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BCL10 — MAPK8
Text-mined interactions from Literome
Bodero et al., Biochem Biophys Res Commun 2003
(MAP Kinase Signaling System) :
UV-light induces p38
MAPK dependent phosphorylation of
Bcl10
Quadros et al., Cancer Biol Ther 2006
(Carcinoma, Squamous Cell) :
This effect is due, in part, to sustained
MAPK dependent
Bcl-xL expression
Alfano et al., J Biol Chem 2006
:
Accordingly, incubation of retinal pigment epithelial cells with uPA elicits a time dependent enhancement of
MAPK and phosphatidylinositol 3-kinase activities as well as the transcriptional
activation of
Bcl-xL anti-apoptotic factor
Chen et al., Toxicology 2009
(Neuroblastoma) :
SB202190 ( p38
MAPK inhibitor ) and SP600125 ( JNK inhibitor )
attenuated mitochondrial depolarization, degradation of
Bcl-2/Bcl-xL , and mitochondrial translocation of Bax
Chen et al., J Cell Physiol 2010
(Neuroblastoma) :
Moreover, phospho-p38
MAPK and phospho-JNK were proved to be involved in Bcl-xL degradation, and overexpression of
Bcl-xL attenuated the cytotoxic effect of notexin
Chen et al., Chem Biol Interact 2010
:
Nitrosative stress induces osteoblast apoptosis through downregulating
MAPK mediated NFkappaB/AP-1 activation and subsequent
Bcl-X ( L ) expression
Zhao et al., Brain Res 2013
(Brain Edema...) :
In addition, we found SB203580 significantly decreased P-p38
MAPK levels, and
inhibited HPC induced mitochondria translocation of
Bcl-xL in the brain of HPC and MCAO treated mice