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MTOR — RAC1

Pathways - manually collected, often from reviews:

• NCI Pathway Database mTOR signaling pathway: RAC1/GTP complex (RAC1) → mTORC2 complex (MTOR-MLST8-RICTOR-MAPKAP1-PRR5) (regulation of actin cytoskeleton organization, collaborate)
  Sarbassov et al., Curr Biol 2004, Jacinto et al., Nat Cell Biol 2004
  Evidence: mutant phenotype
• WikiPathways Target Of Rapamycin (TOR) Signaling: Complex of MLST8-MTOR-MAPKAP1-RICTOR → RAC1 (activation)

Text-mined interactions from Literome

Hernández-Negrete et al., J Biol Chem 2007 : Rapamycin, a widely used inhibitor of mTOR signaling , did not inhibit Rac activity and cell migration induced by leucine, indicating that P-Rex1, which we found associated to both mTOR complexes, is only active when in the mTORC2 complex
Dunaway et al., Mol Cell Biol 2011 : Slit2 stimulates angiogenesis through mTORC2 dependent activation of Akt and Rac GTPase, the activities of which are inhibited in the presence of ephrin-A1
Saci et al., Mol Cell 2011 : Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size ... Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size
Wei et al., Cell Physiol Biochem 2013 : Moreover, both Rac1-GTPase overexpression and activation of mTOR by phosphatidic acid drastically blocked simvastatin induced autophagosome formation in CAMs