UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	age-1	B0334.8	0	chrII 11,523,196	age-1 encodes the C. elegans ortholog of the phosphoinositide 3-kinase (PI3K) p110 catalytic subunit; AGE-1, supplied maternally and embryonically, is a central component of the C. elegans insulin-like signaling pathway, lying downstream of the DAF-2/insulin receptor and upstream of both the PDK-1 and AKT-1/AKT-2 kinases and the DAF-16 forkhead type transcription factor, whose negative regulation is the key output of the insulin signaling pathway; in accordance with its role in insulin signaling, AGE-1 activity is required for regulation of metabolism, life span, dauer formation, stress resistance, salt chemotaxis learning, fertility, and embryonic development; although the age-1 expression pattern has not yet been reported, ectopic expression studies indicate that pan-neuronal age-1 expression is sufficient to rescue life-span defects, while neuronal, intestinal, or muscle expression can partially rescue dauer formation, and neuronal or muscle expression can rescue metabolic defects.
2	F14F9.3	F14F9.3	n/a	chrV 5,139,826	contains similarity to Interpro domain IPR002867 (Zinc finger, C6HC-type)
3	str-19	T23D5.7	n/a	chrV 15,743,832	C. elegans STR-19 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
4	srx-7	C14C6.1	n/a	chrV 561,828	C. elegans SRX-7 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR002651 (Protein of unknown function DUF32), IPR000276 (GPCR, rhodopsin-like)
5	srj-10	F14H3.1	n/a	chrV 16,073,333	C. elegans SRJ-10 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
6	srw-69	F18E3.5	n/a	chrV 7,428,134	C. elegans SRW-69 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
7	T26E4.1	T26E4.1	n/a	chrV 15,780,361	contains similarity to Pfam domain PF01030 (Receptor L domain)
8	T25G12.2	T25G12.2	n/a	chrX 17,245,951	The T25G12.2 gene encodes a homolog of the human gene HSD, which when mutated leads to cortisol 11-beta ketoreductase deficiency (OMIM:218030); T25G12.2 protein is predicted to be mitochondrial with 68% accuracy.
9	srg-22	Y25C1A.10	n/a	chrII 3,092,472	C. elegans SRG-22 protein; contains similarity to Pfam domain PF02118 C.elegans Srg family integral membrane protein contains similarity to Interpro domain IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
10	pqn-11	C09G1.1	n/a	chrX 15,969,125	PQN-11 encodes an unfamiliar protein with a glutamine/asparagine-rich domain that is dispensable for viability and gross morphology.
11	fbxa-89	Y75B8A.21	n/a	chrIII 12,237,580	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
12	F13G3.10	F13G3.10	n/a	chrI 7,313,972	contains similarity to Interpro domain IPR010989 (t-SNARE)
13	str-18	T23D5.6	n/a	chrV 15,741,213	C. elegans STR-18 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
14	C01F6.1	C01F6.1	n/a	chrIV 9,098,665	C01F6.1 encodes a putative calcium-dependent phospholipid binding protein of the copine family; C01F6.1 is required for sperm to normally migrate towards a PUFA-based signal exuded by oocytes; C01F6.1(RNAi) hermaphrodites are infertile, both through aberrant loss of their own sperm and through failure of males to effectively inseminate them.
15	srg-2	C18F10.5	n/a	chrIII 6,259,346	srg-2 encodes a predicted seven transmembrane domain G protein-coupled chemosensory receptor; an SRG-2::GFP fusion protein is expressed exclusively in the cilia of ASK sensory neurons, which are believed to be involved in chemotaxis to lysine and sensory regulation of egg laying; localization of SRG-2 to ASK cilia does not appear to depend upon wild-type activity of either odr-4 or odr-8.
