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CDH18 — HDAC2

Text-mined interactions from Literome

Yamaguchi et al., Cancer Sci 2010 (Gallbladder Neoplasms) : In TGBC2TKB cells, the expression of EZH2 and HDAC1/2 were decreased by SAHA treatment, and p16(INK4a), E-cadherin , and p21were simultaneously activated ; however, no such findings were obtained in HGECs, suggesting that the effect of SAHA depends on the EZH2 mediated tumor suppressor loss
Huang et al., Mol Pharmacol 2011 : This finding, together with the HDAC inhibitor induced up-regulation of KLF4 and E-cadherin , suggests that HDAC inhibitors could activate the expression of these genes through changes in histone methylation status
Iordache et al., International journal of molecular sciences 2012 : RT-PCR assay showed that HDAC inhibitors down-regulated the expression of endothelial genes such as VE-cadherin , CD133, CXCR4 and Tie-2