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PTGS2 — TLR4

Text-mined interactions from Literome

Rhee et al., J Biol Chem 2000 : However, the truncated form ( delta Tlr4 ( P712H ) ) of the missense mutant Tlr4 ( P712H ) found in LPS-hyporesponsive mouse strain ( C3H/HeJ ) inhibits LPS induced NF kappa B activation and COX-2 expression
Lee et al., J Biol Chem 2001 (Adenocarcinoma...) : UFAs inhibit COX-2 expression induced by SFAs, constitutively active Tlr4 , or LPS
Jimenez et al., Proc Natl Acad Sci U S A 2005 : The effects of S. aureus on cyclooxygenase-2 expression were TLR2- and not TLR4 dependent
Fukata et al., Gastroenterology 2006 (Colitis...) : Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling : Role in proliferation and apoptosis in the intestine
Youn et al., Biochem Biophys Res Commun 2006 : Our results demonstrated that auranofin suppressed TLR4 mediated activation of transcription factors, NF-kappaB and IRF3, and expression of COX-2 , a pro-inflammatory enzyme
El-Achkar et al., American journal of physiology. Renal physiology 2007 (Sepsis) : Because Cox-2 is one of the downstream products of TLR4 activation, we hypothesized that sepsis induced changes in renal Cox-2 expression are TLR4 dependent ... The TLR4 dependent Cox-2 expression is mostly restricted to cortical and medullary thick ascending loops of Henle that characteristically express and secrete Tamm-Horsfall protein
Fukata et al., Gastroenterology 2007 (Chronic Disease...) : Mechanistically, we show that TLR4 is responsible for induction of Cox-2 , increased prostaglandin E ( 2 ) production, and activation of EGFR signaling in chronic colitis
Xu et al., Respir Res 2008 (Haemophilus Infections...) : The roles of Toll-like receptor (TLR) 2 and TLR4 , well known NTHi recognizing receptor in lung epithelial cell and gram negative bacteria receptor, respectively, on the NTHi induced COX-2 expression were investigated in the HEK293 cells overexpressing TLR2 and TLR4 in vitro and in the mouse model of NTHi induced pneumonia by using TLR2 and TLR4 knock-out mice in vivo
Moses et al., J Leukoc Biol 2009 (Inflammation...) : TLR4 mediated Cox-2 expression increases intestinal ischemia/reperfusion induced damage
Zheng et al., Gastroenterology 2009 (Colitis...) : The protective component of the host response to dextran sodium sulfate (DSS) induced colitis in the mouse is mediated through the activation of Toll-like receptor (TLR) 4 , the induction of cyclooxygenase (COX)-2 , and prostaglandin E ( 2 ) production
Lin et al., Mol Immunol 2010 : Nevertheless TLR mediated JNK activation as well as the increased protein expression of iNOS and COX-2 remained unchanged when Syk protein was knockdown by siRNA approach
Bernard et al., J Immunol 2010 : We hypothesized that Cox-2 is induced by TLR activation and is necessary for optimal AMP production, and that inhibitors of Cox-2 may therefore inhibit antimicrobial action
Shweash et al., Mol Immunol 2011 (Leishmaniasis) : Leishmania mexicana promastigotes inhibit macrophage IL-12 production via TLR-4 dependent COX-2 , iNOS and arginase-1 expression ... Induction of COX-2 and iNOS was also TLR-4 dependent ... These data demonstrate for the first time the role of TLR-4 in mediating the effects of L. mexicana promastigotes on MAP kinase activation, up-regulation of COX-2 , iNOS as well as arginase-1 expression in macrophages and further shows that PGE ( 2 ), NO and arginase activity all contribute substantially to the inhibition of host cell IL-12 production
Chen et al., Cell Microbiol 2011 : The effect of J96-1 on 5637 cell signalling and COX-2 expression is mediated by Toll-like receptor (TLR)-4
Küper et al., American journal of physiology. Renal physiology 2012 : Enhanced COX-2 expression and activity in the presence of LPS was diminished by TLR4 inhibition ... In conclusion, these results propose that LPS mediates enhanced COX-2 expression in IMCD cells by 1 ) TLR4 mediated activation of the NF-?B signaling pathway, 2 ) TLR4 dependent release of TGF-a with subsequent activation of the EGFR and downstream MAPKs p38 and ERK1/2, and 3 ) TLR4 mediated, EGFR independent activation of JNK that negatively regulates NF-?B activation
Connor et al., Exp Mol Pathol 2013 (Endotoxemia) : Conversely, in lung macrophages, loss of functional TLR4 resulted in increased expression of COX-2 protein and 12/15-LOX mRNA
Joseph et al., Biol Reprod 2013 (Inflammation) : Previously we reported the expression of prostaglandin-endoperoxide synthase 2 ( PTGS2 ), also known as cyclooxygenase 2 (COX-2), in human vaginal cells in response to toll-like receptor ( TLR ) ligands and other proinflammatory stimuli
Wu et al., PloS one 2013 : We showed that the hADSCs expressed Toll-like Receptors (TLR) 1, TLR2, TLR3, TLR4 , and TLR6 and that lipopolysaccharide (LPS) significantly induced the production of pro-inflammatory cytokines ( Cyclooxygenase-2 (Cox-2) , Interleukin-1ß (IL-1ß), Interleukin-6 (IL-6), and Interleukin-8 (IL-8) )