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APC — CDH18
Text-mined interactions from Literome
Tselepis et al., Digestion 2000
(Adenocarcinoma...) :
Progression along this pathway is characterized by changes in intercellular adhesion, in particular, loss of
adenomatous polyposis coli ,
reduced cadherin expression and increased catenin phosphorylation resulting in its nuclear translocation
Malarkannan et al., J Immunol 2012
:
This includes actin polymerization, tubulin multimerization, microtubule organizing center formation, calcium/calmodulin signaling, Pak/Raf/Mek1/2 mediated Erk1/2 activation, formation of maestrosome,
E-cadherin , and CD44 mediated signaling and glycogen synthase
kinase-3/adenomatous polyposis coli mediated ß-catenin
activation