose and induced by ethanol
50	YDR018C	YDR018C	505	n/a	chrIV 483,265	Probable membrane protein with three predicted transmembrane domains homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase