UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	ALE1	YOR175C	631	n/a	chrXV 660,744	Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases key component of Lands cycle may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids
2	RPO31	YOR116C	631	0	chrXV 541,954	RNA polymerase III largest subunit C160, part of core enzyme similar to bacterial beta-prime subunit and to RPA190 and RPO21
3	NOT3	YIL038C	631	n/a	chrIX 281,397	Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
4	DED1	YOR204W	631	n/a	chrXV 723,818	ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs mutations in human DEAD-box DBY are a frequent cause of male infertility
5	HIP1	YGR191W	631	n/a	chrVII 881,325	High-affinity histidine permease, also involved in the transport of manganese ions
6	TOP2	YNL088W	631	n/a	chrXIV 459,847	Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA cleaves complementary strands localizes to axial cores in meiosis
7	ILV2	YMR108W	631	n/a	chrXIII 485,115	Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria expression of the gene is under general amino acid control
8	LYS2	YBR115C	631	n/a	chrII 471,837	Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine activation requires posttranslational phosphopantetheinylation by Lys5p
9	TRL1	YJL087C	631	n/a	chrX 271,243	tRNA ligase, required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR has phosphodiesterase, polynucleotide kinase, and ligase activities localized at the inner nuclear envelope and partially to polysomes
10	RPL31B	YLR406C	631	n/a	chrXII 931,410	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein associates with the karyopherin Sxm1p loss of both Rpl31p and Rpl39p confers lethality
11	KAR1	YNL188W	631	n/a	chrXIV 286,958	Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p
12	RAP1	YNL216W	631	n/a	chrXIV 242,930	DNA-binding protein involved in either activation or repression of transcription, depending on binding site context also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure
13	URA6	YKL024C	631	n/a	chrXI 392,833	Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
14	MER1	YNL210W	631	n/a	chrXIV 251,337	Protein with RNA-binding motifs required for meiosis-specific mRNA splicing required for chromosome pairing and meiotic recombination Mer1p regulon embraces four essential meiotic pre-mRNAs: REC107, HFM1, AMA1 and SPO22
15	FAS2	YPL231W	631	n/a	chrXVI 111,483	Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities
16	ANB1	YJR047C	631	n/a	chrX 525,144	Translation elongation factor eIF-5A, previously thought to function in translation initiation similar to and functionally redundant with Hyp2p undergoes an essential hypusination modification expressed under anaerobic conditions
17	SPA2	YLL021W	631	n/a	chrXII 103,147	Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components potential Cdc28p substrate
18	CNA1	YLR433C	631	n/a	chrXII 1,005,177	Calcineurin A one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1
19	CTR86	YCR054C	631	n/a	chrIII 219,221	Essential protein of unknown function
20	YCR043C	YCR043C	631	n/a	chrIII 206,452	Putative protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus YCR043C is not an essential gene
21	HCM1	YCR065W	631	n/a	chrIII 230,157	Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding suppressor of calmodulin mutants with specific SPB assembly defects telomere maintenance role
22	VAC17	YCL063W	631	n/a	chrIII 17,925	Phosphoprotein involved in vacuole inheritance degraded in late M phase of the cell cycle acts as a vacuole-specific receptor for myosin Myo2p
23	MSH1	YHR120W	631	n/a	chrVIII 351,013	DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches has homology to E. coli MutS transcription is induced during meiosis
24	RAD27	YKL113C	631	n/a	chrXI 225,301	5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair member of the S. pombe RAD2/FEN1 family
25	CLB5	YPR120C	631	n/a	chrXVI 774,528	B-type cyclin involved in DNA replication during S phase activates Cdc28p to promote initiation of DNA synthesis functions in formation of mitotic spindles along with Clb3p and Clb4p most abundant during late G1 phase
26	YMC1	YPR058W	631	n/a	chrXVI 674,212	Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis member of the mitochondrial carrier (MCF) family has similarity with Ymc2p
