UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	tag-125	C14B1.4	0	chrIII 3,706,004	tag-125/C14B1.4 encodes an ortholog of the histone methyltransferase subunit WDR5 (OMIM:609012) that antagonizes SynMuv transcriptional repressors.
2	sra-25	T26E3.9	n/a	chrI 12,687,150	C. elegans SRA-25 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domains IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR000344 (Nematode chemoreceptor, Sra)
3	W04B5.5	W04B5.5	n/a	chrIII 2,414,713	The W04B5.5 gene encodes a phospholipid-independent AKT/PKB kinase.
4	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
5	hda-1	C53A5.3	n/a	chrV 14,526,170	The hda-1 gene encodes a histone deacetylase 1, similar to histone deacetylases RPD3 from yeast and fly; maternal and zygotic expression of hda-1 is required for embryonic viability, and zygotic expression of hda-1 is also required for gonadogenesis and vulval development.
6	unc-71	Y37D8A.13	n/a	chrIII 12,886,268	unc-71 encodes an ADAM, a disintegrin and metalloprotease-containing transmembrane protein that is a member of the metzincin superfamily of proteases; UNC-71 is required non-cell autonomously for motor axon guidance and sex myoblast migration; UNC-71 does not appear to have an active metalloprotease domain, but functions with UNC-6/netrin and integrins INA-1/PAT-3 to provide guidance cues during axonal migration; UNC-71 is expressed in a restricted pattern in the excretory and excretory gland cells, some head neurons, the sphincter muscles, and hypodermal cells surrounding the vulva.
7	W04G3.5	W04G3.5	n/a	chrX 11,074,823	contains similarity to Pfam domain PF00156 Phosphoribosyl transferase domain contains similarity to Interpro domains IPR005946 (Phosphoribosyl pyrophosphokinase), IPR000836 (Phosphoribosyltransferase)
8	dpl-1	T23G7.1	n/a	chrII 9,171,156	dpl-1 encodes the C. elegans ortholog of mammalian DP, the E2F-heterodimerization partner; dpl-1 is a class B synMuv gene whose activity is required for oogenesis as well as embryonic asymmetry and vulval development; in addition, dpl-1 acts with a subset of class B synMuv genes and the MCD-1 zinc-finger protein to promote the killing process during programmed cell death; DPL-1 is a nuclear protein that is widely expressed throughout development in both somatic and germ cell lineages.
9	npp-18	Y43F4B.4	n/a	chrIII 13,297,775	C. elegans NPP-18 protein; contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
10	ppfr-2	D2092.2	n/a	chrI 6,626,089	C. elegans PPFR-2 protein; contains similarity to Pfam domain PF09184 PPP4R2 contains similarity to Interpro domain IPR015267 (Protein phosphatase 4 core regulatory subunit R2)
11	div-1	R01H10.1	n/a	chrIII 10,246,876	div-1 encodes a homolog of the B subunit of the DNA polymerase alpha-primase complex; DIV-1 is required in embryos for the normal timing of interphase in cell divisions, and for the asymmetric distribution of PIE-1 and P granules.
12	hmg-4	T20B12.8	n/a	chrIII 7,380,295	hmg-4 encodes a protein with strong similarity to the highly conserved high mobility group protein SSRP1 (structure-specific DNA recognition protein); by homology, HMG-4 is predicted to be a member of the FACT (facilitates chromatin transcription) complex that functions as a transcription elongation factor; RNAi experiments indicate that hmg-4 is required for locomotion and larval development, and required redundantly with hmg-3, its paralog, for embryonic development.
13	crn-5	C14A4.5	n/a	chrII 10,593,065	C. elegans CRN-5 protein; contains similarity to Pfam domain PF01138 3' exoribonuclease family, domain 1 contains similarity to Interpro domain IPR001247 (Exoribonuclease, phosphorolytic domain 1)
14	lin-46	R186.4	n/a	chrV 12,969,772	lin-46 encodes one of two C. elegans paralogs of bacterial MoeA proteins and mammalian gephyrins (E domain, only); LIN-46 is predicted to function as a scaffolding protein for a developmental timing complex, and may also play a role in molybdenum cofactor biosynthesis; identified in screens for suppressors of precocious heterochronic mutations in lin-14 and lin-28, lin-46 is required for stage-specific developmental events at the third larval and adult stages of development; as a component of the heterochronic pathway, lin-46 appears to act immediately downstream of lin-28, which encodes a predicted RNA binding protein required for cell fate specification at the L2 stage; a LIN-46:GFP fusion protein is detected in the cytoplasm and non-nucleolar part of the nucleus of ventral and lateral hypodermal cells around the time of the larval molts; in addition, the LIN-46 fusion protein is detected in cell bodies and axons of the AVBL/R motor interneurons.
