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ADCY4 — EGF

Text-mined interactions from Literome

Nakagawa et al., Biochem Pharmacol 1991 : Using isolated parotid gland membranes, EGF and bovine galactosyltransferase also stimulated adenylate cyclase ( EC 2.7.4.3 ) activity in a concentration dependent manner
Budnik et al., J Biol Chem 1991 : The epidermal growth factor (EGF) binding sites on bovine luteal cell membrane have been characterized in detail, and evidence has been obtained for a direct stimulatory effect of EGF on membrane associated adenylate cyclase activity ... These results demonstrate that luteal cell adenylate cyclase activity is finely regulated by EGF
Bernier et al., Endocrinology 1991 (Osteosarcoma) : EGF inhibited PTH stimulated adenylate cyclase activity in association with a reduction in PTH receptors and a decrease in the activity of the stimulatory guanyl nucleotide binding protein ( Gs )
Nair et al., J Biol Chem 1990 : Employing antiserum, CS1, generated against a synthetic decapeptide RMHLRQYELL representing the carboxyl terminus of Gs alpha, the involvement of Gs in mediating the effects of EGF on cardiac adenylate cyclase was further investigated
Nair et al., Biochem J 1989 (Second Messenger Systems) : In rat cardiac membranes, EGF also stimulated adenylate cyclase activity in a dose dependent manner, with maximal stimulation ( 35 % above control ) being observed at 10 nM-EGF ... The involvement of a guanine-nucleotide binding protein ( G-protein ) in the activation of adenylate cyclase by EGF was indicated by the following evidence ... First, the EGF mediated stimulation of adenylate cyclase required the presence of the non-hydrolysable GTP analogue, guanyl-5'-yl-imidodiphosphate ( p [ NH ] ppG ) ... Secondly, in the presence of 10 microM-p [ NH ] ppG, the stable GDP analogue guanosine 5'- [ beta-thio ] diphosphate at a concentration of 10 microM blocked the stimulation of the adenylate cyclase by 1 nM- and 10 nM-EGF ... The ability of EGF to stimulate adenylate cyclase was not affected by pertussis-toxin treatment of cardiac membranes ... The experimental evidence in the present paper demonstrates, for the first time, that EGF stimulates adenylate cyclase in rat cardiac membranes through a stimulatory GTP binding regulatory protein, and this effect is manifested in elevated cellular cAMP levels in perfused hearts exposed to EGF
Knecht et al., J Cell Biochem 1983 : FSH-sensitive adenylate cyclase activity, as measured by the conversion of ( 3H ) -ATP to ( 3H ) -cAMP, was inhibited by GnRHa and EGF at 48 h of culture
Budnik et al., Endocrinology 1993 : We report here that pertussis toxin can be used to discriminate between the potentiating effects of EGF and PMA on luteal adenylate cyclase
Iizuka et al., Epithelial Cell Biol 1995 : Similar modulation of the epidermal adenylate cyclase was induced by other adenylate cyclase stimulators ( epinephrine, adenosine and prostaglandin E2 ), but not by bradykinin, thrombin, PAF, or EGF
Stryjek-Kaminska et al., Biochem J 1996 : Isolated pancreatic acinar membranes, which allow access of functional antibodies to individual components of the signal transduction cascade, were used to examine EGF induced regulation of adenylate cyclase activity ... Thus the data of the present study show that EGF regulates adenylate cyclase via activation of Gs and Gi proteins by a tyrosine phosphorylation dependent mechanism in pancreatic acinar membranes
Arimura et al., Life Sci 1998 : An EGF receptor mediated signal attenuates the inhibitory effect of LPA on an adenylate cyclase activity