UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	rps-13	C16A3.9	6e-83	chrIII 6,374,498	rps-13 encodes a small ribosomal subunit S13 protein; by homology, RPS-13 is predicted to function in protein biosynthesis; in C. elegans, RPS-13 activity is required for embryonic and germline development.
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	rpl-9	R13A5.8	n/a	chrIII 7,572,403	rpl-9 encodes a large ribosomal subunit L9 protein that affects fertility and embryonic viability.
4	F44D12.9	F44D12.9	n/a	chrIV 10,020,215	contains similarity to Pfam domain PF01733 Nucleoside transporter contains similarity to Interpro domains IPR001991 (Sodium:dicarboxylate symporter), IPR002259 (Delayed-early response protein/equilibrative nucleoside transporter), IPR016196 (MFS general substrate transporter)
5	R10H10.3	R10H10.3	n/a	chrIV 10,390,865	contains similarity to Pfam domains PF00092 (von Willebrand factor type A domain) , PF00431 (CUB domain) contains similarity to Interpro domains IPR000859 (CUB), IPR016857 (Uncharacterised conserved protein UCP027682, CUB, vWA), IPR002035 (von Willebrand factor, type A)
6	cdr-4	K01D12.11	n/a	chrV 12,407,975	C. elegans CDR-4 protein; contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR010987 (Glutathione S-transferase, C-terminal-like)
7	cpn-4	F49D11.8	n/a	chrI 10,925,036	cpn-4 encodes a calponin homolog, most closely related to its paralog CPN-3 in C. elegans; CPN-4 is somewhat more similar to calponins per se (such as CLP1 and CLP2 in humans) than to the to the calponin paralogs transgelin (SM22 alpha) or neuronal protein NP25.
8	rpl-6	R151.3	n/a	chrIII 7,209,034	rpl-6 encodes a large ribosomal subunit L6 protein.
9	F46E10.11	F46E10.11	n/a	chrV 6,532,557	contains similarity to Interpro domain IPR008197 (Whey acidic protein, 4-disulphide core)
10	cah-3	K05G3.3	n/a	chrX 16,488,368	cah-3 encodes a putative carbonic anhydrase, closely similar to its paralog CAH-5; cah-3 is expressed in intestine and head (including neurons) of L3 larvae through adults, and its transcription is moderately stimulated by DBL-1 and SMA-2; CAH-3 is bound by CKU-80 in two-hybrid assays, but has no obvious function in mass RNAi assays.
11	W07E6.2	W07E6.2	n/a	chrII 482,556	W07E6.2 encodes an ortholog of S. cerevisiae RSA4 that may suppress tumorous growth in the germline; like PRO-1, -2, and -3, W07E6.2 is probably required for ribosome biogenesis, suggesting a link between biogenesis in the distal sheath and control of cell division in the germline.
12	let-754	C29E4.8	n/a	chrIII 7,950,857	let-754 was identified in screens for ethyl methane sulfonate-induced lethal mutations on chromosome III; the let-754 mutation results in mid larval lethality; the molecular identity of let-754 is not yet known.
13	eft-2	F25H5.4	n/a	chrI 9,165,168	eft-2 encodes a homolog of translation elongation factor 2 (EF-2), a GTP-binding protein essential for the elongation phase of protein synthesis; eft-2 is required for embryogenesis and vulval morphogenesis, and is expressed during all stages of development, including the dauer larval stage.
14	R13F6.10	R13F6.10	n/a	chrIII 6,867,259	contains similarity to Interpro domain IPR011990 (Tetratricopeptide-like helical)
15	rps-18	Y57G11C.16	n/a	chrIV 14,825,992	rps-18 encodes a small ribosomal subunit S18 protein.
16	cyp-36A1	C34B7.3	n/a	chrI 8,343,858	C. elegans CYP-36A1 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I)
17	gas-1	K09A9.5	n/a	chrX 15,588,527	The gas-1 gene encodes a 49 kDa subunit of mitochondrial complex I that is required for oxidative phosphorylation, resistance to volatile anesthetics, fecundity, and normal lifespan; gas-1 is expressed in the nematode neuromuscular system; its subcellular distribution appears to be mitochondrial; drug effects on mutants versus wild-type indicate that gas-1 functions at least partially through presynaptic effects; gas-1 mutants have strongly reduced Complex I-dependent metabolism in mitochondria, while Complex II-dependent metabolism is conversely increased in mutants; gas-1 mitochondria look structurally normal.
18	abcf-1	F18E2.2	n/a	chrV 12,762,189	C. elegans ABCF-1 protein; contains similarity to Pfam domain PF00005 ABC transporter contains similarity to Interpro domains IPR003439 (ABC transporter-like), IPR003593 (AAA+ ATPase, core)
19	K04A8.10	K04A8.10	n/a	chrV 6,569,901	contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
20	srt-55	T16H12.8	n/a	chrIII 10,105,558	C. elegans SRT-55 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
21	rps-25	K02B2.5	n/a	chrIV 5,947,351	rps-25 encodes a small ribosomal subunit S25 protein.