15	T13H5.5	T13H5.5	n/a	chrII 8,526,169	contains similarity to Interpro domain IPR001648 (Ribosomal protein S18)
16	tag-298	C01H6.7	n/a	chrI 7,226,247	C. elegans TAG-298 protein; contains similarity to Pfam domain PF00439 Bromodomain contains similarity to Interpro domain IPR001487 (Bromodomain)
17	C39E9.12	C39E9.12	n/a	chrIV 13,094,664	contains similarity to Pfam domain PF02037 SAP domain contains similarity to Interpro domain IPR003034 (DNA-binding SAP)
18	arx-7	M01B12.3	n/a	chrI 3,069,767	arx-7 encodes the C. elegans ortholog of the p16Arc subunit of the actin-related protein (Arp)2/3 complex.
19	C18E3.2	C18E3.2	n/a	chrI 4,211,756	The C18E3.2 gene encodes a homolog of Swp73/BAF60, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; C18E3.2 is probably required during mitosis of the T cells for asymmetric cell division.
20	K08D10.1	K08D10.1	n/a	chrIV 4,182,875	contains similarity to Pfam domain PF06918 Protein of unknown function (DUF1280) contains similarity to Interpro domain IPR009689 (Protein of unknown function DUF1280)
21	F29B9.5	F29B9.5	n/a	chrIV 4,652,758	contains similarity to Pfam domains PF00085 (Thioredoxin) , PF00578 (AhpC/TSA family) contains similarity to Interpro domains IPR011594 (Thioredoxin-like), IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR000866 (Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen), IPR013766 (Thioredoxin domain), IPR006662 (Thioredoxin-related)
22	T14B4.3	T14B4.3	n/a	chrII 6,735,442	contains similarity to Interpro domain IPR012493 (Renin receptor-like)
23	smo-1	K12C11.2	n/a	chrI 1,340,894	C. elegans SMO-1 protein; contains similarity to Pfam domain PF00240 Ubiquitin family contains similarity to Interpro domain IPR000626 (Ubiquitin)
24	rpa-1	F18A1.5	n/a	chrII 7,665,772	rpa-1 encodes the C. elegans ortholog of the replication protein A (RPA) large subunit; by homology, RPA-1 is predicted to function as a DNA-binding and oligonucleotide oligosaccharide-binding (OB) protein that is required for DNA replication, repair, and recombination; large-scale RNAi screens indicate that rpa-1 is essential for embryonic development, and that in yeast two-hybrid assays interacts with the product of M04F3.1, the RPA medium subunit; in situ hybridization studies indicate that rpa-1 transcripts are expressed in germ cells.
25	rpb-3	C36B1.3	n/a	chrI 8,729,359	C. elegans RPB-3 protein; contains similarity to Pfam domains PF01000 (RNA polymerase Rpb3/RpoA insert domain) , PF01193 (RNA polymerase Rpb3/Rpb11 dimerisation domain) contains similarity to Interpro domains IPR011263 (DNA-directed RNA polymerase, RpoA/D/Rpb3-type), IPR011262 (DNA-directed RNA polymerase, insert), IPR011261 (DNA-directed RNA polymerase, dimerisation)
26	rnp-3	K08D10.3	n/a	chrIV 4,175,171	rnp-3 encodes the small nuclear ribonucleoprotein (snRNP)-associated protein RNP-3/U2B''; genetically, rnp-3 appears to function redundantly with rnp-2/U1A: loss of rnp-3 activity alone results in low levels of embryonic and total lethality, while animals doubly mutant for rnp-3 and rnp-2/U1A show much higher levels of embryonic and total lethality; in addition, animals doubly mutant for SAP-1/U2A' and RNP-3/U2B'', display a much more severe phenotype than either single mutation, indicating that in vivo, these proteins have some independent functions; immunoprecipitation experiments indicate that RNP-3 associates with U2 RNA in vivo and that this association does not require the presence of SAP-1/U2A'.
