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IL17D — TLR4

Text-mined interactions from Literome

Molle et al., J Immunol 2007 : IL-27 synthesis induced by TLR ligation critically depends on IFN regulatory factor 3 ... We then show that IL-27 serum levels are dramatically reduced in IRF3 ( -/- ) upon LPS injection, indicating a critical role for IRF3 in TLR4 mediated IL-27 production in vivo
Siegemund et al., Immunobiology 2007 : Using BMDC originating from wild-type ( wt ), TLR2 ( def ) and TLR4 ( def ) mice, we show that in BMDC the induction of IL-12, IL-23, and IL-27p28 by SE is dependent on TLR4 , whereas low-level production of p40 is also mediated by pattern recognition receptors ( PRR ) other than TLR4
Molle et al., J Immunol 2010 : Critical role of the IFN stimulated gene factor 3 complex in TLR mediated IL-27p28 gene expression revealing a two-step activation process ... Thus, in response to TLR4 or TLR3 ligation, the initial induction of the IL-27p28 gene depends on the recruitment of IRF1 and IRF3, whereas transcriptional amplification requires recruitment of the IFN stimulated gene factor 3 complex