Description

This column shows the predicted regulatory module (a combination of transcription factor binding sites) that regulates the gene.

Methods

The approach underlying this annotation is described in Segal, E. et al., Genome-wide discovery of transcriptional modules from DNA sequence and gene expression, Bioinformatics 19(Suppl 1), i273-i282 (2003). The analysis was performed on various pre-existing microarray datasets. A regulatory module is comprised of a set of genes predicted to be regulated by the same combination of DNA sequence motifs. Predictions are based on the co-expression of the set of genes in the module and on the appearance of common combinations of motifs in the upstream regions of genes assigned to the same module.

Action

To view genes that share a regulatory module, select the Regulatory Module option from the sort by menu.

Credits

Thanks to Eran Segal for providing the data analysis that forms the basis for this column.