16	srt-61	T27C10.1	n/a	chrI 10,905,441	C. elegans SRT-61 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
17	F20C5.5	F20C5.5	n/a	chrIV 8,768,884	contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)
18	F36H12.2	F36H12.2	n/a	chrIV 5,275,375
19	srx-93	F59B1.3	n/a	chrV 3,620,070	C. elegans SRX-93 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002651 (Protein of unknown function DUF32), IPR001411 (Tetracycline resistance protein, TetB)
20	F57G8.7	F57G8.7	n/a	chrV 16,329,811	contains similarity to Antarctic bacterium str 643 Metalloproteinase precursor.; TR:Q9KH34
21	F40G12.4	F40G12.4	n/a	chrV 14,268,178	contains similarity to Pfam domain PF03236 Domain of unknown function DUF263 contains similarity to Interpro domain IPR004920 (Protein of unknown function DUF263)
22	F59D12.3	F59D12.3	n/a	chrX 15,649,663	contains similarity to Pfam domain PF04590 Protein of unknown function, DUF595 contains similarity to Interpro domain IPR007669 (Protein of unknown function DUF595)
23	fbxb-108	F08D12.6	n/a	chrII 2,766,099	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
24	R13.2	R13.2	n/a	chrIV 10,826,996	contains similarity to Pfam domain PF00292 'Paired box' domain contains similarity to Interpro domains IPR001523 (Paired box protein, N-terminal), IPR011991 (Winged helix repressor DNA-binding), IPR009057 (Homeodomain-like)
25	srh-52	R08H2.7	n/a	chrV 15,375,587	C. elegans SRH-52 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
26	ZK177.9	ZK177.9	n/a	chrII 5,517,477
27	mdf-1	C50F4.11	n/a	chrV 9,542,977	mdf-1 encodes a coiled-coil domain-containing protein that is orthologous to the Saccharomyces cerevisiae mitotic spindle checkpoint protein Mad1p; consistent with a role as a checkpoint protein, MDF-1 is required in C. elegans for mitotic genome stability and hence, long-term survival and fertility; in vitro, MDF-1 interacts with MDF-2, the C. elegans Mad2p ortholog.
28	C15C6.3	C15C6.3	n/a	chrI 12,209,642	contains similarity to Interpro domains IPR006077 (Vinculin/alpha-catenin), IPR000694 (Proline-rich region)
29	srx-112	T24E12.8	n/a	chrII 3,764,010	C. elegans SRX-112 protein ;
30	ZC412.8	ZC412.8	n/a	chrV 14,879,632	contains similarity to Plasmodium cynomolgi Circumsporozoite protein precursor (CS).; SW:P08675
31	C49F5.3	C49F5.3	n/a	chrX 11,983,268	contains similarity to Phytophthora infestans SECY-independent transporter protein.; TR:Q9T238
32	acr-9	C40C9.2	n/a	chrX 13,644,544	acr-9 encodes a predicted member of the alpha subunit family of nicotinic acetylcholine receptors.
33	T08G5.1	T08G5.1	n/a	chrV 14,019,744	contains similarity to Saccharomyces cerevisiae Protein that may function as a cochaperone, as suggested by the presence of a DnaJ-like domain; SGD:YNL227C
34	T10B5.8	T10B5.8	n/a	chrV 1,843,425	contains similarity to Pfam domain PF00724 NADH:flavin oxidoreductase / NADH oxidase family contains similarity to Interpro domains IPR013785 (Aldolase-type TIM barrel), IPR001155 (NADH:flavin oxidoreductase/NADH oxidase, N-terminal)
35	D1044.4	D1044.4	n/a	chrIII 5,521,831
36	M01G12.7	M01G12.7	n/a	chrI 12,115,167	contains similarity to Arabidopsis thaliana Hypothetical protein.; TR:Q9LZ50
37	ZK1037.1	ZK1037.1	n/a	chrV 15,311,784	contains similarity to Pfam domain PF01030 Receptor L domain contains similarity to Interpro domain IPR000494 (EGF receptor, L domain)
38	srsx-11	C13D9.4	n/a	chrV 4,978,533	C. elegans SRSX-11 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
