Sabroe et al., Immunology 2005
:
CXCR1 and CXCR2 were down-regulated by TLR engagement
Alves-Filho et al., Nat Med 2010
(Sepsis) :
Furthermore, we show that IL-33 reverses the TLR4 induced reduction of CXCR2 expression in neutrophils via the inhibition of expression of G protein coupled receptor kinase-2 ( GRK2 ), a serine-threonine protein kinase that induces internalization of chemokine receptors
Kunii et al., Immunobiology 2011
:
Collectively, it is suggested that commensals promote migration of mast cells into the intestine through the induction of CXCR2 ligands from IECs in a TLR dependent manner