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MYC — SETD2

Text-mined interactions from Literome

Doe et al., Cancer Res 2012 (Breast Neoplasms...) : Here we show that overexpression of Myc significantly stabilizes the a subunit of HIF1 ( HIF1a ) under normoxic conditions and enhances HIF1a accumulation under hypoxic conditions in cells ... Posttranscriptional regulation of HIF1a by Myc led to the induction of HIF1a gene targets ... Normoxic HIF1a protein expression was also dependent on Myc ... Myc dependent stabilization of HIF1a involved either disruption of binding to the VHL complex or posttranslational protein modifications
Chen et al., Biochem Biophys Res Commun 2013 (Colonic Neoplasms...) : We found that the overexpression of c-Myc in colon cancer cells could promote the expression of HIF-1a and that of vascular endothelial growth factor ... The results revealed c-Myc dependent regulation of HIF-1a instead of HIF-1a dependent c-Myc regulation for the first time