Fukata et al., J Biol Chem 1999
:
The coexpression of dominant active Cdc42 with IQGAP1 suppressed the dissociation of alpha-catenin from the cadherin-catenin complex induced by the overexpression of IQGAP1 in L cells expressing E-cadherin ( EL cells )
Sugimoto et al., J Hum Genet 2001
(Stomach Neoplasms) :
IQGAP1 has been reported to encode a ras GAP related protein, and its interaction with cadherin and/or beta-catenin induces a dissociation of beta-catenin from the cadherin-catenin complex, one of the mechanisms for cell-cell adhesion