Gene interactions and pathways from curated databases and text-mining

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CD14 — TLR4

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Filipp et al., Proc Natl Acad Sci U S A 2001 : sCD14 mediated cellular activation does not require membrane CD14 expression, depends on a region of CD14 that is not involved in lipopolysaccharide binding, and requires functional Toll-like receptor 4
Hijiya et al., Pathobiology 2002 : These results show that TLR4 in the presence of soluble CD14 plays a major role in the signaling of LPS in endothelial cells of larger vessels
Farnell et al., Dev Comp Immunol 2003 : Oxidative burst mediated by toll like receptors ( TLR ) and CD14 on avian heterophils stimulated with bacterial toll agonists
Chen et al., J Leukoc Biol 2004 : When the effect of lipopolysaccharide contamination is abrogated, Hsp65 is unable to activate Toll-like receptor (TLR)4 in the presence of CD14 and MD2
Feng et al., Hepatobiliary Pancreat Dis Int 2003 : The expressions of CD14 and TLR4 in KCs induced by LPS were markedly increased in a dose dependent manner ( 10 mg/L-1 microg/L ) or in a time dependent manner ( 0.5 h-24 h ), with the peaked expression of CD14 at 3-6 hours
Hirata et al., J Clin Endocrinol Metab 2005 : We further showed that EECs, not ESCs, required soluble CD14 for TLR4 activation
Lucarelli et al., Eur Cytokine Netw 2004 : On the other hand, TLR9 expression was decreased by SiO ( 2 ) nano-particles, and expression of the co-receptor CD14 was inhibited by Co nanoparticles
Coats et al., J Immunol 2005 : Activation of the TLR4 signaling complex requires the coordinated function of LPS binding protein (LBP), CD14 , MD-2, and TLR4
Botero et al., J Endod 2006 : These results demonstrate that odontoblast-like cells express CD14 and TLR4, and that LPS induced VEGF expression is mediated , at least in part, by TLR4 signaling
Balachandran et al., Int Immunopharmacol 2006 : Similarly, NF-kappa B directed luciferase expression was enhanced by Immulina treatment when cells were co-transfected with vectors expressing proteins supporting TLR2- ( CD14 and TLR2 ) but not TLR4- ( CD14, TLR4, and MD-2 ) dependent activation
Cuschieri et al., Surg Infect (Larchmt) 2007 : Assembly and activation of the TLR4 receptor following LPS binding to CD14 requires the production of ceramide by acid sphingomyelinase
Whitaker et al., Infect Immun 2008 (Leishmaniasis) : Activation by P8 PGLC does not occur in the presence of TLR4 alone and requires both CD14 and myeloid differentiation protein 2 for signaling ; this requirement may be responsible for the limited TLR4 response
Lizundia et al., Innate Immun 2008 : Our findings suggest that human and bovine RSV may activate human and bovine TLR4 receptors, respectively, in the presence of both MD2 and CD14
Roncon-Albuquerque et al., Life Sci 2008 (Fatty Liver...) : These results suggest that CD14 mediated TLR activation might contribute to the cardiovascular and metabolic complications of obesity
Peri et al., Biochem Soc Trans 2010 : Small molecules developed by our group are described that inhibit LPS stimulated TLR4 activation by selectively targeting the LPS-CD14 interaction
Jia et al., Shanghai Kou Qiang Yi Xue 2011 : CD14, TLR4 receptors are involved in P.e-LPS effect and CD14 , TLR2 and TLR4 receptors are involved in P.g-LPS effect in mouse osteoblast ... CD14, TLR4 receptors are involved in P.e-LPS effect and CD14 , TLR2 and TLR4 receptors are involved in P.g-LPS effect in mouse osteoblast
Rallabhandi et al., mBio 2012 (Respiratory Syncytial Virus Infections) : Toll-like receptor 4 (TLR4) , a signaling receptor for structurally diverse microbe associated molecular patterns, is activated by the RSV fusion ( F ) protein and by bacterial lipopolysaccharide (LPS) in a CD14 dependent manner
Zheng et al., Int Immunopharmacol 2012 (Drug-Induced Liver Injury) : We also found that GalN treatment induced TLR4 and CD14 mRNA expression, and LMW significantly inhibited CD14 mRNA expression
Guo et al., Am J Pathol 2013 : In conclusion, these studies show for the first time that LPS causes an increase in intestinal permeability via an intracellular mechanism involving TLR-4 dependent up-regulation of CD14 membrane expression
Zhou et al., Brain Res 2013 (Brain Ischemia...) : The expression of CD14 , a co-receptor of TLR4, was induced by MCAO, while the expression of TLR4 remained unchanged
Kim et al., Mol Med 2013 : We demonstrate that optimal HMGB1 dependent TLR4 activation in vitro requires the coreceptor CD14
Lei et al., J Med Primatol 2013 : Toll-like receptor ( TLR ) stimulation significantly increased IDO protein level in CD14 ( + ), CD56 ( + ), CD1c ( + ), CD11c ( + ), and CD123 ( + ) myeloid cells