39	ver-1	T17A3.1	n/a	chrIII 160,182	C. elegans VER-1 protein; contains similarity to Pfam domains PF00047 (Immunoglobulin domain) (2), PF07714 (Protein tyrosine kinase) , PF00069 (Protein kinase domain) , PF07679 (Immunoglobulin I-set domain) (2)contains similarity to Interpro domains IPR003598 (Immunoglobulin subtype 2), IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR013098 (Immunoglobulin I-set), IPR011009 (Protein kinase-like), IPR009134 (Vascular endothelial growth factor receptor, VEGFR, N-terminal), IPR003596 (Immunoglobulin V-set, subgroup), IPR013783 (Immunoglobulin-like fold), IPR000719 (Protein kinase, core), IPR007110 (Immunoglobulin-like), IPR003599 (Immunoglobulin subtype), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR013151 (Immunoglobulin)
40	H14E04.4	H14E04.4	n/a	chrIII 2,391,147
41	pqn-62	T03G11.1	n/a	chrX 5,200,980	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
42	nhr-111	F44G3.9	n/a	chrV 16,123,891	nhr-111 encodes a member of the nuclear receptor superfamily; by homology, NHR-111 is predicted to function as a ligand-dependent transcriptional regulator, but as loss of nhr-111 activity via large-scale RNAi screens does not result in any abnormalities, the precise role of NHR-111 in C. elegans development and/or behavior is not yet known; an nhr-111 reporter construct is expressed in embryos and early larvae in a pair of neurons in the ventral ganglion of the head and in two cells that may be the somatic gonad precursors.
43	Y40B1B.7	Y40B1B.7	n/a	chrI 13,427,466	contains similarity to Rattus norvegicus Coiled-coil domain-containing protein 86 (Cytokine-induced proteinswith coiled-coil domain).; SW:Q5XIB5
44	lam-3	T22A3.8	n/a	chrI 10,614,936	lam-3 is orthologous to human LAMININ ALPHA-2 (LAMA2; OMIM:156225), which when mutated leads to merosin-deficient congenital muscular dystrophy.
45	srw-142	H05B21.3	n/a	chrV 2,957,658	C. elegans SRW-142 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
46	xnp-1	B0041.7	n/a	chrI 4,668,742	xnp-1 encodes an ATP-dependent DNA helicase of the SNF2 family that is orthologous to human XNP/ATR-X, which is associated with a number of X-linked mental retardation syndromes; in C. elegans, xnp-1 activity is required at high temperatures for embryogenesis, somatic gonad development, fertility, and vulval morphogenesis; in addition, animals doubly mutant for xnp-1 and lin-35/Rb, hpl-2/HP1, or nucleosome remodelling and histone deacetylase (NuRD) complex members such as lin-53 and let-418, display larval arrest with growth cessation but continued cell proliferation; xnp-1 is also required, with lin-35/Rb and hpl-2/HP1, for proper regulation of transgene expression; xnp-1 mRNA, detectable in embryos and the germline by in situ hybridization, is expressed at highest levels in embryos with decreasing levels seen in successive larval stages; xnp-1 transcriptional reporter fusions exhibit strong expression beginning at mid-embryogenesis but fading by embryonic morphogenesis; at hatching, expression is observed in all dividing cells including the P lineage, and at later larval stages expression is observed in the vulval precursor cells.
47	srd-51	F15A2.3	n/a	chrX 13,483,631	C. elegans SRD-51 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR000276 (GPCR, rhodopsin-like)
48	tax-2	F36F2.5	n/a	chrI 9,023,241	tax-2 is orthologous to the human gene ROD PHOTORECEPTOR CNG-CHANNEL BETA SUBUNIT (CNGB1; OMIM:600724), which when mutated leads to disease.
49	srw-55	T05G11.6	n/a	chrV 15,939,538	C. elegans SRW-55 protein; contains similarity to Pfam domain PF06976 Protein of unknown function (DUF1300) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR010726 (Protein of unknown function DUF1300)
50	str-114	F59B1.1	n/a	chrV 3,650,602	C. elegans STR-114 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR003002 (7TM chemoreceptor, subfamily 1)