22	tag-210	W08E3.3	n/a	chrI 13,342,122	C. elegans TAG-210 protein; contains similarity to Pfam domains PF01926 (GTPase of unknown function) , PF06071 (Protein of unknown function (DUF933)) contains similarity to Interpro domains IPR012675 (Beta-grasp fold, ferredoxin-type), IPR013029 (Protein of unknown function DUF933), IPR004396 (Conserved hypothetical protein CHP00092), IPR002917 (GTP-binding protein, HSR1-related), IPR012676 (TGS-like), IPR006073 (GTP1/OBG)
23	mdh-1	F20H11.3	n/a	chrIII 6,607,404	mdh-1 encodes a homolog of malate dehydrogenase that is predicted to be mitochondrial.
24	asg-2	C53B7.4	n/a	chrX 6,841,624	asg-2 encodes a homolog of subunit G of the membrane-bound F0 proton channel portion of ATP synthase (mitochondrial respiratory chain [MRC] complex V); asg-2 activity is required for growth at a normally high rate and for normal osmoregulation; in addition, asg-2 activity is required for response to hermaphrodite contact, the first step in a series of stereotypical male mating behaviors; an ASG-2::GFP fusion localizes to mitochondria and to cilia of the male-specific CEM neurons.
25	F47B10.2	F47B10.2	n/a	chrX 10,894,920	F47B10.2 is orthologous to the human gene HISTIDASE (HAL; OMIM:235800), which when mutated leads to disease.
26	C29F7.2	C29F7.2	n/a	chrX 13,417,071	contains similarity to Pfam domains PF02958 (Domain of unknown function (DUF227)) , PF07914 (Protein of unknown function (DUF1679)) contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR012877 (Protein of unknown function DUF1679, Caenorhabditis species), IPR004119 (Protein of unknown function DUF227), IPR015897 (CHK kinase-like)
27	C25F9.4	C25F9.4	n/a	chrV 19,412,581	contains similarity to Arabidopsis thaliana Putative SWI/SNF-related matrix-associated actin-dependent regulatorsof chromatin subfamily A member 3-like 3 (EC 3.6.1.-) (SMARCA3-likesprotein 3).; SW:Q9FIY7
28	tag-314	F15H10.4	n/a	chrV 10,427,635	C. elegans TAG-314 protein; contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR002867 (Zinc finger, C6HC-type)
29	D2096.8	D2096.8	n/a	chrIV 8,378,494	D2096.8 encodes a protein related in sequence to the conserved NAP (Nucleosome Assembly Protein) family of proteins involved in chromatin remodeling; loss of D2096.8 activity in wild-type and various mutant backgrounds suggests that in C. elegans the product of D2096.8 is required for proper transcriptional regulation that affects a number of biological processes including embryonic and larval development, body morphology, locomotion, and vulval formation.
30	ugt-16	ZC443.6	n/a	chrV 12,826,207	C. elegans UGT-16 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
31	rpl-30	Y106G6H.3	n/a	chrI 10,436,561	rpl-30 encodes a large ribosomal subunit L30 protein; by homology, RPL-30 is predicted to function in protein biosynthesis; in C. elegans, loss of rpl-30 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities.
32	Y17G7B.11	Y17G7B.11	n/a	chrII 12,061,387	contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF02752 (Arrestin (or S-antigen), C-terminal domain) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011022 (Arrestin-like, C-terminal), IPR011021 (Arrestin-like, N-terminal)
33	rps-30	C26F1.4	n/a	chrV 7,776,842	rps-30 encodes two proteins, a small ribosomal subunit S30 protein and ubiquitin, which is cleaved from the ribosomal protein posttranslationally; by homology, S30 is predicted to function in protein biosynthesis and ubiquitin in protein degradation; in C. elegans, loss of rps-30 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities.
34	lgc-50	T20B12.9	n/a	chrIII 7,393,409	C. elegans LGC-50 protein; contains similarity to Pfam domains PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) , PF02932 (Neurotransmitter-gated ion-channel transmembrane region) contains similarity to Interpro domains IPR002289 (Gamma-aminobutyric-acid A receptor, beta subunit), IPR006028 (Gamma-aminobutyric acid A receptor), IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding), IPR006029 (Neurotransmitter-gated ion-channel transmembrane region)
35	ucr-1	F56D2.1	n/a	chrIII 5,593,099	C. elegans UCR-1 protein; contains similarity to Pfam domains PF00675 (Insulinase (Peptidase family M16)) , PF05193 (Peptidase M16 inactive domain) contains similarity to Interpro domains IPR001431 (Peptidase M16, zinc-binding site), IPR011765 (Peptidase M16, N-terminal), IPR000209 (Peptidase S8 and S53, subtilisin, kexin, sedolisin), IPR011237 (Peptidase M16, core), IPR007863 (Peptidase M16, C-terminal), IPR011249 (Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)
36	ptr-24	F46G10.5	n/a	chrX 13,345,071	ptr-24 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-24 has no known function in vivo.
