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CDH18 — IGF2

Text-mined interactions from Literome

Morali et al., Oncogene 2001 : We can show that ( 1 ) IGF-II induces a rapid epithelium to mesenchymal transition ; ( 2 ) IGF1R, the receptor for IGF-II, belongs to the same membrane complex as E-cadherin and beta-catenin ; ( 3 ) IGF-II induces a redistribution of beta-catenin from the plasma membrane to the nucleus and an intracellular sequestration and degradation of E-cadherin ; ( 4 ) IGF-II induces the transcription of beta-catenin/TCF-3 target genes
Pennisi et al., Cancer Res 2002 (Breast Neoplasms...) : Our findings strongly suggest that the IGF-IR plays a role in the stabilization of the E-cadherin-catenin complex, thereby providing one possible explanation for the association between low levels of IGF-IR and a higher risk of mammary tumor metastasis