27	PPH3	YDR075W	631	n/a	chrIV 597,619	Catalytic subunit of protein phosphatase PP4 complex active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair involved in activation of Gln3p to alleviate nitrogen catabolite repression Pph3p and Psy2p localize to foci on meiotic chromosomes
28	RRN6	YBL014C	631	n/a	chrII 200,406	Component of the core factor (CF) rDNA transcription factor complex CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
29	ALK2	YBL009W	631	n/a	chrII 208,209	Protein kinase accumulation and phosphorylation are periodic during the cell cycle phosphorylated in response to DNA damage contains characteristic motifs for degradation via the APC pathway similar to Alk1p and to mammalian haspins
30	URB1	YKL014C	631	n/a	chrXI 414,266	Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle proposed to be involved in the biogenesis of the 60S ribosomal subunit
31	UTP20	YBL004W	631	n/a	chrII 231,376	Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
32	STB6	YKL072W	631	n/a	chrXI 300,732	Protein that binds Sin3p in a two-hybrid assay
33	HEK2	YBL032W	631	n/a	chrII 160,756	RNA binding protein involved in the asymmetric localization of ASH1 mRNA represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation regulates telomere position effect and length similarity to hnRNP-K
34	YBR141C	YBR141C	631	n/a	chrII 527,531	Putative S-adenosylmethionine-dependent methyltransferase green fluorescent protein (GFP)-fusion protein localizes to the nucleolus YBR141C is not an essential gene
35	YBR271W	YBR271W	631	n/a	chrII 745,481	Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm predicted to be involved in ribosome biogenesis
36	ERG7	YHR072W	631	n/a	chrVIII 240,195	Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
37	MNL1	YHR204W	631	n/a	chrVIII 507,514	Alpha-1,2-specific exomannosidase of the endoplasmic reticulum in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation
38	FHL1	YPR104C	631	n/a	chrXVI 735,028	Regulator of ribosomal protein transcription has forkhead associated domain that binds phosphorylated proteins also has forkhead DNA-binding domain but does not bind DNA in vitro suppresses RNA pol III and splicing factor prp4 mutants
39	LSM5	YER146W	631	n/a	chrV 462,725	Lsm (Like Sm) protein part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
40	YNL217W	YNL217W	631	n/a	chrXIV 240,821	Putative protein of unknown function weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases (GFP)-fusion protein localizes to the vacuole null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate
41	ATM1	YMR301C	631	n/a	chrXIII 868,591	Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol
42	FKH1	YIL131C	631	n/a	chrIX 101,508	Forkhead family transcription factor with a minor role in the expression of G2/M phase genes negatively regulates transcriptional elongation positive role in chromatin silencing at HML and HMR regulates donor preference during switching
43	SNL1	YIL016W	631	n/a	chrIX 321,693	Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding has similarity to the mammalian BAG-1 protein
44	URM1	YIL008W	631	n/a	chrIX 342,685	Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA also functions as a protein tag with roles in nutrient sensing and oxidative stress response
45	RRN7	YJL025W	631	n/a	chrX 394,739	Component of the core factor (CF) rDNA transcription factor complex CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
46	POP1	YNL221C	631	n/a	chrXIV 232,381	Subunit of both RNase MRP and nuclear RNase P RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs binds to the RPR1 RNA subunit in RNase P
47	GDS1	YOR355W	631	n/a	chrXV 1,005,921	Protein of unknown function, required for growth on glycerol as a carbon source the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
48	VTC2	YFL004W	631	n/a	chrVI 133,053	Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion
49	CIN2	YPL241C	631	n/a	chrXVI 95,815	GTPase-activating protein (GAP) for Cin4p tubulin folding factor C involved in beta-tubulin (Tub2p) folding mutants display increased chromosome loss and benomyl sensitivity deletion complemented by human GAP, retinitis pigmentosa 2
50	YAR1	YPL239W	631	n/a	chrXVI 99,785	Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress expression repressed by heat shock