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HSPD1 — TLR4

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of LY96-TLR4 → HSPD1 (increases) Vabulas et al., J Biol Chem 2001*
  Evidence: Human fibroblasts transfected with TLR2 or TLR4 plus MD-2 gain responsiveness to HSP60, while TLR2- or TLR4-defective cells display impaired responses.
• KEGG Tuberculosis: HSPD1 → TLR4 (protein-protein, activation)
• NCI Pathway Database Endogenous TLR signaling: HSP60/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-HSPD1-MYD88-TIRAP) → HSP60/TLR4/MD2 (dimer) complex (TLR4-LY96-HSPD1) (modification, collaborate)
  Cohen-Sfady et al., J Immunol 2005
  Evidence: mutant phenotype
• NCI Pathway Database Endogenous TLR signaling: HSP60/TLR4/MD2 (dimer)/MYD88/TIRAP complex (TLR4-LY96-HSPD1-MYD88-TIRAP) → MYD88/TIRAP complex (MYD88-TIRAP) (modification, collaborate)
  Cohen-Sfady et al., J Immunol 2005
  Evidence: mutant phenotype
• NCI Pathway Database Endogenous TLR signaling: HSP60/TLR4/MD2 (dimer) complex (TLR4-LY96-HSPD1) → MYD88/TIRAP complex (MYD88-TIRAP) (modification, collaborate)
  Cohen-Sfady et al., J Immunol 2005
  Evidence: mutant phenotype
• NCI Pathway Database Endogenous TLR signaling: CD14 (CD14) → HSP60/TLR4/MD2 (dimer) complex (TLR4-LY96-HSPD1) (modification, activates)
  Ohashi et al., J Immunol 2000*, Flohé et al., J Immunol 2003*, Cohen-Sfady et al., J Immunol 2005, Kim et al., Circ Res 2009*
  Evidence: mutant phenotype
• NCI Pathway Database Endogenous TLR signaling: TLR4/MD2 complex (LY96-TLR4) → HSP60/TLR4/MD2 (dimer) complex (TLR4-LY96-HSPD1) (modification, collaborate)
  Ohashi et al., J Immunol 2000*, Flohé et al., J Immunol 2003*, Cohen-Sfady et al., J Immunol 2005, Kim et al., Circ Res 2009*
  Evidence: mutant phenotype
• NCI Pathway Database Endogenous TLR signaling: TLR4/MD2 complex (LY96-TLR4) → HSP60 (HSPD1) (modification, collaborate) Ohashi et al., J Immunol 2000*, Flohé et al., J Immunol 2003*, Cohen-Sfady et al., J Immunol 2005, Kim et al., Circ Res 2009*
  Evidence: mutant phenotype
• NCI Pathway Database Endogenous TLR signaling: HSP60/TLR4/MD2 (dimer) complex (TLR4-LY96-HSPD1) → HSP60 (HSPD1) (modification, collaborate) Ohashi et al., J Immunol 2000*, Flohé et al., J Immunol 2003*, Cohen-Sfady et al., J Immunol 2005, Kim et al., Circ Res 2009*
  Evidence: mutant phenotype

Text-mined interactions from Literome

Sasu et al., Circ Res 2001 (Chlamydophila Infections) : Together these results indicate that C pneumoniae and chlamydial hsp60 are potent inducers of human VSMC proliferation and that these effects are mediated , at least in part, by rapid TLR4 mediated activation of p44/p42 MAPK
Ueki et al., Clin Exp Immunol 2002 (Chronic Disease...) : The activity of hsp60 was inhibited by anti-CD14 and anti-Toll-like receptor 4 (TLR4) antibodies, suggesting that both CD14 and TLR4 mediate hsp60 signalling
Equils et al., J Immunol 2006 (Chlamydia Infections...) : Chlamydia heat shock protein 60 induces trophoblast apoptosis through TLR4
Kim et al., Bone 2009 (Bone Resorption) : Furthermore, Western blotting showed that HSP60 up-regulated TLR-2 and TLR-4 expression, and pretreatment with blocking antibodies for TLR-2 and TLR-4 almost completely eliminated the effects of HSP60 on apoptosis, caspase-3 and -9 activation, and activation of NFkappaB and p38 MAPK
Bulut et al., Infect Immun 2009 (Pneumonia, Bacterial) : Heat shock protein 60 derived from Chlamydia pneumoniae ( cHSP60 ) activates Toll-like receptor 4 (TLR4) signaling through the MyD88 pathway in vitro, but it is not known how cHSP60 contributes to C. pneumoniae induced lung inflammation