27	T24G10.2	T24G10.2	n/a	chrIII 5,441,718	contains similarity to Pfam domain PF02201 SWIB/MDM2 domain contains similarity to Interpro domain IPR003121 (SWIB/MDM2)
28	snr-2	W08E3.1	n/a	chrI 13,339,794	C. elegans SNR-2 protein; contains similarity to Pfam domain PF01423 LSM domain contains similarity to Interpro domains IPR001163 (Like-Sm ribonucleoprotein, core), IPR006649 (Like-Sm ribonucleoprotein, eukaryotic and archaea-type, core), IPR010920 (Like-Sm ribonucleoprotein-related, core)
29	gly-20	C03E10.4	n/a	chrV 11,284,282	gly-20 is orthologous to the human gene MANNOSYL (ALPHA-1,6-)-GLYCOPROTEIN BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE (MGAT2; OMIM:602616), which when mutated leads to carbohydrate-deficient glycoprotein syndrome, type II.
30	brf-1	F45E12.2	n/a	chrII 7,307,210	brf-1 encodes an ortholog of mammalian B-RELATED FACTOR (also known as BRF, TDS4, PCF4, or hTFIIIB90); BRF is thought to act as a molecular bridge between TATA-binding protein (TBP) associated factors that functions in TFIIIB (RNA polymerase III associated transcription factors).
31	K03B8.4	K03B8.4	n/a	chrV 11,394,932	contains similarity to Homo sapiens Isoform 2 of SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3; ENSEMBL:ENSP00000349254
32	xpg-1	F57B10.6	n/a	chrI 6,560,500	F57B10.6 is orthologous to the human gene EXCISION REPAIR CROSS-COMPLEMENTING RODENT REPAIR DEFICIENCY, COMPLEMENTATION GROUP 5 (XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP G (COCKAYNE SYNDROME)) (ERCC5; OMIM:133530), which when mutated leads to disease.
33	gfl-1	M04B2.3	n/a	chrIV 11,521,685	gfl-1 encodes an ortholog of human GLIOMA-AMPLIFIED SEQUENCE-41 (GAS41; OMIM:602116, found in increased copy number in low-grade glioma); loss of GLF-1, which is predicted to associate with chromatin, results in potent suppression of the RNA interference (RNAi) mechanism; GLF-1 is also similar to the transcription factors (yeast and human) AF-9 and human ENL, and thus may represent a novel class of transcription factors.
34	F25B3.6	F25B3.6	n/a	chrV 9,581,315	contains similarity to Pfam domain PF03126 Plus-3 domain contains similarity to Interpro domain IPR004343 (Plus-3)
35	ncbp-2	F26A3.2	n/a	chrI 7,642,924	ncbp-2 encodes the C. elegans ortholog of the CBP20 subunit of the nuclear cap binding complex; by homology, NCBP-2 is predicted to play a role in mRNA decay; loss of ncbp-2 activity via RNAi indicates that this gene is essential for embryonic and larval development and in addition, plays a role in reproduction and vulval morphogenesis; staining of C. elegans embryos with an antibody to human CBP20 suggests that NCBP-2 localizes predominantly to the nuclear envelope.
36	R04A9.2	R04A9.2	n/a	chrX 374,567	contains similarity to Pfam domains PF02170 (PAZ domain) , PF02171 (Piwi domain) contains similarity to Interpro domains IPR003165 (Stem cell self-renewal protein Piwi), IPR003100 (Argonaute and Dicer protein, PAZ), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
37	lsm-1	F40F8.9	n/a	chrII 11,127,155	C. elegans LSM-1 protein; contains similarity to Pfam domain PF01423 LSM domain contains similarity to Interpro domains IPR001163 (Like-Sm ribonucleoprotein, core), IPR006649 (Like-Sm ribonucleoprotein, eukaryotic and archaea-type, core), IPR010920 (Like-Sm ribonucleoprotein-related, core)
38	C08B11.8	C08B11.8	n/a	chrII 8,040,793	contains similarity to Pfam domain PF03155 ALG6, ALG8 glycosyltransferase family contains similarity to Interpro domain IPR004856 (ALG6, ALG8 glycosyltransferase)
39	him-10	R12B2.4	n/a	chrIII 5,804,132	him-10 encodes a coiled coil protein that is structurally related to the Nuf2 kinetochore proteins of Schizosaccharaomyces pombe, Saccharomyces cerevisiae, and humans; in C. elegans, him-10 activity is essential for the proper structure and function of mitotic and meiotic kinetochores and thus, for proper attachment and segregation of chromosomes during mitosis and meiosis; during mitosis, HIM-10 localizes to the kinetochore region of the kinetochore-centromere complex from prophase to anaphase; during oocytes meiosis, HIM-10 surrounds chromosomes in diakinesis and prometaphase of meiosis I and meiosis II, while during male meiosis, HIM-10 surrounds spermatocyte chromosomes during metaphase I, anaphase I, and metaphase II.
