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SOST — WNT1

Text-mined interactions from Literome

Winkler et al., J Biol Chem 2005 : We propose that sclerostin and other BMP antagonists do not block Wnt signaling directly
van Bezooijen et al., J Bone Miner Res 2007 : Instead, sclerostin inhibits Wnt signaling that is required for BMP stimulated osteoblastic differentiation ... Transcriptional profiling analysis of osteoblastic cultures indicated that sclerostin specifically affects BMP and Wnt signaling out of many other growth signaling pathways
Kamiya et al., Development 2008 : These findings demonstrate that BMPR1A signaling in osteoblasts restrain endogenous bone mass directly by upregulating osteoclastogenesis through the RANKL-OPG pathway, or indirectly by downregulating canonical Wnt signaling through sclerostin , a Wnt inhibitor and a bone mass mediator
Lin et al., J Bone Miner Res 2009 (Bone Resorption) : We showed that sclerostin selectively inhibited Wnt/beta-catenin in vivo, and sclerostin suppressed the activity of osteoblast and viability of osteoblasts and osteocytes
Kamiya et al., J Bone Miner Res 2010 : We recently reported that osteoblast targeted conditional knockout ( cKO ) of BMP receptor type IA ( BMPRIA ) resulted in increased bone mass during embryonic development, where diminished expression of Sost as a downstream effector of BMPRIA resulted in increased Wnt/beta-catenin signaling ... These results demonstrate that BMPRIA in osteoblasts negatively regulates endogenous bone mass and Wnt/beta-catenin signaling and that this regulation may be mediated by the activities of Sost and Dkk1
Power et al., J Bone Miner Res 2010 (Femoral Neck Fractures...) : By secreting sclerostin , osteocytes may inhibit Wnt signaling and reduce bone formation by osteoblasts
Wu et al., J Clin Invest 2011 (Osteoporosis) : In the absence of Gsa, expression of sclerostin and dickkopf1 (Dkk1), inhibitors of canonical Wnt signaling, was markedly increased ; this was accompanied by reduced Wnt signaling in the osteoblast lineage
Holdsworth et al., J Biol Chem 2012 : A peptide derived from the loop 2 region of sclerostin blocked the interaction of sclerostin with LRP5/6 and also inhibited Wnt1 but not Wnt3A or Wnt9B signaling
Ardawi et al., J Bone Miner Res 2012 (Osteoporosis, Postmenopausal...) : Sclerostin regulates bone formation by inhibiting Wnt pathway signaling
Gaudio et al., J Clin Endocrinol Metab 2012 (Diabetes Mellitus, Type 2...) : The negative association of ß-catenin with sclerostin suggests a biological effect of increased sclerostin on the Wnt signaling, which appears impaired in T2DM
Tamura et al., Clinical calcium 2013 (Wnt Signaling Pathway) : Recently, numerous studies suggest that PTH enhances bone formation through the suppression of sclerostin , DKK1 and sFRP1, inhibitors of Wnt-ß-catenin signal
Włodarski et al., Polish orthopedics and traumatology 2013 : Sclerostin inhibits the Wnt signaling, the main trigger of osteoblasts activity