UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	TUF1	YOR187W	595	n/a	chrXV 684,686	Mitochondrial translation elongation factor Tu comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans
2	MST1	YKL194C	595	n/a	chrXI 77,952	Mitochondrial threonyl-tRNA synthetase
3	CHO1	YER026C	595	n/a	chrV 208,059	Phosphatidylserine synthase, functions in phospholipid biosynthesis catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline
4	LPD1	YFL018C	595	n/a	chrVI 102,377	Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes
5	HEM15	YOR176W	595	n/a	chrXV 662,991	Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway
6	TEC1	YBR083W	595	n/a	chrII 409,899	Transcription factor required for full Ty1 expression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth TEA/ATTS DNA-binding domain family member
7	UBA1	YKL210W	595	n/a	chrXI 40,700	Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation and essential for viability
8	PRD1	YCL057W	595	n/a	chrIII 25,837	Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins
9	CPR3	YML078W	595	n/a	chrXIII 111,276	Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues involved in protein refolding after import into mitochondria
10	BMH1	YER177W	595	n/a	chrV 546,012	14-3-3 protein, major isoform controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
11	MSS51	YLR203C	595	n/a	chrXII 551,305	Specific translational activator for the mitochondrial COX1 mRNA loosely associated with the matrix face of the mitochondrial inner membrane influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase
12	ACP1	YKL192C	595	n/a	chrXI 80,348	Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid activated by phosphopantetheinylation catalyzed by Ppt2p
13	SAC6	YDR129C	595	n/a	chrIV 714,359	Fimbrin, actin-bundling protein cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton
14	BMH2	YDR099W	595	n/a	chrIV 654,017	14-3-3 protein, minor isoform controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
15	CPR5	YDR304C	595	n/a	chrIV 1,072,218	Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues transcriptionally induced in response to unfolded proteins in the ER
16	UBP11	YKR098C	595	n/a	chrXI 634,102	Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins
17	APE3	YBR286W	595	n/a	chrII 775,506	Vacuolar aminopeptidase Y, processed to mature form by Prb1p
18	PAM1	YDR251W	595	n/a	chrIV 961,860	Essential protein of unknown function exhibits variable expression during colony morphogenesis overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype
19	NRG2	YBR066C	595	n/a	chrII 370,368	Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth has similarity to Nrg1p
20	MBA1	YBR185C	595	n/a	chrII 599,541	Membrane-associated mitochondrial ribosome receptor forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes possible role in protein export from the matrix to inner membrane
21	VMR1	YHL035C	595	n/a	chrVIII 30,367	Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity ATP-binding cassette (ABC) family member involved in drug transport potential Cdc28p substrate induced under respiratory conditions
22	KEG1	YFR042W	595	n/a	chrVI 238,759	Integral membrane protein of the ER physically interacts with Kre6p has a role in the synthesis of beta-1,6-glucan in the cell wall required for cell viability
23	AIP1	YMR092C	595	n/a	chrXIII 452,555	Actin cortical patch component, interacts with the actin depolymerizing factor cofilin required to restrict cofilin localization to cortical patches contains WD repeats
24	ASG7	YJL170C	595	n/a	chrX 101,464	Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell specific to a-cells and induced by alpha-factor
25	RFX1	YLR176C	595	n/a	chrXII 509,014	Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters involved in DNA damage and replication checkpoint pathway similar to a family of mammalian DNA binding RFX1-4 proteins
26	NAS6	YGR232W	595	2e-133	chrVII 954,303	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP) ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6
27	ALT1	YLR089C	595	n/a	chrXII 319,126	Alanine transaminase (glutamic pyruvic transaminase) involved in alanine biosynthetic and catabolic processes the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
28	SAP4	YGL229C	595	n/a	chrVII 65,731	Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p
29	LSB1	YGR136W	595	n/a	chrVII 762,790	Protein containing an N-terminal SH3 domain binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
30	LSC1	YOR142W	595	n/a	chrXV 593,551	Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate phosphorylated
31	LPP1	YDR503C	595	n/a	chrIV 1,455,454	Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate involved in control of the cellular levels of phosphatidylinositol and PA
32	LAP2	YNL045W	595	n/a	chrXIV 543,970	Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
33	YLL058W	YLL058W	595	n/a	chrXII 24,432	Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism YLL058W is not an essential gene
34	LDB17	YDL146W	595	n/a	chrIV 193,487	Protein involved in the regulation of endocytosis transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck
35	MPD1	YOR288C	595	n/a	chrXV 852,599	Member of the protein disulfide isomerase (PDI) family interacts with and inhibits the chaperone activity of Cne1p MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation
36	AIM45	YPR004C	595	n/a	chrXVI 564,524	Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha interacts with frataxin, Yfh1p null mutant displays elevated frequency of mitochondrial genome loss may have a role in oxidative stress response
37	ECM3	YOR092W	595	n/a	chrXV 496,047	Non-essential protein of unknown function involved in signal transduction and the genotoxic response induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation