Zhang et al., Life Sci 2012
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As an endogenous ligand of TLR4, HMGB1 activates TLR4 signaling in HSCs to enhance their inflammatory phenotype, indicating that TLR4 signaling need not rely solely on gut derived LPS for activation during liver injury
Zhang et al., Zhonghua Gan Zang Bing Za Zhi 2012
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[HMGB1 mediated activation of TLR4 signaling in hepatic stellate cells ] ... As an endogeous ligand of TLR4, HMGB1 may activate TLR4 signaling and the TLR4 mediated inflammatory response of HSC