40	lsm-4	F32A5.7	n/a	chrII 7,252,636	C. elegans LSM-4 protein; contains similarity to Pfam domain PF01423 LSM domain contains similarity to Interpro domains IPR001163 (Like-Sm ribonucleoprotein, core), IPR006649 (Like-Sm ribonucleoprotein, eukaryotic and archaea-type, core), IPR010920 (Like-Sm ribonucleoprotein-related, core)
41	elb-1	Y41C4A.10	n/a	chrIII 11,719,034	elb-1 encodes an Elongin B ortholog required for chromosome condensation and segregation during mitosis and meiotic division II, and also for cell proliferation (probably through degradation of CKI-1); elb-1(RNAi) animals tend to arrest at the second meiotic cell division, with escapers showing many other defects in chromosomal dynamics and cell cycle control such as abnormal pronuclear rotation and cortical protrusion, aberrant chromosomal structures in the intestine, and deficient germ cell proliferation; ELB-1 interacts with ELC-1 and ELC-2 in bacterial two-hybrid experiments.
42	C05C8.2	C05C8.2	n/a	chrV 7,231,951	contains similarity to Interpro domain IPR004087 (K Homology)
43	C41H7.3	C41H7.3	n/a	chrII 3,006,666	contains similarity to Pfam domain PF03353 DUF278 contains similarity to Interpro domain IPR005020 (Protein of unknown function DUF278)
44	F40G9.2	F40G9.2	n/a	chrIII 191,482	contains similarity to Pfam domain PF05051 Cytochrome C oxidase copper chaperone (COX17) contains similarity to Interpro domain IPR007745 (Cytochrome C oxidase copper chaperone)
45	git-1	F14F3.2	n/a	chrX 10,526,597	C. elegans GIT-1 protein; contains similarity to Pfam domains PF01412 (Putative GTPase activating protein for Arf) , PF00023 (Ankyrin repeat) (2)contains similarity to Interpro domains IPR013724 (Spa2 homology (SHD) of GIT), IPR001164 (Arf GTPase activating protein), IPR002110 (Ankyrin)
46	C24D10.4	C24D10.4	n/a	chrIV 5,160,919
47	tag-216	K08F9.2	6e-16	chrV 15,135,533	C. elegans TAG-216 protein; contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR015943 (WD40/YVTN repeat-like)
48	ZK930.1	ZK930.1	n/a	chrII 11,912,200	contains similarity to Pfam domains PF02985 (HEAT repeat) , PF00069 (Protein kinase domain) , PF00400 (WD domain, G-beta repeat) (2)contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR011046 (WD40 repeat-like), IPR000719 (Protein kinase, core), IPR000357 (HEAT), IPR001680 (WD40 repeat), IPR017442 (Serine/threonine protein kinase-related), IPR015943 (WD40/YVTN repeat-like), IPR016024 (Armadillo-type fold)
49	E02H1.6	E02H1.6	n/a	chrII 9,597,035	E02H1.6 encodes an ortholog of human TAF9 (OMIM:600822; also known as AK6, adrenal gland protein AD-004 like protein, ADLP) and of S. cerevisiae Fap7p; like its human ortholog, E02H1.6 is nuclear, and is predicted to likewise be a TATA box binding protein (TBP)-associated factor mediating activation of RNA polymerase II; E02H1.6 prefers ATP and dATP as phosphate donors; E02H1.6's biochemical activity is unusual, since it also prefers AMP and dAMP as substrates, and tolerates CMP, TMP and shikimate acid as substrates as well; since yeast Fap7p promotes pre-rRNA cleavage, E02H1.6 may be multifunctional; in RNAi assays, E02H1.6 is required for normally fast growth; E02H1.6 is coexpressed with pme-2 in an operon, and thus, like PME-2, may function in DNA repair.
50	tag-229	W09G3.3	n/a	chrI 13,804,628	C. elegans TAG-229 protein; contains similarity to Pfam domain PF08755 Hemimethylated DNA-binding protein YccV like contains similarity to Interpro domain IPR011722 (Hemimethylated DNA-binding region)