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IL6 — MTOR
Text-mined interactions from Literome
Schreml et al., Int Immunopharmacol 2007
:
mTOR-inhibitors simultaneously
inhibit proliferation and basal
IL-6 synthesis of human coronary artery endothelial cells ...
mTOR-inhibitors failed to suppress basal/TNF induced secretion of IL-8 and MCP-1, but
IL-6 synthesis after TNF-induction was
reduced to 35 % ... In contrast to human saphenous vein ECs ( HSVECs ),
mTOR-inhibitors also
reduced basal
IL-6-secretion of HCAECs ( to 55 % ) and cell proliferation was simultaneously inhibited within the same concentration range
Kim et al., J Biol Chem 2008
(Carcinoma, Hepatocellular...) :
Interestingly, we find that the phosphorylation of STAT3 on Ser ( 727 ) and STAT3 transcriptional activity are regulated by
mTOR upon IL-6 stimulation and that STAT3 is
required for
IL-6 inhibition of insulin signaling
Ohtani et al., Blood 2008
(Leishmaniasis, Cutaneous) :
Mammalian target of rapamycin and glycogen synthase kinase 3 differentially
regulate lipopolysaccharide induced
interleukin-12 production in dendritic cells
Song et al., Am J Physiol Cell Physiol 2010
(Cardiomegaly...) :
mTOR overexpression
suppressed LPS induced secretion of
IL-6 ( P < 0.001 ), and the mTOR inhibitors rapamycin and PP242 abolished this inhibitory effect of mTOR
Narita et al., Science 2011
:
mTOR recruitment to the TASCC was amino acid- and Rag guanosine triphosphatase dependent, and disruption of mTOR localization to the TASCC
suppressed interleukin-6/8 synthesis
Song et al., J Pharmacol Exp Ther 2011
:
Conversely, down-regulation of DDIT4 with small interfering RNA dampened the capacity of PDTC to block
IL-6 dependent
mTOR activation
White et al., Am J Physiol Endocrinol Metab 2013
(Cachexia...) :
How
IL-6 can
induce suppression of
mTORC1 signaling remains to be established ... The purpose of this study was to examine
mTOR complex 1 (mTORC1) activation and
regulation by
IL-6 during cancer cachexia ...
IL-6 effects on
mTOR activation were examined in Apc ( Min/+ ) mouse skeletal muscle and C2C12 myotubes