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MTOR — ULK2
Pathways - manually collected, often from reviews:
-
KEGG mTOR signaling pathway:
MTOR
→
ULK1/ULK2/ULK3
(protein-protein, inhibition)
-
NCI Pathway Database mTOR signaling pathway:
mTORC1 complex (MTOR-MLST8-RPTOR)
→
mTORC1/ULK1-2/ATG13/FIP200 complex (MTOR-MLST8-RPTOR-ULK1_ULK2-ATG13-RB1CC1)
(modification, collaborate)
Hosokawa et al., Mol Biol Cell 2009, Jung et al., Mol Biol Cell 2009, Ganley et al., J Biol Chem 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
mTORC1 complex (MTOR-MLST8-RPTOR)
→
ULK1-2/ATG13/FIP200 complex (ULK1_ULK2-ATG13-RB1CC1)
(modification, collaborate)
Hosokawa et al., Mol Biol Cell 2009, Jung et al., Mol Biol Cell 2009, Ganley et al., J Biol Chem 2009
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database mTOR signaling pathway:
mTORC1/ULK1-2/ATG13/FIP200 complex (MTOR-MLST8-RPTOR-ULK1_ULK2-ATG13-RB1CC1)
→
ULK1-2/ATG13/FIP200 complex (ULK1_ULK2-ATG13-RB1CC1)
(modification, collaborate)
Hosokawa et al., Mol Biol Cell 2009, Jung et al., Mol Biol Cell 2009, Ganley et al., J Biol Chem 2009
Evidence: mutant phenotype, assay, physical interaction
Text-mined interactions from Literome
Jung et al., Mol Biol Cell 2009
:
ULK-Atg13-FIP200 complexes
mediate mTOR signaling to the autophagy machinery ... Inhibition of
mTOR by rapamycin or leucine deprivation, the conditions that induce autophagy, leads to dephosphorylation of ULK1, ULK2, and Atg13 and
activates ULK to phosphorylate FIP200 ... These findings demonstrate that the
ULK-Atg13-FIP200 complexes are direct targets of mTOR and important regulators of autophagy in
response to
mTOR signaling
Dunlop et al., Autophagy 2011
:
Interestingly,
ULK1 overexpression also increases phosphorylation of Raptor Ser863 and the mTOR autophosphorylation site, Ser2481 in a
mTORC1 dependent manner
Jung et al., Autophagy 2011
:
In addition,
ULK1 was found to bind raptor, induce its phosphorylation, and
inhibit the kinase activity of
mTORC1