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NOS2 — RHO

Text-mined interactions from Literome

Muniyappa et al., Am J Physiol Heart Circ Physiol 2000 : These data demonstrate for the first time that inhibition of Rho induces iNOS and suggest a role for Rho protein in IL-1beta stimulated NO production in VSMCs
Boer et al., Am J Physiol Heart Circ Physiol 2002 : We studied the amplitude and response time ( RT ; time to 50 % of maximal response ) of pulmonary vasoreactivity and investigated whether the characteristics of pulmonary vasoreactivity could be modulated by endothelium removal, nitric oxide ( NO ) synthase inhibition [ N ( G ) -nitro-L-arginine ( L-NNA ) ], RhoA activation [lysophosphatidic acid (LPA) ] and Rho kinase inhibition ( Y-27632 )
Takemoto et al., Circulation 2002 : Rho-kinase mediates hypoxia induced downregulation of endothelial nitric oxide synthase
Johansson et al., Am J Physiol Regul Integr Comp Physiol 2004 : Rho inhibition with C3 ( 2.5 microg/ml ) increased iNOS expression, whereas SM-MHC expression was slightly decreased ... Rho-kinase inhibition with Y-27632 ( 10 microM ) mediated a decrease in iNOS and a slight increase in SM-MHC expression ... Actin cytoskeletal dynamics and Rho signaling are involved in regulation of cytokine induced iNOS expression in BSMC
Bivalacqua et al., Proc Natl Acad Sci U S A 2004 (Body Weight...) : RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis : a mechanism for diabetes associated erectile dysfunction
Endres et al., Stroke 2004 (Substance Withdrawal Syndrome) : Rho negatively regulates endothelial nitric oxide synthase and Rac contributes to NAD ( P ) H-oxidase activation and superoxide production
Yamanouchi et al., J Vasc Surg 2005 (Disease Models, Animal...) : In addition, we found that pravastatin inhibited Rho-kinase activity and accelerated endothelial nitric oxide synthase expression in human umbilical vein endothelial cells but did not inhibit Rho-kinase activity in vascular smooth muscle cells
Shin et al., J Cereb Blood Flow Metab 2007 (Brain Ischemia...) : Rho-kinase inhibition reduces cerebral infarct size in wild type, but not endothelial nitric oxide synthase deficient ( eNOS-/- ) mice
Trebicka et al., Hepatology 2007 (Liver Cirrhosis) : Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase
Gien et al., Am J Physiol Lung Cell Mol Physiol 2008 (Chronic Disease...) : The effects of Rho kinase activity on angiogenesis, endothelial nitric oxide ( NO ) synthase ( eNOS ) protein expression, and NO production were determined in normal and PPHN PAECs
Hassona et al., Am J Physiol Heart Circ Physiol 2010 (Disease Models, Animal...) : The activation of Rho/ROCK led to the inhibition of endothelial nitric oxide synthase expression ( 39 + or - 5.4 % ; P < 0.05 ) and phosphorylation ( 35 + or - 4.5 % ; P < 0.05 ) but also an increase in myosin light chain 20 phosphorylation ( 372 %, P < 0.05 )