37	phb-2	T24H7.1	n/a	chrII 6,252,083	phb-2 encodes one of two subunits of the mitochondrial prohibitin complex; loss of phb-2 activity via RNAi indicates that phb-2 function is required for mitochondrial biogenesis and maintenance and for embryonic, germline, and somatic gonad development.
38	fshr-1	C50H2.1	n/a	chrV 9,892,316	fshr-1 encodes a putative neuropeptide receptor required for normal acetylcholine secretion by synapses; FSHR-1 is orthologous to human follicle-stimulating hormone receptor (OMIM:136435; mutated in ovarian dysgenesis), thyrotropin receptor (OMIM:603372; mutated in hyperthyroidism), and luteinizing hormone receptor (OMIM:152790, mutated in precocious puberty); fshr-1 mutants have abnormally many GFP::SNB-1 puncta at synapses, suggesting exocytotic defects; the requirement for FSHR-1 and ten other predicted neuropeptide signalling proteins in cholinergic neurotransmission indicates that such signalling is important for regulating acetylcholine release at neuromuscular junctions; possible ligands of FSHR-1 are FLP-1 and NLP-12.
39	F59F5.2	F59F5.2	n/a	chrX 10,534,095	contains similarity to Cryptosporidium parvum Exonuclease ii, possible.; TR:Q7YYI5
40	R102.2	R102.2	n/a	chrIV 10,687,836	contains similarity to Oryza sativa Hypothetical protein.; TR:Q8H050
41	pas-4	C36B1.4	n/a	chrI 8,727,906	pas-4 encodes a proteasome alpha-type seven subunit of the core 20S proteasome subcomplex; loss of pas-4 activity via RNAi results in a wide variety of defects including embryonic and larval lethality, sterility, abnormal locomotion, slow growth, and abnormal transgene expression and subcellular localization; loss of pas-4 activity also results in activation of SKN-1, a transcription factor required in adult worms for the acute response to oxidative stress and maternally for embryonic development.
42	Y53C12B.1	Y53C12B.1	n/a	chrII 9,744,521	contains similarity to Pfam domains PF08625 (Utp13 specific WD40 associated domain) , PF00400 (WD domain, G-beta repeat) (8)contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR013934 (Small-subunit processome, Utp13), IPR015943 (WD40/YVTN repeat-like)
43	pqn-47	F59B10.1	n/a	chrII 10,499,684	pqn-47 encodes a protein with a glutamine/asparagine-rich domain, homologous to human C11orf9 and Drosophila CG3328, that is required for locomotion, vulval development, full body size, cuticular integrity, and general health in mass RNAi assays; pqn-47(cxP5915) homozygotes are sluggish.
44	C01B10.3	C01B10.3	n/a	chrIV 6,620,429	C01B10.3 encodes a paralog of IPP-5, and thus may functionally overlap with ipp-5 in vivo.
45	ugt-12	T19H12.9	n/a	chrV 4,888,389	C. elegans UGT-12 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
46	ifd-2	F25E2.4	n/a	chrX 814,890	ifd-2 encodes a nonessential intermediate filament protein; IFD-2 is predicted to function as a structural component of the cytoskeleton; IFD-2 has no obvious function in RNAi assays.
47	F54H12.6	F54H12.6	n/a	chrIII 7,972,813	contains similarity to Pfam domain PF00736 EF-1 guanine nucleotide exchange domain contains similarity to Interpro domains IPR014038 (Translation elongation factor EF1B, beta and delta chains, guanine nucleotide exchange), IPR001326 (Translation elongation factor EF1B, beta/delta chains, conserved site), IPR014717 (Translation elongation factor EF1B/ribosomal protein S6), IPR010987 (Glutathione S-transferase, C-terminal-like)
48	rpl-4	B0041.4	n/a	chrI 4,646,348	rpl-4 encodes a large ribosomal subunit L4 protein.
49	tag-18	T14G12.3	n/a	chrX 3,732,674	C. elegans TAG-18 protein ;
50	vha-2	R10E11.2	n/a	chrIII 9,782,355	vha-2 and vha-3 encode an ortholog of subunit c of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); the protein encoded by vha-2 and vha-3 (VHA-2/3) is identical; VHA-2/3 is a predicted V-ATPase transmembrane rotor component, whose polypeptide sequence is identical to that of VHA-3; VHA-1 and VHA-2/3 comprise a closely related family of subunit c co-orthologs, predicted to carry protons from the cytosol to a-subunits (VHA-5, VHA-6, VHA-7, or UNC-32) for transmembrane export; VHA-2/3 is dispensable for viability, since vha-2/3(RNAi) animals have mostly healthy progeny; however, VHA-2 is required for ovulation and embryogenesis, since vha-2(RNAi) animals are sterile with polyploid, unmatured oocytes; VHA-2, along with VHA-15 and probably all V-ATPase subunits, is required for systemic RNAi, probably during endocytotic RNAi uptake; VHA-2 is required for necrosis, since vha-2(RNAi) suppresses necrotic neurodegeneration; vha-2 shares an operon with vha-1 and R10E11.6; both vha-2 and vha-1 are expressed in the excretory cell, the rectum, and a pair of cells posterior to the anus.