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TLR4 — TP53

Text-mined interactions from Literome

Shatz et al., Cancer Res 2012 (Adenocarcinoma...) : The effect of DNA stressors on TLR expression was mainly mediated by p53 , and several p53 cancer associated mutants dramatically altered the pattern of TLR gene expression ... In all cell lines tested, TLR3 induction was p53 dependent , whereas induction of TLR9, the most stress-responsive family member, was less dependent on status of p53
Menendez et al., Curr Opin Oncol 2013 (Neoplasms) : Activation of p53 by common antitumor agents results in p53 dependent regulation of expression of most TLR genes in human primary and cancer cell lines, resulting in modulation of TLR downstream responses to cognate ligands ... In addition several tumor associated p53 mutants can also affect TLR gene expression